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6329153 |
Method for evaluating immunosuppressive regimens
The present invention describes a simple technique that provides a biologically relevant measure of the inhibitory effect of cyclosporine in vivo. This ability to measure response to cyclosporine...
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6323028 |
Isolated peptides which comply with HLA-CW16 molecules and uses
The invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and...
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6319711 |
Composition and method for inhibiting reverse transcript of a retrovirus
An antiretroviral composition for inhibiting the action of reverse transcriptase include a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose....
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6316227 |
Nucleic acids encoding interleukin-5 specific recombinant antibodies
An effective anti-IL-5 recombinant antibody molecule comprising heavy and/or light chain antigen-binding residues from a donor antibody.
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6316254 |
Methods for stimulating erythropoiesis using hematopoietic proteins
Methods for stimulating erythropoiesis using the hematopoietic protein thrombopoietin, optionally in combination with erythropoietin, are provided. The methods provided may be used to stimulate...
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6312685 |
Red blood cells covalently bound with two different polyethylene glycol derivatives
Living cells are modified at their surface with specially selected polymers. Covalently attaching specially selected polyethylene glycol (PEG) derivatives to the surface of red blood cells (RBC) in...
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6306575 |
Methods for preparing enriched human hematopoietic cell preparations
The present invention relates to an antibody composition which contains antibodies specific for glycophorin A, CD3, CD24, CD16, CD14, and optionally CD45RA, CD38, CD36, CD38, CD56, CD2, CD19,...
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6306651 |
Specific tolerance in transplantation
In general, the invention features, a method of inducing tolerance in a recipient mammal, e.g., a human, of a first species to a tissue obtained from a mammal, e.g., a swine, e.g., a miniature...
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6303380 |
Construction of retroviral producer cells from adenoviral and retroviral vectors
A combination of adenoviral and retroviral vectors used to construct second generation packaging cells that deliver marker genes to target cells is described. A vector based upon Moloney murine...
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6299650 |
Method for in vitro production of bone
The invention relates to a method for in vitro production of bone tissue, comprising the steps of: (a) applying undifferentiated mammalian cells, in particular autologous marrow cells, on a...
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6297052 |
B cell culture system comprising high density membrane bound CD40 ligand
The present invention provides methods of proliferating B cells as a means of obtaining large numbers of B cells. The present invention further provides methods of differentiating a proliferating B...
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6297050 |
Methods for treating subject with DAGE derived peptides
A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor...
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6294381 |
CD123+ dendritic cells in blood and lymphoid tissues
Dendritic cells (DCs) are the primary antigen presenting cells during the initiation of T cell-dependent immune responses. The cells originate from the bone marrow and have been suggested to...
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6281012 |
Method of preparing suppressor T cells with allogeneic mesenchymal stem cells
A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of suppressor T cells effective to reduce or inhibit host rejection of the...
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6277635 |
Use of interleukin-10 to produce a population of suppressor cells
Interleukin-10 for producing a population of cells which are capable of inhibiting or suppressing reactions to alloantigens, for example in graft-versus-host disease or tissue rejection, is...
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6274341 |
Cytostatic process increases the productivity of cultured cells
Provided by the invention are novel methods, vectors and cells for the recombinant production of desired gene products. In particular, the invention relates to increased production of desired gene...
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6270989 |
Protein production and delivery
The invention relates to novel human DNA sequences, targeting constructs, and methods for producing novel genes encoding thrombopoietin, DNase I, and β-interferon by homologous recombination. The...
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6268138 |
Retroviral vector capable of transducing the aldehyde dehydrogenase-1 gene and making cells resistant to the chemotherapeutic agent cyclophosphamide and its derivatives and analogs
This invention provides viral and retroviral vectors which comprises a nucleic acid molecule encoding a human cytosolic aldehyde dehydrogenase or a glutamylcysteine synthetase or combinations...
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6265215 |
Isolated peptides which complex with HLA-Cw16 and uses thereof
This invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and...
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6265214 |
Methods and compositions for inducing monocyte cytotoxicity
The present disclosure relates to a new lymphokine molecule, referred to as Monocyte Cytotoxicity Inducing Factor (MCF), and its use as in cancer and other types of therapy. The disclosure further...
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6261839 |
Method for the induction of a NK cell-mediated immune response
According to the present invention, there is provided a method for the induction of a NK cell-mediated immune response ex vivo characterized in that a physiological cell suspension containing at...
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6261834 |
Vector for gene therapy
Gene therapy involves the transfer and stable insertion of new genetic information into cells. The present invention is directed to safe vectors for gene therapy and thus provides hybrid parvovirus...
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6258527 |
Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was...
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6251611 |
Method of determining volume dependent hypertension via reduction in phosphorylation
A method of determining the presence of chronic volume dependent hypertension is provided wherein a determination is made as to whether there has been a substantial reduction in phosphorylation of...
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6251675 |
Methods utilizing mutant rev genes encoding transdominant repressors of HIV replication
Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes are described, having the...
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6251665 |
Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom
A method is described whereby dendritic cells derived from the CD34+ and CD34- hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may be...
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6248544 |
Method of measuring bone resorption rate
Tartrate-resistant acid phosphatase (TRAP) has been used as a marker for bone resorption. However, there are two forms of said enzyme in the body: TRAP 5a and TRAP 5b, of which TRAP 5b is a much...
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6242579 |
Antigen found on a small subset of human hematopoietic cells which binds to monoclonal antibody MG1
The subject invention pertains to an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal,...
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6225119 |
Production of megakaryocytes by the use of human mesenchymal stem cells
The present invention is directed to hematopoietic progenitor cells isolated from a tissue specimen, such as marrow cells or peripheral blood, and to the method of co-culturing isolated...
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6221576 |
Process for preparing macrophages, kits, and compositions for the use of this process
The invention relates to a process for preparing a composition comprising macrophages, optionally activated, and/or cells derived from-monocytes with a strong potential for antigen presentation,...
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6218190 |
Method for testing a cell suspension
A method for testing a cell suspension comprises the steps of: (1) diluting a portion of the cell suspension such that the liquid of the diluted suspension has the same osmolality as the extra...
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6218166 |
Adjuvant incorporation into antigen carrying cells: compositions and methods
Disclosed are compositions and methods for enhancing the antibody and T cell response to cellular antigens by incorporating an immunopotentiating agent into the cellular membrane or into an...
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6214333 |
Vasoprotective recombinant adenovirus vector containing a human TFPI gene
A recombinant adenoviral vector encoding the human tissue factor pathway inhibitor (TFPI) gene is disclosed which is useful for transduction of vascular smooth muscle cells at a selected blood...
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6210889 |
Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities
An enriched fetal cell sample is prepared from maternal blood by first separating a maternal blood sample on a three layer density gradient, and collection of the layer containing the lymphocytes...
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6210662 |
Immunostimulatory composition
Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by...
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6207147 |
Cancer immunotherapy using tumor cells combined with mixed lymphocytes
This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise stimulated lymphocytes allogeneic to the subject being...
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6207161 |
Induction of cytolytic T-lymphocytes with cytomegalovirus polypeptides
Immunogens for use in human cytomegalovirus vaccines or skin tests which comprise human cytomegalovirus matrix proteins or fractions thereof are disclosed. It is also disclosed that such matrix...
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6203787 |
Treating tumors using implants comprising combinations of allogeneic cells
This invention provides methods and compositions for treating tumors by implanting near the tumor an alloactivated cell population. The cell population is made up of a plurality of third-party...
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6194205 |
Method for the stimulation of T cells having a desired antigen specificity
T cells having a desired antigen specificity are stimulated by (a) introducing immortalizing genes into antigen-presenting cells in a manner permitting regulation of the expression and/or function...
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6183965 |
Synthetic transcriptional modulators and uses thereof
Novel synthetic transcriptional modulators having at least one selected ligand linked to at least one transcriptional modulating portion are described. The transcriptional modulators of the present...
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6184033 |
Medicinal preparation based on fetal cell suspension having immune substituting effect for patients with acquired immune deficiency syndrome (HIV infection)
The invention relates to a pharmaceutical composition for the treatment of a human having acquired immune deficiency syndrome caused by HIV-infection comprising the cell suspension from either the...
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6174726 |
Method for the immortalization of cells using conditionally transformed helper cells
The invention is directed to a method for the preparation of a conditionally immortalized immortalization-helper cell (fuseme), the fusemes generated by said method, hybridoma cells prepared using...
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6174526 |
Blood-borne mesenchymal cells
The present invention relates to a population of blood borne mammalian cells that express a unique profile of surface markers that includes certain markers typical of connective tissue fibroblasts,...
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6171856 |
Methods and compositions relating to no-mediated cytotoxicity
The present invention relates to methods and compositions for the treatment of diabetes involving free radicals. In particular, the present invention is directed to the treatment or prophylactic...
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6168922 |
Methods and devices for collecting and storing clinical samples for genetic analysis
The present invention relates to devices and methods for the collection, storage, and purification of nucleic acids, such as DNA or RNA, from fluid samples for subsequent genetic characterization,...
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6165785 |
Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications
A method of treatment using immune system suppressor cells and immune system stimulator cells comprises providing stem cells; combining the stem cells with lymphoid-derived cells to produce a...
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6165715 |
Expression systems
The invention relates to new expression systems and in particular to an expression system in which a gene of interest is expressed at an optimal level. The invention provides a recombinant...
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6162609 |
Diagnostic and therapeutic methods based upon Vα24JαQT cells
The present invention is directed to methods that can be used for diagnosing whether an individual either has, or is likely to develop, an autoimmune disease. The methods are based upon determining...
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6159701 |
Method and compositions for treating and diagnosing tumors using adenosine receptor activated cells
Methods of treating and/or imaging tumors utilize A 1 adenosine-receptor activated cells (such as monocytes and macrophages) are described. Activated cells may be administered systemically or...
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6153431 |
Human immunodeficiency virus co-receptor variants associated with resistance to virus infection
The present invention relates to variants of the CCR5 human immunodeficiency virus ("HIV") co-receptor which result in a resistance of CCR5 expressing cells to HIV infection. The detection of such...
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