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6492172 |
Antisense modulation of GU protein expression
Antisense compounds, compositions and methods are provided for modulating the expression of GU Protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6491918 |
Antibody compositions for preparing enriched dendritic cell preparations
The present invention relates to antibody composition that are useful in preparing enriched cell preparations such as human hematopoietic progenitor cells and stem cells and non-hematopoietic tumor...
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6485720 |
Transgene expression systems
The present invention relates to transgene expression systems, related compositions comprising the transgene expression systems, and methods of making and using them. Preferred systems employ an...
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6485971 |
Keratinocyte stem cells
Enrichment for human Keratinocyte Stem Cells KSCs to a high degree of purity can be successfully achieved on the basis of a cell surface component whose expression is proliferation-related in...
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6485919 |
Human metabotropic glutamate receptors, nucleic acids encoding same and uses thereof
In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the...
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6485976 |
Use of adeno-associated virus (AAV) to deliver genes
This invention pertains to a method of protecting pancreatic β-cells from immune system-mediated cell damage through transduction of the cells with an adeno-associated viral vector encoding...
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6482616 |
RCA-free adenoviral vector system and propagation method
The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic...
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6482644 |
Antisense modulation of dual specific phosphatase 8 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Dual specific phosphatase 8. The compositions comprise antisense compounds, particularly antisense...
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6482626 |
Human DNase
This invention relates to a novel human deoxyribonuclease, referred to as LS-DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic...
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6479066 |
Device having a microporous membrane lined deformable wall for implanting cell cultures
A device and method of using the device are provided for implanting cell cultures in a host. The device is formed of a deformable body, a microporous membrane and a sealable port. The shape of the...
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6479283 |
Stimulation, culture and preservation of pancreatic cells
A method for stimulating pancreatic cells to synthesize and/or excrete insulin comprises contacting insulin-producing cells, in particular their aqueous suspension, with a water-soluble cellulose...
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6475998 |
Methods and compositions for the treatment of injury to the central nervous system
The invention provides methods and pharmaceutical compositions thereof for treating injury to the central nervous system (CNS). The method includes administering to the CNS of a patient suffering...
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6475718 |
Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide...
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6475789 |
Human telomerase catalytic subunit: diagnostic and therapeutic methods
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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6472212 |
Methods and compositions for genetically modifying primate bone marrow cells
A method is provided for genetically modifying primate bone marrow cells, comprising isolating bone marrow cells from a primate and, by means which enhance the local concentration of retroviral...
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6468795 |
Antisense modulation of Apaf-1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Apaf-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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6468796 |
Antisense modulation of bifunctional apoptosis regulator expression
Antisense compounds, compositions and methods are provided for modulating the expression of bifunctional apoptosis regulator. The compositions comprise antisense compounds, particularly antisense...
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6468524 |
AAV4 vector and uses thereof
The present invention relates to AAV4 vectors for methods of delivering nucleic acids to cells. Specifically, the present invention provides methods of delivering nucleic acids to specific regions...
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6465000 |
Method for penile augmentation with autogenous dermal cell culture
The present invention relates to a penile augmentation method comprising culturing autodermal cells in a laboratory and inserting this into penis by using scaffold. This method has advantage of...
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6465251 |
Method of promoting b-cell proliferation and activation with CD40 ligand and cyclosporin
We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B...
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6458593 |
Immortalized cell lines and methods of making the same
The present invention relates to methods of immortalizing various primary cell cultures, including pituitary cells, neurons, beta islet cells, glial cells, corneal epithelial cells and follicular...
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6458585 |
Cytokine-free culture of dendritic cells
A method for producing human dendritic cells for therapeutic purposes which allows culture-deriving dendritic cells using no cytokines, or reduced cytokines. The method involves culturing...
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6458590 |
Methods and compositions for treatment of restenosis
The present invention provides sequences capable of inhibiting osteopontin (OPN) expression. In particular, the sequences provided herein are antisense osteopontin oligonucleotide sequences. The...
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6458571 |
Excitatory amino acid transporter 3, EAAT3, polypeptides
The present invention relates to novel mammalian amino acid transporter proteins and the genes that encode such proteins. The invention is directed toward the isolation, characterization and...
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6458591 |
Antisense modulation of phosphorylase kinase Alpha 2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of Phosphorylase kinase alpha 2. The compositions comprise antisense compounds, particularly antisense...
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6455307 |
Antisense modulation of casein kinase 2-alpha prime expression
Antisense compounds, compositions and methods are provided for modulating the expression of Casein kinase 2-alpha prime. The compositions comprise antisense compounds, particularly antisense...
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6455308 |
Antisense modulation of serum amyloid A4 expression
Antisense compounds, compositions and methods are provided for modulating the expression of serum amyloid A4. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6451311 |
Anti-procalcitonin antibodies and the preparation and use thereof
The invention relates to anti-procalcitonin antibodies, their preparation and use, in particular in therapy and diagnostics. The antibodies comprise binding to procalcitonin but not to free...
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6451316 |
Methods for generating antigen-reactive T cells in vitro
The present invention provides methods for generating antigen-reactive T cells in vitro comprising priming immune cells and incubating the primed immune cells in vitro with a non-covalent complex...
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6451602 |
Antisense modulation of PARP expression
Antisense compounds, compositions and methods are provided for modulating the expression of human PARP. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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6451601 |
Transiently immortalized cells for use in gene therapy
The invention provides methods and compositions for expanding cells that are not abundant or are difficult to obtain in pure form in culture, are in short supply (e.g., human cells), or have brief...
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6451540 |
2′-O-alkylthioalkyl and 2′-C-alkythioalkyl containing nucleic acids
A compound having the formula: wherein, R1 represents 2′-O-alkylthioalkyl or 2′-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H,...
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6447768 |
Methods of gene therapy with a DNA sequence encoding NOS
A nucleic acid delivery vehicle for enhancing and/or inducing angiogenesis. This nucleic acid delivery vehicle includes a nucleic acid having at least one sequence coding for a protein capable of...
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6448069 |
Embryo-culturing apparatus and method
An embryo culturing method and apparatus enables a plurality of embryos to be grown in communal clusters in a culturing container. The embryos are kept separate from each other in open...
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6448081 |
Antisense modulation of interleukin 12 p40 subunit expression
Antisense compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p40 subunit. The compositions comprise antisense compounds, particularly antisense...
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6448080 |
Antisense modulation of WRN expression
Antisense compounds, compositions and methods are provided for modulating the expression of WRN. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to...
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6444465 |
Antinsense modulation of Her-1 expression
Compounds, compositions and methods are provided for inhibiting the expression of human Her-1. The compositions comprise oligonucleotides complementary to mRNA targeted to nucleic acids encoding...
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6440678 |
Materials and methods related to the inflammatory effects of secreted amyloid precursor proteins
The present invention provides, inter alia, methods and materials useful to affect the inflammatory/and or neuroprotective effects of secreted amyloid precursor protein. In one broad aspect of the...
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6440739 |
Antisense modulation of glioma-associated oncogene-2 expression
Antisense compounds, compositions and methods are provided for modulating the expression of glioma-associated oncogene-2. The compositions comprise antisense compounds, particularly antisense...
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6440738 |
Antisense modulation of casein kinase 2-beta expression
Antisense compounds, compositions and methods are provided for modulating the expression of Casein kinase 2-beta. The compositions comprise antisense compounds, particularly antisense...
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6440737 |
Antisense modulation of cellular apoptosis susceptibility gene expression
Antisense compounds, compositions and methods are provided for modulating the expression of cellular apoptosis susceptibility gene. The compositions comprise antisense compounds, particularly...
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6436705 |
Shape stabilized erythrocytes
One aspect of the present invention is a method for storing tissues and cells (typically erythrocytes) having the step of (1) stabilizing the cells with a reversible stabilizing agent. This method...
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6436693 |
Method for helper virus-free packaging of a gene vector DNA
The present invention relates to a method for helper virus-free packaging of gene vector DNA into the virus particles of a DNA virus as well as to eukaryotic helper cells for helper virus-free...
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6432709 |
Encapsidation cell lines and expression vectors for transcomplementation of defective retroviral vectors
The present invention relates to novel cell lines, so-called transcomplementation cell lines, which enable the packaging of recombinant retroviral RNAs carrying nucleotide sequences of interest....
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6432711 |
Embryonic stem cells capable of differentiating into desired cell lines
An embryonic stem cell which may be induced to differentiate homogeneously into a desired primary cell line. The embryonic stem cell may be engineered with DNA, which encodes a protein or...
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6432399 |
Treatment of stress and preconditioning against stress
Symptoms of stress such as elevated blood pressure in mammals are treated, and mammalian bodies are preconditioned to manifest reduced adverse reactions to subsequently encountered stresses, by...
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6432655 |
Method of obtaining compositions
This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT 4B receptor and an isolated nucleic acid molecule encoding a human 5-HT 4B receptor, an isolated protein which...
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6428953 |
Method and means for producing high titer, safe, recombinant lentivirus vectors
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a...
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6429010 |
DNA encoding the human synapsin III gene and uses thereof
A new synapsin protein, designated synapsin III, its amino acid sequence, and its human gene have been isolated and characterized. Furthermore, isoforms of synapsin III, e.g., synapsin IIIa, IIIb...
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6428988 |
Methods using cre-lox for production of recombinant adeno-associated viruses
Methods for efficient production of recombinant AAV are described. In one aspect, three vectors are introduced into a host cell. A first vector directs expression of cre recombinase, a second...
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