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4935372 |
Art nucleotide segments, vectors, cell lines methods of preparation and use
A gene and gene product that regulates the expression of the capsidal envelope genes of HTLV-III/LAV and that can be used to regulate the expression of heterologous (non-viral) genes as well is...
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4931275 |
Anti-tumor vaccines and their preparation
There are provided anti-tumor vaccines which contain as active ingredient tumor cells which have been pressure treated so as to augment their antigenic properties, tumor cells treated with...
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4892829 |
Human plasma cell line having rearranged c-myc proto-oncogene
Using a serum-free defined medium, a human cell line, NCI-H929, was established from a malignant effusion occuring in a patient with IgAk myeloma. The cultured cells have the morphologic,...
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4863865 |
Preservation by cold storage
Material which contains water, or is accompanied by an aqueous phase, notably biological cells, cell components or cell aggregates, or differentiated biological tissue is preserved by dispersion in...
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4849329 |
Process for preparing lymphokine activated killer cells
There are disclosed an improved process for preparing lymphokine activated killer (LAK) cells from peripheral blood mononuclear cells, a composition consisting essentially of the LAK cells prepared...
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4844893 |
EX vivo effector cell activation for target cell killing
A method and composition for killing target cells is disclosed. The method utilizes ex vivo IL-2 activation of leucocyte effector cells and arming the activated leucocyte effectors with monoclonal...
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4834975 |
Human monoclonal antibodies to serotypic lipopolysaccharide determinants on gram-negative bacteria and their production
Transformed human lymphocyte cell lines have been produced which secrete human monoclonal antibodies to serotypic determinants on LPS molecules of gram-negative bacteria. These antibodies have been...
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4822735 |
T cell growth factor and method of making same
A mutant T-cell line of HSB-2-ERICR which produces a T cell Growth Factor is disclosed. The Mutant cells are sensitive to HAT Medium.
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4798797 |
Retrovirus associated with lymphadenopathies and adapted to continuous lines of lymphoblastoid B cells, capable of producing retrovirus continuously and process for their production
A retrovirus B-LAV associated with lymphadenopathies and with Acquire Immune Deficiency Syndrome, being adapted to B lymphocytes and capable of being continuously produced by continuous cell lines...
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4764463 |
Platelet cyropreservation
A method for preserving blood platelets by freezing the platelets in contact with a cryoprotectant solution containing a sufficient quantity of prostacyclin for the substantially complete...
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4758513 |
Human T or B cell lines and a process for producing immunologically active substances using the same
This invention relates to a human T or B cell line carrying at least one Ela human adenovirus 12-type gene or fragment thereof; said cell line being capable of spontaneously producing an...
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4752565 |
Cell line producing AIDS viral antigens without producing infectious virus particles
Leu-3 - cells surviving infection with the AIDS retrovirus can be induced with IUdR to express infectious virus. A cellular clone (8E5), isolated by limiting dilution of a mass culture of...
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4728614 |
Mutant human T cell line producing immunosuppressive factor and method for obtaining such mutants
A stable mutant human T cell line is disclosed which secretes a high titer suppressor inducer factor. This suppressor inducer factor in turn induces production of a T cell suppressor factor which...
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4720459 |
Myelomas for producing human/human hybridomas
Human myeloma fusing lines and human/human hybridomas produced therefrom are disclosed. In one embodiment, the myeloma cell line is HAT sensitive, does not secrete detectable levels of Epstein-Barr...
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4714680 |
Human stem cells
Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and...
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4704357 |
Immortalized T-lymphocyte cell line for testing HTLV-III inactivation
This invention is an immortalized T-cell clone, designated ATH8, which is highly sensitive to the cytopathic effect of HTLV-III. The ATH8 T-cell clone is used in mass screening systems to rapidly...
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4675291 |
Human cultured cell line
This invention provides a novel cultured cell line which is derived from human T leukemic cells and which produces a colony-stimulating factor (CSF). This invention also provides a process for...
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4665032 |
Human T cell hybridomas which produce immunosuppressive factors
A human T cell hybridoma comprising the product of: (A) fusion of: (i) a T cell from a patient with ARC or AIDS, wherein said T cell secretes an SSF capable of specifically inhibiting T...
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4652599 |
Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS using permissive cells
A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune...
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4647535 |
Human nonsecretory plasmacytoid cell line
A human non-secretory plasmacytoid HPRT - mutant continuous cell line, can be used for the preparation of human-human hybridomas with human B-lymphocytes and separation of the resulting hybridomas...
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4624921 |
Human lymphoblastold cell line and hybridomas derived therefrom
A 6-thioguanine-resistant subvariant of the EBV-transformed human lymphoblastoid B cell line WI-L2 is described. The subvariant line, designated LTR228, fuses efficiently with human cells....
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4612282 |
Monoclonal antibodies reactive with human breast cancer
Monoclonal antibodies demonstrating a reactivity with human breast cancer are produced. The hybridoma cultures secreting immunoglobins are produced by hydridoma technology. Splenic lymphocytes of...
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4608337 |
Human hybridomas and the production of human monoclonal antibodies by human hybridomas
The present invention provides a stable, continuous human myeloma cell line which is capable of hybridization with antibody-producing cells of humans and other animals, the cell line being a mutant...
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4594325 |
High fusion frequency fusible lymphoblastoid cell line
Human lymphoblastoid cell line capable of acting as a fusion partner in the preparation of hybridomas is grown and selected under conditions whereby a cell line is obtained having greatly enhanced...
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4544632 |
Human T cell lines and method of producing same
This invention provides a human parental T cell line which can fuse with normal human T cells, and hybrid cell lines which are prepared by fusion of the human parental T cells and the human T...
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4473552 |
Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells
An anaerobic method for preserving mammalian blood, mammalian tissue or living-cell containing components of either in a state of suspended animation, and the products of that method, are...
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4464465 |
Cell-driven viral transfer in eukaryotes
Novel method, cells and compositions are provided involving transforming B-lymphocytes to provide immortalization for continuous production of monoclonal antibodies to a predetermined ligand....
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4438032 |
Unique T-lymphocyte line and products derived therefrom
Human T-lymphoblast cell line, Proteinaceous products produced therefrom, messenger RNA and DNA expressing the proteinaceous products. A human T-lymphoblast cell line (Mo) maintained as a...
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4427777 |
Enzymatic conversion of red cells for transfusion
Transfusable type O erythrocytes free of P1 antigenicity which are produced by an alpha-galactosidase conversion of type B antigen to type H antigen. The resulting erythrocytes retain a high level...
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4326027 |
Antiglobulin control cells
Antiglobulin control cells are disclosed wherein reagent human red blood cells are coated with univalent antibody fragments. These control cells provide a high degree of specifity in determining...
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4316962 |
Novel cell line
A cell line, identified by the reference LDV/7, was established from peripheral blood leucocytes of a 75 year old male volunteer, and may be propagated by culturing the cells in a suitable nutrient...
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