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7622630 |
Chimeric cancer models
Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells...
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7604990 |
Methods of regulating differentiation in stem cells
The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and...
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7569221 |
Compositions and methods for identifying agents that alter expression of survivin
Provided are compositions and methods for identifying agents that can modulate expression of the human survivin gene. The compositions include eukaryotic cells that contain a human survivin...
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7557258 |
Endotoxin-nonresponsive model animal
The present invention is to provide a non-human animal model non-responsive especially to endotoxin being a Gram-negative bacteria cell wall fraction, which is useful to elucidate the function of...
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7556805 |
Compositions for treatment of melanoma and method of using same
Melanoma can be treated in a mammalian subject by administering to the subject an immunologically-effective amount of a xenogeneic melanoma-associated differentiation antigen. For example, genetic...
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7544509 |
Method for preparing stem cell preparations
This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an...
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7541183 |
Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling
Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening...
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7527973 |
Antibodies against West Nile Virus and therapeutic and prophylactic uses thereof
The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV),...
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7514594 |
Transgenic animal model of bone mass modulation
The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing...
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7514257 |
Zinc finger transcription factor differentiation proteins
The disclosure describes artificial chimeric transcription factors that include at least one zinc finger domain and that can regulate cellular differentiation, for example, a neuronal cell...
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7510871 |
Alzheimer model for drug screening
The present invention relates to methods and reagents for drug screening. Screening methods are disclosed employing neuronal cells that have been treated so as to exhibit characteristics associated...
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7504254 |
Methods for isolating molecular mimetics of unique Neisseria meningitidis serogroup B epitopes
Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic...
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7501281 |
Compositions, methods and kits related to thrombin, Notch signaling and stamatogenesis and growth of stem cells
The present invention relates to methods based on the interactions of thrombin as a biological regulator. More specifically, the invention relates to the interactions of thrombin with regard to...
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7498168 |
Tooth progenitor cell and method for its production
The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell.
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7494806 |
Retroviral vectors expressing exogenous gene or exogenous nucleic acid sequences
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial...
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7459601 |
Human α synuclein expressing transgenic mice
In methods for screening treatments for, and treatment of, neurodegenerative diseases, aggregation in neurons of NACP/α-synuclein is measured and expression of a non-amyloidogenic protein is...
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7449567 |
Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
The present invention relates to transcription control elements derived from mouse and human genes associated with cytochrome expression, e.g., Cyp3A11 and CYP3A4, respectively. Isolated...
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7442545 |
Neural colony forming assay
A neural colony forming cell (NCFC) assay is described. The assay allows one to distinguish neural stem cells from neural progenitor cells. In one embodiment, the present invention provides a...
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7439060 |
Independent helper virus packaging cell line for propagating viral vectors
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial...
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7435591 |
Compositions and methods for increasing animal size growth rate
The present invention relates to germ line and somatic cells comprising a mutant p27 kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making...
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7425446 |
Antibody composition-producing cell
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a...
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7419825 |
Isolation of neural stem cells using gangliosides and other surface markers
During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number...
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7416848 |
DNA encoding SNORF25 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors,...
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7416840 |
Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells
Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the...
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7413903 |
Methods of regulating differentiation in stem cells
The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and...
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7413900 |
Immortalized fibroblasts
Aspects of the invention provide an immortalized fibroblast cell line capable of the growth and maintenance of human embryonic stem cells. An immortalized fibroblast cell line derived from an early...
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7413898 |
Cells and methods for estimation of effects on neurological dysfunction
The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed...
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7371569 |
Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
Procedures to produce a biologically active human TPO by mammalian cells in in vitro cultures are disclosed. Murine myeloma cells were genetically modified by introducing the gene of human...
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7348156 |
7B2 knockout transgenic animals as models of endocrine disease
In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous...
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7341871 |
Nucleotide sequences for gene regulation and methods of use thereof
The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression...
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7323334 |
Screening and therapeutic methods relating to neurogenesis
The invention provides methods of identifying compounds that modulate neurogenesis. The methods involve providing a compound that modulates prokineticin receptor signaling; contacting a neural stem...
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7321074 |
Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight
Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-3 receptor protein (MC-3R). MC-3R deficient transgenic animals have increased...
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7309811 |
Transgenic mice knockouts of BACE-1
The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for...
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7300763 |
Method of testing myelotoxicity with the use of flow cytometer
The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing...
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7294510 |
Process for producing nerve stem cells, motor neurons, and GABAergic neurons from embryonic stem cells
The present invention provides a method for producing motor neurons and GABAergic neurons characterized by including suspension-culturing embryonic stem cells in the presence or absence of a...
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7285413 |
Isolation tool for viable c-kit expressing cells
A tool for the isolation of c-kit expressing cells is provided. This tool consists of a c-kit plasmid targeting vector which is capable of integrating into the wild type c-kit allele and encodes a...
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7279330 |
Method for identifying modulating compounds of neurotransmitters
A process for identifying compounds that can modulate the release of neuromediators is described in which, for example, at least one compound that is to be tested is brought into contact with a...
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7264923 |
Norovirus infected cell cultures and uses therefor
A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and...
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7253150 |
Gene delivery vehicle expressing the aptosis-inducing proteins VP2 and/or apoptin
The invention relates to gene delivery vehicles which comprise nucleic acid molecules encoding apoptosis-inducing proteins VP2 and/or apoptin (VP3) like activity. VP2 and VP3 are viral proteins of...
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7250255 |
Genes with ES cell-specific expression
The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs...
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7247766 |
Double transgenic mice overexressing human beta secretase and human APP-London
The present invention relates to a novel animal model for amyloidopathies, especially Alzheimer' disease overexpressing human BACE and human APP London. This novel animal model exhibits several...
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7247480 |
Method for producing dendritic cells
Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one...
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7247427 |
Leptin assay
The invention provides a method for determining the presence of leptin in a sample.
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7238360 |
Alteration of cell membrane with B7
Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene...
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7232683 |
Extracellular matrix signaling molecules
Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis,...
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7223556 |
Targeted proteolysis by recruitment to ubiquitin protein ligases
The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and...
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7205148 |
Genome mutation by intron insertion into an embryonic stem cell genome
Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons...
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7189567 |
Method of culturing human chondrocytes
This invention provides a method for rapidly culturing a large amount of human chondrocytes to give normal chondrocytes or a mass thereof. The culture method comprises co-culturing human...
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7186812 |
Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically...
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7169612 |
Use of EDG2 receptor in an animal model of heart failure
Mammals and myocardial mammal cells transformed with G protein coupled receptor EDG2 are presented for use in an animal model for heart failure.
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