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7208481 |
Aminodiphosphonate apolipoprotein E modulators
The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease...
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7202082 |
Immortalized preosteoblasts and method for their production
The present invention relates to novel immortalized pre-osteoblast cell lines derived from the periost and capable of differentiate to osteoblasts. In particular, the present invention pertains to...
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7198947 |
Production of functional proteins: balance of shear stress and gravity
The present invention provides a method for production of functional proteins including hormones by renal cells in a three dimensional co-culture process responsive to shear stress using a rotating...
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7195896 |
Complementary adenoviral vector systems and cell lines
The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic...
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7192768 |
Synchronization of the cytoplasmatic and the nuclear maturation of oocytes in vitro
The present invention relates to a method for in vitro maturation of oocytes comprising the steps of:
(a) culturing one or more GV oocytes in a culture medium, the culture medium comprising a...
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7189561 |
Production of adenovirus vectors with reduced levels of replication competent adenovirus contamination
Methods, cells and recombinant adenoviral vectors are disclosed that permit the production of recombinant adenoviral vector stocks with reduced levels of contamination by replication competent...
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7189567 |
Method of culturing human chondrocytes
This invention provides a method for rapidly culturing a large amount of human chondrocytes to give normal chondrocytes or a mass thereof. The culture method comprises co-culturing human...
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7186558 |
Keratinocytes obtained from embryonic stem cells of mammals
The present invention relates to a method for inducing the differentiation of mammals' embryonic stem cells into keratinocytes, comprising the following steps of:
isolating an extracellular...
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7186517 |
Compositions and methods for monitoring breast cancer treatment
The present invention provides compositions and a method for monitoring breast cancer treatment.
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7179649 |
Differentiation of adipose stromal cells into osteoblasts and uses thereof
The invention provides methods and compositions for differentiating stromal cells from adipose tissue into cells having osteoblastic properties, and methods for improving a subject's bone...
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7176182 |
Methods of enhancing functioning of the large intestine
The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2...
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7176020 |
EBV-infected stomach cancer cell line
An EBV strain infecting epithelial cells and a stomach cancer cell line cancerated by EBV are established to clarify the mechanism of canceration of epithelial cells into stomach cancer by EBV and...
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7176022 |
Directly injectable formulations which provide enhanced cryoprotection of cell products
This invention provides compositions and methods for cryoprotection of recombinant live cancer cells. Specifically, an improved cryoprotective medium is provided which includes a hydroxyethyl...
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7175842 |
Methods of modulating hair growth
The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt...
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7176023 |
Endothelial cells derived from primate embryonic stem cells
A method is described to induce primate embryonic stem cells to differentiate into a relatively homogenous population of endothelial cells. The ES derived endothelial cells have the general...
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7169610 |
Serum-free media for chondrocytes and methods of use thereof
The present invention provides defined serum-free cell culture media useful in culturing fibroblasts, especially articular chondrocytes, that avoids problems inherent in the use of serum-containing...
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7169605 |
Methods of controlling proliferation and differentiation of stem and progenitor cells
A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions...
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7166445 |
Methods and host cells for improved cell culture
The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as...
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7166279 |
Myoblast transfer therapy for relieving pain and for treating behavioral and perceptive abnormalities
An analgesic benefit is realized by continuously supplying a peptide in vivo that activates an opioid receptor or that interferes with the binding of substance P to its receptors. The long-term,...
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7163787 |
Methods for the identification of antiviral compounds
The present invention provides novel methods for determining whether a compound influences a phase in the life cycle of a virus comprising providing a cell with the compound and with at least a...
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7163824 |
Regulation of endogenous gene expression in cells using zinc finger proteins
The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
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7160684 |
Methods of selecting compounds for modulation of bladder function
The present invention involves an assay system and method of selecting compounds useful in the treatment of bladder instability and related bladder conditions through the activation of KCNQ...
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7160722 |
Master bone formation transcription factor: compositions and methods of use
A novel gene expressed selectively by osteoblast lines is provided. Expression of the gene is highly restricted to cells of osteoblast lineage, including precursor cells. Also provided is a method...
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7160724 |
Human cord blood as a source of neural tissue for repair of the brain and spinal cord
The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the...
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7160726 |
Compositions comprising conditioned cell culture media and uses thereof
The invention relates to compositions comprising cell culture medium conditioned by cells grown in three-dimensional culture. The cells used to condition the medium may be genetically modified to...
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7157438 |
Rhob as a suppressor of cancer cell growth and cell transformation
The protein RhoB and its variants as a supressor of cancer cell growth, inhibitor of malignant cell transformation, and modulator of oncogenic signaling, wherein introducing RhoB directly, or...
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7157566 |
Monomeric and dimeric fluorescent protein variants and methods for making same
The present invention relates generally to variant fluorescent proteins, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention...
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7157278 |
Cultured cells from pancreatic islets
A cell composition of endocrine progenitor cells derived from mammalian pancreatic islet cells that can be trans-planted into a diabetic patient such that the cells of the cell composition...
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7153648 |
Dielectrophoretic separation of stained cells
This invention relates generally to the field of cell separation or isolation. In particular, the invention provides a method for separating cells, which method comprises: a) selectively staining...
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7148062 |
Method for generating primate trophoblasts
The first method to cause a culture of human and other primate stem cells to directly and uniformly differentiate into a committed cell lineage is disclosed. Treatment of primate stem cells with a...
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7144729 |
Methods and compositions for tissue regeneration
The present invention provides the use and composition of matter of angiogenic or other growth/cytokine factors expressed by mixtures of allogeneic human cell strains or lines of various types and...
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7138275 |
Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The...
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7135463 |
RHoB as a suppressor of cancer cell growth, cell transformation, and metastasis
The present invention concerns the use of the protein RhoB and its variants to inhibit cancer cell growth, migration, invasion, metastasis, malignant cell transformation, and/or to modulate...
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7132243 |
Clonal expansion of T cells of unknown specificity and identification of ligand recognized by the clonally expanded T cells
A process for clonally expanding T cells of unknown specificity and a process for identifying a peptide ligand recognized by said T cells are provided. A process for clonally expanding T cells of...
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7132285 |
Apoptotic entities for use in treatment of neurodegenerative and other neurological disorders
Treatment and/or prophylaxis, in mammalian patients, of neurodegenerative and other neurological medical disorders is effected by administering to the patient effective amounts of apoptotic bodies...
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7132288 |
Medium for culturing tumor cells
Disclosed is a medium for cultivating tumor cells, comprising the following constituents, as comprised for example in the medium RPMI 1640: (a) fetal calf serum (FCS), (b) penicillin-streptomycin,...
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7132284 |
Adenovirus packaging cell lines
Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus...
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7129086 |
Human marrow stromal cell lines which sustain hematopoiesis
Immortalized human stromal cell lines sustain and expand human hematopoietic precursor cells. The precursor cells are obtained from a blood product and inoculated into a culture medium conditioned...
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7125713 |
Human mullerian duct-derived epithelial cells and methods of isolation and uses thereof
This invention discloses a substantially pure population of human Müllerian duct-derived epithelial cells and methods of isolating and culturing the Müllerian duct-derived epithelial cells. By...
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7122180 |
DNA vectors containing mutated HIV proviruses
The present invention pertains to mutated, non-infectious HIV viral particles, vectors for production of such particles and vaccines employing such vectors. The non-infectious particles are...
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7122208 |
Compositions containing apoptotic entities
Disclosed are methods for treating and preventing neurological disorders which have a significant inflammatory component. The methods of the present invention involve extracting blood from a...
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7115417 |
Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction...
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7115360 |
Isolation and use of solid tumor stem cells
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in...
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7112653 |
Composition and method for preserving progenitor cells
The invention relates to a protein material which is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The protein has an amino acid sequence comprising AQSLSFSFTKFD...
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7109031 |
Methods for inducing the differentiation of monocytes into functional dendritic cells and immunotherapeutic compositions including such dendritic cells
A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are...
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7109026 |
Use of MHC class II ligands as adjuvant for vaccination and of LAG-3 in cancer treatment
The present invention concerns a use of a MHC class II ligand, such as CD4 and LAG-3, for the manufacture of a medicament for preventing or treating pathological conditions involving an antigen...
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7109029 |
Vector constructs
The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such...
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7105346 |
Packaging systems for human recombinant adenovirus to be used in gene therapy
Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with...
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7105345 |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are...
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7105170 |
Latent human tuberculosis model, diagnostic antigens, and methods of use
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens...
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