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7621606 |
Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The...
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7618622 |
Treatment of Parkinson's disease and related disorders using postpartum derived cells
Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to...
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7618621 |
Mammalian multipotent neural stem cells and compositions, methods of preparation and methods of administration thereof
This invention relates to novel mammalian multipotent neural stem cells (MNSCs), compositions thereof, and methods of preparing and administering the cells to diseased, aged or damaged tissue such...
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7605128 |
Neurogenerative or neurotrophic factors for mitigating a symptom of ischemia
This invention pertains to the identification of neurogenerative and/or neurotrophic factors that can induce migration of stem cells to neural tissue and/or induce proliferation and/or...
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7604993 |
Combined regulation of neural cell production
This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating...
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7604992 |
Generation of neural stem cells from undifferentiated human embryonic stem cells
The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into...
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7601518 |
Secretion of neublastin
The present invention concerns improved methods and compositions for producing a Neublastin polypeptide as well as local delivery of Neublastin to specific regions of the nervous system including...
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7595295 |
Use of pleiotrophin to promote neurogeneration
The invention provides methods for promoting neuron survival in patients by administering pleiotrophin, or nucleic acids encoding pleiotrophin. Uses of the invention include promoting neuron graft...
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7595194 |
Isolation of mammalian CNS glial-restricted precursor cells
Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of...
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7588938 |
Neural stem cell-collagen-bioreactor system to construct a functional embryonic brain-like tissue
A method of generating tissue from stem and progenitor cells is disclosed. Primary mammalian stem cells and progenitor cells are placed in an extracellular matrix. The matrix is maintained in a...
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7582292 |
Adipose tissue derived stromal cells for the treatment of neurological disorders
The present invention relates to a treatment of neural injury and neurodegenerative diseases. Also included in the present invention is the use of adipose tissue derived stromal cells for the...
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7563862 |
Neural regeneration peptides and methods for their use in treatment of brain damage
The invention discloses a family of peptides termed NRP compounds or NRPs that can promote neuronal migration, neurite outgrowth, neuronal proliferation, neural differentiation and/or neuronal...
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7563586 |
Method of identifying a modulator of a voltage-gated sodium channel using cells expressing Nav1.8 and p11
The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7560281 |
Use of TGF beta superfamily antagonists to make dopaminergic neurons from embryonic stem cells
This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies...
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7557182 |
Molecules for transporting a compound across the blood-brain barrier
The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptide derived from aprotinin and from aprotinin analogs as well as conjugates...
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7557078 |
Morphogen-induced nerve regeneration and repair
Disclosed are therapeutic treatment methods, compositions and devices for maintaining neural pathways in a mammal, including enhancing survival of neurons at risk of dying, inducing cellular repair...
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7544511 |
Stable neural stem cell line methods
A systematic and efficient method for establishing stable neural stem cell lines and neuronal progenitor lines is described. The resulting cell lines provide robust, simple, and reproducible...
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7544509 |
Method for preparing stem cell preparations
This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an...
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7544478 |
Method for screening for compounds that modulate P16 mediated regulation of NMDA receptors
Discovered is a novel protein and variants thereof whose activity at the NMDA receptor causes an increased efflux of calcium ions through the channel of said receptor. This activity is...
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7534765 |
Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin
The present invention relates to a method to increase oligodendrocytes and oligodendrocyte precursor cells through administration of prolactin or a prolactin inducing agent.
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7524640 |
Inhibiting Smad2/3 signaling promotes neurite outgrowth in dorsal root ganglia
Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3...
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7524489 |
Regeneration and repair of neural tissue using postpartum-derived cells
Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived...
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7521199 |
Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the...
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7517521 |
Method of isolating human neuroepithelial precursor cells from human fetal tissue
A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from...
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7504257 |
Embryonic stem cells and neural progenitor cells derived therefrom
The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production...
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7501281 |
Compositions, methods and kits related to thrombin, Notch signaling and stamatogenesis and growth of stem cells
The present invention relates to methods based on the interactions of thrombin as a biological regulator. More specifically, the invention relates to the interactions of thrombin with regard to...
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7498168 |
Tooth progenitor cell and method for its production
The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell.
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7485457 |
Isolated/cloned human NT2 cell lines expressing serotonin and GABA
Human cells isolated and/or cloned from human NT2 cells for expressing serotonin (5HT) and gamma-aminobutyric acid (GABA) are disclosed. These cells can be used as cellular minipumps to release...
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7468277 |
Enriched preparation of human fetal multipotential neural stem cells
The present invention relates to a method of separating multipotential neural progenitor cells from a mixed population of cell types. This method includes selecting a promoter which functions...
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7459152 |
Erythropoietin administration to improve graft survival
The present invention provides methods, compounds and kits for increasing the viability of cells. The methods involve treating cells that make up a tissue graft with erythropoietin before, during...
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7445931 |
Compositions and methods for enrichment of neural stem cells using ceramide analogs
The present invention provides compositions and methods for human neural cell production. More particularly, the present invention provides cellular differentiation methods employing amphiphilic...
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7445776 |
Method for producing human intervertebral disc cells for implantation
There is provided a method for growing human intervertebral cells. Disc tissue is surgically removed from a normal disc of a patient, the cells expanded by feeding with a cell stimulant such as a...
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7442545 |
Neural colony forming assay
A neural colony forming cell (NCFC) assay is described. The assay allows one to distinguish neural stem cells from neural progenitor cells. In one embodiment, the present invention provides a...
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7439066 |
Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV)
The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to...
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7435586 |
Method of purification of cells
The present invention relates generally to a method for the generation of a substantially homogeneous population of undifferentiated cells. More particularly, the present invention relates to the...
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7419827 |
Cell lines
Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the...
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7419826 |
Human schwannoma cell line
In a preferred embodiment, the present invention relates to a Schwannoma cell line derived from a Schwann tumor in a patient with Neurofibromatosis type 2 (NF2) and immortalized with HPV E6-E7...
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7419825 |
Isolation of neural stem cells using gangliosides and other surface markers
During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number...
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7413898 |
Cells and methods for estimation of effects on neurological dysfunction
The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed...
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7410797 |
Meningeal-derived stem cells
Stem cell lines derived from meningeal tissue such as dura mater, pia mater, or arachnoid mater, are disclosed. In various embodiments, the stem cell lines include greater than 80%, greater than...
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7405284 |
Reducing cellular dysfunction caused by mitochondrial gene mutations
A synthetic, nuclear-encoded ND4 gene was linked to a mitochondrial targeting sequence and a FLAG epitope tag. This fusion construct was inserted into a rAAV vector. The ND4 fusion protein was...
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7393830 |
Prolactin induced increase in neural stem cell numbers
The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ,...
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7381561 |
Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagents that bind to cell surface markers are provided.
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7368115 |
Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (PACAP)
The present invention relates to a method of increasing the number and/or differentiation of neural stem cells and/or neural stem cell progeny using pituitary adenylate cyclase-activating...
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7361505 |
Multipotent neural stem cell compositions
The invention provides in vitro cell culture compositions consisting of neurospheres and culture medium, wherein the neurospheres consist of undifferentiated cells that are nestin + , glial...
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RE40209 |
Cell potential measurement apparatus having a plurality of microelectrodes
A cell potential measurement apparatus, which uses a planar electrode enabling a multi-point simultaneous measurement of potential change arising from cell activities, is provided which can conduct...
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7323334 |
Screening and therapeutic methods relating to neurogenesis
The invention provides methods of identifying compounds that modulate neurogenesis. The methods involve providing a compound that modulates prokineticin receptor signaling; contacting a neural stem...
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7323333 |
Materials and methods for regulating process formation in cell culture
The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells...
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7320872 |
Ependymal neural stem cells and method for their isolation
The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3,...
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