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8110375 |
High throughput assay for cancer cell growth inhibition
A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media...
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8026080 |
Real time electronic cell sensing system and applications for cell-based assays
The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring...
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7807439 |
Staphylococcus aureus-specific detection media and identifying and/or counting method using same
The invention concerns a medium for specific detection of Staphylococcus aureus and/or discrimination between positive-coagulase Staphylococcus and negative-coagulase enabling Staphylococcus to...
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7625719 |
Microsample treatment apparatus
A method of using a microsample treatment apparatus and an apparatus for detecting chemotaxis of cells and separating chemotactic cells includes a number of wells that are connected to each other...
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7537913 |
High throughput assay for cancer cell growth inhibition
A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media...
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7374906 |
Biological assays using gradients formed in microfluidic systems
The present invention discloses a device for monitoring chemotaxis or chemoinvasion. The present invention further provides a flexible assay system and numerous assays that can be used to test...
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7364899 |
Device for monitoring haptotaxis
The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first...
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7364874 |
Mediucm for detecting Van A and Van B vancomycin-resistant entercocci and method of using the same
Van A and Van B vancomycin resistant enterococci detection media as well as a method of selectively detecting Van A and Van B vancomycin resistant enterococci clinically important in vancomycin...
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7312046 |
Method of screening compounds using a nanoporous silicon support containing macrowells for cells
A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of...
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7297531 |
Apparatus and method for testing liquid samples
An article for holding a liquefied sample for the quantification of biological material in the sample includes a device having a reaction chamber enclosing a volume therein, the reaction chamber...
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7270996 |
Automated bioculture and bioculture experiments system
The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system...
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7262021 |
Method for antimicrobial susceptibility testing of microorganisms
Media, kits, and methods are disclosed for use in processes requiring microbial culture. More specifically, the invention provides carrageenan-stabilized agar-based microbial culture media for kits...
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7186565 |
Sampling and toxicity monitoring device and method
A method and apparatus for testing an aqueous or gaseous environment for the presence of at least one chemical is provided in order to determine the toxicity of the chemical and optionally, the...
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7172859 |
System and method for optimizing tissue barrier transfer of compounds
The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and...
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7138270 |
Assay device and method for chemical or biological screening
An assay device (1) comprises a base (2) and glass plate lid (3). The base (2) has an array of shallow microwells (4), each having a flat rim (9), all rims being co-planar. When the lid (3) is...
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7106889 |
Image analysis systems and devices for use therewith
An image analysis system for automated reading of printed multi-character codes, for example on antibiotic susceptibility testing disks, makes use of an orientation means, for example an underline...
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7026137 |
Hepatitis
A screening method of identifying a compound for treating hepatitis. Also disclosed is a method for evaluating responsiveness of a subject having hepatitis to a drug.
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7011939 |
Apparatus and method for electrophysiological testing
A method and apparatus for running a plurality of tests concurrently to obtain data relating to the electrophysiological properties of receptors and channels in biological membranes of test...
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6872545 |
Microbiological analyzer using colorimetric means for biochemical color and growth determinations
A microbiological analyzer for performing ID tests on samples using colorimetric techniques to generate a pixel-wise colored map of a test region of interest and also performing MIC tests on...
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6852526 |
Transdermal assay with magnetic clamp
The transdermal assay apparatus includes first, second, and third members. The first member has one or more sample surfaces, each of which is configured to receive a sample thereon. The second...
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6649365 |
Indolamine derivatives for detecting peptidase activity in culture media
Compounds of formula X—NH—R, in which X represents an optionally substituted indol-3-yl group and R represents the acyl residue of an amino acid or of a peptide, enabling the detection of pep...
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6632656 |
Microfabricated apparatus for cell based assays
Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each...
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6627432 |
Liquid flow and control in a biological test array
A microbiological test array with a generally flat base having a plurality of upwardly projecting microwells connected by a microchannel to an open reservoir formed in a top surface generally...
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6611765 |
System for validation and interpreting results of antimicrobial susceptibility tests of micro-organisms
The invention concerns a method for analyzing results of antimicrobial susceptibility tests of micro-organisms, the test consisting in summarily identifying which species the micro-organism belongs...
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6485928 |
Use of granulysin as an antimicrobial agent
The T cell activation marker, granulysin, is demonstrated to be an effective antimicrobial agent. It is used in vitro and in vivo to reduce the population of viable cells in a microbial population....
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6365368 |
Rapid method for the detection and quantification of microbes in water
The present invention concerns methods of testing water for microbe contamination. The methods of the invention comprise supplementing existing methods with assays using specific reagents such as...
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6309889 |
Nano-grid micro reactor and methods
The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member having a top surface, a bottom surface,...
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6284526 |
Method and apparatus for determining the sensitivity of a microorganism to a growth altering agent
A method and an apparatus for determining the concentration at which a growth-altering agent has an appreciable effect on the growth of a target microorganism are provided. The method comprises the...
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6265229 |
Method and device for detection of specific target cells in specialized or mixed cell populations and solutions containing mixed cell populations
The invention relates to a method and apparatus for detecting specific target cells in a simple and time-saving way, using paramagnetic particles, antibodies recognizing the Fc portions of...
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6235541 |
Patterning antibodies on a surface
Substrates are patterned with antibodies attached thereto at discrete locations from which absorption resistant coating is removed by selectively controlled mechanical scribing contact to avoid...
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6225079 |
Microtitration unit
A microtitration unit being at least one container of transparent material for accommodating biological test reaction mixtures. The container is subdivided into at least two chambers suitable for...
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6197575 |
Vascularized perfused microtissue/micro-organ arrays
Systems including (1) a micromatrix and perfusion assembly suitable for seeding and attachment of cells within the matrix and for morphogenesis of seeded cells into complex, hierarchical tissue or...
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6093566 |
Flow-through system and method for toxicity testing
A method and apparatus for evaluating the effects of toxic substances in the environment on aquatic organisms is disclosed. The apparatus allows for exposure of test organisms, placed in test...
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6022700 |
High throughput biological sample preparation device and methods for use thereof
Disclosed is a novel biological sample preparation (BSP) device and a method of using such a device that enables inexpensive and flexible high throughput sample preparation and visualization for...
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5922593 |
Microbiological test panel and method therefor
A microbiological test panel assembly used in microorganism identification (ID) and antimicrobial susceptibility determinations (AST) testing is provided. The microbiological test panel assembly...
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5916801 |
Nectophotometer
A computer interfaced device for rapidly quantifying levels of toxicity to small aquatic organisms in aqueous environments. The device has a plurality of test chambers containing replicates of a...
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5753456 |
Method for quantification of biological material in a liquid sample
An article adapted for holding a liquid sample for quantification of biological material in the liquid sample. The article includes a bag having an upper surface sheet and a lower surface sheet...
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5702915 |
Toxicity detecting biosensor system
A biosensor for detecting the toxicity of a sample includes a solid-state area image pickup element, a culture container positioned on an upper surface of a light-receiving portion of the element,...
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5674702 |
Determination of the toxicity of water using an anaerobic bacterial culture
Procedure and relative equipment for determining the presence of toxic substances in water destined for drinking and/or in water effluents, based on the inhibition of the production of biogas...
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5654165 |
Antibacterial drug inspection method and apparatus therefor
A test solution including bacteria is added to a liquid sample in which antibacterial drug exists and to a liquid sample in which no antibacterial drug exists, and existence or non-existence of...
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5620895 |
Apparatus for quantification of biological material in a liquid sample
An article adapted for holding a liquid sample for quantification of biological material in the liquid sample. The article includes a bag having an upper surface sheet and a lower surface sheet...
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5612188 |
Automated, multicompartmental cell culture system
The present invention relates to an in vitro system for physiological and metabolic evaluation of substances for use in living beings. The system includes one or more cell culture chambers, each...
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5552288 |
Chromogen agar color reactive test sheet
A moist unitary non-laminar chromogen agar color reactive test sheet for use in a simplified enzyme-linked immunosorbent assay (ELISA) for the diagnosis of viral, fungal, bacterial and parasitic...
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5543327 |
Apparatus for conducting the cytotoxicity assays on tumor cells
A method and apparatus for assaying the sensitivity of biopsied tumor cells to chemotherapeutic agents using a predetermined amount of chemotherapeutic agent in an easily deliverable form is...
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5422270 |
One-step tray test for release of soluble mediators and apparatus therefore
A microculture tray comprising a plurality of pairs of wells, each pair of wells connected by a trough which extends downwardly approximately 2/3 of the depth of the well so that the wells in the...
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5312731 |
Method and apparatus for studying a reaction pattern of a cell or cell aggregates during perfusion with different media
A method and apparatus for a high time resolution study of a reaction pattern of a cell or cell aggregates by light transmission microscopy during perfusion by different media. The apparatus...
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5242806 |
Method for conducting the cytotoxicity assays on tumor cells
A method and apparatus for assaying the sensitivity of biopsied tumor cells to chemotherapeutic agents using a predetermined amount of chemotherapeutic agent in an easily deliverable form is...
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5196313 |
Method for the evaluation of anticoccidial activity of compounds using 2,3,5-triphenyltetrazolium chloride and trypan blue indicators
A method for the rapid and reliable in vitro determination of the anticoccidial activity of chemotherapeutic agents. The invention involves incubating free-living sporozoites in a nutrient medium...
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5187096 |
Cell substrate electrical impedance sensor with multiple electrode array
An apparatus and method for monitoring cell-substrate impedance comprises upper and lower substrates each containing strips of metal foil which cross to form well areas. Holes in the upper...
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5156948 |
Method and kit for diagnosis of diseases
An improved simplified enzyme-linked immunosorbent assay (ELISA) for the diagnosis of viral, fungal, bacterial and parasitic diseases. The diagnostic test is designed for use in non-laboratory...
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