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7611895 |
Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
The invention relates to materials and methods for producing equivalents of tissues of the ocular surface, especially conjunctival tissue equivalents. The method of the invention involves biopsy of...
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7608454 |
Vascularization enhanced graft constructs
A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement...
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7588936 |
Generating teeth from bone marrow cells
The present invention is based on the discovery that teeth primordia can be generated using bone marrow cells and that bone marrow cells may be employed to generate teeth without the need for...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7547447 |
Bioartificial lacrimal gland
The present invention provides a bioartificial lacrimal gland which contains at least one unit that includes (a) a permeable housing having an interior and an exterior; (b) an outlet connecting the...
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7541188 |
Skin substitutes and uses thereof
The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of...
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7537904 |
Cell for measuring the ability to control the activity of a ligand-responsive transcription control factor
The present invention provides an animal cell expressing a gene coding a ligand-responsive transcription control factor and securely maintaining a DNA comprising in a molecule, the following genes...
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7524493 |
Nucleic acid constructs cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension
A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged...
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7521231 |
Method for preparing engineered tissue
A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is...
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7498168 |
Tooth progenitor cell and method for its production
The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell.
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7498167 |
Keratinocytes expressing exogenous angiogenic growth factors
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
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7488599 |
Methods for culturing mammalian taste cells
The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular...
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7449333 |
Methods and compositions for tissue regeneration
The present invention provides the use and composition of matter of angiogenic or other growth/cytokine factors expressed by mixtures of allogeneic human cell strains or lines of various types and...
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7449306 |
Systems and methods for screening pharmaceutical chemicals
A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response...
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7439327 |
Stem cell factor-like proteins and uses thereof
The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4 v polynucleotides and polypeptides. The invention further relates to the...
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7435808 |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1...
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7425427 |
Method for staining corneocytes, method for preparing corneocytes specimen and skin analysis system
A method for preparing corneocytes specimen, which comprises stripping off corneocytes from the surface of a skin using an adhesive material, staining the corneocytes in a solution of stain in...
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7416889 |
Methods and compositions for repairing cartilage
Disclosed is a method for inducing repair of a joint tissue in a mammal includes the steps of removing a sample of synovial membrane from a joint of the mammal, isolating type B synoviocytes from...
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7407805 |
Skin substitutes with improved barrier function
The present invention relates to in vitro cultured skin substitutes, and in particular to in vitro cultured skin substitutes that have improved barrier function. In some embodiments, improved...
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7361506 |
Differentiation of specialized dermal and epidermal cells into neuronal cells
Cells are generated from skin biopsies for use in cell implantation by identifying a source of skin cells that have a surface concentration of at least one cell selected from the group consisting...
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7358086 |
Mammalian two-hybrid system for screening for modulators of the accumulation of metabolic products
This invention utilizes a two-hybrid system to screen for agents that modulate the ability of a cell to degrade or to accumulate a metabolic product or to selective kill a cell or to selectively...
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7341829 |
In situ growth, freezing and testing of cultured cells
The present invention provides methods and compositions for the in situ growth, freezing and testing of cultured cells. In particular, the present invention provides methods and compositions for...
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7316927 |
Culture of goblet cells
The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans,...
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7316897 |
Process, device and reagent for cell separation
A cell separation process for the isolation of pathogenic cells in a small concentration in a biological fluid specimen, including treating the biological specimen to modify in a differential...
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7306943 |
Keratinocytes useful for the treatment of wounds
The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds.
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7300794 |
Accelerated culture system for intestinal epithelial cell monolayers
The present invention provides a unique medium for the cultivation of intestinal cell lines. The medium allows for the development of a highly differentiated intestinal epithelial cell monolayer in...
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7267965 |
Means and methods for regulating gene expression
The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell...
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7244552 |
Artificial dermis and production method therefor
Artificial dermis ( 1 ) obtained from plasma with platelets ( 2 ) and human fibroblasts. The plasma with platelets ( 2 ) is obtained from the fractionating of total blood ( 4 ) from the patient ( 8...
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7229761 |
Method of constructing a synthetic polynucleotide
A method of constructing a synthetic polynucleotide, the method including selecting a first codon of a parent polynucleotide that encodes a polypeptide for replacement with a synonymous codon,...
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7226606 |
Cancer-associated antigens and methods of their identification and use
The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in...
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7217570 |
Organotypic intestinal culture and methods of use thereof
An organotypic culture comprises an artificial stroma overlayed with epithelial cells isolated from a human colon or intestine. The stroma comprises a mixture of collagen and human fibroblasts...
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7186558 |
Keratinocytes obtained from embryonic stem cells of mammals
The present invention relates to a method for inducing the differentiation of mammals' embryonic stem cells into keratinocytes, comprising the following steps of:
isolating an extracellular...
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7186554 |
Methods and compositions for human bladder epithelial cell culture
The present invention provides methods for culturing normal and malignant human bladder epithelial cells for many generations, and compositions of matter to be used in the methods.
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7169382 |
Reconstructed epidermis/skin equivalent comprising a ceramide 7 and /or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds
A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the...
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7160726 |
Compositions comprising conditioned cell culture media and uses thereof
The invention relates to compositions comprising cell culture medium conditioned by cells grown in three-dimensional culture. The cells used to condition the medium may be genetically modified to...
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7144729 |
Methods and compositions for tissue regeneration
The present invention provides the use and composition of matter of angiogenic or other growth/cytokine factors expressed by mixtures of allogeneic human cell strains or lines of various types and...
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7135335 |
Method for separating cells using immunorosettes
The present invention relates to methods for separating cells using immunorosettes. The method involves contacting a sample containing nucleated cells and red blood cells with an antibody...
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7132284 |
Adenovirus packaging cell lines
Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus...
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7115360 |
Isolation and use of solid tumor stem cells
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in...
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7097972 |
Method and composition for regulating apoptosis
This invention provides non-naturally occurring and isolated naturally occurring nucleic acid molecules which encode proteins designated pro-Yama, p11 Yama and p20 Yama. This invention also...
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7074618 |
Adenoviral E1A/E1B complementing cell line
Adenovirus packaging cell lines for growth of E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA), are provided. Methods for producing adenovirus...
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7074552 |
Method of forming vascularized kidney tissue
A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to...
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7067121 |
Transplants for myocardial scars
A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal...
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7049139 |
Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
The invention relates to materials and methods for producing equivalents of tissues of the ocular surface, especially conjunctival tissue equivalents. The method of the invention involves biopsy of...
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7049133 |
Regulation of gene expression through manipulation of mRNA splicing and its uses
A cis-acting nucleotide sequence which is capable of rendering the removal of introns from a precursor transcript encoded by a gene, which gene harbors at least one such cis-acting nucleotide...
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7026164 |
Adenovirus packaging cell lines
Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus...
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7022520 |
Cell culture media for mammalian cells
A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells.
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7015039 |
Separating epithelium from stroma in LASEK surgery
A method of separating the epithelium and the stroma of a cornea includes providing a solution that includes a detaching agent diluted in a culture medium and applying the solution to the surface...
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6998513 |
Human inflammatory breast carcinoma xenograft capable of lymphovascular invasion and methods for its use
The present invention provides human transplantable inflammatory breast carcinoma xenografts. Such xenografts exhibit a number of unique characteristics which allows their use in experimental...
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6998264 |
Replication of biological tissue
Biological tissues are grown in a low shear, microgravity environment by culturing connective tissue cells to form a three-dimensional structure, which is thereafter co-cultured with endothelial...
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