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7534580 |
PSP94 diagnostic reagents and assays
In the serum, PSP94 occurs as a free form or is associated with a carrier protein. PSP94 in its bound form has been quantified in the blood of prostate cancer patients and these measurements have...
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7527939 |
Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP
A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are...
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7511123 |
Immuno-interactive fragments of the alpha-C subunit of inhibin
Novels immuno-interactive fragments of the (alpha)C portion of a mammalian inhibin alpha subunit are disclosed, together with their variants and derivatives for producing antigen-binding molecules...
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7507550 |
Analytical sandwich test for determining NT-proBNP
The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal...
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7429483 |
Use of nerve growth factor for the storage, culture or treatment of cornea
The nerve growth factor (NGF) is used for the storage of corneas in culture, for the production and the storage in vitro of single cell populations of the corneal morphological and functional unit...
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7393655 |
Methods of identifying melanin concentrating hormone receptor antagonists
This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells...
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7312089 |
Detection of erythropoietin and erythropoietin receptor
The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents...
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7294706 |
Identification of receptor and heparin binding sites in FGF4 by structure-based mutagenesis
The present invention provides methods and compositions that may be used to modulate binding of a fibroblast growth factor (FGF) polypeptide to an FGF receptor (FGFR). In preferred embodiments, the...
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7264939 |
Method of detecting native proBNP
The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the...
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7227004 |
Antibodies to vascular endothelial cell growth factor
The present invention provides monoclonal antibodies, and portions thereof, which are capable of specifically binding to human vascular endothelial cell growth factor (hVEGF) or hVEGF-related...
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7112662 |
Anti-metasin antibodies and their methods of use
The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its...
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7079675 |
Histological assessment
A method of measuring oestrogen or progesterone receptor (ER or PR) comprises identifying in histopathological specimen image data pixel groups indicating cell nuclei, and deriving image hue and...
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7067113 |
Methods for identifying compounds for regulating muscle mass or function using dopamine receptors
Screening methods for identifying compounds that bind to or activate (D 1 or D 5 dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in...
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7015023 |
Compositions and methods for detection of active proteases
A novel assay system is disclosed for detecting the presence or amount of selected active proteases in biological samples. The assay system utilizes a chimeric protease detector protein composed of...
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7014847 |
Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders,...
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6960472 |
Monoclonal antibodies against N-Terminus proBNP
Monoclonal antibodies having high affinity for N-terminus pro brain natriuretic peptide (NT-proBNP) are described. The monoclonal antibodies are prepared against a synthetic peptide having the...
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6949380 |
Transdifferentiation of epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Disclosed is a method of transdifferentiating an epidermal basal cell into a cell having one or more morphological, physiological and/or immunological features of a neural progenitor, neuronal, or...
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6929924 |
C-peptide specific assay procedure
The present invention relates to a specific C-peptide assay method which can eliminate all interference due to proinsulin and its intermediates, in particular des-31,32-proinsulin and/or...
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6814967 |
Antibodies to cortistatin: neuropeptides, compositions and methods
The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with...
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6767721 |
Flea ecdysone nucleic acid molecules and uses thereof
The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea...
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6716594 |
Monoclonal antibody
The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to...
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6680373 |
P2U2 receptor antibodies
A novel subtype of the P 2 -purinergic receptor, referred to as the P 2U2 receptor, is disclosed. This receptor is activated by four of its agonists in the following order of specificity:...
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6677124 |
Monoclonal antibody recognizing C-terminus of hBNP
A hybridoma producing a monoclonal antibody recognizing the C-terminus of human brain natriuretic peptide (hBNP) was cultivated in a medium or the abdominal cavity of a mouse to recover the...
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6413726 |
Antibodies that specifically bind Cytostatin III
The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and...
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6339143 |
Methods of using antibodies against hormone-related determinants
This invention provides methods for detecting the presence of human malignant cells in a sample of tumor cells; determining whether a tumor present in a human subject is malignant; obtaining an...
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6248546 |
Assay of IGFBP complex
A method of assaying the growth hormone status of an individual by immuno-assay for the 150 KDa Insulin-like Growth Factor ternary complex (IGF/IGFBP-3/ALS). Alternatively, a binary complex may be...
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6235490 |
Immunoassay of human growth hormone with a molecular weight of about 20,000
An animal cell capable of producing an antibody specific to a human growth hormone having a molecular weight of 20,000 (20 k hGH) was prepared from an animal immunized with 20 k hGH. The animal...
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6197938 |
Monoclonal antibody specific for 20K human growth hormone and a cell line producing the monoclonal antibody
An animal cell capable of producing an antibody specific to a human growth hormone having a molecular weight of 20,000 (20 k hGH) was prepared from an animal immunized with 20 k hGH. The animal...
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6183971 |
Human betacellulin-specific antibodies and uses thereof
Disclosed are an antibody which have a binding activity to human betacellulin protein or a mutein thereof with specificity; especially a monoclonal antibody which does not have cross reactitivity...
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6162902 |
Human BNP-specific antibodies
The present invention provides reagents and assays for the quantification of hBNP in biological fluid samples such as plasma or serum. Antibodies are provided which are monospecific to epitopes...
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6124439 |
OB polypeptide antibodies and method of making
The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and...
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6043086 |
Neurotactin and uses therefor
The present invention relates to the identification and characterization of a novel, membrane-anchored chemokine, neurotactin. Sequence analysis of neurotactin reveals that, while it includes an...
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6025143 |
Antibodies directed against peptides derived from the SMR1 polypeptide
The present invention relates to peptides and polypeptides derived from the submaxillary gland of the rat. In particular, the present invention discloses a purified peptide of formuls: ...
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5981197 |
Monoclonal antibody, hybridoma, their production and use thereof
A monoclonal antibody is produced from a cloned hybridoma, and the monoclonal antibody combines specifically with basic fibroblast growth factor (bFGF). Therefore, the monoclonal antibody can be...
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5980894 |
Antibodies to leukemia inhibitory factor
The invention relates to monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the...
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5976876 |
Antibodies specific for hLH β core fragment
This invention provides an antibody which specifically binds to hLHβcf without cross-reacting with hLH, hLHβ or hCGβcf. In an embodiment, the monoclonal antibody is designated B505. In a further...
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5959086 |
Antibodies specific for human pancreatitis associated protein
The invention relates to the family of the protein (PAP) associated with acute pancreatitis in man and in the rat. It also relates to the nucleotide fragments coding for the above proteins. Also...
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5935801 |
Monoclonal antibody that detects apoptotic antigen
A monoclonal antibody which specifically binds to an antigen on the membrane of mitochondria in apoptotic cells. The antigen is a 38 kD protein that is detectable in cells undergoing apoptosis and...
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5907033 |
Anti-oncostatin M monoclonal antibodies
The present invention relates to monoclonal antibodies that define Oncostatin M, a novel cytokine. The monoclonal antibodies of the invention are capable of binding to Oncostatin M, inhibiting...
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5885831 |
Nuclear localization factor associated with circadian rhythms
The invention includes a nucleic acid encoding a nuclear localization protein which binds to, stabilizes and translocates to the nucleus a protein involved in circadian rhythms. Also included are...
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5871735 |
Isoferritin as a marker for pathological pregnancy
The present invention relates to a method of diagnosis of pathological pregnancy which relies on an evaluation of the amount of placental isoferritin (PLF) in the serum or amniotic fluid of a...
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5849499 |
Monoclonal antibody to acetylated lysine residues in recombinant bovine somatotropin
Provided are hybridomas for producing monoclonal antibodies against acetylated lysine residues of rbSt. The antibodies are specific to the presence of at least a single acetylated lysine in a...
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5843430 |
Methods of treating disease using sertoli cells and allografts or xenografts
The present invention describes a method of treating a disease that results from a deficiency of a biological factor which comprises administering to a mammal Sertoli cells and cells that produce...
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5837241 |
Method of treating heart failure using leukemia inhibitory factor antagonists optionally with endothelin antagonists
A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion,...
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5807550 |
Antibodies specifically recognizing somatotropin binding proteins
The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding...
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5798213 |
Monoclonal antibodies
The present invention provides monoclonal antibodies against peptides having an amino acid sequence described in Sequence No. 1 or No. 2, the peptides being found in human thymidine phosphorylase...
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5750390 |
Method and reagent for treatment of diseases caused by expression of the bcl-2 gene
An enzymatic RNA molecule which cleaves bcl.2 mRNA associated with development or maintenance of follicular lymphoma.
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5702906 |
Antibodies to neurotrophic factor-4 (NT-4)
A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and...
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5702705 |
Antibody methods for the treatment of a hormone-mediated disease
Cleavage site blocking antibody that binds to prohormones, preferable Tumor Necrosis Factor, thereby preventing the formation of prohormone fragment(s) by proteolysis of the prohormone, and uses of...
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5698196 |
Antibodies specific for neutrophic chemotactic factor
The present invention relates to an isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a...
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