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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7553928 |
Use of des-Aspartate-angiotensin I as an agent for the treatment and prevention of glomerulosclerosis and renal failure
The present invention relates generally to a method for the treatment and/or prophylaxis of renal-related disorders. More particularly, the present invention contemplates a method for the treatment...
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7517972 |
Nucleic acid sequences encoding a bitter taste receptor, T2R76
Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods...
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7514545 |
Inducible eukaryotic expression system
Compositions and methods for the inducible expression of genes in eukaryotic cells. Expression of a nucleotide sequence of interest is controlled by a regulatory fusion protein that consists of a...
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7510874 |
Stable cell lines expressing HERG1a and HERG1b
A line of cultured mammalian cells includes HERG1b subunits and optionally HERG1a subunits.
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7494806 |
Retroviral vectors expressing exogenous gene or exogenous nucleic acid sequences
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial...
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7442546 |
Method of modulating inflammatory response
A method of immunomodulation by contacting the bodily fluid of a patient with renal tubule cells outside of the kidney.
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7435808 |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1...
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7416848 |
DNA encoding SNORF25 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors,...
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7326570 |
Induction of tubular morphogenesis using pleiotrophin
Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are...
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7297526 |
Human DNase
DNA isolates coding for human DNase and methods of obtaining such DNA are provided, together with expression systems for recombinant production of human DNase useful in therapeutic or diagnostic...
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7267965 |
Means and methods for regulating gene expression
The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell...
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7253150 |
Gene delivery vehicle expressing the aptosis-inducing proteins VP2 and/or apoptin
The invention relates to gene delivery vehicles which comprise nucleic acid molecules encoding apoptosis-inducing proteins VP2 and/or apoptin (VP3) like activity. VP2 and VP3 are viral proteins of...
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7235393 |
Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues
A method for isolating AAV viruses from cellular DNA of non-human primate (NHP) tissues by transfecting the DNA of NHP into 293 cells, rescuing the virus and amplifying it through serial passages...
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7223585 |
Viral purification methods
The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of...
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7217566 |
Attached cell lines
The present invention provides novel cell lines that may have improved adhesive qualities, transgene expression level, growth rate, and/or growth rate in serum free medium or even chemically...
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7211406 |
Potassium channel
A novel polypeptide which is useful in searching for a therapeutic agent for diabetes, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell...
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7198947 |
Production of functional proteins: balance of shear stress and gravity
The present invention provides a method for production of functional proteins including hormones by renal cells in a three dimensional co-culture process responsive to shear stress using a rotating...
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7186506 |
Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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7148037 |
Platelet-derived growth factor D, DNA coding therefor, and uses thereof
PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing...
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7125705 |
Polynucleotides for use in recombinant adeno-associated virus virion production
Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors...
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7112421 |
Nucleic acids encoding BAFF receptor, chimeric proteins and methods and compositions related thereto
Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including same. Methods of treating tumorigenic and autoimmune...
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7094600 |
Screen for sodium channel modulators
A method or screen for assessing the potential of a compound to treat a pathological condition, such as arrhythmia, which is manifested by an increased late sodium current in a heart is disclosed....
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7074552 |
Method of forming vascularized kidney tissue
A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to...
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7045335 |
Alphavirus replicon vector systems
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent...
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7033750 |
Recombinant P53 adenovirus methods and compositions
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected...
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7029914 |
DNA encoding SNORF36 receptors
This invention provides isolated nucleic acids encoding mammalian SNORF36 receptors, purified mammalian SNORF36 receptors, vectors comprising nucleic acid encoding mammalian SNORF36 receptors,...
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7029857 |
Processes for obtaining compounds employing SNORF72 receptors
This invention provides isolated nucleic acids encoding mammalian SNORF62 and SNORF72 receptors, purified mammalian SNORF62 and SNORF72 receptors, vectors comprising nucleic acid encoding mammalian...
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7022520 |
Cell culture media for mammalian cells
A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells.
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6972194 |
Use of polyacrylamide gel for forming a connective-tissue capsule in a mammal for cultivating allogenic and xenogenic cells
The invention relates to the field of medicine and more particularly it relates to the problem of vaccination against tumor cells and vaccinotherapy of oncological diseases, and also to a method of...
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6943019 |
Methods and vector constructs useful for production of recombinant AAV
Methods for efficient production of recombinant AAV employ a host cell containing a first nucleic acid molecule comprising from 5′ to 3′, a parvovirus P5 promoter, a spacer, an AAV rep sequence...
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6913927 |
Non-adenoviral gene product-based complementing cells for adenoviral vectors
The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which...
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6867022 |
Replication deficient adenovirus vectors and methods of making and using them
The invention provides novel replication deficient adenovirus vectors and methods for making and using these viruses. The invention also provides vector systems and kits using a serotype specific...
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6844192 |
Adenovirus E4 protein variants for virus production
A method of packaging a recombinant viral vector is carried out by: (a) providing a packaging cell, the packaging cell containing and expressing a nucleic acid encoding a mutant adenovirus E4orf6...
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6770444 |
Methods of identifying or screening for agents that binds the Ob-Re
This invention provides an isolated nucleic acid encoding a polypeptide, a purified polypeptide, vectors comprising isolated nucleic acid encoding a polypeptide, cells comprising such vectors,...
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6764844 |
DNA sequence encoding a novel glucuronyl C5-epimerase
An isolated or recombinant DNA sequence coding for a mammalian, including human, glucuronyl C5-epimerase or a functional derivative thereof capable or converting D-glucuronyl acid (GlcA) to...
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6734005 |
Matrix metalloproteinases
The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes;...
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6730507 |
Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration
This invention responds to a long felt need, by providing in one embodiment, a helper virus based on the Ad2 serotype for use in the Cre/loxP system for the generation of Ad vectors deleted of all...
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6723552 |
DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells...
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6692736 |
Cell-specific adenovirus vectors comprising an internal ribosome entry site
Disclosed herein are replication-competent adenovirus vectors comprising co-transcribed first and second genes under transcriptional control of a heterologous, target cell-specific transcriptional...
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6670182 |
Assays for β-amyloid processing
The invention relates to the design, construction and use of eukaryotic cell lines useful in the identification of inhibitors of β-amyloid processing. More specifically, the invention relates to...
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6653131 |
Method of treating systemic inflammatory response syndrome
A method for treating systemic inflammatory response syndrome (SIRS) by contacting the bodily fluid of a patient with renal tubule cells outside of the kidney.
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6653101 |
Recombinant DNA method and host cells
The present invention provides a process and host cell for use in increasing the amount of a desired protein by a cell line. The process and the cell line use a first transcription unit containing...
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6642051 |
Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
High-efficiency AAV packaging constructs and methods for their use are provided. in the present invention. These high-efficiency packaging constructs comprise an activating element (such as the P1...
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6620618 |
Complementary cell line for the growth of adenovirus mutants with a deleted protease gene
An adenovirus vector/packaging cell line system is disclosed, in which the vector replication is blocked by deletion of a single gene, which deletion does not interfere with any other viral...
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6613569 |
Inducible packaging cell lines for lentivirus vectors
Novel packaging cell lines for production of lentiviral vectors are disclosed. The cell lines utilize an ecdysone-inducible system for virus production, thereby avoiding the cytotoxic effect of...
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6596508 |
CRE-inducible expression system
The present invention relates to an expression system for the expression of desired gene. The expression system of the present invention comprises a cyclic AMP sensitive promoter operably linked to...
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6528303 |
Neuropeptide Y-Y5 receptor
The invention provides isolated DNA molecules encoding the human, mouse and rat NPY-Y5 receptors. These isolated DNA molecules can be used to express the NPY-Y5 receptors in cells which can then be...
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6518413 |
Utrophin gene expression
Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic...
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6482626 |
Human DNase
This invention relates to a novel human deoxyribonuclease, referred to as LS-DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic...
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