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7618943 |
Fusion polypeptides, and use thereof in antivascular tumor therapy
The present invention relates to fusion polypeptides, comprising at least two peptides. The invention further relates to the use of these fusion proteins in antivascular therapy of neoplastic...
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7618818 |
Method for detecting leptin receptor ligands
The present invention relates to a method for detecting leptin receptor ligands by measuring the energy transfer between fusion proteins comprising a leptin receptor and an energy donor protein or...
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7618817 |
Genetically modified human natural killer cell lines
The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell...
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7618786 |
Method for identifying modulators of human orexin-2 receptor
The present invention provides a new method for identifying modulators of human orexin-2 receptor without utilizing recombinantly produced nucleic acid molecules encoding human orexin receptor...
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7618775 |
Expanding the eukaryotic genetic code
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include...
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7618770 |
Methods and apparatus for reducing protein content in sperm cell extenders
The inventive technology relates to methods and apparatus for reducing protein content in sperm cell extenders and may include one or more of the following features: techniques for reducing protein...
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7618622 |
Treatment of Parkinson's disease and related disorders using postpartum derived cells
Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to...
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7618621 |
Mammalian multipotent neural stem cells and compositions, methods of preparation and methods of administration thereof
This invention relates to novel mammalian multipotent neural stem cells (MNSCs), compositions thereof, and methods of preparing and administering the cells to diseased, aged or damaged tissue such...
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7618452 |
Artificially produced, three-dimensional muscle tissue
The invention relates to a device for producing a three-dimensional circular muscle body from a carrier substance and from cell cultures incorporated therein comprising a cell culture dish ( 1 )...
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7615676 |
Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production
A transgenic screen and method for screening biological and chemical test substances or molecules for their ability to influence or modulate the production of BDNF in cells, includes a fusion gene...
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7615374 |
Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions
Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
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7612250 |
Nuclear transfer embryo formation method
A nuclear transfer embryo is formed by destabilizing microtubules of an oocyte, whereby essentially all endogenous chromatin collects at a second polar body during meiosis of an oocyte. The oocyte...
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7612190 |
Method for targeting a polypeptide onto cellular surface
The present invention relates to a polypeptide having an activity for targeting a heterogeneous polypeptide to a surface of cytoplasmic membrane, a nucleic acid encoding the polypeptide, a...
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7612185 |
Nucleic acid biosensors
Sensors comprising aptazymes capable of detecting the presence and concentration of effectors, as well as methods of using such sensors, are disclosed.
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7612167 |
Human hematopoietic growth regulatory gene product
The present invention relates to novel human hiwi protein and genes that encode such proteins. The invention is directed toward the isolation and characterization of human hiwi proteins. The...
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7611868 |
Recombinant modified adenovirus fiber protein
Recombinant adenoviruses comprising modified fiber proteins which expand the tropism of the adenovirus in comparison to wild-type virus are disclosed. The modified fiber proteins described herein...
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7611865 |
Polynucleotides encoding truncated glial cell line-derived neurotrophic factor
Disclosed are novel proteins, referred to as truncated glial cell line-derived neurotrophic factor (truncated GDNF) proteins, that promote dopamine uptake by dopaminergic cells and promote the...
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7611857 |
IL-receptor like molecules and uses thereof
The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists...
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7608707 |
siRNA targeting survivin
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene...
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7608705 |
Oligonucleotides, agents containing these oligonucleotides, and the use thereof
The invention relates to particular oligonucleotides, pharmaceutical agents that contain these oligonucleotides, and to the therapeutic use thereof. The oligonucleotides are, in particular, capable...
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7608704 |
Secreted proteins
The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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7608698 |
Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
This invention provides HIF-3α nucleic acid and sequences. Also provided are methods for using HIF-3α nucleic acids, proteins, fragments, antibodies, probes, and cells, to characterize HIF-3α,...
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7608454 |
Vascularization enhanced graft constructs
A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement...
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7608452 |
Polynucleotides encoding cytokine receptor zcytor19
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used...
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7608431 |
Fed-batch process for production of erythropoietin in human embryonic retina cells that express adenovirus E1A
The invention provides processes for recombinant production of erythropoietin (EPO) in a human embryonic retina cell that expresses at least an adenoviral E1A protein, wherein said EPO is produced...
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7608430 |
Interferon-γ antagonists and therapeutic uses thereof
Polypeptides and multimeric polypeptides capable of binding interferon γ which are useful therapeutically in methods of treating interferon γ-related conditions or diseases.
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7608428 |
Polynucleotide encoding an IL-28B polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7608427 |
Polynucleotide encoding an IL-28B polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7608425 |
Methods for protein expression in mammalian cells in serum-free medium
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies,...
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7608423 |
Expanding the eukaryotic genetic code
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include...
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7608422 |
Simian immunodeficiency virus (SIV) molecular clone encoding mutant gag gene lacking inhibitory/instability regions
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host...
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7604991 |
Method of generating islet beta-cells from exocrine pancreatic cells
The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF...
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7604990 |
Methods of regulating differentiation in stem cells
The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and...
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7604989 |
Inhibition of apoptosis process and improvement of cell performance
The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is...
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7604934 |
Method of screening candidate compounds for susceptibility to biliary excretion by endogenous transport systems
A method of screening a candidate compound for susceptibility to biliary excretion. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile...
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7604933 |
Method for sorting tumor cells
The present invention relates to a method for storing cells, wherein the cells are stored in a composition comprising a base nutritive medium and liposomes at temperatures in the range of −196°...
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7601885 |
Transgenic plant comprising a cassava vein mosaic virus promoter and a heterologous nucleic acid sequence
The invention relates to compositions and methods useful for the production of transgenic plants. In particular, the invention relates to cassava vein mosaic virus (CsVMV) promoter sequences and...
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7601826 |
Genes and polypeptides relating to human pancreatic cancers
The present application provides novel human genes C1958V1 or C1958V2 whose expression is markedly elevated in pancreatic cancers compared to corresponding non-cancerous tissues. The genes and...
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7601825 |
Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer
A novel gene (designated 121P1F1) and its encoded protein, and variants thereof, are described wherein 121P1F1 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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7601812 |
Immunomodulating agents from parasitic worms and method for isolation thereof
The invention relates to active agents from parasitic worms, in particular Schistosoma mansoni , which induce a T-helper type 2 response (Th2 immune response).
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7601807 |
Protease, DNA encoding the same, and method for manufacturing protease
A protease having the following characteristics:
(i) a molecular weight of 21,000±1,000 (by SDS-PAGE) and (ii) specific protease activity cutting the Gly-Phe site of a peptide or protein...
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7601805 |
Photoprotein with improved bioluminescence
Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium.
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7601699 |
Production of reprogrammed cells with restored potential
A method for treating cells and/or nuclear transfer units and/or stem cells in culture with such compounds, individually or in combinations, is described. The method results in a globally...
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7601687 |
Mechanism for identifying drugs for the treatment of type II diabetes
Insulin resistance is a central feature of type II diabetes and other diseases, and may affect every tissue of the body, including the pancreatic beta cell. Insulin signaling is mediated by a...
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7601533 |
Reverse two-hybrid systems
Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ...
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7601518 |
Secretion of neublastin
The present invention concerns improved methods and compositions for producing a Neublastin polypeptide as well as local delivery of Neublastin to specific regions of the nervous system including...
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7601516 |
Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
The invention provides novel heterodimeric fusion proteins comprising a first polypeptide including an alpha subunit of FSH (αFSH) linked directly or indirectly to a binding partner of neonatal Fc...
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7601514 |
Nucleic acid encoding PRO10268 polypeptides
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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7601501 |
Controlling osteogenesis by inhibition of osteogenic suppressors
The present invention provides methods of screening for agents that inhibit the activity or expression of one or more polypeptides that contribute to the suppression of osteogenesis. The invention...
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7601343 |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
Disclosed are cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells (e.g., dendritic cells...
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