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7619060 |
Cytoplasmic polyhedrosis virus protein complex of a polyhedrin and a VP3 polypeptide
It is intended to provide a protein complex and a production process whereby the protein complex can be efficiently produced without lowering its function. It is also intended to provide use of the...
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7582449 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7579168 |
Human Dickkopf-related nucleic acid molecules
Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides...
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7575753 |
SRSV detection kit
This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related virus constituting peptides selected from the following peptide groups (a) to (k), respectively: (a) a...
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7563781 |
Triazolopyrimidine derivatives
The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.
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7563612 |
Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin B-subunit and uses thereof
The present invention relates to a chimeric nucleic acid molecule encoding a fusion protein having a human lutropin hormone-receptor domain and a human chorionic gonadotropin-β subunit domain, the...
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7563596 |
Method of modulating tissue growth using Frzb protein
An isolated cDNA encoding a growth-inducing protein, Frzb, capable of stimulating bone, cartilage, muscle and nerve tissue formation. Frzb binds to and modulates the activity of Wnt growth factors...
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7556805 |
Compositions for treatment of melanoma and method of using same
Melanoma can be treated in a mammalian subject by administering to the subject an immunologically-effective amount of a xenogeneic melanoma-associated differentiation antigen. For example, genetic...
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7534603 |
Fusion protein delivery system and uses thereof
The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is...
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7531626 |
Tenebrio antifreeze proteins
A novel class of thermal hysteresis (antifreeze) proteins (THP) that have up to 100 times the specific activity of fish antifreeze proteins has been isolated and purified from the mealworm beetle, ...
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7528245 |
Efficient protein expression system
Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified...
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7517972 |
Nucleic acid sequences encoding a bitter taste receptor, T2R76
Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods...
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7485713 |
Polypeptides comprising growth hormone receptor extracellular domain and glycosylphosphatidylinositol
The present invention relates to polypeptides which comprise a receptor binding domain of a cytokine and a domain which includes a signal sequence for the attachment of glycosylphosphatidylinositol...
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7482141 |
Methods and compositions for vitamin K epoxide reductase
The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide...
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7479549 |
Recombinant canine thyroid stimulating hormone and methods of production and use thereof
The invention includes a nucleic acid having a sequence at least 98% homologous to SEQ ID NO: 1, which encodes the α subunit of canine thyroid stimulating hormone (TSH). The invention also...
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7465571 |
Endoglucanases
In one aspect, the invention provides a purified thermostable enzyme derived from the archael bacterium AEPII 1a. In one aspect, the enzyme has a molecular weight of about 60.9 kilodaltons and has...
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7456007 |
β-secretase enzyme compositions and methods
Disclosed is an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of...
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7452706 |
Recombinant bacterial phytases and uses thereof
A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native...
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7446183 |
Fusion protein comprising growth hormone and growth hormone receptor
This invention relates to agents which bind to cell surface receptors; methods to manufacture said agents; therapeutic compositions comprising said agents; and screening methods to identify novel...
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7435808 |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1...
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7432419 |
Compositions and methods for the treatment of Pierce's disease
Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The...
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7432347 |
Cytoplasmic polyhedrosis virus polyhedrin protein complex
To provide a useful objective protein coated with a protective protein, a protein complex that is produced in cells and has a structure that the objective protein is occluded with the viral...
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7427658 |
Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor
The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. Only lysates of insect cells which have...
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7425614 |
Neuroprotective therapeutics preventing ERK/MAPK activation through the NMDA receptor
Methods for identifying neuroprotective compounds, as well as compositions and methods for treating subjects suffering from neurological diseases or disorders are provided.
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7416848 |
DNA encoding SNORF25 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors,...
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7413732 |
Baculovirus expression system
The application relates for method for cloning the gene comprising the steps of: 1. Providing a replication-deficient baculovirus vector, 2. Providing a rescue vector comprising (a) nucleic acid...
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7410778 |
Estrogen receptor genes and utilization thereof
A gene coding for any of the following estrogen receptors (a) to (c): (a) an estrogen receptor comprising the amino acid sequence represented by amino acid numbers 153 to 602 in the amino acid...
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7405038 |
Stable cell lines resistant to apoptosis and nutrient stress and methods of making same
Cell lines that are commonly used for protein expression are engineered to include genes that encode suppressors of apoptosis (SA). Insect cell lines expressing these SA genes are resistant to...
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7402430 |
MHC class II antigen-presenting systems and methods for activating CD4+ T cells
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC...
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7375205 |
Elongase genes and uses thereof
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these...
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7354611 |
Fecundity-promoting supplement for the insidious flower bug reared on artificial diet
A new protein supplement for insect rearing contains extracts of insect eggs or cultured insect egg embryonic cell lines from insects such as Plodia interpunctella and Ephestia kuehniella ...
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7288400 |
Nucleic acids encoding esterases and methods of making and using them
The invention relates to esterases and to polynucleotides encoding the esterases. In addition methods of designing new esterase method of use thereof are also provided. The esterases have increased...
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7279329 |
Expression system for producing collagen
A DNA molecule consisting of the nucleotide sequence of SEQ ID NO: 1, which encodes a collagenous (COL1) domain and a C-terminal noncollagenous (NC1) domain of type XXI collagen. Expression systems...
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7273727 |
Fusion proteins for prodrug activation
The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity...
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7271002 |
Production of adeno-associated virus in insect cells
A method of producing an adeno-associated virus (AAV) in an insect cell comprising (i) providing at least one insect cell-compatible vector comprising a first nucleotide sequence comprising at...
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7270989 |
Method of producing non-bovine chymosin and use hereof
A method of recombinantly producing a non-bovine pre-prochymosin, prochymosin or chymosin derived from ruminant species including deer species, buffalo species, antelope species, giraffe species,...
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7262039 |
Polypeptide
This invention relates to a novel polypeptide having an α1,3-fucosyltransferase activity, a method for producing the polypeptide, a DNA encoding the polypeptide, a method for producing the DNA, a...
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7256280 |
Cell cycle nucleic acids, polypeptides and uses thereof
The invention provides isolated nucleic acids and their encoded proteins that are involved in cell cycle regulation. The invention further provides recombinant expression cassettes, host cells,...
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7253341 |
Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof
Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of...
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7247466 |
Amino acid racemase having low substrate specificity and process for producing racemic amino acid
The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the...
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7247451 |
Antithrombin protein and DNA sequences from black fly
The invention is drawn to anti-thrombin proteins from the salivary glands of the species, Simulium . Methods for recombinant production of the protein as well as biomedical uses are provided.
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7244586 |
DNA molecules encoding ligand-gated ion channels from Drosophila melanogaster
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Drosophila melanogaster ligand-gated ion channel proteins. The present invention also...
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7226762 |
Gene coding for glucose-6-phosphate-dehydrogenase proteins
The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These...
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7226745 |
Plant vitamin E biosynthetic enzymes
This invention relates to an isolated nucleic acid fragment encoding a vitamin E biosynthtetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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7223555 |
Method for detecting elevated activity of oxidases in insects
A method for checking for elevated activity of mixed-function oxidases using a single insect, includes homogenizing a single insect in an acid pH buffer, preferably by grinding it in a small tube,...
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7220576 |
Methods and compositions for protein expression and purification
Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
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7211406 |
Potassium channel
A novel polypeptide which is useful in searching for a therapeutic agent for diabetes, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a cell...
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7208304 |
β1,3-galactosyltransferases from C. jejuni
This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a...
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7208303 |
Bacterial nitric oxide synthases and uses thereof
The present invention relates to isolated nucleic acid molecules encoding nitric oxide synthases. The isolated nucleic acid molecules and their encoded protein or polypeptides are useful in methods...
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7208273 |
Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia
The present invention is directed to a specific mutation in SCN5A which causes drug-induced torsade de pointes or ventricular fibrillation. Persons with the mutation are predisposed to developing...
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