Matches 601 - 650 out of 730 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >
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5674750 Continuous selective clonogenic expansion of relatively undifferentiated cells  
A system is provided for selective clonogenic expansion of relatively undifferentiated cells, including (a) a tube containing a plurality of beads of a size which permits a plurality of the...
5672486 Protein polyligands joined to a stable protein core  
Stable polyligands are provided by preparing fused proteins, where the fused protein comprises a ligand at one terminus and a subunit of a multimeric unit protein at the other terminus, where the...
5670351 Methods and compositions for the ex vivo replication of human hematopoietic stem cells  
Methods, including culture media conditions, which provide for ex vivo human stem cell division and stable genetic transformation and/or the optimization of human hematopoietic progenitor cell...
5670352 Stable growth transformation of human T-lymphocytes by Herpesvirus saimiri (H. saimiri) subgroup C  
The invention concerns the transformation of human T-lymphocytes to stable growth by infecting said T-cells with strains of H. saimiri subgroup NonA NonB, preferably subgroup C. The transformed...
5670147 Compositions containing cultured mitotic human stem cells  
Methods, including culture media conditions, which provide for ex vivo human stem cell division and/or the optimization of human hematopoietic progenitor cell cultures and/or increasing the...
5665557 Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof  
The invention relates to methods of obtaining compositions enriched in hematopoietic stem cells by separating out an enriched fraction of cells expressing the marker CDw109. Methods of obtaining...
5665588 DNA encoding natural killer lytic associated protein  
A unique gene sequence encoding a natural killer lytic associated molecule (natural killerlytic associated protein) has been isolated. Using recombinant DNA techniques, the natural killerlyric...
5658761 Stromal cell lines from human bone marrow and their use  
A human bone marrow stromal cell line, which is characterized in that the cells of the cell line, after irradiation which results in the growth being arrested, remain adherent, is suitable for use...
5654167 Antimicrobial proteins, compositions containing same and uses thereof  
The present invention provides purified polypeptides useful as antimicrobial agents. These polypeptides comprise human polymorphonuclear leukocyte polypeptides having molecular weights of about...
5652130 Retroviral vectors expressing tumor necrosis factor (TNF)  
A drug delivery virion which contains an expression system for the desired protein active ingredient packaged in an envelope derived from a retrovirus is especially useful in administering...
5650299 Cells producing stem cell proliferation factor  
The present invention is directed to an autocrine growth factor. In particular, it relates to the production, purification and uses of stem cell proliferation factor (SCPF). In various cell lines,...
5650309 Viral vectors  
Vectors are provided which stably transduce cells, rendering the cells resistant to a target virus. The vectors are amplified upon infection of the cell by a target virus, and spread throughout an...
5646032 Recombinant foamy virus vectors for medicinal, and diagnostic uses, and processes for preparing recombinant foamy virus vectors  
The present invention relates to the preparation of novel vector systems which are generated by in-vitro recombination, using gene technology, of nucleic acids from foamy virus species and of...
5646009 Hybrid vector and method resulting in protein overproduction by eukaryotic cells  
A hybrid vector carrying a first and second DNA segments operationally linked thereto, the first DNA segment encoding a protein capable of cross-linking to the cap structure of mRNA and mediating...
5635385 Multi-unit ribozyme inhibition of oncogene gene expression  
A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles...
5629159 Immortalization and disimmortalization of cells  
Methods and compositions for the conditional immortalization of cells are provided.
5622853 T lymphocyte precursor  
A population of T lymphocyte precursor cells is disclosed. In bone marrow, the earliest identifiable T lymphocyte precursor is CD34 + , CD7 + and Leu 8 + ++. Methods of isolation and methods of...
5618693 Interleukin-2 signal transducers and binding assays  
The invention provides methods and compositions relating to interleukin 2 signal transducers, particularly an isolated human signal transducer and activator of transcription 5 (hStat 5), or a...
5610053 DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells  
A newly-characterized chromatin insulator element isolated from the DNA of a higher eukaryotic organism and contained in vector constructs is described. The insulator element of the invention...
5605821 Expression control sequences of the P-selectin gene  
DNA molecules and methods for the regulated expression of a gene in endothelial cells or megakaryocytes, are described, wherein the 5' flanking region of the P-selectin gene, or portions thereof,...
5605814 DNA encoding human prostaglandin receptor EP2  
A novel prostaglandin receptor has been identified and DNA encoding the receptor has been isolated, purified, sequenced and expressed in host cells. This DNA encoding the novel prostaglandin...
5591430 Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof  
Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the...
5589345 Cultures of permanent lines of human promyelocytic cells and their uses for the screening of molecules utilizable in particular in the treatment of leukemias  
The invention concerns permanent cell lines of human promyelocyte cells characteristic of acute promyelocytic leukemias, these cells being cytogenetically characterized by a translocation t(15;17),...
5587300 Method to increase regulatory molecule production  
The present invention provides a method to increase the production of a regulatory molecule, i.e., a molecule that regulates cell behavior, such as a cytokine or a protooncogene, in a population of...
5583035 HIV antisense expression vectors  
The present invention relates to the targeted blocking of the genetic information of the viral messenger ribonucleic acid (mRNA) for virus replication (e.g. of HIV) in transfected, haematopoietic...
5583053 Macrophage cell line for use in the detection of antinuclear antibodies  
The macrophage cell line, IT-1 (KCCM-10038) was derived from normal human bone marrow. IT-1 cells are characterized by excellent adherence onto glass slides used in immunofluorescence assays, and...
5583028 Recombinant vaccinia virus as DNA constructs encoding HSV glycoproteins  
Disclosed and claimed are DNA constructs encoding HSV glycoproteins. The constructs are recombinant vaccinia virus, and host cells infected by the recombinant vaccinia virus are also disclosed and...
5580760 FUSE binding protein and cDNA therefor  
The Far Upstream Element (FUSE) of the human c-myc gene, stimulates expression in undifferentiated cells. A FUSE binding protein (FBP), also referred to as DROME (DNA-binding regulator of c-myc...
5580761 Method of conferring resistance to immunodeficiency viral infection  
In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes...
5578442 Graft copolymers of polycationic species and water-soluble polymers, and use therefor  
In accordance with the present invention, there are provided methods to render cells non-adhesive and/or non-immunogenic with respect to macromolecules typically encountered in culture media or in...
5565337 Hybridoma-producing NSO myeloma cell line  
This invention relates to an NSO myeloma cell line which has increased fusion frequency, and to a method of producing said cell line. The NSO cell line of the invention, when fused with B cells,...
5565358 Enhancer and silencer sequences isolated from the GPIIB promoter  
An amplifier sequence and a silencer sequence of the GPIIb promoter are disclosed. The amplifier sequence includes sequence domains (I) and (II), and the silencer sequence includes sequence domain...
5558995 Peptides which are derived from tumor rejection antigen precursor molecule MAGE-1, which complex to MHC molecule HLA-C clone 10, and uses thereof  
The invention relates to the identification of complexes of HLA-C-clone 10 and MAGE-1 derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this...
5556954 Hematopoietic stem cell specific gene expression  
The subject application relates to a hematopoietic stem cell specific promoter and to a hematopoietic stem cell specific enhancer and to uses therefor. The invention also includes a hematopoietic...
5556782 Transformed mammalian cells capable of expressing cecropin b  
Novel means have been discovered for increasing the resistance of a mammalian host (including humans) to diseases caused by intracellular bacteria, protozoa, and viruses. Novel means have also been...
5554528 Compositions and methods for inhibition of HIV production  
All lines of mammalian origin which have been stably transformed with a chimeric toxin gene expressed under the regulatory control of HIV cis-acting sequences and HIV trans-acting factors are...
5554529 Cell lines and methods for assaying human interchromosomal recombination  
Cell lines useful for analysis of human homologous interchromosomal recombination are described. The cell lines carry endogenous mutant alleles of a selectable gene and can regenerate a selectable...
5554527 Agent for the storage and suspension of cells, especially erythrocytes  
The invention relates to an agent for the preservation, storage and suspension of cells, especially erythrocytes, which contains a chelating agent for multiply charged metal ions, in addition to...
5550054 Hematopoietic restricted tyrosine kinase (BPK)  
Novel hematopoietic-restricted tyrosine kinases are provided, where the tyrosine kinases provide for autophosphorylation and transphosphorylation. Modulation of the activity of the subject...
5545550 Human virus associated with chronic fatigue immune deficiency syndrome and assay therefore  
A method for the detection of the presence or absence of antibodies which bind to antigens of an NMA virus Deficiency is disclosed. This method comprises contacting a solution containing antigens...
5541103 CD34+ peripheral blood progenitor cells obtained by ex vivo expansion  
Patients suffering from certain types of cancer are treated by high-dose chemotherapy. In order to allow a recovery a process for the ex vivo expansion of peripheral blood progenitor cells is...
5534430 Cell strain capable of multiplying an Epstein-Barr virus  
The present invention relates to a cell strain capable of separating and multiplying an EB virus and derived from human lymphocyte cancer cells and a method of separating and multiplying the EB...
5534631 Cellular factor ILF  
A gene encoding a cellular factor that binds to NFAT-like elements in the HIV-LTR has been obtained by λgt11 expression cloning using oligonucleotides corresponding to these binding motifs. This...
5523227 DNA encoding calcium-signal modulating cyclophilin ligand  
DNA and protein compositions are provided for calcium-signal modulating cyclophilin ligand which are shown to act in the calcium-dependent pathway for activation of a number of genes. The DNA...
5521295 Nucleic acids encoding hybrid receptor molecules  
Provided are hybrid receptor molecules wherein one domain of the receptor is derived from the cytokine superfamily of receptors and other domain is derived from a heterologous family of receptors....
5502176 Myeloid cell specific promoter  
The subject application is drawn to a method of transfecting a myeloid cell line and a method of producing a selected product in a myeloid cell. The invention also includes myeloid cell specific...
5489519 Multidrug resistance protein  
A novel protein associated with multidrug resistance in living cells and capable of conferring multidrug resistance on a cell is disclosed and nucleic acids encoding the novel isoforms are...
5487891 Human anti-RH(D) monoclonal antibodies reagents and hybridomas and methods of RH typing using anti-RH(D) monoclonal antibodies and reagents  
The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system;...
5482858 Polypeptide linkers for production of biosynthetic proteins  
Disclosed are a family of synthetic proteins having binding affinity for a preselected antigen, and multifunctional proteins having such affinity. The proteins are characterized by one or more...
5480825 AG-F human T cell line with unique phenotype and cytokine secretions  
A human T cell line, designated AG-F, the cells of which: a) are capable of adherent growth as well as growth in suspension; b) have a short doubling time of approximately eight to nine hours; c)...
Matches 601 - 650 out of 730 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >