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5480825 |
AG-F human T cell line with unique phenotype and cytokine secretions
A human T cell line, designated AG-F, the cells of which: a) are capable of adherent growth as well as growth in suspension; b) have a short doubling time of approximately eight to nine hours; c)...
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5476786 |
Biosynthetic antibody binding sites
Disclosed are a family of synthetic proteins having affinity for a preselected antigen. The proteins are characterized by one or more sequences of amino acids constituting a region which behaves as...
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5468624 |
Cell lysis activity of a modified fragment of the glucocorticoid receptor
A cell lysis factor which is a modified fragment of the human glucocorticoid receptor. The modified fragment designated 398-465*, when transfected into and expressed in a host cell, effects cell...
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5460965 |
DNA and RNA encoding proteins useful in the regulation of KB-containing genes, and cells containing same
Proteins, and corresponding DNA and RNA sequences, useful for the regulation of expression of κB-containing genes are disclosed. These proteins are useful to either stimulate or inhibit the...
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5459056 |
Human T cell line chronically infected with HIV
A human T cell clone containing an integrated copy of HIV in a latent state, but inducible to productive replication by an activating agent is provided. The clone of the present invention allows in...
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5459054 |
Cells encapsulated in alginate containing a high content of a- l- guluronic acid
Cells such as mammalian or genetically modified cells are encapsulated in high-G alginate that provokes reduced immune response during transplantation or implantation. The alginate contains greater...
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5447852 |
DNA encoding cyclophilin C, and recombinant methods employing it
The cloning and characterization of a new binding protein class, cyclophilin C (cyp C) and homologous proteins, is provided which is capable of binding to, e.g., the immunosuppressive drug...
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5432076 |
Alteration of the interaction of a T-cell receptor with a protein-tyrosine kinase
This invention concerns alteration of the interaction of PTKs and T-cell receptors. We have found that PTKs and T-cell receptors are complexed within the T-cell and the formation of this complex...
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5429948 |
Human cell line stably expressing 5cDNAS encoding procarcinogen-activating enzymes and related mutagenicity assays
An immortal human cell line stably expressing a multiplicity of cytochrome P450s is provided. Preferably, the cell line is MCL-5, which stably expresses cytochrome P450 IA1, IA2, IIA3, IIIA4, and...
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5424197 |
H. saimiri-HTLV-X region vector
An H. saimiri-HTLV-1 or 2 X region vector is disclosed. This vector can be used to establish continuous cell lines of difficult to grow cells, such as human T-cells. It can also be used to obtain...
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5415874 |
Natural killer cell lines and clones with antigen specificity
Lymphocytes of NK phenotype were cultured with stimulator cell lines in the presence of growth factor containing medium. The resulting lines and clones derived from these lines expressed CD16...
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5407794 |
Oxazine stained lymphocytes and method
Peripheral blood lymphocytes displayed a plurality of sizes and colors when exposed first to a fixative solution of C.I. basic blue 141, then to an aqueous alkaline solution of the same dye and...
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5354686 |
Extracellular matrix protein adherent T cells
Substantially purified mature T cells, including αβT cells and γδ T cells, are capable of binding to an extracellular matrix protein, particularly to one or more of a collagen, a fibronectin, a...
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5354664 |
DNA encoding a human thrombomodulin having a modified glycosaminoglycan (GAG) binding site
Thrombin-binding substances capable of promoting anti-thrombin III activity and inhibiting platelet aggregation, and by themselves possessing anti-thrombin activity are disclosed. The...
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5354678 |
Production of recombinant adeno-associated virus vectors
Simplified methods to produce recombinant adeno-associated virus (rAAV) vectors are described. The methods involve the use of chimeric plasmids which incorporate the Epstein Barr nuclear antigen...
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5324643 |
Method of conferring resistance to retroviral infection
In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes...
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5322787 |
Cytokine and bioassay therefor
The present invention contemplates a method for detecting a cytokine in a sample, said method comprising contacting an effective mount of said sample with an effective mount of SPGM-1 cells for a...
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5272082 |
Cytotoxic T-ALL cell lines and uses therefor
The invention provides cytotoxic T-ALL cell lines, and modified cytotoxic T-ALL cell lines which contain a heterologous DNA sequence. The DNA sequence may encode a product capable of stabilizing or...
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5270199 |
Human mannose-binding protein
Purified human mannose-binding protein and fragments thereof, nucleic acid producing these fragments, and vectors and cells including such nucleic acid are disclosed. The peptides and antibodies to...
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5266480 |
Three-dimensional skin culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5256560 |
Primitive cell colony stimulating factors and lymphohematopoietic progenitor cells
The invention derives from the discovery of cells, non-adherent (NA) cells, which have properties indicating that they may be pluripotent lymphohematopoietic progenitor cells. These cells, and the...
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5256534 |
CD4.sup.+, latently HIV-1-infected hematopoietic progenitor cells
The present invention relates to a unique physiologic model of chronic human immunodeficiency virus type-1 (HIV-1) infection. In particular, the present invention relates to a chronically infected...
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5252479 |
Safe vector for gene therapy
Gene therapy involves the transfer and stable insertion of new genetic information into cells. The present invention is directed to safe vectors for gene therapy and thus provides hybrid parvovirus...
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5250431 |
Alteration of the interaction of a T-cell receptor with a proteintyrosine kinase
This invention concerns alteration of the interaction of PTKs and T-cell receptors. We have found that PTKs and T-cell receptors are complexed within the T-cell and the formation of this complex...
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5229115 |
Adoptive immunotherapy with interleukin-7
There is disclosed an immunotherapy method for treating an individual with cancer or a viral infection comprising obtaining lymphoid cells previously exposed to a specific antigen, culturing the...
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5223417 |
Method for transforming human B lymphocytes
Disclosed herein is a method for transforming human B-cells preferably by infecting them with Epstein-Barr virus followed by transforming the Epstein Barr virus infected cells with an activated...
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5198356 |
Monophenotypic in vitro cell lines of megakaryocytic lineage, products produced thereby and methods
Human monophenotypic cloned cell lines of megakaryocytic lineage are established in vitro through use of adherent stromal cells in long term human bone marrow culture. Long term bone marrow...
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5182205 |
Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor
The present invention provides nucleotide sequences which are selectively expressed in pre-B cells, probes comprising a polynucleotide hybridizing specifically to such a nucleotide sequence and...
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5178999 |
Epstein-barr virus transformed cell lines superinfected with a second virus
A cell line transformed by EBV and infected with a virus, e.g., HIV, which cell line does not release extracellular virus, but which forms syncytia when 1) these cells are co-cultivated with...
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5149635 |
Messenger RNA stabilization in animal cells
Disclosed is a method of increasing production of proteins, e.g., human tPA, in mammalian cells which normally secrete immunoglobulins. Degradation of mRNA transcribed from recombinant DNA is...
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5147798 |
Monophenotypic xenograft of megakaryocytic lineage and origin
A continuous cell line of megakaryocytic origin is disclosed. This novel continuous cell line has been established in athymic nude mice. The cells of the established cell line monophenotypic for...
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5139947 |
Antigenic noninfectious HIV-producing cloned T cell
The invention is a cloned T cell prepared by infecting a human T cell, H9, with HTLV-III B, which cloned human T cell is antigenic for HTLV-III B, does not have a syncytium-forming activity, and...
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5137824 |
CSF-1 gene promoter
A CSF-1 gene promoter region is disclosed. This nucleotide base sequence is useful as a promoter for gene expression in animal cells.
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5135915 |
Method for the treatment of grafts prior to transplantation using TGF-.beta .
A method is provided for the treatment of grafts such as tissue or organs prior to transplantation into a suitable host. The grafts are incubated, coated, or perfused with TGF-β for an effective...
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5132222 |
Established cell line, KML.sub.1-7, which produces B-cell differentiation factor (BCDF)
A novel established cell line, KML 1 -7, obtained by collecting lymphoid cells from an animal with autoimmune disease, culturing them in a culture medium containing the supernatant of a culture in...
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5128259 |
Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation
Factor-dependent cell line, HU-01, provides the first in vitro system in which human CD34 positive hematopoietic cells have been induced to undergo complete differentiation into enucleated...
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5128245 |
Establishment, characterization and differentiation of a new megakaryocytic cell line, the dami cells
A stable mutant human megakaryocytic cell line is disclosed which is useful for the study of megakaryocytopoiesis, platelet formation and production, platelet component formation, and the...
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5126259 |
Human B. Lymphoblastoid cell, hybridoma, antibody and production of antibody
The present invention provides human B lymphoblastoid cell line AC-33, which is novel, and excellent in proliferativity and fusion capability, and works well as the parental line for obtaining a...
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5126260 |
Human erythroid-specific transcriptional enhancer
A human erythroid specific enhancer element is described. The enhancer element can be used to enhance transcription of a structural gene in erythroid cells. Methods for gene therapy employing the...
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5122468 |
Hut-78 cell lines infected with HTLV-III which secrete gp160
Human Immunodeficiency Virus (HIV) glycoprotein gp160 is produced in its native form using a clone of HUT78 cells chronically infected with HTLV-III 451 , known as 6D5 451 , and grown in serum-free...
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5108920 |
Retrovirus isolated from human lymphoma cell lines
A novel retrovirus isolated from human lymphoma cells is disclosed. The retrovirus is characterized by a C-type retroviral particle of approximately 100 nm diameter; and an approximately 27,000...
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5061620 |
Human hematopoietic stem cell
Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are...
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5059518 |
Stabilized lyophilized mammalian cells and method of making same
A method of lyophilizing mammalian cells to produce preserved human cells, hybridoma cell lines, tissue cells, and control cells for immunoassays and other hematological measurements. Prior to...
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5024946 |
Human monoclonal antibody to antigen of gastric cancer and B-cell line for producing this antibody, method for preparing this B-cell line and antibody, antigen and method of preparation of this antigen
The present invention relates to a human B-cell line capable of producing a human monoclonal antibody against an antigen found on gastric cancer cell lines or tissues. The B-cell line is formed by...
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4996194 |
Pressure treated autoimmune specific T cell compositions
Composition for the prevention and treatment of autoimmune diseases are provided which comprise as an active ingredient membrane material shed from autoimmune T lymphocytes, or activated T...
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4994386 |
Production of HBLV virus in the HSB-2 cell line
A method of producing Human B-Lymphotropic Virus (HBLV) in the HSB-2 cell line.
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4981790 |
Stable TatIII cell lines, TatIII gene products, and assay methods
This invention describes stable tat III cell lines. It is disclosed that by transfecting a preselected tat III cell line with a vector containing a sufficient amount of the HTLV-III LTR...
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4970161 |
Human interferon-gamma
A DNA sequence on which a chromosomal DNA sequence coding for human interferon-γ (HuIFN-γ) and having a TATA box is ligated to a sequence of a promoter. Cell cultures transformed with said DNA...
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4952499 |
Genes and their encoded proteins which regulate gene expression of the interleukin-2 receptor and of human lymphotropic retroviruses
The present invention is directed to genes, termed Rpt-1 (regulatory protein T lymphocyte-1), which are expressed at higher levels by resting CD4 + helper/inducer T cells relative to activated CD4...
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4950598 |
Process for making T cell hybridomas
Human T-T hybridomas are made by fusing an azaserine-hypoxanthine (AH) sensitive T leukemia cell line, preferably the AH-sensitive mutant of the Jurkat leukemia line identified as J3R7, with normal...
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