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8012464 |
G-CSF-albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
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7968684 |
IL-18 binding proteins
The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human...
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7847079 |
Albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
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7750133 |
Vascular endothelial cell growth inhibitor, VEGI-192a
This invention discloses two new VEGI isoforms named VEGI-192a and VEGI-192b consisting of 192 amino acid residues. These isoforms show endothelial cell-specific expression and share a C-terminal...
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7629168 |
Insulin expressing human pancreatic islet cell line capable of reversibly proliferating and use thereof
A reversibly immortalized human pancreatic islet cell line containing an hTERT gene and an SV40T gene each interposed between a pair of LoxP sequences, characterized in that it is capable of...
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7601342 |
Cell fusions and methods of making and using the same
The invention is concerned with fusions of dendritic cells and antigen presenting cells. Also provided are methods of making and using these cell fusions, including methods of adoptive...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7544487 |
Fusion proteins containing recombinant cytotoxic RNAses
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse...
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7244616 |
Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present...
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7041813 |
Canine herpes virus alpha transinducing factor nucleic acid molecules
The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid...
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7008781 |
Method of enhancing the biological activity of ligands
Novel fusion polypeptide ligands that bind Eph family receptors or the Tie-2 receptor are identified, and methods for making the fusion polypeptide ligands in biologically active form are...
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6777205 |
Host cells expressing recombinant human erythropoietin
The gene coding for human erythropoietin (EPO) was obtained from human genomic DNA. Thc gene used does not include sequences from regions at i 5′ of the first translated ATG and ii 3′ of the sto...
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6689365 |
Single-chain fertility hormones with fsh and LH activity
Glycosylated or nonglycosylated proteins of the formula FSHβ-(linker1)n1-LHβ(1-X)-(linker2)n2-αwherein FSHβ is a vertebrate follicle stimulating hormone β subunit or a variant ther...
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6652848 |
Dendritic cell hybrids
Immunostimulatory compositions that contain fused cells formed by fusion between dendritic cells and non-dendritic cells, methods of using these compositions, and methods of generating dendritic...
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6566097 |
Feline cytokine protein
A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing...
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6451759 |
Noncleavable Fas ligand
This invention generally provides polypeptides comprising a noncleavable form of a Fas ligand and having a capacity to activate a Fas receptor-mediated pathway involved in cell death,...
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6451305 |
Methods for stimulating T cell responses to tumor cells expressing LFA-3 and a CD28 or CTLA4 ligand
Methods for stimulating a T cell response to a tumor cell in a subject with a tumor which involve modifying the tumor cell to express a CD2 ligand and a CD28 or CTLA4 ligand, are disclosed. Methods...
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6365356 |
Receptors that regulate cell signaling relating to chemokines
A method for discovering molecules that regulate cell signaling specific to the dual presence of Duffy antigen receptor for chemokines (DARC) and a chemokine receptor selected from the group...
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6284485 |
Nucleic acids encoding osteoprotegerin
The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone...
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6238889 |
Molecular cloning and expression of the Pro8 isoform of human IL-3
The invention relates to nucleotide sequences encoding human interleukin-3 (hIL-3) as well as recombinant DNAs, expression cassettes, transformed host cells, and recombinant expression methods...
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6187550 |
Methods and cell lines for screening compositions and genes for ability to interact with IL-1β and ice processing
Embodiments of the present invention are directed to non-naturally occurring cells and methods for screening compositions and genes which interact with interleukin 1 beta and interleukin-1 beta...
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6103501 |
Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
Single-chain agonists and/or antagonists of the glycoprotein hormones are disclosed. These proteins are of the formula β1 -(linker1)m -α-(linker2)n -β2 (1);or β1 -(linker1)m -β2 -(linker2)n -α (...
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6060270 |
Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
Methods, including culture media conditions, which provide for isolation and purification of renal tubule stem cells and for in vitro kidney tubulogenesis are disclosed. The methods rely on...
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6001649 |
Chemokine NC28 (monocyte chemotactic protein-3, MCP-3) polypeptides and their recombinant production
A new chemotactic cytokine, NC28 or Monocyte Chemotactic Protein-3 (MCP-3), is provided. Fragments of the cytokine comprising its 13 C-terminal amino acids also exhibit chemotactic activity. The...
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5985613 |
Use of an "immunodeficiency-virus suppressing lymphokine (ISL) "to inhibit the replication of viruses, in particular of retroviruses
An isolated polypeptide which inhibits the replication of retroviruses in peripheral blood lymphocytes and i) is encoded by the DNA sequence shown in SEQ ID NO: 1 or complementary sequences; or ii)...
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5981214 |
Production of proteins using homologous recombination
Methods and compositions are provided for expression of mammalian genes in culture. An amplifiable gene is introduced by homologous recombination in juxtaposition to a target gene, the resulting...
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5976522 |
Lymphocyte chemoattractant factor and uses thereof
Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.
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5958737 |
Single-chain β subunit dimers of the glycoprotein hormones and recombinant materials related thereto
Single-chain forms of the glycoprotein hormone quartet, at least some members of which are found in most vertebrates, are disclosed. In one embodiment of these single-chain forms, the α and β s...
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5916770 |
Macrophage stimulating protein variant and method for producing the same
The present invention relates to a macrophage stimulating protein wherein a cysteine residue at position 672 from the N-terminus in the amino acid sequence of native form macrophage stimulating...
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5874250 |
DNA encoding for a protein containing the extracellular domain of lymphocyte activation gene 3
The present invention relates to a protein containing the extracellular domain of LAG-3, and DNA sequences coding for the protein and the pharmaceutical and biological uses of the protein.
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5858721 |
Three-dimensional cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5834245 |
PRLTS proteins and DNA's encoding the same
A gene is provided which is present in the deletion region of a chromosome common in lung cancer, hepatocellular carcinoma and colorectal cancer and encodes a novel protein, a protein encoded by...
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5830705 |
Method for recombinant production of human pluripotent granulocyte colony-stimulating factor
Disclosed are novel polypeptides possessing part or all of the primary structural conformation and one or more of the biological properties of a mammalian (e.g., human) pluripotent granulocyte...
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5824789 |
Human growth factors, nucleotide sequence encoding growth factors, and method of use thereof
This invention provides novel human growth factor polypeptides, nucleotides encoding the growth factor polypeptides, and uses for the growth factor polypeptides and polynucleotides.
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5759818 |
N-terminal CTP extended pharmaceutical peptides and proteins
"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides at the aminoterminus to alter their clearance patterns. "Complete" CTP units have the amino acid...
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5702919 |
DNA encoding canine granulocyte macrophage colony stimulating factor
Canine granulocyte macrophage colony stimulating factor (caGM-CSF) corresponding to that found in canine serum and/or tissues, structural variants thereof, genes that encode these materials,...
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5695954 |
DNA encoding two fish neuropeptides
Novel DNAs are provided which code for fish PACAP and GHRH-like peptide. Methods are provided for production of fish PACAP and fish GHRH-like peptide by expression of the novel DNAs. Additionally,...
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5674711 |
Heteropolymeric protein production methods
Cultured mammalian cells transfected with new vectors comprising full-length or partial α and β subunit genomic DNA sequences produce significantly higher levels of dimeric glycoprotein hormone t...
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5665863 |
Polypeptides having granulocyte colony stimulating activity, their preparation and pharmaceutical compositions containing them
New polypeptides having granulocyte colony stimulating activity, preparation thereof and pharmaceutical compositions containing said polypeptides.
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5661007 |
Bone morphogenetic protein-9 compositions
Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed, The proteins may be used in the treatment of bone and cartilage defects and in wound healing...
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5658759 |
Recombinant DNA expression vectors
The invention provides expression vectors containing the promoter, enhancer and substantially complete 5'-untranslated region including the first intron of the major immediate early gene of human...
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5652118 |
Nucleic acid encoding a novel morphogenic protein, OP-3
Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for...
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5652123 |
Protein having interleukin 13 activity, recombinant DNA coding for this protein, transformed cells and microorganisms
The subject of the present invention is a protein having cytokine type activity, or a precursor of this protein, which comprises the following amino acid sequence (a1): ##STR1## in which Xaa...
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5641657 |
DNA encoding an interleukin-6 splice variant
Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical...
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5637480 |
DNA molecules encoding bone morphogenetic protein-10
Purified Bone Morphogenetic Protein-10 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used...
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5633147 |
Transforming growth factor αH1
Disclosed is a human TGFα-H1 polypeptide and DNA (RNA) encoding such TGFα-H1 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and for producing a...
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5624823 |
DNA encoding procine interleukin-10
Purified DNA encoding porcine IL-10, porcine IL-10, and methods of inducing immunological tolerance and inhibiting graft versus host disease.
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5618715 |
Oncostatin M and novel compositions having anti-neoplastic activity
Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from...
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5612195 |
Recombinant production of a human interferon (IFN)-gamma antagonist cytokine
A cytokine that is a specific antagonist of induction by interferon-gamma of the expression of class II histocompatibility antigens at the cell surface is disclosed. The cytokine is naturally...
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5605815 |
Nucleic acids encoding and expression of parathyroid hormone-like peptide
There is disclosed the nucleic acid and amino acid sequences for the human PTH-Like Peptide and derivatives. PTH-Like Peptide is the humoral mediator of humoral hypercalcemia of malignany or HHM...
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