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5770430 |
Cellular injury response element and uses thereof
The present invention provides a vector with a DNA sequence coding for a cellular injury element promoter from nucleotides -74 to -35 of the GADD153 promoter, relative to the start of...
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5767261 |
Lepidopteran GABA gated chloride channel and nucleic acids encoding subunits thereof
The present invention provides isolated nucleic acids encoding lepidopteran gamma aminobutyric acid (GABA) gated chloride channels. In a preferred embodiment, the nucleic acids encoding...
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5760203 |
Gap gene sequences
Guanosine triphosphatase activating protein (GAP) DNA sequences are described that are useful as cancer diagnostics, particularly to detect cancer cells that express the ras oncogene protein p21 by...
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5756327 |
Recombinant mycobacterial isoleucyl-tRNA synthetase genes, tester strains and assays
Isolated and/or recombinant nucleic acids encoding mycobacterial isoleucyl-tRNA synthetase have been characterized. Recombinant DNA constructs and vectors having a sequence which encodes...
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5756299 |
Human carbonyl reductase
The present invention provides a human carbonyl reductase (HCRD) and polynucleotides which identify and encode HCRD. The invention also provides genetically engineered expression vectors and host...
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5753477 |
Magneto-biolistic methods
The present invention discloses methods to transfect cells, comprising applying a strong magnetic field in pulses so as to affect a plurality of substance-carrying magnetic microparticles, the...
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5753507 |
Plant geraniol/nerol 10-hydroxylase and DNA coding therefor
The present invention provides novel plant DNA sequences coding for geraniol/nerol 10-hydroxylase (G10H). Methods for using the complete or partial G10H coding sequence as a probe for diagnostic,...
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5750383 |
Baculovirus cloning system
Disclosed herein is a novel baculovirus cloning system. The new cloning system is a marker-rescue system, using an essential gene, e.g. gp64. In this system, a gene essential for viral replication,...
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5747338 |
Method and construct for screening for inhibitors of transcriptional activation
A collision construct is provided that contains a first regulatory sequence containing a first promoter linked to a reporter gene which is also linked to a second regulatory sequence containing a...
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5741705 |
Method for in vitro cell growth of eucaryotic cells using low molecular weight peptides
A method and kit for growing eucaryotic cells using a hydrolyzate of a protein material containing peptides and free amino acids. The material contains L-glutamine, preferably in an amount of...
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5739307 |
Polynucleotide encoding neurturin neurotrophic factor
A novel growth factor, neurturin, is disclosed. The human and mouse amino acid sequences have been identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequences and the...
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5736135 |
Method for making variant secreted proteins with altered properties
A screening method for the selection of mutagenized proteins that are normally secreted by cells is described. The method includes the development of a cloning vector for the expression of...
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5728580 |
Methods and culture media for inducing single cell suspension in insect cell lines
Non-carboxylated sulfated polyanions have been successfully used to rapidly obtain and maintain stable single-cell suspension of BTI-TN5B1-4 cells, a cell line which has a high intrinsic capacity...
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5723316 |
α-1-antichymotrypsin analogues having chymase inhibiting activity
The invention provides analogues of α-1-antichymotrypsin having amino acid substitutions at position 358. α-1-antichymotrypsin analogues having amino acid substitutions at positions 356-361 and...
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5723329 |
DNA encoding retinoid receptor X (RXR) alpha and gamma; corresponding vectors and host cells
The present invention relates to novel receptor polypeptides, which, upon interaction with certain ligands, or activation by certain compounds, modulate transcription of certain genes by binding to...
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5716823 |
Human respiratory virus preparahons and processess
This invention discloses compositions of DNA and proteins that are useful for preparing vaccines against human respiratory syncytial virus HRSV!. The DNA compositions include structural genes...
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5714316 |
Chimeric envelope proteins for viral targeting
The present invention provides compositions and methods for targeting recombinant retroviral particles specifically to cells of interest for delivery of desired therapeutic or toxic agents. The...
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5712380 |
DNA encoding a soluble VEGF inhibitor
The vascular endothelial cell growth factor (VEGF) inhibitors of the present invention are naturally occurring or recombinantly engineered soluble forms with or without a C-terminal transmembrane...
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5712382 |
Plant adenylosuccinate lyase and DNA coding therefor
The present invention provides novel plant DNA sequences coding for native adenylosuccinate lyase (ADSL). Methods for using the complete or partial ADSL coding sequence as a probe for diagnostic,...
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5710018 |
Mammalian influx peptide transporter
The present invention provides isolated DNA compounds and recombinant DNA vectors that encode mammalian influx peptide transporter activity. The invention also provides host cells transformed with...
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5703046 |
Treatment method using recombinantly produced human membrane cofactor protein (MCP)
Human membrane cofactor protein, a protein involved in regulation of complement activity, has been purified to homogeneity. The gene encoding this protein has been retrieved and permits deduction...
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5695959 |
Recombinant expression of insecticidally effective spider toxin
This invention provides a family of insecticidally effective proteins and particular members of that family which may be isolated from the venom of the spider Filistata hibernalis, DNA encoding...
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5695957 |
Polypeptides and DNA encoding same, associated with human malaria parasites
The invention provides proteins from the merozoite stage of the malaria parasite forming a conserved sequence in a broader sequence, fragments and derivatives thereof, DNA coding for the proteins...
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5693488 |
Transmembrane tyrosine phosphatase, nucleic acids encoding the same, and methods of use thereof
The present invention relates to regulation and control of cellular processes by transmembrane protein tyrosine phosphatases, and to ligands that agonize or antagonize tyrosine phosphorylation...
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5688764 |
Insecticidal peptides from spider venom
This invention relates to the purification of a family of insecticidally effective peptides isolated from the spider, Calisoga sp., characterized by their neurotoxic effect on insect pest and low...
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5688691 |
Insect retinoid-like receptor compositions and methods
The present invention relates to the discovery of novel insect receptor polypeptides, which, when complexed with certain ligands, or otherwise activated by certain compounds, modulate transcription...
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5686305 |
Establishment of new cell lines from Pseudaletia unipuncta with differential responses to baculovirus
This disclosure presents the establishment of a new cell line from Pseudaletia unipuncta embryos. This cell line demonstrated the ability to produce high numbers of baculoviruses in cell culture....
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5674747 |
Viral vector coding for juvenile hormone esterase
A diagnostic or control composition is useful to characterize or control insects and comprises a nucleotide sequence coding for juvenile hormone esterase (JHE). The coding sequence may be combined...
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5674485 |
Insect diagnostic and control compositions with truncated JHE
A recombinant expression vector is provided that is capable of expression in a host insect and includes a coding sequence for juvenile hormone esterase that, when expressed, lacks the signal...
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5674739 |
Human gene FOHY030 coding for tumor progression inhibitor
The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumor progression in cells involved in human tumors such as melanomas, breast,...
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5674708 |
α-1-antichymotrypsin analogues having elastase inhibitory activity
The present invention provides an analogue of human α-1-antichymotrypsin wherein the amino acid at position 358 is selected from the group consisting of isoleucine, valine, alanine, aspattic acid,...
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5670360 |
Mammalian receptors for glucagon-like-peptide-1 (GLP-1), corresponding DNA and recombinant expression systems, and screening assays for GLP-1 agonists and enhancers
The present invention relates to a recombinant glucagon like peptide-1 (GLP-1), to a DNA construct which comprises a DNA sequence encoding a GLP-1 receptor, to methods of screening for agonists of...
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5670342 |
NDF peptides
Novel peptides are described which are biologically active derivatives of the EGF-like domain of NDF/heregulins and which stimulate the proliferation and differentiation of colon epithelial cells...
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5670362 |
DNA encoding an Eimeria 100kD antigen
The invention is concerned with novel Eimeria proteins with immunogenic properties as well as with DNA sequences encoding these proteins. These proteins can be administered to chickens thereby...
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5665588 |
DNA encoding natural killer lytic associated protein
A unique gene sequence encoding a natural killer lytic associated molecule (natural killerlytic associated protein) has been isolated. Using recombinant DNA techniques, the natural killerlyric...
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5665592 |
Feline immunodeficiency virus isolate NCSU.sub.1
Disclosed is an isolated and purified feline immunodeficiency virus (FIV) culture having the identifying characteristics of FIV isolate NCSU 1 . A biologically pure culture of host cells containing...
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5663070 |
Recombinant production of a soluble splice variant of the Fas (Apo-1) antigen, fas TM
The invention provides soluble forms of the Fas (Apo-1 ) protein comprising both the intracellular and extracellular domains of the full-length polypeptide. Exemplified is a naturally-occurring...
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5663059 |
Human phospholipase inhibitor
The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase...
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5658758 |
Polynucleotides encoding cytostatin I
A human cytostatin I polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing...
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5658759 |
Recombinant DNA expression vectors
The invention provides expression vectors containing the promoter, enhancer and substantially complete 5'-untranslated region including the first intron of the major immediate early gene of human...
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RE35585 |
DNA vector with isolated cDNA gene encoding metallopanstimulin
A novel DNA sequence is disclosed which encodes a protein associated with many human cancers. This protein is designated as metallopanstimulin-1 (MPS-1) since (1) it is associated with metal ions,...
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5656457 |
DNA sequence for the unique sequence herpes simplex virus type 2-glycoprotein G protein and method of expressing said unique sequence of HSV-2gG
Disclosed are recombinant, synthetically and otherwise biologically produced novel proteins and polypeptides which are encoded by the DNA sequence for HSV-2 glycoprotein G (gG) or fragments of said...
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5656422 |
Compositions and methods for detection of 2,4-dichlorophenoxyacetic acid and related compounds
Methods and compositions are provided for the detection of 2,4-dichlorophenoxyacetic acid (2,4-D) and other phenoxy ether compounds. The phenoxy ether bond of 2,4-D is enzymatically cleaved by...
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5654176 |
Fusion proteins containing glutathione-s-transferase
A recombinant DNA molecule comprising a nucleotide sequence which codes for expression of a fusion protein in which a foreign protein or peptide is fused with the enzyme glutathione-S-transferase,...
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5652118 |
Nucleic acid encoding a novel morphogenic protein, OP-3
Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for...
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5650501 |
Serine/threonine kinase and nucleic acids encoding same
A serine/threonine kinase protein which is associated with mitotic and meiotic cell division and which is characterized by having a kinase domain in its N-terminus and three PEST regions in the...
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5646040 |
Mammalian tub gene
The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the...
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5646011 |
Cisplatin resistance gene and uses therefor
Isolated nucleic acids which can confer on a cell at least a 5-fold increase in cisplatin resistance relative to a cisplatin sensitive cell are disclosed. The nucleic acids of the invention can...
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5643750 |
Human neuronal beta subunits of voltage-operated calcium channels and the use thereof
The present invention relates to human neuronal beta subunits of voltage-operated calcium channels and the use thereof in screening methods for finding pharmaceuticals which modulate the activity...
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5643752 |
Tissue inhibitor of metalloproteinases
The present invention provides a nucleic acid sequence which encodes a novel tissue inhibitor of metalloproteinases (TIMP-4) which was isolated from cells of human uterus. The invention provides...
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