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6165715 |
Expression systems
The invention relates to new expression systems and in particular to an expression system in which a gene of interest is expressed at an optimal level. The invention provides a recombinant...
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6165790 |
Antisense modulation of PI3 kinase p55 gamma expression
Antisense compounds, compositions and methods are provided for inhibiting the expression of PI3 kinase p55 gamma. The compositions comprise antisense compounds, particularly antisense...
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6165786 |
Antisense modulation of nucleolin expression
Antisense compounds, compositions and methods are provided for inhibiting the expression of Nucleolin. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6162601 |
Human pinin splice variant
The invention provides a human pinin splice variant (PNIN) and polynucleotides which identify and encode PNIN. The invention also provides expression vectors, host cells, agonists, antibodies and...
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6159714 |
Catalytic DNA
Nucleic acid able to cause specific cleavage of a bond between two ribonucleotides in an RNA-containing molecule. The RNA-containing molecule has the structure: 5'-XnUHZCUGANGAGYm-3' wherein each...
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6159692 |
Method and reagent for inhibiting human immunodeficiency virus replication
An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
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6156303 |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
The present invention provides isolated adenovirus-associated viruses ("AAV"), including AAV isolates designated AAV3B and AAV6. The invention also provides nucleic acid molecules of AAV3B (SEQ ID...
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6156305 |
Implanted tumor cells for the prevention and treatment of cancer
A method to prevent or treat cancer in a patient comprising: administering a first set of tumor cells; where at least some of the first tumor cells have at least one tumor antigen corresponding to...
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6156518 |
Methods of using DNA encoding human alpha 1 adrenergic receptors
This invention provides an isolated nucleic acid, vectors, transformed mammalian cells and non-human transgenic animals that encode and express normal or mutant alpha 1a, alpha 1b and alpha 1c...
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6156316 |
Oncogene fusion protein peptide vaccines
Fusion-point spanning peptides, for example BCR-ABL fusion breakpoint peptides associated with chronic myelogenous leukemia (CML), bind major histompatibility complex molecules, such as HLA class I...
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6153597 |
Pharmaceutical composition useful for nucleic acid transfection, and use thereof
A pharmaceutical composition useful for nucleic acid transfection is disclosed. The composition contains, in addition to a nucleic acid and at least one transfection agent, at least one compound...
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6153431 |
Human immunodeficiency virus co-receptor variants associated with resistance to virus infection
The present invention relates to variants of the CCR5 human immunodeficiency virus ("HIV") co-receptor which result in a resistance of CCR5 expressing cells to HIV infection. The detection of such...
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6153593 |
Laminin 5 and the formation of basement membrane structure
The use of laminin-5 to promote formation of basement membrane and to form skin equivalents and to improve grafting of keratinocyte sheets.
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6153429 |
Cell lines useful for in vitro assay for indentification of carcinogens
Disclosed test cells are useful for evaluating the carcinogenicity of a compound using a transformation assay. The test cell preferably is transfected with an oncogenic viral recombinant nucleic...
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6149907 |
Treatments using sertoli cells
A method of treating a disease is provided that results from a deficiency of a biological factor which comprises administering to a mammal Sertoli cells and also cells that produce the biological...
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6150162 |
Antisense modulation of CD44 expression
Antisense compounds, compositions and methods are provided for modulating the expression of CD44. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to...
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6150338 |
Gene therapy for alleviating erectile dysfunction
The present invention is directed towards gene therapy for erectile dysfunction through delivery and expression of a recombinant vector containing a DNA sequence encoding a protein involved in the...
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6146827 |
Rath genes and polypeptides and methods for the treatment and diagnosis of immune disorders
The present invention relates, first, to the identification of novel nucleic acid molecules, termed RATH genes and RATH gene products encoded by such nucleic acid molecules, or degenerate variants...
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6146888 |
Method of enriching for mammalian stem cells
Mammalian stem cells are obtained and maintained in vitro whose genome has at least one nucleic acid construct encoding an antibiotic resistance gene operatively linked to a promoter specific for...
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6146831 |
Cellular models for diabetes and other diseases associated with mitochondrial defects
The present invention relates to genetic mutations in mitochondrial genes that segregate with diabetes mellitus. The invention provides methods for detecting such mutations, as a diagnostic for...
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6140119 |
Expression of estrogen receptors in type I and type II human breast epithelial cells
A method is described for culturing morphologically and antigenically distinguishable types of normal human breast epithelial cells (HBEC) derived from reduction mammoplasty. Type I HBEC showed...
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6140125 |
Antisense inhibition of bcl-6 expression
Antisense compounds, compositions and methods are provided for modulating the expression of bc1-6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6140052 |
cMYC is regulated by Tcf-4
The APC tumor suppressor protein binds to β-catenin, a protein recently shown to interact with Tcf/Lef transcription factors. Here, the gene encoding a Tcf family member that is expressed in...
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6140076 |
Ig superfamily `dlair` receptors expressed in monocytes
DNA clones encoding a receptor in the Ig superfamily and a related soluble variant have been isolated from a human monocyte library. The invention provides receptor polypeptides, nucleic acids...
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6136779 |
Methods of specifically transcriptionally modulating the expression of gene of interest
The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an...
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6136603 |
Antisense modulation of interleukin-5 signal transduction
Compositions and methods are provided for antisense modulation of interleukin-5 signal transduction. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding...
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6136604 |
Antisense inhibition of methionine aminopeptidase 2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of methionine aminopeptidase 2. The compositions comprise antisense compounds, particularly antisense...
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6132962 |
Retroviral vectors comprising an anti-hiv or other nucleic acid
This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent or a...
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6133029 |
Replication defective viral vectors for infecting human cells
Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the...
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6132966 |
Method and reagent for inhibiting hepatitis C virus replication
An enzymatic RNA molecule which specifically cleaves RNA of a hepatitis C virus.
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6133032 |
Antisense modulation of PI3 kinase p110 beta expression
Antisense compounds, compositions and methods are provided for modulating the expression of PI3 kinase p110 beta. The compositions comprise antisense compounds, particularly antisense...
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6130086 |
Composition for an in vitro fertilization medium
The present invention aims to provide a medium composition for in vitro fertilization, in particular, a composition usable in the culture of ova or early embryos which are fertilized eggs, the...
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6130088 |
Antisense modulation of telomeric repeat binding factor 1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Telomeric Repeat Binding Factor 1. The compositions comprise antisense compounds, particularly antisense...
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6127176 |
Mutant cell lines unresponsive to interleukin 1
Mutant cell lines which have lost their ability to respond to IL-1 are provided. In one embodiment, the mutant cell line lacks or is essentially free of IL-1 receptor associate kinase (IRAK), an...
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6126935 |
Pellets obtained from cell cultures of keratinocytes and their use in wound healing
The present invention relates to a process for treating a skin surface wound of a human. The process includes topically applying a keratinocyte pellet fraction onto the wound to result in wound...
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6127175 |
Cells for the production of recombinant adenoviruses
The invention relates to cells usable for the production of defective adenoviruses comprising, inserted into their genome, a portion of the region E4 of an adenovirus genome carrying the reading...
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6124104 |
Chromosome 13-linked breast cancer susceptibility gene
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer...
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6121047 |
Antisense modulation of SHP-1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of SHP-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6117674 |
Pathogen propagation in cultured three-dimensional tissue mass
A process for propagating a pathogen in a three-dimensional tissue mass cultured at microgravity conditions in a culture vessel containing culture media and a culture matrix is provided. The...
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6117675 |
Retinal stem cells
The invention relates to stem cells isolated from the retina of mammals and retinal cells differentiated from these stem cells. The invention also relates to a method of isolating retinal stem...
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6117676 |
Transfected human amniotic cells and method for producing a gene product
The present invention provides a human amniotic cell in which a gene desired to be expressed is introduced, and wherein said human amniotic cell expresses the product encoded by said gene. The...
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6114167 |
Ribozymes targeting the MoMLV PSI packaging sequence and the HIV tat sequence
A cell comprising a synthetic non-naturally occurring oligonucleotide compound comprises nucleotides whose sequence defines a conserved catalytic region and nucleotides whose sequence hybridizes...
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6114599 |
Recombinant β-cell and uses thereof
The present invention provides a recombinant, glucose-regulated insulin producing beta cell whose proliferation is controlled by tetracycline or a derivative thereof. The present invention also...
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6110458 |
Cancer therapy utilizing ex vivo gene transduction
A method is provided for eliminating cancer cells from a population of cells containing cancer cells and noncancerous cells in vitro or in vivo comprising: (a) providing a mixture of noncancerous...
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6110743 |
Development and use of human pancreatic cell lines
This invention relates to cell lines, particularly mammalian cell lines, established by transforming the cells with vectors, preferably retroviral vectors, containing two or more oncogenes under...
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6110741 |
Gonadotrophin releasor hormone-containing composition for embryo culture and method for in vitro fertilization
In vitro incubation of primate embryos in the presence of added exogenous gonadotrophin releasor hormone (GnRH), results in enhanced chorionic gonadotrophin production associated with increased...
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6110459 |
Transplants for myocardial scars and methods and cellular preparations
A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal...
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6110664 |
Antisense inhibition of G-alpha-S1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-S1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6107028 |
Ribozymes for treating hepatitis C
A method of inhibiting hepatitis C virus RNA replication or expression is provided. The method consists of introducing two or more ribozymes specific for hepatitis C virus RNA into a cell infected...
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6107091 |
Antisense inhibition of G-alpha-16 expression
Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-16. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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