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5925547 |
Nucleic acid encoding novel protein domain which binds tyrosine phosphorylated proteins
The present invention generally relates to novel protein domains which bind to tyrosine-phosphorylated proteins. More particularly, the present invention provides non-SH2 protein domains that bind...
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5925750 |
Nucleic acid encoding polypeptide of a growth factor receptor family
Polypeptide of a growth factor receptor family, having a specific sequence and presenting all or part of the following properties: it encourages and/or is involved in the proliferation and/or...
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5916773 |
Recombinant production of fusion proteins comprising erythropoietin and GM-CSF components
It is described a hybrid molecule of formula GM-CSF-L-EPO or EPO-L-GM-CSF useful for the stimulation of hematopoiesis, comprising GM-CSF and EPO molecules fused together by means of a linker L...
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5914261 |
Family of MAP2 protein kinases
The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and...
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5911982 |
Hz-1 virus persistence-associated-gene 1 (PAG1) promoter uses therefor, and compositions containing same or products therefrom
Disclosed and claimed is the promoter, full-length or truncated, of the persistence-associated gene 1 (pag1) of Hz-1 virus, vectors containing the promoter, including with exogenous coding DNA,...
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5891676 |
Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system
A method to express rotavirus genes in a baculovirus system. Different clones are used to express rotavirus genes for all of the viral proteins. These proteins are isolated in their native...
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5885835 |
Kit for in vitro cell growth of eucaryotes using low molecular weight peptides containing L-glutamine
A method and kit are provided for growing eucaryotic cells using a hydrolyzate of a protein material containing peptides and free amino acids. The hydrolyzed protein material contains L-glutamine,...
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5877019 |
Animal 2-5A-dependent RNases and encoding sequences therefor
2-5A-dependent RNase, an endoribonuclease that requires 5'-phosphorylated 2',5'-linked oligoadenylates (2-5A), functions in the molecular mechanism of interferon action. Recombinant, 2-5A-dependent...
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5876962 |
Expression vectors for the synthesis of proteins and plasmid replicons and sequence cassettes for use in constructing such vectors
Expression vectors for the expression of proteins, particularly eukaryotic proteins are provided which are based on novel plasmid replicons. Sequence cassettes useful in constructing such vectors...
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5877017 |
Isolated nucleic acid molecule encoding peptides which form complexes with MHC molecule HLA-Cw*1601 and uses thereof
A family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor rejection...
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5874253 |
DNA encoding megakaryocyte differentiation factor
A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA,...
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5874300 |
Campylobacter jejuni antigens and methods for their production and use
The present invention provides an isolated nucleic acid encoding an approximately 26 kilodalton antigen, PEB1A, of Campylobacter jejuni, or an antigenic fragment thereof, wherein the antigen is...
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5869335 |
Method of growing rickettsiae in Ixodes scapularis tick cell culture and preparing antigens and vaccines of rickettsiae
The invention is directed to methods of culturing rickettsiae in Ixodes scapularis cell lines. The methods of the invention provide for culture of microorganisms such as Anaplasma marginale,...
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5861279 |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
A baculovirus/insect cell expression system in which both α and β subunit of human IL-5 receptor can be over-expressed together in Sf9 cells has been developed. This system is able to express the...
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5858778 |
SF caspase-1 and compositions for making and methods of using the same
A substantially pure protein, Caspase-1, is disclosed. An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes Caspase-1, is disclosed. An isolated nucleic acid...
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5858713 |
Calcium permeable insect sodium channels and use thereof
The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of an insect having a mutation therein which renders the sodium channel...
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5858353 |
Insect viruses, sequences, insecticidal compositions and methods
Insect viruses capable of killing at least one target insect pest quicker than previously described viruses and DNA sequence conferring that phenotype of faster killing are provided. Further...
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5856139 |
Proline-rich acidic protein
The present invention provides a human proline-rich acidic protein (PRAP) and polynucleotides which identify and encode PRAP. In addition, the invention provides expression vectors and host cells,...
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5854002 |
Method of identifying compounds that bind to the insect gaba receptor
The present invention provides a method of measuring the ability of a compound to bind to the GABA recognition site of an insect GABA receptor. The invention further provides host cells that...
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5851797 |
Tie ligand-3, methods of making and uses thereof
The present invention provides for an isolated nucleic acid molecule encoding TIE ligand-3. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3. The...
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5849523 |
Aedes aegypti densovirus expression system
The present invention is directed to use of Aedes aegypti densonucleosis virus (Aedes DNV or AeDNV) as a heterologous gene expression system. The invention described herein provides promoters from...
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5849897 |
Nucleic acid molecule encoding ciliary neurotrophic factor receptor
The present invention relates to the ciliary neurotrophic factor (CNTF) receptor, and provides for CNTF receptor nucleic acid and amino acid sequences. It also relates to (i) assay systems for...
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5846768 |
Invertebrate apoptosis gene `GRIM` and methods of producing the protein encoded thereby
Disclosed is a Drosophila grim gene and encoded GRIM polypeptide, an activator of apoptosis. The disclosed nucleic acid sequences are useful in the production of the protein and as hybridization...
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5843775 |
Human dorsal tissue affecting factor (noggin) and nucleic acids encoding same
Novel dorsal growth inducing factors, complexes including the factors, and DNA or RNA coding sequences for the factors are described.
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5843736 |
Prevention of viral infection by the induction of apoptosis and/or the use of an antiviral gene, hem1
Disclosed is a new, effective and general methodology to prevent viral infection, which methodology is divided into two parts: 1) induction of the apoptosis (programmed cell death) of a host upon...
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5843716 |
Polynucleotide encoding a proline-rich membrane protein
The present invention provides a human proline-rich membrane protein (PRMP) and polynucleotides which identify and encode PRMP. The invention also provides genetically engineered expression vectors...
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5843727 |
Polynucleotides encoding a human tumor-associated membrane protein
The present invention provides a human tumor-associated membrane protein (TAMPH) and polynucleotides which identify and encode TAMPH. The invention also provides expression vectors, host cells,...
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5843712 |
Sindbis virus expression system for recombinant antibody production
This invention provides a method of expressing a multimeric polypeptide. This invention also provides a method of expressing biologically active recombinant antibodies. This invention also provides...
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5840870 |
Polynucleotides PANC1A and PANC1B associated with pancreatic cancer
The present invention provides polynucleotide sequences designated PANC1A and PANC1B which are associated with a genomic sequence related to pancreatic cancer as well as other cancers. The present...
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5840578 |
Methods for determining susceptibility to lead poisoning
A DNA sequence encoding the δ-amino levulinate type 2 gene, methods to detect the gene, diagnostic kits to detect the gene and recombinant vectors containing the type 2 gene sequence.
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5840304 |
T-cell receptor βsubunit polypeptides
Oligonucleotide sequences are provided coding for T-cell-specific antigen receptors or fragments thereof. The oligonucleotide sequences can be used as probes for detecting helper and cytotoxic...
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5837493 |
Human galectins
The present invention provides two novel human galectins (designated individually as GAL-5HA and GAL-5HB, and collectively as GAL-5H) and polynucleotides which identify and encode GAL-5H. The...
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5834293 |
Cytochrome P450 arachidonic acid epoxygenase genetic mutation associated with hypertension
The invention provides an isolated nucleic acid encoding the rat P450 2C11 arachidonic acid epoxygenase, or a human homologue thereof, having a mutation associated with salt induced hypertension....
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5834298 |
Gene encoding the human homolog of MAD2
This invention provides isolated nucleic acid encoding human MAD2, isolated human MAD2 protein. This invention further provides a method of detecting the presence of MAD2 in a tissue sample, a...
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5827689 |
FabD polynucleotides
FabD polypeptides and DNA (RNA) encoding such FabD and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FabD for the...
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5827705 |
Molecule and method for importing DNA into a nucleus
The invention provides a nuclear targeting molecule having a nucleic acid sequence which consists of SEQ ID NO:1 or a nuclear targeting portion of SEQ ID NO:1. The invention further provides a...
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5824878 |
Microorganism and insecticide
Bacillus thuringiensis serovar japonensis strain Buibui (FERM BP-3465) belonging to Bacillus thuringiensis serovar japonensis and capable of producing insecticidal toxin proteins to kill...
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5821089 |
Amino acid modified polypeptides
Incorporation of certain amino acid analogs into polypeptides produced by cells which do not ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the...
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5817782 |
Lag 1:gene for increasing the longevity of eukaryotes
The present invention provides a unique eukaryotic gene, called LAG1, which controls the longevity of eukaryotic cells. According to the present invention, overexpression of LAG1 in older cells has...
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5817501 |
DNA encoding suppressin protein and uses thereof
A unique gene sequence encoding a suppressin protein has been isolated. Using recombinant DNA techniques, the suppressin protein may be produced in useful quantities. Methods for preparing the gene...
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5814479 |
Bsk receptor-like tyrosine kinase
The present invention provides a nucleic acid sequence encoding a receptor-like tyrosine kinase designated, Bsk. The Bsk receptor-like tyrosine kinase is expressed predominantly in the brain,...
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5814486 |
Herpes simplex virus glycoprotein D variants
The present invention provides variant HSV-1 glycoprotein D and HSV-2 glycoprotein D molecules capable of preventing infection of cells by herpes simplex virus types 1 and/or 2. Also provided are...
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5814464 |
Nucleic acids encoding TIE-2 ligand-2
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2...
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5807712 |
DNA encoding lymphocyte chemoattractant factor (LCF) and uses thereof
Purified DNA encoding lyphocyte chemoattractant factor (LCF) and the recombinant proteins expressed from such DNA are disclosed. In addition, the invention provides methods for suppressing an...
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5798257 |
Nucleic acid encoding human MTS-1 protein
The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the...
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5795765 |
Gene encoding endoglycoceramidase
An isolated DNA having a sequence encoding a polypeptide possessing endoglycoceramidase activity or functionally equivalent variants thereof, and a method for producing a polypeptide possessing...
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5792644 |
DNA encoding an Eimeria 200 kd antigen
The invention is concerned with novel Eimeria proteins with immunogenic properties as well as with DNA sequences encoding these proteins. These proteins can be administered to chickens thereby...
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5789233 |
DNA encoding an Eimekia 50 KD antigen
The invention is concerned with novel Eimeria proteins with immunogenic properties as well as with DNA sequences encoding these proteins. These proteins can be administered to chickens thereby...
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5780289 |
Coccidiosis poultry vaccine DNA encoding an elmeria 20K antigen
The invention is concerned with novel Eimeria proteins with immunogenic properties as well as with DNA sequences encoding these proteins. These proteins can be administered to chickens thereby...
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5780286 |
Arginase II
The invention relates to Arginase II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists...
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