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8153426 |
Preparation of antigen-presenting human gamma-delta T cells and use in immunotherapy
The invention relates to a method for the preparation of efficient antigen-presenting human γδ T cells, to the γδ T cells prepared by such a method, and to their use in immunotherapy, vac...
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8133728 |
Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease
Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial...
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8129185 |
Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses
Based upon a strong correlation between regulator T cells (Treg cells) and suppressing or preventing a cytotoxic T cell response, provided are methods for the production of ex vivo activated and...
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8124069 |
Immunogenic peptides
The invention provides relatively short immunogenic peptides, and biologically active variants thereof, associated with leukemia which elicit an immune response. Nucleic acids encoding the...
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8124408 |
Preparation of inactivated artificial antigen presenting cells and their use in cell therapies
Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their...
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8119401 |
IL-10 gene transfer to peripheral mononuclear cells
The present invention to methods for producing mononuclear cells overexpressing IL-10. The method comprises the ex vivo introduction of an expression construct comprising a nucleotide sequence...
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8080416 |
Method for determining the immunogenicity of an antigen
The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic...
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8076133 |
Method for obtaining antigen-specific Tr1 regulatory lymphocytes
The invention relates to a method for preparing antigen-specific Tr1 regulatory lymphocytes. The inventive method involves the use of artificial antigen-presenting cells expressing a molecule from...
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8076134 |
CD4+CD25− T cells and Tr1-like regulatory T cells
The invention provides CD4+CD25− T cells and Tr1-like regulatory T cells (i.e., contact-independent Type 1-like regulatory T cells), processes for their production and their use for regulatory p...
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8076135 |
Method of preparing a treatment effective amount of allogeneic T-cells
Ex-vivo prepared T-cells are harvested from cell culture conditions and formulated in medium suitable for infusion. The formulation is made by labeling the cells with one or more agents which have...
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8071373 |
Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic...
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8071374 |
Methods for preparing T-cells for cell therapy
T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more...
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8053235 |
Methods of generating antigen-specific CD4+CD25+regulatory T cells, compositions and methods of use
The present invention provides methods for generating mammalian T cell populations comprising antigen-specific CD4+CD25+ regulatory T cells from freshly isolated CD4+CD25− T cells. The method c...
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8034334 |
Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy
A method of promoting the regression of a cancer in a mammal comprising: (i) administering to the mammal nonmyeloablative lymphodepleting chemotherapy, and (ii) subsequently administering: (a)...
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8017110 |
Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process...
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8017730 |
T cell receptors which specifically bind to VYGFVRACL-HLA-A24
The present invention provides isolated T cell receptors (TCRs) having the property of specifically binding to the VYGFVRACL (SEQ ID NO:1)-HLA-A24 peptide-MHC. Such TCRs are useful, either alone or...
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8012470 |
Method for ex vivo immunization using heterologous intact bispecific and/or trispecific antibodies
According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of: a) isolating autologous tumor cells;b) treating the tumor...
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8012750 |
T-cell activation device
A biodegradable device for activating T-cells includes a biodegradable support and a binder attached to the biodegradable support, the binder having reactivity to one or more agents capable of...
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7998736 |
Adoptive immunotherapy with enhanced T lymphocyte survival
The invention provides for compositions, e.g., pharmaceutical compositions, comprising a T lymphocyte, or a population thereof, expressing at least one recombinant polynucleotide encoding a...
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7998681 |
Diagnosis and therapy of antibody-mediated inflammatory auto-immune disorders
The present invention describes diagnosis and treatment of antibody-mediated inflammatory auto-immune diseases. The biochemical mechanisms underlying such disorders are described as characteristic...
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7977095 |
Generation and isolation of antigen-specific T cells
The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods...
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7972848 |
Isolation and identification of cross-reactive T cells
Cross-reactive T cells recognizing both MBP93-105 and HHV-61-13 peptides represent a significant subset of T cells with some degree of TCR degeneracy. It appears that the recognition of the...
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7968097 |
Identification of Hla-A2-presented T-cell epitopes derived from the oncofoetal antigen-immature laminin receptor protein and uses thereof
The present invention relates to the immunotherapB of cancer, in particular several tumor entities including hematological malignancies. The present invention relates to tumor-associated T-helper...
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7960175 |
Process for producing human-origin immunocompetent cell
It is an object of the present invention to provide an immunodeficient animal capable of generating human-derived lymphoid cells, a human-derived lymphoid cell, and a method for producing a human...
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7939321 |
TADG-15: an extracellular serine protease overexpressed in carcinomas
The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression...
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7919265 |
Antibody-based method for isolating Th1 and Th2 helper lymphocytes from human peripheral blood
A negative isolation method for separately isolating preparations of Th1 and Th2 helper lymphocytes from peripheral blood mononuclear cells involving the use of novel combinations of monoclonal...
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7910368 |
Method of extended culture for antigen-specific cytotoxic lymphocytes
The present invention is a method for inducing cytotoxic T cell having an antigen-specific cytotoxic activity, a method for maintaining the cell, a method for continuously culturing the cell or a...
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7901673 |
Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process...
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7901902 |
Methods and compositions for identifying a cellular immune response against prostate cancer
Filamin-B peptides, compositions comprising such peptides, and methods of using such peptides to assess an immune response against such peptides are described. An immune response against the...
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7892828 |
Method of identifying a MHC class I restricted T cell response
Described are peptides and polypeptides derived from the MUC-1 polypeptide which are able to activate Cytotoxic T Lymphocyte (CTL) response, analogues of such peptides and polypeptides nucleotide...
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7884184 |
Regulatory T cell epitopes, compositions and uses thereof
The invention is directed to T cell epitopes wherein said epitopes comprises a peptide or polypeptide chain comprising at least a portion of an immunoglobulin constant or variable region. The...
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7867488 |
Use of dendritic cells (DCs) expressing interleukin 12 (IL-12)
The present invention discloses the use of active dendritic cells (DCs) releasing interleukin 12 (IL-12) which are loaded with an antigen against a specific pathogen or a specific tumor and, due to...
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7829331 |
Use of urea-adjuvated polypeptides for diagnosis, prophylaxis and treatment
The invention relates to a method for infiltration of polypeptides in cells. The invention further relates to the use of the cells and urea-adjuvated polypeptides for the diagnosis, treatment or...
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7816134 |
Method of extensive culture of antigen-specific cytotoxic T cells
The present invention provides methods for inducing, maintaining and expanding CTL (cytotoxic T cell) having an antigen-specific cytotoxic activity at a high level, which is useful in the adoptive...
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7811816 |
Isolated CD8 +T lymphocytes specifically cytotoxic for a disease causing target cell
Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial...
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7731953 |
Methods for use of TSLP and agonists and antagonists thereof
Methods are disclosed herein for specifically inducing proliferation of CD4+ T cells. The methods are of use in treating immunodeficiencies, such as an immunodeficiency produced by infection with...
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7723111 |
Activated dual specificity lymphocytes and their methods of use
The present invention relates to preventive, therapeutic, and diagnostic compositions and methods employing lymphocytes having T-cell receptors and chimeric receptors. In particular, the invention...
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7722862 |
Regulatory T cells suppress autoimmunity
The invention provides methods for producing an autoantigen-specific regulatory T cell enriched composition, and resultant compositions and methods of use.
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7718196 |
Rapamycin-resistant T cells and therapeutic uses thereof
Methods for generating highly enriched Th1/Tc1 and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug,...
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7718356 |
Heteroduplex tracking assay
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown...
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7713688 |
Methods and compositions for depleting specific cell populations from blood tissues
The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even...
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7678571 |
Procedure for the large-scale T-lymphocytes culture in a homogeneous system
The present invention refers to a procedure for the large-scale amplification of human lymphocytic cell lines for therapeutic use, consisting of a homogeneous culture system. The claimed invention...
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7678572 |
Methods for preparing T-cells for cell therapy
T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more...
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7575925 |
Cell preparations comprising cells of the T cell lineage and methods of making and using them
The invention relates to cell preparations comprising cells of the T cell lineage, methods for preparing same, and uses of the cell preparations.
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7572631 |
Activation and expansion of T cells
The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of...
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7514537 |
Chimeric immunoreceptor useful in treating human gliomas
The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region cap...
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7494806 |
Retroviral vectors expressing exogenous gene or exogenous nucleic acid sequences
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial...
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7491534 |
Methods for altering cell fate to generate T-cells specific for an antigen of interest
The invention provides methods for altering the expression profile of a cell to convert the cell from one cell type to a desired cell type (e.g., T-cells). These reprogrammed cells may be used in a...
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7476535 |
TRP2 isoform TRP2-6b containing HLA-A2 restricted epitopes
The present invention relates to a new and potent tumor antigen capable of causing T cells to elicit an immune response and methods of its use in the detection, prevention, and treatment of cancer,...
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7446191 |
DNA construct encoding CE7-specific chimeric T cell receptor
Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular...
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