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6855519 |
Methods for enhancing the production of interferon in cell culture
Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production,...
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6852534 |
Method to determine an engrafting cell dose of hematopoietic stem cell transplant units
A method to determine an engrafting cell dose of hematopoietic stem cell transplant units from transplant sources having nucleated cells selected from the group consisting of cord blood, bone...
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6852533 |
Purified populations of stem cells
The invention is directed to a purified population of mammalian endothelial, muscle, or neural stem cells. The invention further provides methods for isolating such populations of cells; methods...
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6852537 |
Transgenic circulating endothelial cells
A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected...
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6849452 |
Methods for activating natural killer (NK) cells and means for carrying out said methods
The present invention relates to a process for activating natural killer cells comprising bringing NK cells into contact with dendritic cells in vitro, ex vivo or in vivo. The invention also...
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6841151 |
Chondrocyte cell-lines
The invention relates to chondrocytes and chondrocyte cell-lines for use especially in studying arthritic conditions and also for developing skeletal tissue for use in repair and/or replacement...
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6838081 |
Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient
The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in...
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6835377 |
Osteoarthritis cartilage regeneration
For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: (1) regenerate...
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6835566 |
Human lineage committed cell composition with enhanced proliferative potential, biological effector function, or both; methods for obtaining same; and their uses
A method for obtaining lineage committed human cells imbued with enhanced proliferative potential, biological function, or both, comprising culturing lineage committed human cells under...
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6830929 |
In vitro construction of SV40 viruses and pseudoviruses
The invention relates to constructs capable of infecting mammalian cells comprising at least one semi-purified or pure SV40 capsid protein and a constituent selected from the group consisting of an...
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6828147 |
Method of modifying cytotoxic cells and uses thereof
TALL-104 cells, and other cytotoxic T cell lines, may be modified to increase the cytotoxicity thereof, to enhance growth properties, and/or to provide a preferred phenotype, e.g., expression of...
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6825324 |
Antibodies to receptor protein tyrosine kinases
The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver...
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6821778 |
Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
This invention relates to methods of using human dendritic cells to present antigens for the induction of antigen-specific T cell-mediated immune responses. In particular, it relates to the...
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6812023 |
Methods of producing membrane vesicles
The present invention relates to methods of preparing biological material, for use in various experimental, diagnostic or therapeutic uses, including immunotherapy treatment or prophylaxy of...
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6805861 |
Immunotherapy using cytotoxic T lymphocytes (CTL)
A method of treating a patient with a disease wherein the patient contains diseased cells which cells contain, or are associated with, an abnormal molecule or an abnormally elevated amount of a...
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6797480 |
Purification of heat shock/stress protein cell surface receptors and their use as immunotherapeutic agents
The present invention relates to receptors for heat shock proteins (HSPs), such as gp96, Hsp70 and Hsp90. The heat shock receptor is associated with the cell membranes of a subset of antigen...
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6797269 |
Mesenchymal stem cells as immunosuppressants
The present invention provides a method to modulate immune responses using antigen presenting human mesenchymal stem cells to induce specific T cell anergy. The present invention also provides a...
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6790662 |
Method of isolating CD8&plus cells, and related hybridoma cells antibodies and polypeptides
This invention provides a method of isolating CD8 + cells which employs an antibody which specifically binds to CD8 molecules present on the surface of CD8 + cells but does not activate the CD8 +...
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6790634 |
Methods and compositions relating to phosphorylated myosin light chain 1
Two novel phosphorylation sites of myosin light chain 1 (MLC 1 ) are described. Methods of monitoring phosphorylation of MLC 1 to identify new cardiac and skeletal muscle protective agents,...
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6784155 |
Inhibitor and stimulator of stem cell proliferation and uses thereof
Disclosed and claimed are methods for the isolation and use of stem cell modulating factors for regulating stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery....
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6770749 |
P53-specific T cell receptor for adoptive immunotherapy
The present invention relates to molecular cloning of cDNA for both A and B chains of hu p53-specific, HLA restricted mu TCR, transfer of the cDNA to hu T cells, and functional expression of the...
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6770478 |
Erythrocytic cells and method for preserving cells
A dehydrated composition is provided that includes freeze-dried erythrocytic cells. Alcohol (e.g., sterol or cholesterol) is at least partially removed from erythrocytic cells including...
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6767737 |
Stem cells bearing an FGF receptor on the cell surface
A composition of substantially purified pluripotent stem cells are positive both for fibroblast growth factor receptor (FGFR) and a phenotype indicative of a primitive state, such as CD34 + , CD34...
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6747010 |
NKT cell-activating agents containing α-glycosylceramides
An objective of the present invention is to provide NKT cell-activating agents, therapeutic agents for autoimmune diseases (for example, systemic lupus erythematosus, systemic sclerosis, ulcerative...
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6743624 |
Process for continuous purification and concentration of leukocytes from blood
Process and apparatus for the continuous purification and concentration of leukocytes from blood, characterized in that said process comprises the following steps: (a) seperating plasma from the...
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6737051 |
Cell compositions containing macrophages, presenting anti-infectious and hematopoietic properties
The invention relates to a cell composition containing macrophages, presenting anti-infectious and hematopoietic properties. More particularly, the invention relates to a cell composition...
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6733746 |
Hematopoietic cell culture nutrient supplement
The present invention provides a serum-free supplement which supports the growth of hematopoietic cells in culture. Also provided are a medium comprising a basal medium supplemented with the...
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6730303 |
Fused G-CSF and IL-3 proteins and uses thereof
Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional...
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6723561 |
Materials and methods relating to the transfer of nucleic acid into quiescent cells
Materials and methods for transferring nucleic acid encoding a polypeptide for treating a disease or disorder into populations of quiescent cells such as haematopoietic stem cells (HSCs), using...
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6719901 |
System for the production of an autologous thrombin
A system for the production of autologous thrombin, comprising a centrifuge including a blood reservoir for receiving and separating an autologous anticoagulated blood sample having multiple...
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6716425 |
Method of preventing cancer recurrence
Methods for treating cancer in a mammalian patient having cancer and a functional immune system, and for preventing recurrences of cancer following completion of cancer therapy, are described. The...
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6713056 |
Combined preparation for the treatment of neoplasic diseases or of infectious diseases
The present invention relates to combined preparation containing as active substance the following individual components, in the form of a kit-of-parts: monocyte derived cells, particularly...
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6709864 |
Adipogenic differentiation of human mesenchymal stem cells
A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from...
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6703016 |
Apoptotic bodies, monocyte derived cells containing the same, a process for their preparation and their uses as vaccines
The present invention relates to apoptotic bodies derived from human tumor cells or cell lines recovered from patient's tumor biopsy and induced to apoptotis, said apoptotic bodies having the...
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6696267 |
Methods and compositions for screening Icrac modulators
The present invention relates to compositions and methods directed at screening or characterizing compounds that modulate the activity of calcium channels in cells preferably, calcium-release...
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6692958 |
Cord blood-derived activated lymphocytes, preparations containing said lymphocytes as main ingredient and method and kit for producing said preparations
Activated lymphocytes derived from cord blood are excellently effective for preventing and treating various types of tumors and various types of infection. With interleukin 2 and/or anti-CD3...
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RE38423 |
Process for in vitro analysis of toxic and allergenic substances
The invention concerns a process for in vitro evaluation of a potentially allergenic or tissue irritating substances, characterized in that blood cells are cultivated in the presence of serial...
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6676937 |
Compositions and methods for modulating vascularization
The present invention generally provides methods for modulating formation of new blood vessels. In one embodiment, the methods include administering to a mammal an effective amount of granulocyte...
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6673605 |
Established cell line of microglia
The present invention relates to an established cell line of microglia having the following properties: (a) form: having a macrophage-like or globular form in the presence of...
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6673606 |
Therapeutic uses for mesenchymal stromal cells
Human mesenchymal stromal cells can be induced to differentiate into oligodendrocytes and neurons, respectively. For these cell types, therefore, MSCs can be a therapeutic source, either in vitro...
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6673573 |
Expression of immunoglobulin-cytokine fusion proteins in malignant B cells
According to the invention, there is provided a vector for the expression of immunoglobulin-cytokine fusion proteins in malignant B cells at least containing operably linked to each other (a) a...
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6670123 |
Method for detecting hematopoietic stem cells
The present invention provides an isolated nucleic acid encoding KIAA0918, an isolated nucleic acid that hybridizes under high stringency conditions to a nucleic acid that is complementary to a...
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6667175 |
Generation of antigen specific T suppressor cells for treatment of rejection
This invention provides a method of generating antigen specific allospecific human suppressor CD8+CD28− T cells. This invention also provides a method of generating xenospecific human suppressor...
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6667151 |
Vaccines and immunotherapeutics derived from the human immunodeficiency virus (HIV) trans-activator of transcription protein for the treatment and prevention of HIV disease
Anti-lentivirus vaccines and immunotherapeutics and methods for preparing and using same are disclosed. The vaccines and immunotherapeutics are produced using non-immunosuppressive lentivirus...
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6660523 |
Dendritic cells; methods
Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided.
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6653134 |
Isolated stromal cells for use in the treatment of diseases of the central nervous system
Methods of treating a human patient having a disease, disorder or condition of the central nervous system are disclosed. The methods include obtaining a bone marrow sample from a human donor,...
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6653101 |
Recombinant DNA method and host cells
The present invention provides a process and host cell for use in increasing the amount of a desired protein by a cell line. The process and the cell line use a first transcription unit containing...
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6649366 |
Methods and compositions related to modulators of annexin and cartilage homeostasis
The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the...
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6649595 |
Regulation of biological events using novel compounds
Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.
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6645763 |
Immortalized bone marrow mesenchymal stem cell
The present invention provides a safe immortalized bone marrow mesenchymal stem cell obtained by transferring a cell proliferation factor gene inserted between a pair of site-specific recombination...
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