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7101710 |
Two-stage culture protocol for isolating mesenchymal stem cells from amniotic fluid
A method of harvesting mesenchymal stem cells from human amniotic fluid uses a two-stage culture protocol comprising culturing human amniocytes and then culturing mesenchymal stem cells. For...
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7094603 |
Materials and methods for treating oncological disease
Novel methods are disclosed for treating oncological disorders in an individual or animal using a superantigen expressed in tumor cells. A gene encoding a superantigen, such as an M-like protein of...
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7094601 |
Microinjection of cryoprotectants for preservation of cells
A preservation method for biological material having cell membranes includes microinjecting the cells with sugar; preparing the cells for storage; storing the biological material; and recovering...
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7081337 |
Methods for modulating transcriptional activation using mint proteins
The present invention is directed to isolated nucleic acids encoding Mint protein variants having enhanced abilities to modulate the transcriptional activation mediated by the cytoplasmic tail of...
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7081360 |
Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
Modified forms of G protein-coupled receptors which display altered ligand binding and/or coupling properties are provided as well as cells expressing such receptors and assays utilizing these...
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7078232 |
Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
The invention provides cells, methods and compositions based upon the use of adipose tissue-derived adult stem cells in the repair of articular cartilage fractures or defects. The invention is...
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7078231 |
Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
The invention discloses a substantially pure population of human pancreatic progenitor cells and methods of isolating and culturing the pancreatic progenitor cells. By carefully manipulating the...
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7074618 |
Adenoviral E1A/E1B complementing cell line
Adenovirus packaging cell lines for growth of E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA), are provided. Methods for producing adenovirus...
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7070994 |
Packaging cells
The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titer than normal. In addition,...
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7070993 |
Lentiviral packaging constructs
The present invention provides novel lentiviral packaging constructs that are useful for the establishment of stable packaging cell lines and producer cell lines. In particular, the present...
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7067474 |
Agents for treating human illnesses based on β-catenin, and the production and use thereof
The present invention relates to peptides that affect the interaction of the protein β-catenin with a transcription factor or a tumor suppressor protein. Such peptides are derived either from the...
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7067121 |
Transplants for myocardial scars
A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal...
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7060492 |
Isolation of spore-like cells from tissues exposed to extreme conditions
Highly undifferentiated spore-like cells can be isolated from many different tissues and bodily fluids after those tissues and fluids have been exposed to extreme conditions. The spore-like cells...
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7060494 |
Growth of human Mesenchymal Stem Cells (hMSC) using umbilical cord blood serum and the method for the preparation thereof
A method of isolating and growing human mesenchymal stem calls (hMSC) by culturing human stem cells in human umbilical cord blood serum. For this purpose blood is collected from the umbilical cord...
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7056738 |
Early stage multipotential stem cells in colonies of bone marrow stromal cells
Marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs were shown to contain both small,...
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7052692 |
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells...
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7049139 |
Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering
The invention relates to materials and methods for producing equivalents of tissues of the ocular surface, especially conjunctival tissue equivalents. The method of the invention involves biopsy of...
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7045349 |
Method of islet isolation using process control
Advanced Islet Separation Technology incorporates an automated method, automated control methodology, process control interface, and automated apparatus to separate (isolate) and process pancreatic...
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7045353 |
Directed differentiation of human embryonic cells
Methods are described for mapping a pathway of differentiation of a population of embryonic cells which includes exposing the cells to an exogenous factor and measuring gene expression products...
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7045284 |
Method for selective inactivation of viral replication
Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA...
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7041438 |
Use of human embryonic stem cells for drug screening and toxicity testing
This disclosure provides an improved system for culturing human pluripotent stem (pPS) cells in the absence of feeder cells. The role of the feeder cells can be replaced by supporting the culture...
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7041817 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
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7041507 |
Transdiffentiation of transfected epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Disclosed is an in vitro method of transdifferentiating an epidermal basal cell into a cell having one or more morphological, physiological and/or immunological features of a glial cell. Also...
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7037717 |
Cell line and screening method with the use of the same
An object of the present invention is to establish a clonal cell line of undifferentiated mesenchymal cells capable of differentiating into chondrocytes and adipocytes from a normal adult animal...
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7033750 |
Recombinant P53 adenovirus methods and compositions
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected...
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7033831 |
Islet cells from human embryonic stem cells
This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote...
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7033587 |
Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a...
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7029913 |
Primate embryonic stem cells
A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+);...
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7026164 |
Adenovirus packaging cell lines
Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus...
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7026301 |
Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
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7022499 |
Nucleic acids encoding differentiation inhibitor delta 2
Amino acids constituting a physiologically active molecule human delta 2; a gene arrangement thereof; and an antibody thereto. The human delta 2 molecule, at least the amino acid sequence described...
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7022520 |
Cell culture media for mammalian cells
A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells.
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7018806 |
Method for identifying endocrine disruptors and kit for carrying out the same
A method for identifying an endocrine disrupter using a cell line having aromatase activity, particularly, a human granulosa-like tumor cell line; and a kit for carrying out the method is disclosed.
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7015036 |
Human liver cell line
In this application is described the establishment and maintanence of a normal human hepatocyte cell line able to support complete development of malaria parasite development in vitro. Advantages...
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7015037 |
Multiponent adult stem cells and methods for isolation
The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also...
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7015039 |
Separating epithelium from stroma in LASEK surgery
A method of separating the epithelium and the stroma of a cornea includes providing a solution that includes a detaching agent diluted in a culture medium and applying the solution to the surface...
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7011828 |
Implanting neural progenitor cells derived for human embryonic stem cells
The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the...
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7011829 |
Tissue filler
Disclosed are a tissue filler and tissue reconstruction method using the same that enables missing or reduced tissue of a body to recover to a normal state thereof, and the tissue filler comprised...
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7011976 |
Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
Replication competent adenoviral vectors specific for cells expressing alfa-fetoprotein (AFP) are provided. These replication-competetent adenoviral vectors comprise adenovirus genes essential for...
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RE39006 |
Method of detecting hematopoietic progenitor cells
Improved method for detecting and/or counting the appearance of hematopoietic progenitor cells which comprises the steps of mixing a blood sample with a reagent capable of detecting immature cells...
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7005411 |
Method for modulating nerve cell function
The amount of active Robo expressed on a cell is modified by modulating the effective amount of a Comm polypeptide in contact with the cell, whereby the amount of expressed active Robo is modulated...
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7005511 |
Fluorescent protein variants and methods for making same
The present invention relates generally to variant fluorescent proteins, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention...
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7005277 |
Defective adenoviruses and corresponding complementation lines
Novel defective adenoviruses for the transfer and expression of an exogenous nucleotide sequence in a host cell or organism. The invention also relates to novel complementation lines and to the...
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7001767 |
Method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies
The invention concerns a method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies, or prion, comprising steps which consist in: providing a culture or...
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6998264 |
Replication of biological tissue
Biological tissues are grown in a low shear, microgravity environment by culturing connective tissue cells to form a three-dimensional structure, which is thereafter co-cultured with endothelial...
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6998513 |
Human inflammatory breast carcinoma xenograft capable of lymphovascular invasion and methods for its use
The present invention provides human transplantable inflammatory breast carcinoma xenografts. Such xenografts exhibit a number of unique characteristics which allows their use in experimental...
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6991795 |
Protein delivery system using human papillomavirus virus-like particles
Human Papillomavirus virus like particles (VLPs) have been constructed so that they contain a modified L2 protein. The L2 protein has been minimized and is fused to a second protein or peptide. The...
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6989268 |
Recombinant adenoviral vector and methods of use
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a...
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6987024 |
Human ovarian mesothelial cells and methods of isolation and uses thereof
The invention discloses a substantially pure population of human ovarian mesothelial cells and methods of isolating and culturing the ovarian mesothelial cells. By carefully manipulating the...
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6984521 |
HEK293 cell line for activity studies and HTS system of α1G T-type Ca2+ channel
There is provided a cell line that is prepared by transforming HEK293 cell with a human Kir2.1 gene using a retrovirus expression system, wherein the HEK293 expresses a stable α 1G T-type calcium...
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