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5643776 |
Insect diagnostic and control compositions
A diagnostic or control composition is useful to characterize or control insects and comprises a nucleotide sequence coding for juvenile hormone esterase (JHE). The coding sequence may be combined...
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5641649 |
Expression of osteogenic factor OP-1 in cells of spodoptera frugiperda infected with recombinant baculovirus
The present invention is directed towards a method of producing a DNA sequence encoding human osteogenic protein, OP-1, using recombinant DNA techniques. The DNA sequence encoding OP-1 is utilized...
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5641657 |
DNA encoding an interleukin-6 splice variant
Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical...
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5641665 |
Plasmids suitable for IL-2 expression
The present invention relates to plasmids suitable for IL-2 expression, particularly, human IL-2 expression, and related methods.
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5641655 |
Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide
DNA constructs useful in the production of thrombopoietin are disclosed. In general, the DNA constructs comprise a first DNA segment encoding a fusion of an amino-terminal secretory peptide joined...
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5639651 |
Gap-related gene, human IQGAP1
A purified nucleic acid encoding the IQGAP1 protein, a novel member of the GTPase activating protein family, useful in the diagnosis and treatment of tumors.
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5639454 |
Recombinant baculovirus with broad host range
Insect control agents comprising a gene encoding a protein that affects the host range of baculoviruses. A unique gene encoding a protein of 25.7 kdal, p25.7, isolated from a baculovirus from the...
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5633149 |
Polynucleotide encoding novel chemokine expressed in inflamed adenoid
The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for...
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5633161 |
Murine gene fomy030 coding for tumor progression inhibitor
The present invention relates to compositions for the diagnosis, prevention and treatment of tumor progression. Novel nucleic acid molecules are identified that are expressed at higher levels in...
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5633147 |
Transforming growth factor αH1
Disclosed is a human TGFα-H1 polypeptide and DNA (RNA) encoding such TGFα-H1 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and for producing...
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5629188 |
Human alanyl-tRNA synthetase proteins, nucleic acids and tester strains comprising same
Isolated, recombinant nucleic acids which encode alanyl-tRNA synthetase (AlaRS) of human origin have been used to make expression constructs and transformed host cells for the production of...
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5629193 |
Paraoxonase
Human paraoxonase enzyme and DNA (RNA) encoding such paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such...
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5624832 |
β1 6 N-acetylglucosaminyltransferase, its acceptor molecule, leukosialin, and a method for cloning proteins having enzymatic activity
The present invention provides a novel β1➝6 N-acetylglucosaminyltransferase, which forms core 2 oligosaccharide structures in O-glycans, and a novel acceptor molecule, leukosialin, CD43, for...
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5624827 |
DNA sequences encoding the plant toxin gelonin
The present invention provides the nucleotide sequence for a synthetic gene for the plant toxin gelonin and a process for producing, cloning and expressing this synthetic gene. The DNA sequence for...
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5624817 |
Mutations in the gene encoding the alpha chain of platelet glycoprotein Ib
The subject invention provides purified polypeptides encoded by naturally-occurring wild-type platelet glycoprotein Ib alpha having a mutation which renders the polypeptide more reactive with yon...
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5622856 |
High efficiency helper system for AAV vector production
Novel nucleic acid molecules are provided having adeno-associated virus (AAV) coding regions that are capable of expressing necessary AAV functions to complement an AAV vector in the production of...
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5622839 |
Recombinant production of human calcitonin receptor polypeptides
Human calcitonin receptors have been cloned, sequenced and expressed by recombinant means. The receptors and antibodies thereto may be used in screening systems to identify agonists and antagonists...
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5622851 |
Human deoxycytidylate deaminase gene
The present invention is directed to a DNA molecule encoding a gene for human deoxycytidylate deaminase. The DNA molecule comprises 26,764 base pairs. A 1317 base pair 5' untranslated region is...
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5618715 |
Oncostatin M and novel compositions having anti-neoplastic activity
Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from...
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5618717 |
DNA encoding human AlkB
A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such...
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5618695 |
DNA encoding HEM-1, a gene expressed by sclerosing hemangioma cells
An isolated and purified DNA sequence encoding hemangioma factor-1 is provided. A host cell transformed with a DNA sequence encoding hemangioma factor-1 and a method of introducing and expressing...
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5616500 |
Trichohyalin and transglutaminase-3 and methods of using same
The sequences of a pair of human proteins, trichohyalin and transglutaminase-3, in addition to the sequence of the mouse transglutaminase-3 protein, have been discovered. The enzyme...
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5612190 |
DNA molecule encoding bovine group I phospholipase A.sub.2 receptor
The present invention provides a bovine group I phospholipase A 2 receptor comprising an amino acid sequence from Leu in the 486 position to Pro in the 940 position of SEQ ID No. 1, and a gene...
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5605830 |
Murine and human c-Myc interacting protein
A partial murine cDNA clone and a human cDNA clone, each encoding a c-Myc interacting polypeptide termed MIP-99, are provided. Also provided are methods of using the nucleic acid sequences,...
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5602008 |
DNA encoding a liver expressed chemokine
The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also...
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5597707 |
Tumor associated antigen recognized by the murine monoclonal antibody L6, its oligonucleotide sequence and methods for their use
The present invention definitively identifies and characterizes the tumor-associated antigen immunologically recognized by the murine monoclonal antibody L6. Further, the present invention provides...
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5595902 |
DNA encoding human protein kinase C (iota)
The present invention relates to protein kinase C (iota). The present invention provides this protein in a substantially pure form and also provides nucleotide sequences encoding the protein. The...
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5595884 |
Papillomavirus E2 transactivation repressor proteins and DNA
This invention relates to E2 trans-activation repressors which interfere with normal functioning of the native full-length E2 transcriptional activation protein of the papillomavirus. This...
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5593862 |
Nucleic acids encoding drosophila tipE cation channel proteins and recombinant expression of the same
The present invention provides for the isolation of genomic fragments from Drosophila melanogaster encoding tipE protein, which protein is required for expression of functional voltage dependent...
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5593883 |
Ancient microorganisms
The recovery of live ancient bacteria, fungi and other biological material from various sources fossilized in amber or related resins is described. Several ancient bacterial strains have been...
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5593859 |
Synthesis of human procollagens and collagens in recombinant DNA systems
The invention is transfected cells, substantially all of which contain at least one human collagen gene and express fibrillar collagen molecules derived using methods for synthesizing collagen and...
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5589363 |
DNA encoding tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
DNA enclosing a tissue factor protein mutant capable of neutralizing the ability of endogenous tissue factor to induce coagulation is provided. A representative tissue factor mutant designated...
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5589338 |
Nucleic acids encoding a mutant form of human serum albumin involved in familial dysalbuminemic hyperthyroxinemia
Modified forms of human serum albumin (HSA) wherein the arginine at position 218 is substituted by a less basic amino acid show strong thyroxin-binding activity. Recombinant materials for...
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5589372 |
Squalene synthetase
Nucleic acid sequences, particularly DNA sequences, coding for all or part of a squalene synthetase, expression vectors containing the DNA sequences, host cells containing the expression vectors,...
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5587310 |
Chimeric blood coagulation proteins
Chimeric blood coagulation proteins are disclosed. The proteins are (i) coagulation factor V in which at least one A3, C1 or C2 domain exon thereof is replaced with the homologous exon of...
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5587302 |
T cell growth factor
The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports...
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5585264 |
Nucleotide sequences encoding recombinant bovine herpesvirus type-1 GI, GIII and GIV polypeptides
Recombinant subunit vaccines against bovine herpesvirus type 1 (BHV-1) are provided, as well as methods of vaccination, methods of recombinantly producing the subunit antigens or nucleotide...
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5585270 |
Polynucleotides encoding connective tissue growth factor
Polynucleotides encoding connective tissue growth factor (CTGF) are provided. An exemplary polynucleotide of the invention is shown in SEQ ID NO:1. Expression vectors containing CTGF polynucleotide...
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5583030 |
Method for obtaining antifungal and herbicidal compounds that target the first committed step in shingolipid long-chain base biosynthesis
The invention provides the LCB1 and LCB2 genes of the yeast Saccharomyces cerevisiae that encode subunits of the enzyme serine palmitoyltransferase (SPT), the first enzyme leading to synthesis of...
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5583031 |
Empty major histocompatibility class II heterodimers
The invention features an isolated sample of mammalian class II major histocompatibility heterodimers which are membrane-associated or in soluble form, and which are capable of binding added...
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5580775 |
High affinity, brain-specific nucleic acids encoding a L-proline transporter, and vectors, and host cells comprising the same
The anatomical distribution, nucleic acid sequence, pharmacological properties, and inferred structural features of a cDNA encoding a high affinity, Na + -dependent rat brain L-proline transporter...
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5563060 |
Micro-libraries for screening cell populations
Micro-scale methods are applied in producing, maintaining, replicating, screening, manipulating and sub-cloning cell libraries. By means of the micro-scale methods of the invention, micro-libraries...
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5559021 |
DNA encoding a novel mammalian transporter homologous to neurotransmitter transporters and uses thereof
This invention provides an isolated nucleic acid molecule encoding a mammalian rB21a transporter, an isolated protein which is a mammalian rB21a transporter, vectors comprising an isolated nucleic...
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5552303 |
DNA encoding epithelium-derived T-cell factor
There is disclosed a mammalian epithelium-derived T-cell factor (EFT) polypeptide, derivatives thereof, DNA sequences, recombinant DNA molecules and transformed host cells that produce ETF...
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5550221 |
Nucleic acid molecule encoding the amphotropic virus receptor
The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has...
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5547871 |
Heterologous signal sequences for secretion of insect controlling proteins
Seven heterologous signal sequence are described for use with genes for insect controlling proteins, such that when the signal sequence and protein genes are inserted into an insect virus, that...
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5541310 |
Herbicide resistant plants
Disclosed are plants, plant tissue and plant seed, whose growth and development are tolerant of, or resistant to various imidazole and triazole herbicidal compounds, at levels which normally are...
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5521073 |
TIE-2 ligand, and method of making
The present invention provides for an isolated nucleic acid molecule encoding human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds human TIE-2...
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5516657 |
Baculovirus vectors for expression of secretory and membrane-bound proteins
The invention provides Baculovirus vectors comprised of a promoter upstream from a signal peptide. The Baculovirus vectors allow for the expression of a glycosylated protein in the late term of...
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5514578 |
Polynucleotides encoding insect steroid hormone receptor polypeptides and cells transformed with same
Polynucleotide sequences which encode ecdysone receptors have been isolated and expressed in host cells.
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