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6479261 |
Methods of using interleukin-3 (IL-3) mutant polypeptides for ex-vivo expansion of hematopoietic stem cells
The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid...
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6475718 |
Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide...
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6475748 |
Method for differentiating human peripheral blood granulocytes
Disclosed is a method for differentiating human peripheral blood granulocytes which comprises cultivating the granulocytes in the presence of an interferon and acting an immune complex on said...
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6475483 |
Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens for treating autoimmune diseases
A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic...
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6475790 |
Assay for screening agents that alter angiogenesis
A multicellular in vitro assay which models the combined stages of angiogenesis is disclosed. The assay permits the evaluation of drug candidates for their potential utility in treating...
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6472212 |
Methods and compositions for genetically modifying primate bone marrow cells
A method is provided for genetically modifying primate bone marrow cells, comprising isolating bone marrow cells from a primate and, by means which enhance the local concentration of retroviral...
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6464729 |
Reconstituted mineralized cartilage tissue
A biological material comprising a continuous layer of cartilaginous tissue reconstituted in vitro which contains components associated with cartilage mineralization. The biological material may be...
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6465170 |
Method for depleting viral and molecular pathogens in a biological material
A method for depleting viral and molecular pathogens in a biological material containing one or several biological substances to be recovered is disclosed, wherein the biological material is...
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6465251 |
Method of promoting b-cell proliferation and activation with CD40 ligand and cyclosporin
We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B...
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6458585 |
Cytokine-free culture of dendritic cells
A method for producing human dendritic cells for therapeutic purposes which allows culture-deriving dendritic cells using no cytokines, or reduced cytokines. The method involves culturing...
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6455299 |
Methods of use of viral vectors to deliver antigen to dendritic cells
This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing T antigen specific cytotoxic T lymphocytes. This invention...
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6455306 |
Transfusable oxygenating composition
The present invention relates to a process for producing a transfusable, oxygenating composition of human red blood cells by the ex vivo culturing, expansion and differentiation of human primitive...
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6451316 |
Methods for generating antigen-reactive T cells in vitro
The present invention provides methods for generating antigen-reactive T cells in vitro comprising priming immune cells and incubating the primed immune cells in vitro with a non-covalent complex...
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6440735 |
Dendritic cell vaccine containing telomerase reverse transcriptase for the treament of cancer
The invention provides a method of activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the context...
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6440407 |
Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 (IL-3) multiple mutation polypeptides
The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a variant of human interleukin-3 (hIL-3) which...
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6436411 |
Cancer treatment method
Treatment of tumors, including their metastases, is described. Retrieved cytokines and other molecules from the growth medium of human monocytes stimulated ex vivo with gamma globulin, or other...
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6436705 |
Shape stabilized erythrocytes
One aspect of the present invention is a method for storing tissues and cells (typically erythrocytes) having the step of (1) stabilizing the cells with a reversible stabilizing agent. This method...
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6432399 |
Treatment of stress and preconditioning against stress
Symptoms of stress such as elevated blood pressure in mammals are treated, and mammalian bodies are preconditioned to manifest reduced adverse reactions to subsequently encountered stresses, by...
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6428973 |
Compositions and methods for evaluating bone resorption
Compositions and methods for the evaluation of bone resorption and bone resorption-related diseases are disclosed. The compositions include a human osteoclast-like cell line capable of resorbing...
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6429012 |
Cell population containing non-fetal hemangioblasts and method for producing same
Methods are provided for expanding populations of non-fetal hemangioblasts, for example a method including (a) providing a first cell population containing non-fetal hemangioblasts; and (b) growing...
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6426222 |
Method for inducing osteoblast differentiation of human extramedullary adipose tissue cells
A method for inducing osteoblast differentiation and/or for obtaining cells engaged in osteoblast differentiation, starting from human extramedullary adipose tissue cells, comprising the step...
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6417208 |
Method of identification of inhibitors of PDE1C
The present invention provides a method of identifying novel agents that increase glucose dependent insulin secretion in pancreatic islet cells as well as methods of treating diabetes using the...
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6410516 |
Nuclear factors associated with transcriptional regulation
Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an...
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6410319 |
CD20-specific redirected T cells and their use in cellular immunotherapy of CD20&plus malignancies
Genetically engineered, CD20-specific redirected T cells expressing a cell surface protein-having an extracellular domain comprising a receptor which is specific for CD20, an intracellular...
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6383481 |
Method for transplantation of hemopoietic stem cells
This invention relates to a method of transplanting hemopoietic stem cells which Comprises subjecting a recipient to a radiation treatment using an effective exposure dose for hemopoietic stem cell...
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6383807 |
Method of transforming T lymphocytes
The present invention discloses a method for transforming hematopoietic cells, in particular, T lymphocytes. The method involves co-culturing target cells, such as T lymphocytes, with pseudo-viral...
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6379953 |
Ligands that modulate differentiation of mesenchymal stem cells
Disclosed are compositions and methods for accelerating the differentiation of human MSCs into the osteogenic lineage with resultant enhanced de novo bone formation. This makes possible improved...
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6379952 |
Method for cell selection utilizing azlactone-functional supports
Azlactone-functional supports are used to provide cell selection from a mixture such as bone marrow or peripheral blood having a desired target cell population. An azlactone-functional support is...
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6376475 |
Control of immune responses by modulating activity of glycosyltransferases
The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated...
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6372494 |
Methods of making conditioned cell culture medium compositions
Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known...
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6368593 |
Enhanced immunogenic cell populations prepared using H2 receptor antagonists
This invention provides a method to enhance alloactivation in a mixed lymphocyte culture. Alloactivated cells are effective in treating tumors when implanted into a tumor site or coinjected with...
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6365404 |
Hematopoietic cell method for treatment of HIV infection
The risk of drug resistance in HIV infection is reduced by profoundly suppressing the viral load using novel hematopoietic cells. Modified CD4 lymphocyte host cells are used to “capture” virons...
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6362010 |
Methods and compositions for release of CD3430 cells from affinity matrices
Compounds and methods are provided for use in purification of CD34 + cells and specific surface antigens thereof. The present invention discloses methods for releasing CD34 + cells, as well as...
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6361997 |
Genetically modified CD34-negative adherently growing stem cells and their use in gene therapy
The invention relates to the use of genetically modified, very early haematopoietic and mesenchymal stem cells (negative for the expression of the surface molecule CD34) in the individual gene...
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6358703 |
Expression system for factor VIII
This invention describes a protein-free production process for proteins having factor VIII procoagulant activity. The process includes the derivation of stable human cell clones with high...
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6359119 |
Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as therapeutic agents and as imaging agents for diagnostic purposes. In...
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6358736 |
Method for increasing the antigen presenting ability of leukemia cells
The present invention relates to methods of increasing the antigen presenting ability of leukemia cells by contacting them with an agent which increases the intracellular calcium level. Methods of...
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6355410 |
Method of reducing cell proliferation by inhibiting the Na&plus /H&plus exchanger and inducing apoptosis
The Na + /H + exchanger isoform 1 (NHE-1) is primarily responsible for the regulation of the intracellular pH (pH i ). It is a ubiquitous amiloride-sensitive growth factor activatable exchanger....
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6355790 |
Inhibition of HIV replication using a mutated transfer RNA primer
Modified tRNA molecules are provided which inhibit HIV-1 replication. A tRNA molecule has a modified aminoacyl acceptor stem with a 3′ segment which has reduced complementarity to the HIV primer...
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6342344 |
Antibody composition for isolating human cells from human-murine chimeric hematopoietic cell suspensions
The present invention relates to an antibody composition which contains antibodies directed to murine leukocyte and murine erythroid cells. This composition is used in a novel negative selection...
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6342390 |
Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep...
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6340569 |
Monoclonal antibody and antigens specific therefor and methods of using same
Disclosed herein are hybridomas, antibodies produced thereby, antigens, and cells identified or isolated therewith. The dendritic like cells preferably have dendritic morphology and B cell...
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6340592 |
Human cell lines
The invention relates to a method for producing human cell lines and cell and cell-lines produced by such a method. The method comprising the use of precursor or undifferentiated cells treated with...
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6339150 |
Mutant rex genes encoding transdominant repressors of HIV/HTLV replication
Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of...
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6338942 |
Selective expansion of target cell populations
Methods and systems are provided for the selective expansion of target cell populations, and methods of treating patients with cell populations and products.
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6335174 |
Oncofetal antigen specific t-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10
The present invention provides a method of determining the success of a cancer therapy in an individual, comprising the step of measuring the frequency of occurence of an oncofetal antigen-specific...
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6333171 |
CD4 gene regulatory sequences specifically expressed in mature T cells
The present invention relates to compositions and methods for the expression of nucleic acids or polypeptides into mature T lymphocytes. The invention relates more specifically to methods of...
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6329153 |
Method for evaluating immunosuppressive regimens
The present invention describes a simple technique that provides a biologically relevant measure of the inhibitory effect of cyclosporine in vivo. This ability to measure response to cyclosporine...
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6323028 |
Isolated peptides which comply with HLA-CW16 molecules and uses
The invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and...
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6319711 |
Composition and method for inhibiting reverse transcript of a retrovirus
An antiretroviral composition for inhibiting the action of reverse transcriptase include a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose....
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