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7601799 |
Methods and means to promote gut absorption
The present invention relates to epidermal growth factor (EGF) producing lactic acid bacteria and their use to increase intestinal villi height and to promote gut absorption. In particular, the...
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7282352 |
Homogeneity and secretion of recombinant proteins in mammalian systems
The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide...
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RE39792 |
Method for culturing Chinese hamster ovary cells
A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal...
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7166445 |
Methods and host cells for improved cell culture
The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as...
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7091004 |
Regulation of translation for recombinant protein production
The invention provides cells that produce increased levels of recombinant protein by modulating the activity of translational regulator gene products that are downstream targets of PKB alpha,...
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7083978 |
Nucleic acid encoding PRO1111 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7008781 |
Method of enhancing the biological activity of ligands
Novel fusion polypeptide ligands that bind Eph family receptors or the Tie-2 receptor are identified, and methods for making the fusion polypeptide ligands in biologically active form are...
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6797515 |
Regulated autocrine growth of mammalian cells
Methods of production of desired recombinant proteins, polypeptides and peptides are disclosed which utilize mammalian host cells engineered for autonomous and regulated growth in low cost...
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6780607 |
Method for cell-free protein complete post-translational modification
The present invention relates to methods of production of the completely post-translationally modified protein by combination of cell-free protein synthesis and cell-free co- and post-translational...
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6777205 |
Host cells expressing recombinant human erythropoietin
The gene coding for human erythropoietin (EPO) was obtained from human genomic DNA. Thc gene used does not include sequences from regions at i 5′ of the first translated ATG and ii 3′ of the...
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6710025 |
Treatment of damaged tissue using agents that modulate the activity of alpha-smooth muscle actin
The present invention is directed to therapeutic methods that are based upon an ability to modulate cellular contraction. This is accomplished by administering agents that either inhibit or induce...
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6689365 |
Single-chain fertility hormones with fsh and LH activity
Glycosylated or nonglycosylated proteins of the formula FSHβ-(linker 1 ) n 1 -LHβ(1-X)-(linker 2 ) n 2 -α wherein FSHβ is a vertebrate follicle stimulating hormone β subunit or a variant...
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6670178 |
In Vivo production and delivery of insulinotropin for gene therapy
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes...
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6663894 |
Intraocular transplantation of encapsulated cells
Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition comprising encapsulated cells which produce polypeptides, more particularly polypeptides...
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6656729 |
Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
The present invention is to methods of obtaining plant-derived compositions that inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use...
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6485942 |
Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production
Described herein are vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminus heparin binding domain. The variants exhibit reduced clearance rates for systemic...
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6485721 |
Biologically active substance-secreting hybrid gel
The present invention provides a biologically active substance secreting hybrid gel, which consists essentially of a biopolymeric gel and cells containing an expression vector with a gene encoding...
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6482405 |
In situ injection of antigen-presenting cells with genetically enhanced cytokine expression
The use of professional antigen presenting cells genetically modified to enhance expression of an immunostimulatory cytokine is disclosed for the treatment of individuals having tumors or...
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6455300 |
Method and compositions for monitoring DNA binding molecules in living cells
The present invention provides a method of screening for a compound that binds to a selected nuclei acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell...
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6455283 |
Nucleic acids encoding vascular endothelial cell growth factor-E (VEGF-E)
The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor...
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6423693 |
Growth hormone releasing hormone expression system and methods of use, including use in animals
Vectors which establish controlled expression of recombinant GHRH genes within tissues at certain levels. The vector includes a 5′ flanking region which includes necessary sequences for...
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6284491 |
Biologically active synthetic thyrotropin and cloned gene for producing same
Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH...
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6284485 |
Nucleic acids encoding osteoprotegerin
The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone...
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6248723 |
Method for treatment of inflammatory disease
The present invention relates to a method to protect a mammal from a disease involving inflammation by treating that mammal with a TGFβ-regulating agent. The present invention also relates to a...
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6245550 |
Cytokine family member EF-7
EF-7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EF-7 polypeptides and...
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6210949 |
Mouse MTS2 gene
The present invention relates to the Multiple Tumor Suppressor (MTS) genes in mice, their expression products, and their homology to the human MTS genes. The human MTS genes are involved in human...
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6207146 |
Gene expression in mammalian cells
Proteins such as human β-interferon or human erythropoietin are prepared by culturing mammalian cells which harbour a nucleic acid sequence comprising: (i) a coding sequence which encodes the...
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6194169 |
Enhanced expression of human platelet-derived growth factor in Pichia pastoris
Enhanced yields of the platelet-derived growth factor (PDGF) B-chain are obtained using the Pichia pastoris yeast system. Yields of both wild-type and mutant human proteins are enhanced when the...
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6187550 |
Methods and cell lines for screening compositions and genes for ability to interact with IL-1β and ice processing
Embodiments of the present invention are directed to non-naturally occurring cells and methods for screening compositions and genes which interact with interleukin 1 beta and interleukin-1 beta...
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6103501 |
Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
Single-chain agonists and/or antagonists of the glycoprotein hormones are disclosed. These proteins are of the formula β 1 -(linker 1 ) m -α-(linker 2 ) n -β 2 ...
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6048724 |
Method of producing clonal cell strains which express exogenous DNA encoding glucagon-like peptide 1
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes...
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6020189 |
Fibroblast growth factor homologous factors (FHFs) and methods of use
The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic...
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6001649 |
Chemokine NC28 (monocyte chemotactic protein-3, MCP-3) polypeptides and their recombinant production
A new chemotactic cytokine, NC28 or Monocyte Chemotactic Protein-3 (MCP-3), is provided. Fragments of the cytokine comprising its 13 C-terminal amino acids also exhibit chemotactic activity. The...
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5989538 |
Mpl ligand analogs
Mpl ligand analogs having one or more changed glycosylation sites as compared to a naturally occurring mpl ligand sequence of a corresponding number of amino acids are disclosed. The invention also...
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5980885 |
Growth factor-induced proliferation of neural precursor cells in vivo
A method is described for inducing in vivo proliferation of precursor cells located in mammalian neural tissue by administering to the mammal a fibroblast growth factor and at least one additional...
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5958737 |
Single-chain β subunit dimers of the glycoprotein hormones and recombinant materials related thereto
Single-chain forms of the glycoprotein hormone quartet, at least some members of which are found in most vertebrates, are disclosed. In one embodiment of these single-chain forms, the α and β...
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5935819 |
Process for producing a pharmaceutical preparation of PDGF-AB
The recombinant production of PDGF-AB in mammalian cells is disclosed by means of a bicistronic vector system in which an IRES sequence is located between the first and second cistrons and in which...
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5916770 |
Macrophage stimulating protein variant and method for producing the same
The present invention relates to a macrophage stimulating protein wherein a cysteine residue at position 672 from the N-terminus in the amino acid sequence of native form macrophage stimulating...
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5908763 |
DNA encoding GM-CSF and a method of producing GM-CSF protein
A method for preparing and isolating a transformation vector containing CSF/cDNA is described. The method comprises: preparing RNA from a cell that produces CSF; preparing polyadenylated...
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5888815 |
Cell cultivation method and medium
The invention relates to a method of cultivating mammalian cells expressing recombinant Factor VIII in a serum-free cell culture medium of the type that normally requires the presence of human...
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5888814 |
Recombinant host cells encoding TNF proteins
A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function....
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5871959 |
Method of producing hepatocycte growth factor/scatter factor and related cell lines
A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing...
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5856137 |
Nucleic acids encoding and recombinant production of the β subunit of lutenizing hormone
Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector...
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5834249 |
Process for production of protein
A process for production of a desired protein comprising the steps of: a culturing animal cells capable of producing the desired protein in a medium containing trichostatin compounds; and ...
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5834245 |
PRLTS proteins and DNA's encoding the same
A gene is provided which is present in the deletion region of a chromosome common in lung cancer, hepatocellular carcinoma and colorectal cancer and encodes a novel protein, a protein encoded by...
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5795779 |
Human interferon-β (IFN-β) produced in Chinese hamster ovary (CHO) cells
β-interferon is produced in Chinese hamster ovary cells (CHO) in high amounts.
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5716411 |
Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft
The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen...
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5714382 |
Synthetic plasmids and transformants comprising a feline interferon cDNA
A synthetic plasmid in which DNA encoding protein of a feline interferon is integrated, a transformant obtainable by the transformation of a host cell by the use of the synthetic plasmid and a...
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5712119 |
Methods and compositions for high protein production form recombinant DNA
Disclosed herein are improved methods and compositions for achieving enhanced protein production expressed from non-native gene constructs, including single chain sFv and derivative sequences. The...
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5703048 |
Protection against liver damage by HGF
The present invention provides methods for preventing occurrence or progression of liver damage using hepatocyte growth factor. In the methods, a preventatively effective amount of the hepatocyte...
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