Patents in Class 435/343.200

Matches 1 - 50 out of 80

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Match	Document	Document Title
1	7524498	Human immunomodulatory monoclonal antibodies for the treatment of cancer The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation...
2	7332582	Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation...
3	7309489	Mouse CD40 ligand-specific antibodies and hybridomas There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human...
4	7259247	Anti-human T-cell costimulating polypeptide monoclonal antibodies A polypeptide (8F4 molecule) with a T-cell costimulating biological activity is disclosed, as well as monoclonal antibodies against said 8F4 molecule and hybridoma cells which produce the...
5	7220411	*WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST* Compositions comprising anti-CCR5 antibody This invention provides a composition for inhibiting HIV-1 infection comprising at least two compounds in synergistically effective amounts for inhibiting HIV-1 infection, wherein at least one of...
6	7138119	Compositions and methods for inhibition of HIV-1 infection This invention provides a composition which comprises an admixture of three compounds, wherein: (a) one compound is an antibody which binds to a CCR5 receptor; (b) one compound retards attachment...
7	7087396	Monoclonal antibody and method and kit for immunoassay of soluble human ST2 A method for determining a soluble human ST2 in a sample conveniently at a high sensitivity and an assay kit are provided. By an immunological method comprising a step for bringing a sample into...
8	6987171	Human CD28 specific monoclonal antibodies for antigen-non-specific activation of T-lymphocytes The invention teaches human-compatible monoclonal antibodies which are specific against human CD28 and human T-lymphocytes of several to all sub-groups to activate without occupancy of an antigen...
9	6893813	Methods for treatment of HIV and other infections using a T cell or viral activator and anti-retroviral combination therapy Disclosed is a method for treating infection with a pathogen. The method involves administration of: (1) a substance which induces active pathogen replication in a cell latently infected with HIV...
10	6875609	Methods for the early diagnosis of ovarian cancer The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically,...
11	6849258	LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response...
12	6803039	Human monoclonal antibody against a costimulatory signal transduction molecule AILIM Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal...
13	6790662	Method of isolating CD8&plus cells, and related hybridoma cells antibodies and polypeptides This invention provides a method of isolating CD8 + cells which employs an antibody which specifically binds to CD8 molecules present on the surface of CD8 + cells but does not activate the CD8 +...
14	6737059	Methods of inhibiting inflammatory processes and alleviating symptoms associated with multiple sclerosis Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory disease processes associated with the...
15	6602503	Recombinant anti-VLA-4 antibody molecules The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific...
16	6541611	LO-CD2b antibody A monoclonal antibody which binds to baboon and human CD2, and in particular LO-CD2b antibody. The antibody may be employed to prevent and inhibit an immune response in human patients, such as when...
17	6515111	Monoclonal antibody which inhibits transendothelial migration of human mononuclear leukocytes The present invention relates to a monoclonal antibody against human mononuclear leukocytes which is capable of inhibiting transmigration of human mononuclear leukocytes after their adhesion to...
18	6511665	Antibodies to interleukin-1 receptors The present invention provides monoclonal antibodies and binding proteins which specifically bind to the IL-1 receptor. Also provided are methods for detecting IL-1 receptors on cells, and for...
19	6485970	Immunointeractive antibody The present invention relates generally to immunointeractive molecules and their use inter alia in the detection and/or purification of T-cell antigen binding molecules (TABMs). The ability to...
20	6403091	Methods for inhibiting the rejection of a transplant organ in a subject with 5C8-specific antibodies This invention provides for a method for inhibiting rejection of a transplant organ in a subject which comprises administering to the subject an antibody capable of binding to a protein which is...
21	6365404	Hematopoietic cell method for treatment of HIV infection The risk of drug resistance in HIV infection is reduced by profoundly suppressing the viral load using novel hematopoietic cells. Modified CD4 lymphocyte host cells are used to “capture” virons...
22	6365343	Intercellular adhesion molecule powder formulation The present application discloses a finely divided, dry powdered pharmaceutical composition which is specially adapted to be administered as an insufflate which includes the following ingredients: ...
23	6331615	Nucleic acid molecule encoding heavy or light chain of an antibody which specifically recognizes a protein specifically recognized by monoclonal antibody 5c8 (anti-CD40 ligand) The present invention provides for an isolated nucleic acid molecule encoding a light chain protein of an antibody, wherein the antibody binds specifically to a protein specifically recognized by...
24	6312692	Method of treating graft-versus-host disease with anti-GP39 antibodies and bone marrow cells A method of treating graft-vs-host diseases by administration of bone marrow and an anti-gp39 antibody specific to human gp39 is provided.
25	6287569	Vaccines with enhanced intracellular processing Method for generating in a patient a cellular immune response to a target protein or portion thereof comprising the step of introducing into cells of the patient a vector containing a nucleotide...
26	6280957	Costimulatory blockade and mixed chimerism in allo-transplantation Use of the blockade of costimulation and hematopoietic stem cells in allograft transplantation.
27	6274347	Method of producing a cell surface bound lam-1 specific antibody A shed form of leukocyte adhesion molecule-1 (LAM-1, L-selectin) is present in high levels in human plasma. Quantitative methods of detecting shed LAM-1 (sLAM-1) by Western blot and ELISA analysis...
28	6268214	Vectors encoding a modified low affinity nerve growth factor receptor In the course of therapy following an allogeneic bone marrow transplant (allo-BMT) in which lymphocytes were removed from the transplant, donor lymphocytes are introduced after a delay to...
29	6242579	Antigen found on a small subset of human hematopoietic cells which binds to monoclonal antibody MG1 The subject invention pertains to an antigen that is expressed on a subset of human, hematopoietic mononuclear cells, including a hematopoietic stem cell population, but is not expressed on normal,...
30	6242176	Papillomavirus cellular receptor The present invention provides methods and reagents for treating or preventing papillomavirus infection. In one aspect, the invention provides reagents and methods for attenuating the ability of...
31	6235525	Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid...
32	6232088	Treatment and prevention of immune rejection reactions Provided, among other things, is a method of preventing or ameliorating transplantation rejection reactions comprising treating the donor tissue with a rejection reaction preventing or ameliorating...
33	6210671	Humanized antibodies reactive with L-selectin Humanized immunoglobulins specifically reactive with L-selectin are prepared employing recombinant DNA technology for use in e.g., treatment of inflammatory disorders.
34	6207156	Specific antibodies and antibody fragments The present invention relates to methods and products for immunotherapy resulting in the stimulation of T-cell proliferation. The products of the invention are peptides that bind to CTLA-4 and...
35	6190863	Sugar chain-recognizing antibodies and remedies for HIV infectious diseases The present invention is directed to a sugar-chain-recognizing antibody which belongs to the IgM isotype and which recognizes Gg4Cer(Galβ1-3GalNAcβ1-4Galβ1-4GlcβCer) or GM2 which appears on HIV...
36	6166186	Monoclonal antibody which binds to a human-Th2-specific protein and hybridoma The present specification provides a means for specifying the condition and type of immune-related diseases on the basis of knowledge about the polarization of the distribution of helper T-cell...
37	6156307	Immortalization of dendritic cells with v-myc oncogene The present invention refers to immortalized dendritic cells, to a process for their production from primary cultures and to their use for the activation, in vivo or in vitro, of T lymphocytes in...
38	6113898	Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies The present invention relates to the identification of macaque antibodies to human B7.1 and B7.2 by screening of phage display libraries or monkey heterohybridomas obtained using B lymphocytes from...
39	5976877	Proteins produced by human lymphocytes DNA sequence encoding these proteins and their pharmaceutical and biological uses Disclosed herein are monoclonal antibodies which specifically bind a protein comprising the peptide sequence represented by the sequence SEQ ID No. 1 or an immunogenic sequence of such a protein...
40	5976522	Lymphocyte chemoattractant factor and uses thereof Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.
41	5961974	Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human...
42	5951983	Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response...
43	5883223	CD9 antigen peptides and antibodies thereto Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
44	5876716	Method of using an antibody to the TN antigen for the inhibition of HIV infection A monoclonal or other antibody to the carbohydrate antigen Tn can be used to inhibit or slow the progression of AIDS or ARC. The antigen can be used in a vaccine, for immunisation.
45	5876950	Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy The present invention provides monoclonal antibodies, antigen binding fragment and recombinant binding proteins specific for human gp39. These antibodies are specific for at least eight different...
46	5876717	Polypeptides capable of binding to heavy chains of IL-2 receptors The present invention relates to (1) polypeptide capable of binding to β chain of IL-2 receptor and having the inhibitory activity of the binding between IL-2 and β chain of IL-2 receptor, and...
47	5853721	Antibody to interleukin-12 receptor The present invention relates to a novel antibody against the IL-12 receptor and a novel combination of anibodies anainst the IL-12 receptor. The novel anti-IL-12 receptor anbody, designated as...
48	5854070	Murine and humanizer 23F2G antibodies and cell lines expressing said antibodies Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory processes associated with the multiple...
49	5843430	Methods of treating disease using sertoli cells and allografts or xenografts The present invention describes a method of treating a disease that results from a deficiency of a biological factor which comprises administering to a mammal Sertoli cells and cells that produce...
50	5831068	Method to increase the density of antigen on antigen presenting cells Disclosed is a method for presenting an antigen in the form of a peptide on the surface of a cell. The method involves inhibiting the activity of an MHC class I pathway-associated component (e.g.,...

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