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6143565 |
Stable insect virus-cell expression system
A stable transformed insect cell line has been achieved by infecting an insect cell culture with fluid obtained from a female parasitoid wasp, such as Glyptapanteles indiensis. The fluid contains...
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6140093 |
Polynucleotides encoding paraoxonase
Human paraoxonase enzyme and DNA (RNA) encoding such paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such...
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6140468 |
Recombinant human prostate specific antigen
The present invention relates to the production and purification of human prostate specific antigen (hPSA) by recombinant-DNA-technology. hPSA was produced in an active form by the baculovirus...
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6140076 |
Ig superfamily `dlair` receptors expressed in monocytes
DNA clones encoding a receptor in the Ig superfamily and a related soluble variant have been isolated from a human monocyte library. The invention provides receptor polypeptides, nucleic acids...
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6135942 |
Nucleic acids proteins of a D. melanogaster insulin-like gene and uses thereof
The present invention relates to a D. melanogaster insulin-like gene and methods for identifying insulin-like genes. The methods provide nucleotide sequences of a D. melanogaster insulin-like gene,...
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6132987 |
Recombinant mammalian monocyte chemotactic protein-1 (MCP-1) receptors (MCP-1R, CCR-2)
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6132983 |
Luciferases
Proteins are provided having luciferase activity with greater heat stability than wildtype luciferases by replacing the glutamate equivalent to that at position 354 of Photinus pyralis luciferase...
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6130074 |
Recombinant insect virus with reduced capacity for host-to-host transmission in the environment and methods to produce said virus
A noninfectious insect virus is described having an altered genetic element whose function is restored by genetic complementation, thereby again producing the insect infectious form of the virus....
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6118050 |
Hydroxyphenylpyruvate dioxygenase gene from arabidopsis and method of screening for inhibitors thereof
The present invention provides purified isolated nucleic acids encoding arabidopsis 4-hydroxyphenylpyruvate dioxygenase (HPPD), plasmids encoding HPPD, and transformed cells capable of expressing...
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6106867 |
Gelatinized propolis food products
A propolis food product that contains propolis active ingredients with improved bio-absorbability and is readily ingested. The propolis food products containing propolis extracts are gelled by...
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6107069 |
Recombinant kynurenine-3-hydroxylase enzyme and process for its preparation
The present invention provides an isolated polynucleotide encoding for the kynurenine-3-hydrolase (Kyn-3-OHase) and methods of transiently expressing thereof.
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6107057 |
Pichia secretory leader for protein expression
Polynucleotides, vectors, and host cells comprising a polynucleotide having a fragment of a leader sequence and a second nucleotide sequence that encodes a polypeptide heterologous to the leader...
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6103526 |
Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using
Disclosed and claimed is a new insect cell line, Sf900+, ATCC CRL-12579. The insect cell line was established from Lepidoptera, Noctuidae, Spodoptera frugiperda Sf-9 (ATCC CRL-1771) through...
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6100077 |
Isolation of a gene encoding diacylglycerol acyltransferase
This invention provides an isolated nucleic acid which encodes a diacylglycerol acyltransferase (DGAT); a vector comprising the isolated nucleic acid which encodes a diacylglycerol acyltransferase...
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6099847 |
Chimeric Gag pseudovirions
The present invention provides, inter alia, recombinant chimeric nucleic acids encoding a Gag-fs-fusion partner fusion protein; a pseudovirion comprising a retroviral Gag protein and a fusion...
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6093396 |
Modified glutamic acid decarboxylase (GAD)
A modified GAD especially characterized by a substantially preserved immunogenicity in connection with diabetes compared with a non-modified GAD and a reduced or non-existent effectivity in...
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6090584 |
Baculovirus artificial chromosomes and methods of use
An baculovirus artificial chromosome is disclosed which has the lef-8 gene inactivated. The baculovirus artificial chromosome allows the cloning and expression of heterologous genes in insect and...
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6087169 |
HKABY60: polynucleotide encoding a helix-loop-helix ubiquitous kinase family polypeptide
HKABY60 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HKABY60 polypeptides and...
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6077662 |
Virus-like particles, methods and immunogenic compositions
The present disclosure provides retrovirus-like particles which comprise retrovirus env proteins, immunogenic compositions comprising retrovirus-like particles, methods for the production of...
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6074864 |
Cloned DNA for synthesizing unique glucocerebrosidase
Glucocerebrosidase produced by recombinant methods and having use for treatment of Gaucher's disease is disclosed. A cDNA for encoding the specific protein is taught along with the method of...
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6063582 |
Methods of screening for compounds that interact with human P.sub.2u2 purinergic receptor
A novel subtype of the P 2 -purinergic receptor, referred to as the P 2U2 receptor, is disclosed. This receptor is activated by four of its agonists in the following order of specificity:...
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6046025 |
Expression of heterologous proteins in drosophila cells
The present invention provides a novel method for expression of high levels of heterologous proteins in Drosophila cells.
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6037150 |
Insect sequences for improving the efficiency of secretion of non-secreted proteins in eukaryotic cells
An expression cassette useful for the secretion of a heterologous protein from eukaryotic cells comprising a DNA sequence encoding a promoter functionally linked to a DNA sequence coding for the...
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6033903 |
Method of expressing and secreting soluble extracellular domains of human gonadotropin hormone receptors
The extracellular domain, or fragment thereof, of a gonadotropin glycoprotein hormone receptor is expressed and secreted in a soluble and functionally hormone-binding form. A recombinant...
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6034230 |
Nucleic acids encoding myocardial peptides
Disclosed are novel peptides that modulate inflammatory heart disease. Also disclosed are DNA molecules encoding the peptides, and methods of making the peptides.
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6033870 |
Human transmembrane protein
The invention provides a novel human integral membrane protein (TMP-2) and polynucleotides which encode TMP-2. The invention also provides expression vectors, host cells, agonists, antisense...
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6027937 |
Method for propagation of insecta germ cells
A method is disclosed for the in vitro growth and proliferation of germ cells obtained from the ovarioles of an insect. By culturing these cells in a medium supplemented with soluble cytokines and...
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6025480 |
Isolated nucleic acid molecules encoding P57KIP2
This invention provides an isolated nucleic acid molecule encoding a mammalian p57 KIP2 . This invention also provides vectors comprising the isolated nucleic acid molecule encoding a mammalian p57...
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6022705 |
Insect sodium channels gene from insecticide-susceptible and insecticide-resistant house flies
The present invention is directed to isolated nucleic acid molecules encoding a voltage-sensitive sodium channel (VSSC) of Musca domestica, the VSSC being capable of conferring insecticide...
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6017734 |
Unique nucleotide and amino acid sequence and uses thereof
Provided are hydrophobic targeting sequences, which may serve to target heterologous proteins to a variety of cellular membranes. In particular, the structural components of the nuclear envelope,...
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6017535 |
cDNA sequence of Dengue virus serotype 1 (Singapore strain)
DENI-S275/90 (ECACC V92042111) is a new strain of Dengue virus serotype 1. The complete cDNA sequence of this virus has been cloned and protein-coding fragments thereof have been used in the...
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6013515 |
Cofactors for HIV-1 protein Tat and methods of use therefor
Methods of isolating and characterizing Tat-interacting proteins (TIPs) are disclosed. These Tat-interacting proteins comprise a material selected from the group consisting of a protein, active...
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6008046 |
Drug and pesticide screening
The present invention relates to methods and reagents for drug and pesticide screening. Screening methods are disclosed employing normal and mutant receptors, allowing for the testing of large...
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6008045 |
Nucleic acid encoding human DNA polymerase α
The human DNA polymerase α catalytic polypeptide has been functionally over-expressed by a recombinant baculovirus in insect cells at >1000 fold higher levels than that found in cultured normal...
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6001592 |
Polypeptide gene cDNA, vector containing said cDNA, host cells transformed with said vector, method of producing said polypeptide, DNA encoding said polypeptide
cDNAs were synthesized from the mRNA isolated from the mantle epithelial tissue of pearl oyster (Pinctada fucata) using reverse transcriptase and joined to a vector to give a cDNA library. A cDNA...
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6001365 |
In vitro activation of cytotoxic T cells
The present invention relates to a rational, elegant means of producing, loading and using Class I molecules to specifically activate CD8 cells in vitro, and their therapeutic applications in the...
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5998184 |
Basket-type bioreactor
Improved hollow fiber bioreactor systems and cell culture methods are described. The improvement includes means which may be a novel basket bioreactor for extending the extracapillary space of a...
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5985600 |
Nucleic acid encoding delta opioid receptor
Nucleic acid molecules comprising a nucleotide sequence encoding a mammalian delta opioid receptor are disclosed. The invention provides recombinant materials for the production of mammalian delta...
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5965393 |
Method for enhancing foreign gene expression in baculovirus expression vector system
The baculovirus homologous region (hr1) sequence has been disclosed as a transcriptional enhancer of foreign gene expression. An additional copy of the hr1 element contained within a recombinant...
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5962232 |
Protein kinase molecules
The invention provides human protein kinase molecules (HPKM) and polynucleotides which identify and encode HPKM. The invention also provides expression vectors, host cells, antibodies, agonists,...
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5955314 |
Regulator of cell signaling
The present invention provides a human regulator of G-protein signaling (HRGS) and polynucleotides which identify and encode HRGS. The invention also provides genetically engineered expression...
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5955301 |
Human glutamate-binding protein
The present invention provides a human glutamate-binding protein (HGLUBP) and polynucleotides which identify and encode HGLUBP. The invention also provides genetically engineered expression vectors...
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5955359 |
Method of growing granulocytic ehrlichiae of the Ehrlichia phagocytophila genogroup in promyelocytic leukemia cell culture, and preparing antigens and vaccines of said granulocytic ehrlichiae
Methods for the in vitro cultivation, propagation, and production of antigens of Ehrlichia phagocytophila genogroup granulocytic Ehrlichia species, including Ehrlichia equi and the agent of human...
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5952002 |
Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor
Novel proteins of the Chicken Anemia Virus are described and compositions for preventing or treating infections with that virus (CAV), in particular vaccines less pathogenic than the CAV itself,...
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5945287 |
Nucleic acids encoding two human heat shock protein homologs, and methods of detection thereof
The invention provides two human heat shock protein homologs (HSPHH-1, HSPHH-2) and polynucleotides which identify and encode HSPHH-1 and HSPHH-2. The invention also provides expression vectors,...
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5945271 |
Artificial media for rearing entomophages comprising sticky, cooked whole egg
An improved artificial diet or growth medium for rearing entomophages (predatory arthropods and parasitic insects). The diet also finds use as a bait and feeding stimulant for entomophages, and as...
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5935810 |
Mammalian ob polypeptides capable of modulating body weight, corresponding nucleic acids, and diagnostic and therapeutic uses thereof
The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to...
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5935818 |
Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof
This invention provides an isolated mammalian nucleic acid molecule encoding an alternatively spliced prostate-specific membrane (PSM') antigen. This invention provides an isolated nucleic acid...
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5928926 |
Isolation and cloning of the human ARSA-I gene and uses thereof
The present invention provides DNA encoding a human ARSA-I protein selected from the group consisting of: (a) isolated DNA which encodes a human ARSA-I protein; (b) isolated DNA which hybridizes to...
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5928939 |
Vascular endothelial growth factor-b and dna coding therefor
VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides,...
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