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5792655 |
Method for culturing T lineage precursor cells under conditions of high oxygen concentration
The present invention provides culture methods of T lineage precursor cells comprising a step of culturing the T lineage precursor cells under a condition that a dissolved oxygen concentration in...
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5789247 |
Expression in non-tumoral human lymphoblastoid lines with an integrative vector
A plasmid vector designed for transforming lymphoblastoid cells, immortalized by Epstein Barr virus, for producing heterologous proteins, which comprises the bacterial DNA elements required for its...
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5776778 |
Growth factor preparation of thymocyte cell culture medium its production and use
The present invention relates to a growth factor preparation derived from a mixed lymphocyte culture, and a process for its production. The invention also relates to a cell culture medium...
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5776754 |
Preserved cell preparations for flow cytometry and immunology
This invention discloses a population of cells which have been preserved in non-frozen hydrated form, and which have been chemically treated in a manner that renders them metabolically inert and...
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5772994 |
Hematopoietic facilitatory cells and their uses
The present invention relates to mammalian hematopoietic facilitatory cells (FC). In particular, it relates to the isolation, characterization and uses of the FC. The FC of the present invention...
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5766944 |
T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
A procedure for carrying out T cell differentiation of CD34+ stem cells in an in vitro culture of thymic epithelial fragments whereby the differentiated T cells achieve full immunocompetence. The...
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5766859 |
Ribonuclease L inhibitor as an indicator of chronic fatigue syndrome
Chronic fatigue syndrome in an individual is diagnosed by determining the level of RNase L inhibitor mRNA or protein in peripheral blood mononuclear cells. Significantly decreased levels of RLI...
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5766880 |
Isolated nucleic acid molecules encoding multidrug resistance proteins
A novel protein associated with multidrug resistance in living cells and capable of conferring multidrug resistance on a cell is disclosed. Nucleic acids encoding the novel multidrug resistance...
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5766588 |
Tumor immunotherapy using anti-idiotypic antibodies
The present invention relates to methods which utilize anti-idiotypic antibodies, or fragments thereof, for tumor immunotherapy or immunoprophylaxis. Monoclonal anti-idiotypic antibodies which...
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5767073 |
D4 gene and methods of use thereof
The sequence, molecular structure and expression of a cDNA clone, denoted D4, of human and murine origin, preferentially expressed in hematopoietic cells is described herein. The human cDNA clone...
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5763156 |
Inhibition of complement mediated inflammatory response
A composition and methods for use thereof relating to polypeptides having the ability to act as an inhibitor of complement C5b-9 complex activity. The compositions contain an 18 kDa protein found...
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5763266 |
Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
Methods, compositions and devices are provided for the growth of human stem and/or hematopoietic cells in culture. Bioreactors are provided in which diverse cell types are simultaneously-cultured...
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5759793 |
Method for mammalian cell separation from a mixture of cell populations
The invention provides a method for both the positive and negative selection of at least one mammalian cell population from a mixture of cell populations utilizing a magnetically stabilized...
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5759805 |
CD69 transcriptional regulatory elements
The present invention provides recombinant polynucleotides comprised of elements that regulate transcription and/or expression of coding sequences. These regulatory elements have been isolated from...
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5760012 |
Methods and compounds for curing diseases caused by mutations
The invention concerns the use of duplex oligonucleotides having both 2'-deoxyribonucleotides and ribonucleotides, wherein there is base pairing between the two types of nucleotides. The sequence...
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5756097 |
Lymphokine activated effector cells for antibody-dependent cellular cytotoxicity (ADCC) treatment of cancer and other diseases
This invention relates to processes and compositions for the immunotherapeutic treatment of cancer and non-malignant tumors. More particularly, this invention relates to processes and compositions...
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5753464 |
DNA encoding a polypeptide having pre-B cell growth-supporting ability
This invention relates to a gene encoding a polypeptide having pre-B cell growth-supporting ability, and an adhesion molecule of the polypeptide consisting of 318 amino acid residues having pre-B...
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5753221 |
Transformed erythrocytes, process for preparing the same, and their use in pharmaceutical compositions
The invention relates to compositions of erythrocytes that have been modified following hypotonic lysis and resealing by addition of 2',3'-dideoxycytidine-5'-triphosphate (ddCTP) or...
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5747308 |
Recombinant DNA method
There is described a method for obtaining a eukaryotic cell containing in its DNA multiple copies of a GS gene, comprising: transforming a eukaryotic glutamine auxotroph with a GS gene; selecting...
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5747325 |
Devices comprising genetically engineered βcells
The present disclosure relates to the application of genetic engineering to provide artificial β cells, i.e. cells which can secrete insulin in response to glucose. This is achieved preferably...
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5744361 |
Expansion of human hematopoietic progenitor cells in a liquid medium
The use of individual or combinations of cytokines, particularly IL-3, GM-CSF, and c-kit ligand are employed for long-term hematopoiesis in serum free culture in the absence of stromal cells. The...
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5744354 |
Calcineurin inhibitory compounds and anchoring protein to induce IL-2 gene expression
The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are...
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5744353 |
Cytolytic T cell lines which bind to complexes of tumor rejection antigens and HLA-B44 molecules
Tumor rejection antigens presented by HLA-B44 molecules are described. These peptides are useful in diagnostic and therapeutic methodologies. The tumor rejection antigens are derived from MAGE...
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5744456 |
Methods for obtaining production of a gene product in a host cell in vivo or in vitro using a DNA molecule for integration site independent gene expression
Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant...
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5741706 |
Anti-HIV ribozymes
GUC and GUA ribozymes which cleave HIV RNA are provided. The ribozymes cleave HIV RNA in vitro and in vivo. When the ribozymes are expressed in cells, they inhibit HIV replication in the cells.
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5736359 |
Isolated DNA molecules for integration site independent gene expression in mammalian host cells
Vectors for the integration of a gene into the genetic material of a mammalian host cell such that the gene may be expressed by the host cell comprise a promoter and the gene and include a dominant...
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5733542 |
Enhancing bone marrow engraftment using MSCS
Method and preparations for enhancing bone marrow engraftment in an individual by administering (i) a culturally expanded mesenchymal stem cell preparation and (ii) a bone marrow graft. The...
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5728581 |
Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
The present invention provides methods and bioreactors for expanding stem cells in a population of cells substantially enriched in hematopoietic stem cells and substantially free of stromal cells....
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5726041 |
Method for detecting a receptor-ligand complex using a cytochrome P450 reporter gene
An improved method for measuring the activity of a promoter sequence in a mammalian cell using a reporter gene is provided. The improvement involves using a reporter cassette containing a DNA...
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5716776 |
Enrichment by preferential mitosis of fetal lymphocytes from a maternal blood sample
A method is presented for selective stimulation of fetal lymphocytes to divide in culture after treatment of mixed adult-fetal blood samples. This method is particularly useful for diagnosing...
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5716845 |
Immortalized lymphocytes for production of viral-free proteins
This invention is directed to construction of recombinant plasmids that contain the Epstein-Barr virus ("EBV") genetic information involved in the immortalization of human lymphocytes, but that...
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5710037 |
Retroviral vector particles
A retroviral vector which includes a nucleic acid sequence encoding a retroviral envelope. The nucleic acid sequence encoding a retroviral envelope includes a first nucleic acid sequence encoding a...
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5705349 |
Methods for preparing polynucleotides encoding orphan receptor ligands
Methods for obtaining cells that produce a ligand for an orphan receptor and methods for preparing polynucleotide molecules that encode ligands for orphan receptors are disclosed. The methods...
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5702702 |
Modified cytotoxic tall cell line and compositions and methods for manufacture and use thereof as therapeutic reagents for cancer
The invention provides a modified human cytotoxic T cell line, which is characterized by dual activity in vitro and in vivo against malignant cells and virus-infected cells. Also provided are...
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5700640 |
Inducers of gamma globin gene expression and screening assays therefor
Methods for stimulating gamma globin gene expression in a mammalian cell comprising contacting the cell with a compound selected from valeric acid and certain isomers, derivatives or salts thereof,...
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5700691 |
Method for the preparation of in vitro-derived human neutrophil precursor cells
A composition of human neutrophil precursor cells is disclosed wherein at least 16% of the cells are human myeloblasts and promyelocytes. The myeloblasts and promyelocytes are derived from human...
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5695994 |
Isolated cytolytic T cells specific for complexes of MAGE related peptides and HLA molecules
The invention involves a nonapeptide derived from the tumor rejection antigen precursor encoded by gene MAGE-3. This nonapeptide is presented by HLA molecules HLA-A1. The resulting complexes are...
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5693535 |
HIV targeted ribozymes
An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
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5691177 |
Recombinant retroviruses expressing a protein that converts a pro-drug into a cytotoxic agent
Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the...
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5691208 |
Magnetic separation apparatus and method
Improved magnetic separators, devices and methods for magnetic separation procedures are provided. The improved separation devices contain matrices which provide uniform pores or channels that...
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5686264 |
Compositions and methods relating to transdominant Tat mutants
Transdominant HIV tat substitution and truncated gene mutants of 72 amino acid residues or less are disclosed. The mutated genes encode mutant Tat proteins which are capable of inhibiting the...
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5686576 |
Differentiated megakaryocyte line producing novel megakaryocyte differentiation factor
Differentiated megakaryocytes produced by introducing an activated oncogene into blast-megakaryocytes is disclosed. Also disclosed are novel megakaryocyte differentiation factors and platelets...
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5686278 |
Methods for enhanced retrovirus-mediated gene transfer
A method to increase the efficiency of transduction of hematopoietic cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and...
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5686068 |
Isolated peptides derived from MAGE-2, cytolytic T cells specific to complexes of peptide and HLA-A2 molecules, and uses thereof
New peptides derived from the MAGE-2 molecule and which bind to HLA-A*0201 molecules are disclosed. Some of these are especially useful because, when complexed to their HLA-A*0201 partner...
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5679641 |
Peptides of human P53 protein for use in human T cell response inducing compositions, and human P53 protein-specific cytotoxic t-lymphocytes
A peptide comprising an amino acid sequence derived from human p53 protein, wherein said amino acid sequence has the ability to bind to a human MHC Class I molecule. Its use in prophylactic or...
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5677139 |
In vitro differentiation of CD34.sup.+ progenitor cells into T lymphocytes
The invention involves a method for the in vitro T cell production. A monolayer of non-human primate thymic stromal cells are cocultured in vitro with primate hematopoietic T cell progenitor cells....
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5677143 |
Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
The invention relates to a cellular protein which is specific and has high affinity for nucleic acid sequences characteristic of an intact TAR RNA loop sequence of the HIV LTR TAR region. The...
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5677147 |
HIV-2 virus variants
HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V...
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5677136 |
Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
A method for obtaining human hematopoietic stem cells is provided by enrichment for stem cells using a novel stem cell marker. Compositions enriched for stem cells are obtained using novel antibody...
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5674723 |
Nucleic acid molecules which immortalize human or animal cells and uses thereof
The present invention concerns DNA sequences which are suitable for immortalizing human or animal cells, processes for isolating such DNA sequences as well as processes for producing immortalized...
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