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8182813 |
Human C-FMS antigen binding proteins
Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen...
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8173134 |
ECD carboxy-terminal deletion FGFR4 fusion proteins and methods of producing them
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
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8173424 |
Internalizing ErbB2 antibodies
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the...
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8168409 |
Compositions and methods relating to anti-IGF-1 receptor antibodies
The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric...
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8158419 |
Transgenic non-human animals for producing chimeric antibodies
The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial...
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8158757 |
Compositions and methods for treating and diagnosing cancer
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in...
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8153129 |
Antibodies against human cytimegalovirus (HCMV)
The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV...
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8147844 |
Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the...
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8143385 |
Nucleic acids coding for antibodies against human IL-21 receptor and uses therefor
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists...
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8124352 |
Methods and compositions for targeting HEPSIN
Anti-HEPSIN monoclonal antibodies, and methods for using the antibodies, are provided.
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8114965 |
Compositions of PSMA antibodies
The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a...
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8105598 |
Human monoclonal antibodies that specifically bind IGF-II
Disclosed herein are isolated monoclonal human antibodies that specifically binds insulin-like growth factor II (IGF-II) with an equilibrium dissociation constant (Kd) of 1 nM or less, wherein the...
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8101381 |
Human cytokine receptor
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides polynucleotides, vectors, cells, and methods of production related to...
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8101179 |
Anti-CD20 monoclonal antibody
A murine anti-CD20 monoclonal antibody having cell growth inhibitory activities is disclosed. Cell growth inhibitory activities include apoptosis against human CD20 antigen expressing cells in...
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8092798 |
Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also...
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8093010 |
Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
The present invention relates to a method for providing molecules that are capable of inhibiting angiogenesis, comprising the steps of providing a range of molecules; testing whether these...
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8092804 |
Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
Binding members, especially antibody molecules, for interleukin (IL)-4 receptor alpha (IL-4Rα), and their therapeutic use e.g. in treating or preventing disorders associated with IL-4Rα, IL-4 a...
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8067564 |
Methods of obtaining a specific binding member that binds eotaxin
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralize eotaxin-1 activity. The...
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8062867 |
Fusion partner for production of monoclonal rabbit antibodies
The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not...
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8062864 |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the...
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8058418 |
Polynucleotides encoding heavy and light chains of antibodies to OPGL
Compositions comprising polynucleotides encoding heavy and light chains of antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of making such antibodies are described.
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8043829 |
DNA encoding chimeric toxin peptide fusion proteins and vectors and mammalian cells for recombinant expression
Disclosed is a composition of matter comprising a ShK toxin peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the...
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8044180 |
FcγRIIB specific antibodies and methods of use thereof
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind F...
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8038993 |
Cytotoxic antibodies directed against antibodies inhibiting factor VIII
The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human factor VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the variable...
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8008257 |
ANF fusion proteins
A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence...
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8008073 |
Anti-Mpl antibodies
Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also...
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8003774 |
Identification and engineering of antibodies with variant Fc regions and methods of using same
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises...
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7998480 |
Human BNP immunospecific antibodies
The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for...
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7994287 |
Antibodies which bind human CXCR3
Antibodies and antigen-binding fragments of antibodies that bind human CXCR3 are disclosed. In preferred embodiments, the antibodies are human. Nucleic acids and vectors encoding the antibodies or...
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7994302 |
Fully human monoclonal antibodies to IL-13
The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies...
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7989219 |
Bispecific capturing molecule
A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the...
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7981416 |
Humanized immunomodulatory monoclonal antibodies for the treatment of immunodeficiency
The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation...
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7977461 |
Anti-platelet membrane glycoprotein VI monoclonal antibody
The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI...
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7968684 |
IL-18 binding proteins
The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human...
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7964711 |
Compositions comprising polynucleotides encoding TACI-immunoglobulin fusion proteins and methods for producing the same
Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The...
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7939069 |
Human BNP immunospecific antibodies
The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for...
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7932360 |
Recombinant production of mixtures of antibodies
The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding...
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7927834 |
Recombinant production of mixtures of antibodies
The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding...
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7919257 |
Method for selecting a single cell expressing a heterogeneous combination of antibodies
The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being...
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7919607 |
Nucleic acids encoding humanized anti-tag 72 CC49 antbodies
The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody...
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7915396 |
Nucleic acid molecules encoding minimally immunogenic variants of SDR-grafted humanized antibody CC49
Humanized anti-TAG-72 CC49 monoclonal antibodies are disclosed herein. The antibodies include a light chain Complementarity Determining Region (L-CDR)1, a L-CDR2, and a L-CDR3; and a heavy chain...
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7906625 |
Humanized anti-amyloid antibody
Compositions for treating neurodegenerative or amyloidgenic disorders such as Alzheimer's disease (AD) are provided. More particularly, humanized anti-amyloid-beta antibodies, compositions...
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7897153 |
Chimera of human IgE receptor α-chain and avian constant immuno-globulin domains for the determination of serum IgE
The instant application inter alia relates to chimeric fusion constructs comprising the extracellular portion of human FcεRIα and at least one avian constant immunoglobulin domain and the use t...
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7892543 |
Reshaped human anti-HM 1.24 antibody
The invention provides a reshaped human anti-HM 1.24 antibody having: (A) an L chain having (1) the C region of a human L chain, and (2) the V region of an L chain having the FR of a human L chain...
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7879322 |
Compositions and methods for use for antibodies against sclerostin
The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An...
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7879990 |
Polynucleotides encoding antibodies that bind to the C35 polypeptide
The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human...
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7846435 |
Humanized antibodies that recognize Verotoxin II and cell line producing same
The invention provides humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2). The antibodies are useful for treating patients suffering from, or at risk of...
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7847067 |
Antibodies to NTB-A
Anti-NTB-A antibodies and antigen-binding fragments thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding fragments are described. Also described are...
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7824681 |
Human monoclonal antibodies that specifically bind IGF-II
Disclosed herein are isolated monoclonal human antibodies that specifically binds insulin-like growth factor II (IGF-II) with an equilibrium dissociation constant (Kd) of 1 nM or less, wherein the...
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7820410 |
Proteins with high immunoreactivity and method for their production
The invention relates to (glyco-) proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81%, preferably >90%. The inventive monoclonal antibodies are produced using a...
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