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7618817 |
Genetically modified human natural killer cell lines
The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell...
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7618786 |
Method for identifying modulators of human orexin-2 receptor
The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor...
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7618622 |
Treatment of Parkinson's disease and related disorders using postpartum derived cells
Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to...
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7618621 |
Mammalian multipotent neural stem cells and compositions, methods of preparation and methods of administration thereof
This invention relates to novel mammalian multipotent neural stem cells (MNSCs), compositions thereof, and methods of preparing and administering the cells to diseased, aged or damaged tissue such...
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7612167 |
Human hematopoietic growth regulatory gene product
The present invention relates to novel human hiwi protein and genes that encode such proteins. The invention is directed toward the isolation and characterization of human hiwi proteins. The...
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7611895 |
Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
The invention relates to materials and methods for producing equivalents of tissues of the ocular surface, especially conjunctival tissue equivalents. The method of the invention involves biopsy of...
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7611852 |
Functional cardiomyocytes from human embryonic stem cells
Human embryonic stem cells form embryoid bodies in culture which contain differentiated human cells. Some of the human cells in embryoid bodies differentiate into cardiomyocytes. Here the...
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7604992 |
Generation of neural stem cells from undifferentiated human embryonic stem cells
The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into...
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7604934 |
Method of screening candidate compounds for susceptibility to biliary excretion by endogenous transport systems
A method of screening a candidate compound for susceptibility to biliary excretion. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile...
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7601534 |
Method for multiplying stem cells
The use of a cellular development inhibitor in a controlled manner in order to maintain an undifferentiated stem cell state, especially one of human stem cells, whereby cell division is permitted.
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7595431 |
Mouse models of human prostate cancer
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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7595043 |
Method for processing and using adipose-derived stem cells
The present invention relates to a device comprising a cell carrier portion containing regenerative cells, e.g., stem and progenitor cells, and a cell carrier containment portion. The device is...
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7592176 |
Method of forming mesenchymal stem cells from embryonic stem cells
This invention relates to methods of producing a substantially homogenous population of mesenchymal stem cells derived from embryonic stem cells. Also, disclosed is a homogenous population of...
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7588937 |
Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells...
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7585676 |
Retroviral vector
Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.
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7585672 |
Differentiation of stem cells to endoderm and pancreatic lineage
Methods are described to increase the proportion of endoderm committed cells and pancreatic lineage cells in a culture of human embryonic stem cells which are undergoing differentiation. The method...
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7585670 |
Automated methods for isolating and using clinically safe adipose derived regenerative cells
Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g.,...
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7585618 |
Treatment of diabetes with milk protein hydrolysate
A milk protein hydrolysate which is preferably caseinoglycomacropeptide and/or a whey protein in a bioavailable form is used for the manufacture of a composition for the treatment or prevention of...
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7582479 |
Primate embryonic stem cell line
A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+);...
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7582292 |
Adipose tissue derived stromal cells for the treatment of neurological disorders
The present invention relates to a treatment of neural injury and neurodegenerative diseases. Also included in the present invention is the use of adipose tissue derived stromal cells for the...
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7575924 |
Methods and compositions relating to improved lentiviral vectors and their applications
The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic...
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7563586 |
Method of identifying a modulator of a voltage-gated sodium channel using cells expressing Nav1.8 and p11
The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound...
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7556805 |
Compositions for treatment of melanoma and method of using same
Melanoma can be treated in a mammalian subject by administering to the subject an immunologically-effective amount of a xenogeneic melanoma-associated differentiation antigen. For example, genetic...
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7547551 |
Transfection of eukaryontic cells with linear polynucleotides by electroporation
The present invention provides an improved method for gene delivery in eukaryotic cells by electroporation, preferably in human hematopoietic cells, particular dendritic cells. The method of the...
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7547546 |
Progenitor cells from wharton's jelly of human umbilical cord
Human progenitor cells are extracted from perivascular tissue of human umbilical cord. The progenitor cell population proliferates rapidly, and harbours osteogenic progenitor cells and MHC−/−...
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7547545 |
Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
The invention relates to methods for inducing marrow stromal cells to differentiate into neural cells by way of increasing intracellular levels of cyclic AMP. The invention also encompasses methods...
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7544661 |
Self-assembling peptide amphiphiles and related methods for growth factor delivery
Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related...
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7544497 |
Compositions for manipulating the lifespan and stress response of cells and organisms
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and...
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7541183 |
Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling
Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening...
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7534610 |
3D tissue constructs on the basis of colloidal crystals surface modified by sequential layering
A cell growth matrix for optimizing 3D organization nutrient delivery, controlling release of differentiation factors and facilitating attachment of cells to a scaffold Colloidal crystals and...
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7527974 |
Embryonic stem cells derived from human somatic cell—rabbit oocyte NT units
The present invention discloses a process for obtaining somatic cell derived embryonic stem cells (encoded by reprogrammed somatic cell nuclei), ES cell-like cells or other types of embryo-derived...
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7527971 |
Adult stem cell lines
The present invention is directed to a new cell line, VIT4-G9, which has been deposited as ATCC Accession number PTA-8683.
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7527968 |
Regeneration initiating cells
Methods and compositions for treating hyperglycemia and pancreatic damage as well as stimulating the repair or regeneration of islet cells are disclosed.
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7524640 |
Inhibiting Smad2/3 signaling promotes neurite outgrowth in dorsal root ganglia
Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3...
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7524489 |
Regeneration and repair of neural tissue using postpartum-derived cells
Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived...
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7521231 |
Method for preparing engineered tissue
A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is...
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7514261 |
Platelet-derived growth factor protection of cardiac myocardium
The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.
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7514260 |
Feeder independent extended culture of embryonic stem cells
Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem...
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7514259 |
Isolation and transplantation of retinal stem cells
The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in...
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7514075 |
Systems and methods for separating and concentrating adipose derived stem cells from tissue
Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g.,...
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7510876 |
Definitive endoderm
Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive...
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7510874 |
Stable cell lines expressing HERG1a and HERG1b
A line of cultured mammalian cells includes HERG1b subunits and optionally HERG1a subunits.
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7507581 |
Inhibition of pancreatic islet aggregation
A method for improving the health and viability of pancreatic islets and improving the outcome of pancreatic islet transplantations is described. The method includes incubating the islets with an...
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7504258 |
Tissue engineered cellular sheets, methods of making and use thereof
The disclosure provides methods and composition to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel....
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7504257 |
Embryonic stem cells and neural progenitor cells derived therefrom
The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production...
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7501238 |
Skin substitutes for irritancy testing
The present invention relates to in vitro cultured skin substitutes, preferably to in vitro cultured skin substitutes that have improved barrier function. In particular, the present invention...
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7498169 |
Extending tissue preservation
A method of sustaining cells is provided. The method can include providing a non-perfluorocarbon cell storage medium, providing a pre-oxygenated liquid perfluorocarbon in contact with the storage...
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7498168 |
Tooth progenitor cell and method for its production
The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell.
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7494806 |
Retroviral vectors expressing exogenous gene or exogenous nucleic acid sequences
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial...
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7491534 |
Methods for altering cell fate to generate T-cells specific for an antigen of interest
The invention provides methods for altering the expression profile of a cell to convert the cell from one cell type to a desired cell type (e.g., T-cells). These reprogrammed cells may be used in a...
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