|
Match
|
Document |
Document Title |
|
|
6982168 |
Immortal human prostate epithelial cell lines and clones and their applications in the research and therapy of prostate cancer
The present invention relates to immortalized, malignant, human, adult prostate epithelial cell lines or cell lines derived therefrom useful in the diagnosis and treatment of prostate cancer. More...
|
|
|
6982171 |
Cell motility and chemotaxis test device and methods of using same
The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member...
|
|
|
6972194 |
Use of polyacrylamide gel for forming a connective-tissue capsule in a mammal for cultivating allogenic and xenogenic cells
The invention relates to the field of medicine and more particularly it relates to the problem of vaccination against tumor cells and vaccinotherapy of oncological diseases, and also to a method of...
|
|
|
6969610 |
Methods of modifying cell structure and remodeling tissue
Disclosed is a method of modifying cell structure which includes: increasing the intracellular concentration of biliverdin reductase, or a fragment or variant thereof, in a mammalian cell under...
|
|
|
6969532 |
Compounds inhibiting COX-2 and iNOS promoter activities
A new chemical compound for treating human inflammatory diseases, tissue damage, stroke, septic shock and cancer. This chemical compound is produced from a process including the following steps:...
|
|
|
6969583 |
Method for detecting variant HBV
The present invention relates generally to an assay for detecting variant Hepatitis B viruses (HBVs) which exhibit altered sensitivity to agents. The variant HBVs are delivered to cells using a...
|
|
|
6964855 |
Peptides for detection to Anaplasma phagocytophilum
The invention provides compositions and methods for the detection and quantification of A. phagocytophilum (formerly known as Ehrlichia equi ) antibodies and antibody fragments.
|
|
|
6956114 |
Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
The present invention relates to the field of DNA recombinant technology. More specifically, this invention relates to fusion proteins comprising an ATP generating polypeptide joined to a...
|
|
|
6955898 |
Targeting pharmaceutical agents to injured tissues
The present invention provides new compositions and methods to induce therapeutic angiogenesis locally utilizing a collagen binding domain to target an angiogenesis modulating agents. Fusion...
|
|
|
6955802 |
Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
Provided are genetically engineered cells comprising a neural stem cell and retroviral expression system in the neural stem cell, which is capable of expressing homeodomain transcription factor...
|
|
|
6949381 |
Immortalized human skin cell lines and novel serum-free medium useful for the production thereof
The present invention relates to improved continuous (immortalized) cell lines, in particular keratinocytes and melanocytes derived from normal human skin tissue. The present invention also relates...
|
|
|
6949690 |
Methods of assessing the effect of a gene of interest on human prostate cancer progression
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
|
|
|
6943016 |
Human adult astrocytes, their preparation and uses thereof
The invention provides an essentially pure preparation of human adult astrocytes, and a method of producing same. The purified astrocytes are useful for the treatment of neurodegenerative disorders...
|
|
|
6936593 |
Method of down-regulating gene expression
Disclosed is a method of down-regulating the expression of a gene in an animal, wherein a pharmacological formulation comprising a chimeric oligonucleotide complementary to the gene is orally...
|
|
|
6927060 |
Methods to prepare and use epidermal stem cells
A method to prepare epidermal stem cells, and isolated epidermal stem cells, is provided. Also provided are methods of using epidermal stem cells, e.g., for cell based therapies.
|
|
|
6924128 |
Packaging cell lines for generation of high titers of recombinant AAV vectors
AAV vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantities of such recombinant vectors in amounts that would be...
|
|
|
6919209 |
Method of genetically modifying very primitive quiescent human hematopoietic stem cells
This invention relates to a method for transducing extremely primitive hematopoietic stem cells with high efficiency, using an adeno-associated vector. This vector stably transforms highly...
|
|
|
6916642 |
Vertebrate telomerase genes and proteins and uses thereof
Nucleic acid molecules encoding vertebrate telomerase are provided. Gene products, expression vectors and host cells suitable for expressing telomerase are also provided. Methods for identifying...
|
|
|
6916655 |
Cultured skin and method of manufacturing the same
A cultured skin and a grafting cultured skin sheet are provided, each of which is a cultured reconstructive skin with a high take rate using cells collectable from cells originated from tissue...
|
|
|
6913925 |
Human mesencephalon cell lines and methods of use therefor
Conditionally-immortalized human mesencephalon cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons, including dopaminergic neurons. The cell lines and/or...
|
|
|
6913924 |
Population of interferon producing cells
Dendritic cell subsets, and various methods of making and using same are provided. In particular, methods for making a defined subset of dendritic cells are provided.
|
|
|
6913927 |
Non-adenoviral gene product-based complementing cells for adenoviral vectors
The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which...
|
|
|
6911324 |
Induction of beta cell differentiation in human cells
The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1...
|
|
|
6908764 |
Recombinant human cell for bone and cartilage cell formation
The invention relates to a recombinant human cell of undifferentiated mesenchyma for bone and cartilage cell formation, the human cell having the ability to express Tbr-1, Brachyury or another...
|
|
|
6905875 |
Non-disruptive three-dimensional culture and harvest system for anchorage-dependent cells
A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect...
|
|
|
6905831 |
Real time measurement of cellular responses
Living cells can be stably modified to emit different colors from the cytoplasm and nucleus, thus permitting analysis of the status of said cells and the effect of agents on said cells either by...
|
|
|
6902929 |
Retroviral vectors, methods for their preparation and their use for gene transfer into CD4-positive cells
The invention relates to the production and use of retroviral vectors for cell specific gene transfer, specially to a production method of retroviral vectors containing capsid particles of murine...
|
|
|
6900053 |
Antisense modulation of fibroblast growth factor receptor 2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 2. The compositions comprise antisense compounds, particularly...
|
|
|
6900051 |
Process for obtaining mammalian insulin secreting cells in vitro and their uses
The present invention relates to a process for obtaining mammalian insulin secreting cells in vitro, characterized in that it contains the following steps: a) preparation of the mammalian...
|
|
|
6897061 |
Transdifferentiation of glial cells
A process for generating multipotent cells from glial cells using in vitro techniques to dedifferentiate fetal or adult mammalian glial cells into multipotent cells. The multipotent cells may...
|
|
|
6897064 |
Cell or tissue-culturing carrier, and culturing method
A cell or tissue-culturing carrier which can effectively regenerate an intended a cell or tissue, while suppressing an excessive growth of fibroblasts, and a method of culturing a cell or tissue by...
|
|
|
6897045 |
Adeno-associated virus vectors
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated...
|
|
|
6887706 |
Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells
A method of differentiating embryonic stem cells into neural precursor cells is disclosed. In one embodiment the method comprises the steps of (a) obtaining an embryonic stem cell culture, (b)...
|
|
|
6887707 |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates...
|
|
|
6884621 |
Method and carrier for culturing multi-layer tissue in vitro
The present invention provides method and carrier for culturing multi-layered tissue in vitro, wherein few amounts of tissue blocks and cells are positioned within a porous multi-layer carrier...
|
|
|
6881413 |
Humanized biomaterials, a process for their preparation and their applications
The invention relates to humanized biomaterial comprising a porous biocompatible composite material customized and implanted with monocyte derived cells preferably with macrophages.
|
|
|
6878383 |
Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
The invention provides a composition for promoting regeneration of tissue which has degenerated in a subject as a result of a disease or disorder and a method of using the composition is provided....
|
|
|
6878687 |
Protein HMAAD57
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
|
|
|
6878545 |
Method for separating viable cells from cell suspensions
The invention relates to a method of separating viable cells from cell suspensions using hydrocyclones, which method can, especially, be carried out continuously.
|
|
|
6872569 |
In vitro production of haploid germ cells
The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The...
|
|
|
6863884 |
Pseudotyped retroviral vectors
The present invention provides pseudotyped retroviral vectors and packaging systems and methods of using such vectors for retroviral-mediated gene transfer. In particular, the present invention...
|
|
|
6858582 |
Composition containing porous microparticle impregnated with biologically-active compound for treatment of infection
Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to...
|
|
|
6855519 |
Methods for enhancing the production of interferon in cell culture
Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production,...
|
|
|
6852520 |
DSP-2 dual-specificity phosphatase
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase...
|
|
|
6852531 |
Compositions and methods for reproducing and modulating mammalian messenger RNA decapping
An in-vitro system in which mammalian messenger RNA decapping occurs is provided, for use in identifying modulators, deficiencies, and other aspects of the regulation of RNA turnover.
|
|
|
6846674 |
Genetically modified fibroblast cells
The invention relates to genetically modified fibroblast cells which comprise the following properties: (a) a gene, encoding a subunit of the transcription factor AP-1, of its genome is inactivated...
|
|
|
6844192 |
Adenovirus E4 protein variants for virus production
A method of packaging a recombinant viral vector is carried out by: (a) providing a packaging cell, the packaging cell containing and expressing a nucleic acid encoding a mutant adenovirus E4orf6...
|
|
|
6841151 |
Chondrocyte cell-lines
The invention relates to chondrocytes and chondrocyte cell-lines for use especially in studying arthritic conditions and also for developing skeletal tissue for use in repair and/or replacement...
|
|
|
6838284 |
Cell culture medium containing growth factors and L-glutamine
The invention relates to a culture medium for culturing cells, in particular human cells in a process for tissue engineering bone. The medium comprises glucose, a mineral, a vitamin, a growth...
|
|
|
6838262 |
Isolated DNA molecule encoding rank ligand
Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to regulate an immune response. The ligands are also...
|