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Document Title |
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8173372 |
Methods of donor specific crossmatching
The detection of endothelial cell antibodies has been proven clinically important for successful organ transplantation. Disclosed are methods of isolating Tie-2+ and CD34− precursor endothelial c...
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8153359 |
Toxicity assay based on human blastocyst-derived stem cells and progenitor cells
An in vitro toxicity assay based on human blastocyst-derived stem cells for the detection of toxicity in the human species is provided, which enables novel detection of in vitro human toxicity for...
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8137965 |
Methods and compositions for tissue regeneration
A kit is disclosed that includes a first component comprising alginate, wherein the first component is comprised in a first sterile vial, and a second component comprising cells comprising...
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8084048 |
Vascularization enhanced graft constructs
A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement...
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8030068 |
Method for culturing mammalian taste cells
The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular...
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7998737 |
Cell culture of keratinocytes under non-differentiating conditions
The present invention relates to a cell culture medium comprising (a) an inhibitor of bone morphogenetic protein-4 (BMP-4) and (b) an inhibitor of pigment epithelium-derived factor (PEDF, also...
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7985537 |
Methods for determining the hair follicle inductive properties of a composition
The present invention provides a method for determining hair inductive properties of a composition comprising injecting a composition comprising dissociated dermal cells and epidermal cells into...
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7985587 |
Methods of culturing dermal papilla cells
The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt...
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7972821 |
Production of functional proteins: balance of shear stress and gravity
A method for the production of functional proteins including hormones by renal cells in a three dimensional culturing process responsive to shear stress uses a rotating wall vessel. Natural mixture...
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7955790 |
Skin substitutes with improved barrier function
The present invention relates to in vitro cultured skin substitutes, and in particular to in vitro cultured skin substitutes that have improved barrier function. In some embodiments, improved...
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7955846 |
Compositions comprising female germline stem cells and methods of use thereof
The present invention relates to female germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
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7915042 |
Keratinocytes expressing exogenous angiogenic growth factors
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
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7879605 |
Methods and compositions for tissue regeneration
Disclosed is a composition comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting...
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7846726 |
Human fetal bladder-derived epithelial cells
This invention discloses a substantially pure population of human urinary bladder-derived epithelial cells and methods of isolating and culturing the urinary bladder-derived epithelial cells. In...
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7824671 |
Retinal pigment epithelial cell cultures on amniotic membrane and transplantation
The present invention relates to a composition for implantation in the subretinal space of an eye, the composition including amniotic membrane, which may be cryopreserved human amniotic membrane,...
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7824913 |
Bioengineered tissue constructs and methods for producing and using thereof
Cultured tissue constructs comprising cultured cells and endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold...
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7820440 |
Means and methods for producing adenovirus vectors
The invention relates to methods and means for producing adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present...
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7816133 |
Preparation of fibroblast-populated connective tissue substitute
Disclosed is a method for in vitro growing of connective tissue substitute, said connective tissue substitute being populated with fibroblasts, a connective tissue substitute obtainable by such a...
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7807148 |
Organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1a
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
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7806937 |
Tissue engineered female reproductive organs
The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital...
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7794704 |
Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
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7795025 |
Methods for producing enriched populations of human retinal pigment epithelium cells
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
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7795022 |
Vascularization enhanced graft constructs
A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement...
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7794977 |
Means and methods for regulating gene expression
The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell...
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7790028 |
Systems, methods, and devices relating to a cellularized nephron unit
The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.
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7785876 |
Cultivation of hair inductive cells
The present invention relates to culturing cells which may be used in hair induction. In one aspect of the invention there is provided a method for cultivation of hair inductive cells, comprising...
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7776596 |
Vascularization enhanced graft constructs
A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of urinary...
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7763461 |
Antitumor vaccination using allogeneic tumor cells expressing alpha (1,3)-galactosyl transferase
The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. Through ex vivo gene therapy protocols tumor cells are engineered to express an α ...
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7754481 |
Keratinocytes useful for the treatment of wounds
The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds.
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7736896 |
Methods for producing enriched populations of human retinal pigment epithelium cells
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
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7727538 |
Methods and compounds for the treatment of mucus hypersecretion
A method of treating mucus hypersecretion, the causative factor in chronic obstructive pulmonary disease (COPD), asthma and other clinical conditions involving COPD, comprises administering a...
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7718426 |
Preparation method of a hair dermal papilla cell preparation, composition and method for regenerating hair follicles, and animal having regenerated hair follicles
The present invention provides a method for preparing a hair dermal papilla cell preparation comprising preparing a cell suspension by removing epidermal tissue from skin tissue and subjecting the...
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7700351 |
Methods and compositions for tissue regeneration
Disclosed is a kit comprising a first component comprising fibrinogen, aprotinin, and a buffered solution, and a second component comprising, fibroblasts, keratinocytes, thrombin, glycerol, human...
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7691593 |
Regulation of lung tissue by patched therapeutics and formulations and uses related thereto
The present application relates to a method for modulating the growth state of an lung tissue, or a cell thereof, e.g., by ectopically contacting the tissue, in vitro or in vivo, with a hedgehog...
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7618786 |
Method for identifying modulators of human orexin-2 receptor
The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor...
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7608454 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Vascularization enhanced graft constructs
A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement...
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7588936 |
Generating teeth from bone marrow cells
The present invention is based on the discovery that teeth primordia can be generated using bone marrow cells and that bone marrow cells may be employed to generate teeth without the need for...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7547447 |
Bioartificial lacrimal gland
The present invention provides a bioartificial lacrimal gland which contains at least one unit that includes (a) a permeable housing having an interior and an exterior; (b) an outlet connecting the...
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7541188 |
Skin substitutes and uses thereof
The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of...
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7537904 |
Cell for measuring the ability to control the activity of a ligand-responsive transcription control factor
The present invention provides an animal cell expressing a gene coding a ligand-responsive transcription control factor and securely maintaining a DNA comprising in a molecule, the following genes...
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7524493 |
Nucleic acid constructs cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension
A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged...
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7521231 |
Method for preparing engineered tissue
A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is...
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7498168 |
Tooth progenitor cell and method for its production
The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell.
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7498167 |
Keratinocytes expressing exogenous angiogenic growth factors
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
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7488599 |
Methods for culturing mammalian taste cells
The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular...
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7449306 |
Systems and methods for screening pharmaceutical chemicals
A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response...
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7435808 |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1...
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7421105 |
Method for staining corneocytes, method for preparing corneocytes specimen and skin analysis system
A method for preparing corneocites specimen, which comprises stripping off corneocites from the surface of a skin using an adhesive material, staining the corneocites in a solution of stain in...
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7416889 |
Methods and compositions for repairing cartilage
Disclosed is a method for inducing repair of a joint tissue in a mammal includes the steps of removing a sample of synovial membrane from a joint of the mammal, isolating type B synoviocytes from...
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