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6146890 |
Method and system for cultivating macrophages
A method of cultivating macrophages from blood, including collecting a quantity of blood, fractionating the quantity of blood into a plasma fraction, a white blood cell fraction generally including...
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6146827 |
Rath genes and polypeptides and methods for the treatment and diagnosis of immune disorders
The present invention relates, first, to the identification of novel nucleic acid molecules, termed RATH genes and RATH gene products encoded by such nucleic acid molecules, or degenerate variants...
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6146888 |
Method of enriching for mammalian stem cells
Mammalian stem cells are obtained and maintained in vitro whose genome has at least one nucleic acid construct encoding an antibiotic resistance gene operatively linked to a promoter specific for...
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6136306 |
Method for treating tumors
A method is provided for treatment of a mammalian patient having a tumor by administering to the patient allogenic donor lymphocytes that have been co-cultured in the presence of the...
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6136952 |
Human jagged polypeptide, encoding nucleic acids and methods of use
The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have...
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6129912 |
Polyethylene glycol-protein compositions which reduce the antigenic display of red blood cells
The present invention provides a composition of matter, comprising a red blood cell coated a polymeric mixture of polyethylene glycol and albumin. Also provided is a method of blocking blood group...
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6130087 |
Methods for generating cytotoxic T cells in vitro
The present invention provides methods for generating antigen-reactive cytotoxic T cells in vitro comprising culturing immune cells and antigenic cells that have at least one MHC allele in common...
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6121044 |
Potent antigen presenting cell composition
A method of obtaining a blood-cell fraction enriched for potent antigen presenting cells is disclosed. The method includes obtaining a monocyte-depleted lymphocyte fraction, culturing the cell...
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6114167 |
Ribozymes targeting the MoMLV PSI packaging sequence and the HIV tat sequence
A cell comprising a synthetic non-naturally occurring oligonucleotide compound comprises nucleotides whose sequence defines a conserved catalytic region and nucleotides whose sequence hybridizes...
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6114306 |
Cytokine related to hemolytic anemia and method of use
Pyruvate kinase deficiency is a blood disease characterized by hemolytic anemia. PCR analysis of cDNA leukocytic extracts of patients with hereditary pyruvate kinase deficiency anemia revealed two...
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6114113 |
High efficiency genetic modification method
A method is provided for producing a population of genetically modified T cells. In the method, an in vitro population of T cells is activated by contacting said population with a CD3 binding...
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6096540 |
Differentiation of granulocytic and monocytic progenitor cells
The present invention demonstrates that M-CSF responsiveness and the M-CSFR expression can be used to discriminate monocytic and granulocytic cells within a population of cells which strongly...
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6093381 |
Modulation of the sensitivity of tumor cells to chemotherapeutics
Disclosed is a method for improving the treatment of a cancer patient which is undergoing (adjuvant) chemotherapy. Prior to or concomitant with the patient receiving adjuvant chemotherapy, the...
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6093533 |
Method of measuring bone resorption activity with a highly enriched population of prefusion osteoclast cells
Methods of obtaining enriched populations of osteoclast precursor cells which can be released from tissue culture dishes and used for biochemical studies are described. Osteoblastic cells and bone...
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6090625 |
Method of increasing the relative number of CD34.sup.+ cells in a cell population
A method of increasing the relative number of CD34 + cells in a cell population is described. The method comprises contacting the cell population with an agent that causes the relative number of...
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6090602 |
Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent
An antiretroviral composition for inhibiting the action of reverse transcriptase include a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose....
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6087178 |
Method for down regulating CD4 expression in a T cell
Medicaments and methods of using the same are disclosed for treating or preventing diseases resulting from undesirable cell adhesion of IL-1 receptor positive cells to biological materials,...
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6086900 |
Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes
The present invention provides methods and compositions delivery of agents into the cytoplasm of cells. Particularly, it concerns the use of membrane-penetrating toxin proteins to deliver drugs to...
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6083725 |
Tranfected human cells expressing human α-galactosidase A protein
A therepeutic method whereby an individual suspected of having an α-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to...
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6083720 |
Dodecahedral adenoviral protein complex, composition containing same and uses thereof
A native or recombinant adenoviral protein complex, a pharmaceutical composition containing said protein complex, and the uses thereof for treating and preventing human and animal diseases, are...
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6083751 |
Chimeric receptors for the generation of selectively-activatable TH-independent cytotoxic T cells
The invention provides cytotoxic T lymphocytes that express a chimeric cell surface receptor. The chimeric receptor enables the lymphocytes to become activated and to proliferate (via a T H ...
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6077708 |
Method of determining progenitor cell content of a hematopoietic cell culture
The invention provides a method of determining the content of progenitor cells in a hematopoietic cell culture. The method comprises measuring one or more metabolic parameters of the culture, such...
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6077519 |
Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients
Methods are provided for eluting peptides that are bound to major histocompatibility complex ("MHC") molecules expressed on the cell surfaces of viable cells that have at least one MHC-peptide...
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6074639 |
Ex vivo expansion of hematopoietic cells using interleukin-3 (IL-3) variant fusion proteins
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
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6074836 |
Method of marking eukaryotic cells
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6071422 |
Particle separation method and apparatus
An apparatus and method are disclosed for filtering or separating particles. The apparatus has a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A...
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6068836 |
Cell compositions for use in transplantation
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6069296 |
Regulators of G-protein signalling
Disclosed is substantially pure DNA encoding a C. elegans Egl-10 polypeptide; substantially pure Egl-10 polypeptide; methods of obtaining RGS encoding DNA and RGS polypeptides; and methods of using...
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6066318 |
Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional...
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6063983 |
Monoclonal lymphocytes and methods of use
A monoclonal preparation of lymphocytes, their production and use.
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6060258 |
Neutrophil chemotactic lymphokine, and method for the diagnosis of drug hypersensitive granulocytopenia using the same
The invention provides a neutrophil chemotactic lymphokine having an isoelectric point at 6.8-7.0, a cell line producing the lymphokine, and an agent for diagnosing drug-induced granulocytopenia,...
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6056951 |
Method of reducing the chance of attack of cells in a body by the cellular immune system
A method of reducing the chance of disease resulting from mononuclear cells in a body attacking desirable cell antigens in the body, such as antigens expressed by normal body cells or desirable...
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6051693 |
CLNH11-specific antibodies
CLNH11-specific hybridomas, human monoclonal antibodies and their uses are provided. The antibodies distinguish a human neoplastic cell from a normal cell of the same tissue type. The monoclonal...
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6051229 |
Human-human hybridom for neoplasms CLNH5 and CLNH11 specific antibody compositions
CLNH5 and CLNH11 specific hybridomas, human monoclonal antibodies and their uses are provided. The antibodies distinguish a human neoplastic cell from a normal cell of the same tissue type. The...
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6048525 |
Cells designed as traps and their use as medicines
A cell, particularly a hematopoietic cell population wherein the cells are trapped with respect to activation by an antigen to which the immune system of the host; (human or animal) is to be made...
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6040134 |
Method of diagnosing preclinical diabetes
The present invention relates to a method of diagnosing preclinical insulin-dependent diabetes mellitus by determining the T cell response to a specific islet cell antigen fetal antigen 1 (FA1) or...
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6040177 |
High efficiency transduction of T lymphocytes using rapid expansion methods ("REM")
The present invention provides a rapid expansion method (termed "REM"), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes. REM involves culturing...
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6033661 |
Composition and method for allogenetic mononuclear cell immunotherapy
A method of treating autoimmune diseases is provided which involves administering an effective amount of allogeneic mononuclear cells or a molecule derived from these cells to an individual...
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6025153 |
Selectable vectors for human T cells
Selectable Herpesvirus saimiri vectors which have a selection gene inserted into a junction region of the L- and H-DNA are described. Vectors of this type are able persistently to infect human T...
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6022538 |
Method of treating malignancies
A method of treating tumors which involves a synergistic combination of chemotherapy and cell therapy is provided. The method of the invention permits reduced amounts of chemotherapeutic agents to...
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6019987 |
Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof
Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the...
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6020172 |
Nucleic acid delivery with ovine adenoviral vectors
A method of delivering a nucleic acid molecule to a human cell which involves exposing to the cell a viral vector containing a DNA molecule including a nucleic acid sequence encoding the genome of...
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6015554 |
Method of reconstituting human lymphoid and dendritic cells
The invention relates to methods of enriching for hematopoietic cell populations enriched in myeloid and/or lymphoid progenitor cells based on cell specific markers. The methods also provide an...
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6010905 |
Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells
The present invention relates to methods of increasing the antigen presenting ability of monocytes by contacting them with an agent which increases the intracellular calcium level. Methods of...
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6010696 |
Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
Method and preparations for enhancing hematopoietic progenitor cell engraftment in an individual by administering (i) a culturally expanded mesenchymal stem cell preparation and (ii) hematopoietic...
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6008004 |
Identification of a CD34+ bone marrow precursor for dendritic cells in blood and lymphoid tissues
Dendritic cells (DCs) are the primary antigen presenting cells during the initiation of T cell-dependent immune responses. The cells originate from the bone marrow and have been suggested to...
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6008040 |
Procedures for efficient separation of cells, cellular materials and proteins
A process and device are provided for achieving cascade flow to achieve rapid separations of target components from fluid mixtures is provided. The devices of the invention have a cascading flow...
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6004743 |
Method and apparatus for bulk enrichment of a population or subpopulation of cells
A cell population or subpopulation enrichment procedure for separating undesired populations or subpopulations from a biological sample utilizing relatively heavy, dense particles and gravity...
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6004812 |
In-vitro T-lymphopoiesis system
The present invention provides an in vitro T-lymphopoiesis system in which a population of T-cells is produced from precursor cells expressing CD34. The T-lymphopoiesis system of the present...
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6001589 |
Method of identifying proteins modified by disease states related thereto
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and...
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