Matches 201 - 250 out of 251 < 1 2 3 4 5 6 >
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5643787 Adenocarcinoma cell basement membrane composition  
Methods and compositions are provided for the culture of human primary carcinomas and in situ carcinomas. Feeder layers derived from a human parotid basal cell carcinoma, having the HMS-1...
5643782 Immortalized epithelial cell lines  
An immortalized epithelial lens cell line obtained from human lens epithelial cells infected with hybride adenovirus/SV40 (Ad12-SV40), and methods for making and using the cell line are disclosed.
5643746 Human epidermal gene promoter  
The present invention relates to promoter elements from human type I transglutaminase (TGase I) genes for controlled gene expression of both human TGase I and heterologous proteins. These promoter...
5628781 Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves  
Implant materials having porosity are provided by the present invention. Methods for treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a...
5618718 Production of a contractile smooth muscle  
A contractile smooth muscle cell construct and a method for preparing the smooth muscle cell construct are described. The smooth muscle cell construct is comprised of (i) smooth muscle cells that...
5605821 Expression control sequences of the P-selectin gene  
DNA molecules and methods for the regulated expression of a gene in endothelial cells or megakaryocytes, are described, wherein the 5' flanking region of the P-selectin gene, or portions thereof,...
5576206 Human papilloma virus genes and their use in gene therapy  
A process of immortalizing cells with isolated HPV-16, 18, 31, 33 or 35 E6 and E7 genes or the E7 gene alone to produce non-tumorigenic immortalized cell lines which retain the differentiated...
5558861 Modified microbially-produced cellulose gel with human epidermal cells adsorbed thereon for use as a skin graft or vulnerary cover  
Disclosed is a gel of microbially-produced cellulose, characterized in that the microbially-produced cellulose is modified by (1) physically or chemically bonding an animal cell adhesive protein to...
5536656 Preparation of tissue equivalents by contraction of a collagen gel layered on a collagen gel  
Tissue equivalents are produced by applying a solution of collagen without cells to a permeable membrane, gelling to produce a collagen gel on the membrane, applying a mixture of collagen and a...
5518915 Three-Dimensional mucosal cell and tissue culture system  
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
5516650 Production of activated protein C  
Methods are disclosed for producing a protein which has substantially the same biological activity as human protein C or human activated protein C. The protein is produced by mammalian host cells...
5496722 Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom  
Normal mammalian tissue and the culturing process has been developed for the three groups of organ, structural and blood tissue. The cells are grown in vitro under microgravity culture conditions...
5474770 Biological support for cell cultures constituted by plasma proteins coagulated by thrombin, its use in the preparation of keratocyte cultures, their recovery and their transport for therapeutic purposes  
The present invention relates to a biological support for cell cultures formed by the coagulated mixture of a concentrate of plasma proteins and thrombin. The protein concentrate is obtained by...
5470737 Stably-transformed cells expressing human thiopurine methyltransferase  
A recombinant DNA sequence is provided which encodes human thiopurine methyl transferase (TPMT), as well as a mammalian cell line having said recombinant DNA sequence incorporated into the genome...
5462870 Human diploid salivary gland epithelial cell lines  
Described is a biologically pure culture of an immortal human parotid based epithelial cell. The present invention is concerned with the establishment in serum-free medium of normal diploid...
5451521 Procoagulant proteins  
This invention relates to recombinant Factor VIII:c variants, methods to produce the variants and pharmaceutical compositions containing same. The variants of this invention are characterized by...
5443954 Immortalized non-tumorigenic human bronchial epithelial cell lines  
Immortalized human bronchial epithelial and human mesothelial cell lines have been obtained. Various uses of these cell lines have been described.
5436152 Immortal human mammary epithelial cell lines  
Immortalized human epithelial cell sublines are provided. The novel cell lines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The novel cells...
5432060 Immortalized human bronchial epithelial cell line  
Human bronchial epithelial cell lines permanently transformed by human papilloma viruses have been obtained. These cell lines are useful for the study of growth and differentiation in bronchial...
5427935 Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes  
Material such as biological material is encapsulated within a semi-permeable hybrid membrane bead by suspending the material in a medium which comprises an effective amount of a gelling inducer;...
5420033 Epithelial cell line expressing a cystic fibrosis phenotype  
An airway epithelial cell line (CF/T43) was developed by infecting cultured cystic fibrosis (CF) airway epithelial cells with the pZIPneoSV(X)1/SV40T retrovirus and selecting for Genetian (G418)...
5344774 Human intracisternal A-type retroviral particles associated with sjogren's syndrome  
The present invention relates to purified preparations of a novel retrovirus, to methods of diagnosis and treatment of Sjogren's syndrome, novel cell lines, and model systems for the study of...
5342774 Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1  
The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it....
5334527 Epidermal graft system  
The present invention involves a readily produced skin autograft or silograft composite suitable for the supplementation or replacement of injured skin. A sheet of collagen-coated pliable material...
5298417 Cryopreserved in vitro cultured epithelial tissue and method  
A process for preserving cultured epidermal sheets by incubating the sheets at room temperature in media with a glycerol or dimethylsulfoxide cryopreservant for a predetermined period of time and...
5266480 Three-dimensional skin culture system  
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
5240846 Gene therapy vector for cystic fibrosis  
The present invention comprises gene therapy for treating cystic fibrosis(CF). Delivery and expression of a single copy of a normal CFTR gene leads to stable correction of the Cl channel regulation...
5238840 Immortal human mammary epithelial cell sublines  
Two immortalized human mammary epithelial cell sublines are provided. The sublines do not undergo terminal differentiation and senescence upon exposure to high calcium concentrations. The sublines...
5210037 Method to enhance TPA production  
A medium supplement which promotes the secretion of tPA from cells producing this protein natively or by virtue of recombinant transformation without the concomitant addition of contaminating...
5175092 Vitro toxicology kit and method therefor  
A method is described for producing tissue from cells, such as keratinocyte, epithelial or endothelial cells, in vitro. Cells are grown on a porous cell-growth substrate having specific growth...
5166059 Gene therapy using gene fusions for genetic or acquired disorders  
Gene therapy utilizing an MDR1 linked fusion coding sequence has been disclosed. ADA activity has been introduced into cells using MDR1 linked fusion gene.
5147790 Serum-independent human cell lines, process for producing same, and processes for producing proteins therefrom  
Human cell lines which proliferate in the absence of serum or of any macromolecular growth factors are produced by a three step procedure comprising removing serum containing culture medium from...
5135915 Method for the treatment of grafts prior to transplantation using TGF-.beta .  
A method is provided for the treatment of grafts such as tissue or organs prior to transplantation into a suitable host. The grafts are incubated, coated, or perfused with TGF-β for an effective...
5100676 Cool storage of cultured epithelial sheets  
The viability of cohesive sheets of cultured epithelial cells such as keratinocytes used as wound dressings is maintained or improved by storage at a temperature within the range of 8°-25° C.,...
5040677 Container for storage and distribution of a skin wound dressing  
Disclosed is a container for the storage and distribution of a cultured epithelial, generally planar, living, skin wound dressing that allows the dressing to be gently removed by lifting...
4996154 Method for growing cellular tissue  
A method is described for producing tissue from cells, such as keratinocyte, epithelial or endothelial cells, in virto. Cells are grown on a porous cell-growth substrate having specific growth...
4983515 Labeled cryopreserved cells for use as targets in cytotoxicity assays  
Biological cells which are fluorophore-labeled can be stored frozen for a long period of time. After thawing the cells can be used as targets in fluorophore-release cytotoxicity assays.
4980286 In vivo introduction and expression of foreign genetic material in epithelial cells  
Epithelial cells expressing foreign genetic material are described. The foreign genetic material can be DNA or RNA which does not occur in epithelial cells; DNA or RNA which occurs in epithelial...
4980290 Human uroepithelial cell  
Immortalized human uroepithelial cells are disclosed. One cell line is not spontaneously tumorigenic, but can be tumorigenically transformed by certain carcinogens. Another is a tumorigenic variant...
4940666 Process and defined medium for growth of human epidermal keratinocyte cells  
Disclosed are novel methods and materials for generating in vitro cultured populations of human epidermal keratinocyte cells having a characteristic colony-forming efficiency of greater than 20%....
4931275 Anti-tumor vaccines and their preparation  
There are provided anti-tumor vaccines which contain as active ingredient tumor cells which have been pressure treated so as to augment their antigenic properties, tumor cells treated with...
4885238 Immortalized human bronchial epitherial mesothelial cell lines  
Immortalized human bronchial epithelial and human mesothelial cell lines have been obtained. Various uses of these cell lines have been described.
4808532 Continuous human cell lines and method of making same  
Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the...
4798796 Cell lines and their use for the production plasminogen activators  
Human cell lines that proliferate in the absence of serum or of any macromolecular growth factors are produced by a process comprising removing serum containing culture medium from the culture of a...
4757019 Method for obtaining pure, stable tissue cultures of human melanocytes  
Human melanocyte cells are grown in tissue culture medium containing fibroblast growth suppressor plus tumor growth promoters at pH 7.2 to about 7.4. In a stepwise procedure, Langerhans,...
4608339 Protoplast fusion method for high-frequency DNA transfection in human cells  
A modified protoplast fusion method and cell line is disclosed that stably transfects human cells with pSV2-derived plasmids at frequencies greater than 10 -3 . This procedure makes it possible to...
4533637 Culture medium  
On the new findings that cyclodextrin shows no cytotoxicity or only slight cytotoxicity on cell growth and that lipophilic substances such as unsaturated fatty acids and lipophilic vitamins when...
4517304 Production of viral antigens  
Antigens specific to respiratory syncytial virus are produced on the surface of cells by: (1) culturing in vitro cells derived from a human or animal mucosa, (2) inoculating the cultured...
4514499 Cell culture using a monolithic support  
A novel immobilized cell composite used in a novel apparatus/method for cell culture. The composite comprises: (a) a high surface area monolithic support having a multiplicity of mutually...
4423145 Enhanced growth medium and method for culturing human mammary epithelial cells  
Methods are disclosed for isolating and culturing human mammary epithelial cells of both normal and malignant origin. Tissue samples are digested with a mixture including the enzymes collagenase...
Matches 201 - 250 out of 251 < 1 2 3 4 5 6 >