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7566530 Method for detecting PrP using at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand  
The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least...
7541160 ELISA for VEGF  
The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions,...
7534580 PSP94 diagnostic reagents and assays  
In the serum, PSP94 occurs as a free form or is associated with a carrier protein. PSP94 in its bound form has been quantified in the blood of prostate cancer patients and these measurements have...
7408027 Tools for the diagnosis and treatment of Alzheimer's disease  
The invention relates to epitopes of the tau protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are...
7291333 Blockade of protein C activation reduces microvascular surgical blood loss  
A method of inhibiting microvascular bleeding is provided. Antibody to protein C administered to a patient in a pharmaceutically acceptable carrier prevents anticoagulation by greater than 90% of...
7273925 Methods and products for regulating lectin complement pathway associated complement activation  
The invention relates to methods and products for regulating lectin complement pathway associated complement activation. The methods include both in vitro and in vivo methods for inhibiting lectin...
7241578 Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit  
The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an...
7183108 Selection and uses of lactic acid bacteria strains modulating non-specific immunity  
The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said...
7022521 Methods and compositions for treating platelet-related disorders using MPL pathway inhibitory agents  
The invention relates to the treatment of subjects for the purpose inhibiting vaso-occlusive events, including thrombosis and embolism, by administering agents which reduce the number of...
6998468 Anti-C2/C2a inhibitors of complement activation  
The invention relates to C2a inhibitors, which bind to C2a and block the functional activity of C2a in complement activation. The inhibitors include antibody molecules, as well as homologues,...
6989241 Assay for rapid detection of human activated protein C and highly specific monoclonal antibody therefor  
A highly specific monoclonal antibody, produced by a hybridoma cell has been found. A new assay, highly specific for activated protein C (APC) has been developed which will permit rapid...
6969516 Immunological compositions and methods of use to transiently alter mammalian central nervous system myelin to promote neuronal regeneration  
A method is described comprising the combined administration of a novel composition comprising serum complement proteins with complement-fixing antibodies to induce transient disruption of myelin...
6964854 Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis  
The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis of...
6960472 Monoclonal antibodies against N-Terminus proBNP  
Monoclonal antibodies having high affinity for N-terminus pro brain natriuretic peptide (NT-proBNP) are described. The monoclonal antibodies are prepared against a synthetic peptide having the...
6956107 Inhibitors of complement activation  
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as...
6893831 Immunoassay of PIVKA-II  
The present invention provides an immunoassay for specifically measuring with high sensitivity PIVKA-II in serum or plasma through antigen-antibody reaction by adding an animal serum containing...
6838250 Immunoassay for C-reactive protein  
The present invention relates to new CRP immunoassay compositions. The compositions include a low affinity anti-human CRP monoclonal antibody, and an antiidiotypic antibody raised against it. The...
6830896 Process for analyzing annexin-V in urine, and application thereof  
The present invention provides a process and regent for analyzing annexin-V, wherein the measurement of a concentration of annexin-V can be easily carried out without need for addition of chemicals...
6793920 Antithrombotic agent and anti-von willebrand factor monoclonal antibody  
A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet...
6733980 Diagnostic method for detection of molecular forms of eosinophilic cationic protein (ISO-ECPS)  
Diagnostic methods comprise measuring specifically the level of at least one iso-eosinophilic cationic protein (iso-ECP) in a sample from an individual to be diagnosed, and comparing the measured...
6544786 Method and vector for producing and transferring trans-spliced peptides  
A method for trans-splicing peptides is provided. In the method, at least two extein peptides are provided, or are synthesized by recombinant methods, the extein peptides having co-reacting...
6534058 Anti-C5 monoclonal antibodies  
The invention relates to C5 inhibitors, which inhibit type II endothelial cell activation, wherein the inhibition is manifested by the suppression of E-selectin. These inhibitors are useful in...
6524862 Complex of lipoprotein with hemoglobin or hemoglobin analog  
A selective complex of a lipoprotein with hemoglobin or a hemoglobin analogue. A method of assaying hemoglobin or a hemoglobin analogue in a sample, comprising reacting the sample with a...
6485970 Immunointeractive antibody  
The present invention relates generally to immunointeractive molecules and their use inter alia in the detection and/or purification of T-cell antigen binding molecules (TABMs). The ability to...
6451599 Monoclonal antibodies reactive with fibrin (ogen) degradation products generated by matrix metalloproteinases  
The invention provides monoclonal antibodies which are reactive with fibrin(ogen) degradation products (FDPS) generated by matrix metalloproteinases (MMPs), such as MMP-3, MMP-7, and membrane-type...
6451545 Monoclonal antibody specific to anti-human fibrin monomer, process for producing the same, hybridomas, and immunoassay method  
Provided are a monoclonal antibody making it possible to detect a native fibrin monomer, which is produced at the initial state of blood coagulation, and soluble fibrin; a hybridoma; and an...
6391568 Method for determining platelet reactivity in a whole blood sample  
The present invention provides a method for the quantification and assessment of platelet activation in whole blood samples and monitoring of antiplatelet pharmacologic agents. The method for...
6365155 Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and use of the same  
Ancrod-specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof are used in pharmaceutical preparations and in diagnosis. Cells which express these antibodies, antibody...
6355245 C5-specific antibodies for the treatment of inflammatory diseases  
The use of anti-C5 antibodies, e.g., monoclonal antibodies, to treat glomerulonephritis (GN) is disclosed. The administration of such antibodies at low dosage levels has been found to significantly...
6248546 Assay of IGFBP complex  
A method of assaying the growth hormone status of an individual by immuno-assay for the 150 KDa Insulin-like Growth Factor ternary complex (IGF/IGFBP-3/ALS). Alternatively, a binary complex may be...
6228360 Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody  
Anti-thrombotic agents containing humanized antibodies which bind to von Willebrand factor.
6221659 Blood coagulation protein antagonists and uses therefor  
Coagulation protein antagonists are disclosed, which include monoclonal-type antibodies and related cell lines disclosed for the production of specific, neutralizing antibodies against factors VII...
6150114 Method and reagent for monitoring blood levels of antiplantelet compounds  
A method for determining the amount of an antiplatelet compound in a subject being treated with the compound which comprises calculating the ACT number of the subject's blood containing a reagent...
6043087 Monospecific antibody reactive with matrix metalloproteinase cleavage products of fibrin(ogen)  
The invention provides a monospecific antibody that is specifically reactive with enzymatically mediated degradation products of fibrin(ogen) (i.e., fibrin, fibrinogen, and related substances). The...
6025143 Antibodies directed against peptides derived from the SMR1 polypeptide  
The present invention relates to peptides and polypeptides derived from the submaxillary gland of the rat. In particular, the present invention discloses a purified peptide of formuls: ...
6010903 Anti-human ceruloplasmin monoclonal antibody  
Disclosed is a monoclonal antibody which specifically reacts with active human ceruloplasmin as well as a method for diagnosing Wilson's disease using the same. The monoclonal antibody of the...
5972632 Anticomplement activity assays  
Immunoassays for complement components, complement activation products or, preferably both, can be used to determine an acceptable level of anticomplement activity (AC) in plasma derived...
5972628 Pyruvatekinase-iosenzyme typ-M2 (Tumor-M2-PK)-specific antibody/process for the preparation and use thereof  
A qualitative, quantitative, as well as local determination of pyruvatkinase (ATP:pyruvate-2-O-phosphotransferase, EC 2.7.1.40)-isoenzyme typ M2 (Tumor-M2-PK) is possible in blood, plasma, tissue...
5955582 Antibody against a 3-aminophenylboronic-glycated protein complex and its use in an immunoassay  
Methods of preparing a boronate-antigen complex for immunization of animals, a monoclonal antibody specific for the same, an immunoassay method for detection of the complex and a method of...
5888753 Monoclonal antibodies against the plasmin-antiplasmin complex, a method for the preparation thereof and the use thereof  
The invention relates to monoclonal antibodies (MAbs) and fragments thereof which have a specific affinity for the plasmin-antiplasmin complex and which display no affinity or only a very low...
5877006 DNAs encoding chimeric immunoglobulin light or heavy chains and fragments thereof having variable regions derived from monoclonal antibody 7E3, and vectors and host cells comprising same  
Platelet-specific, chimeric immunoglobulin and immunoglobulin fragments are described. The chimeric molecules are made up of a nonhuman antigen binding region and a human constant region. Preferred...
5876947 Monospecific antibody reactive with Fibrinogen and fibrinopeptide B  
The invention provides monospecific antibodies that are specifically reactive with fibrinopeptide B (FPB) and with fibrinogen and fragments thereof containing the amino acid sequence defined by SEQ...
5866689 Monoclonal antibodies to GP130 protein  
Monoclonal antibodies recognizing gp130 protein and binding to the protein to inhibit IL-6 functions completely (that is to the same level as that is the absence of IL-6) when present in enough...
5858361 Monoclonal anti-idiotypic anti-CA125 antibodies and pharmaceutical compositions containing them  
Disclosed is an anti-idiotypic antibody which reacts with an anti-CA125 antibody and competes with CA125 in its binding to said anti-idiotypic antibody are disclosed which have essentially the same...
5851524 Human monoclonal anti-rhesus (D) antibodies and cell lines producing same  
The invention relates to 2 human monoclonal antibodies of sub-classes IgG1 and IgG3, against the hesus D antigen and to a pharmaceutical composition containing a mixture of the said antibodies,...
5849288 Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells  
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and in which xenogeneic hematopoietic...
5837540 Method of producing fibrin-specific antibodies using soluble fibrin polymers as an immunogen  
The subject invention relates to a method for producing antibodies using as an immunogen a composition comprising soluble crosslinked DesAABB fibrin polymers and soluble non-crosslinked DesAABB...
5834214 Detection of pancreatitis-associated protein for screening for cystic fibrosis  
The invention relates to in vitro detection of human pancreatitis-associated protein (hPAP) for the purpose of screening for cystic fibrosis. hPAP is quantitated in a biological sample, preferably...
5830681 Immunoassays for and monoclonal antibodies to prothrombin activation peptide F1.2  
Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of prothrombin activation peptide F1.2, which can be used in immunoassays to predict...
5821068 Anti-human soluble fibrin antibody, hybridoma, and immunoassaying method  
A monoclonal antibody that reacts with a human soluble fibrin but not with a human fibrinogen; a hybridoma that secretes the above antibody; and a method of assaying a human soluble fibrin with the...
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