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7556805 |
Compositions for treatment of melanoma and method of using same
Melanoma can be treated in a mammalian subject by administering to the subject an immunologically-effective amount of a xenogeneic melanoma-associated differentiation antigen. For example, genetic...
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7544509 |
Method for preparing stem cell preparations
This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an...
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7521228 |
Spider silk protein encoding nucleic acids, polypeptides, antibodies and methods of use thereof
Spider silk protein encoding nucleic acids, polypeptides and antibodies immunologically specific therefore are disclosed. Methods of use thereof are also provided.
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7488573 |
In vivo angiogenesis assay
A method for evaluating in vivo a test substance for angiogenesis modulation activity, including the steps of providing a rodent pup having a pupillary membrane system in a first eye, injecting...
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7425446 |
Antibody composition-producing cell
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a...
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7332333 |
Host cells containing multiple integrating vectors
The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating...
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7321074 |
Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight
Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-3 receptor protein (MC-3R). MC-3R deficient transgenic animals have increased...
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7300763 |
Method of testing myelotoxicity with the use of flow cytometer
The objects of the present invention are to solve low test efficiency and low accuracy which are problems encountered in the conventional methods for testing myelotoxicity of a drug by observing...
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7279330 |
Method for identifying modulating compounds of neurotransmitters
A process for identifying compounds that can modulate the release of neuromediators is described in which, for example, at least one compound that is to be tested is brought into contact with a...
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7273727 |
Fusion proteins for prodrug activation
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity...
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7247424 |
Screening method for a substance having hypoglycemic activity by using STAT-induced inhibitor of STAT function-1
The present invention discloses a screening method for a substance, which could be a therapeutic agent for diabetes with insulin resistance through regulating a function of a molecule involved in...
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7244616 |
Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present...
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7132286 |
Method for neural stem cell differentiation using valproate
The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or neuron in vitro or in vivo. Particularly, the invention provides for a...
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7132287 |
Method for neural stem cell differentiation using 5HT-1A agonists
The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron in vitro or in vivo. Particularly, the invention provides for...
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7098027 |
Method for remyelinating a demyelinized lesion due to injury in the brain or spinal cord
Demyelinated axons were remyelinated in the demyelinated rat model by collecting bone marrow cells from mouse bone marrow and transplanting the mononuclear cell fraction separated from these bone...
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7060869 |
Fluorescent protein sensors for detection of analytes
Fluorescent indicators including a binding protein moiety, a donor fluorescent protein moiety, and an acceptor fluorescent protein moiety are described. The binding protein moiety has an...
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7045335 |
Alphavirus replicon vector systems
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent...
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7029915 |
Method for differentiating rat hepatic stem cells to insulin-producing cells
Highly purified hepatic stem cells are trans-differentiated into pancreatic endocrine hormone-producing cells by culturing them in vitro in a medium containing high levels of glucose. These...
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7005411 |
Method for modulating nerve cell function
The amount of active Robo expressed on a cell is modified by modulating the effective amount of a Comm polypeptide in contact with the cell, whereby the amount of expressed active Robo is modulated...
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7005299 |
Expression of heterologous genes according to a targeted expression profile
A gene trap vector comprises a DNA construct containing an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence; this expression unit is used in gene...
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6969608 |
Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
Current sources of neural stem and progenitor cells for neural transplantation are essentially inaccessible in living animals. This invention relates to neural precursor cells (stem cells,...
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6960470 |
Diagnostic methods for drug screening for Alzheimer's disease
Methods of screening candidate drugs for the treatment of Alzheimer's disease are provided. Employing tissue slices of mutant mouse hippocampal cells having an extra copy of a mutant form of the...
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6953692 |
Device and method for seed-train expansion of mammalian cells
A device and method for seed-train expansion of a source of mammalian cells and their use in production of proteins expressed by the cells comprising the use of a dedicated inoculation bioreactor...
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6943016 |
Human adult astrocytes, their preparation and uses thereof
The invention provides an essentially pure preparation of human adult astrocytes, and a method of producing same. The purified astrocytes are useful for the treatment of neurodegenerative disorders...
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6936457 |
DNA ENCODING HUMAN α AND β SUBUNITS OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR, CELLS TRANSFORMED THEREWITH, AND RECOMBINANT CELL LINE EXPRESSING A HUMAN α AND β SUBUNIT OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR
Isolated nucleic acid molecules, i.e., DNA or RNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for...
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6924128 |
Packaging cell lines for generation of high titers of recombinant AAV vectors
AAV vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantities of such recombinant vectors in amounts that would be...
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6908764 |
Recombinant human cell for bone and cartilage cell formation
The invention relates to a recombinant human cell of undifferentiated mesenchyma for bone and cartilage cell formation, the human cell having the ability to express Tbr-1, Brachyury or another...
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6897061 |
Transdifferentiation of glial cells
A process for generating multipotent cells from glial cells using in vitro techniques to dedifferentiate fetal or adult mammalian glial cells into multipotent cells. The multipotent cells may...
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6890724 |
Methods and compositions for neural progenitor cells
The invention relates to methods and compositions for the isolation of neural progenitor cells.
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6872569 |
In vitro production of haploid germ cells
The present invention relates to a method of in vitro spermatogenesis involving Sertoli cells and diploid germ cells from a testis of a male mammal to yield differentiated haploid spermatids. The...
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6835565 |
Alzheimer's disease secretase
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell...
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6825037 |
Recombinant transferrins, transferrin half-molecules and mutants thereof
Recombinant transferrin, non-glycosylated recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant...
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6803233 |
Model for Alzheimer's disease and other neurodegenerative diseases
The present invention provides a model for studying the development of, and/or pathologies associated with neurodegenerative diseases, and agents that can alter such development and/or pathologies....
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6790612 |
Reporter gene system for use in cell-based assessment of inhibitors of the hepatitis C virus protease
A cell-based assay system in which the detection of the reporter gene activity, or secreted alkaline phosphatase (SEAP), is dependent upon the protease activity of the Hepatitis C virus NS3 gene...
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6753146 |
System and method for evaluating agents which prevent oxidative damage
An in vitro system for identifying agents capable of inhibiting or preventing oxidative damage is provided. The disclosed in vitro system comprises a mouse fibroblast culture derived from a...
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6740519 |
Immortalized, homozygous stat1-deficient mammalian cell lines and their uses
The present invention is directed to immortalized STAT1-deficient mammalian cell lines. STAT1 is a signal transducer and activator of transcription that becomes phosphorylated when cells are...
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6730821 |
Transgenic mice containing retina-specific nuclear receptor gene disruptions
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
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6682910 |
Human erythropoietin gene: high level expression in stably transfected mammalian cells
The Apa I restriction fragment of the human erythropoietin gene, for producing high titers of biologically active hormone from stably transfected cell lines.
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6673605 |
Established cell line of microglia
The present invention relates to an established cell line of microglia having the following properties: (a) form: having a macrophage-like or globular form in the presence of...
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6670139 |
Cell-free assay using oncogene-induced apoptosis to identify inhibitors of apoptosis in drug-resistant cells
The present invention relates to a method of identifying a compound (agent) which modulates apoptosis in transformed cells. In one embodiment, the invention is a method of identifying a compound...
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6670178 |
In Vivo production and delivery of insulinotropin for gene therapy
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes...
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6663894 |
Intraocular transplantation of encapsulated cells
Compositions and methods for reducing ocular diseases by implanting in an eye of a subject a composition comprising encapsulated cells which produce polypeptides, more particularly polypeptides...
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6657104 |
Transgenic mouse model for cardiac hypertrophy and methods of use thereof
Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided...
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6649811 |
Transgenic mouse expressing the human cyclooxygenase-2 gene and neuronal cell cultures derived therefrom
The invention provides for transgenic mice whose genomes comprise a gene encoding human cyclooxygenase-2 under the control of a neuron-specific promoter. The transgenic mice of the instant...
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6641526 |
Development of normal offspring from oocytes injected with freeze-dried spermatozoa
The invention provides a method for freeze-drying spermatozoa to obtain at least one reconstituted spermatozoon whose head (nucleus) is capable of fertilizing an oocyte to produce a live offspring....
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6635478 |
Production of recombinant proteins using herpes virus promoters and VP16 transactivators
Stable cell lines are produced to express high levels of a gene product of interest using VP16, a herpes simplex virus transactivator, and a promoter from herpes simplex virus which is a target for...
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6610540 |
Low oxygen culturing of central nervous system progenitor cells
The present invention relates to the growth of cells in culture under conditions that promote cell survival, proliferation, and/or cellular differentiation. The present inventors have found that...
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6593138 |
Cryopreserving somatic cells with an arabinogalactan containing cryopreservation medium
Methods and compositions for cryopreserving somatic cells are provided. In one embodiment, a cell cryopreservation medium is provided which includes an effective amount of arabinogalactan to...
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6586251 |
Methods of modifying eukaryotic cells
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells....
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6583333 |
Lymphoma-susceptible transgenic mice and methods for studying drug sensitivity of lymphomas
A mouse expressing myc in B cells, because of defective function of one or more tumor suppressor genes, is useful for the testing of anti-lymphoma agents and for the testing of genes which may have...
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