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7514239 |
Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods...
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7514594 |
Transgenic animal model of bone mass modulation
The present invention relates to methods and materials used to express the HBM protein in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing...
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7514600 |
Stabilizing solutions for submicronic particles, methods for making the same and methods of stabilizing submicronic particles
Stabilizing solutions for submicronic particles, methods for making the same and methods of stabilizing submicronic particles is disclosed.
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7514225 |
Method for screening an agent that modulates activity of macrophage migration inhibitory factor
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF...
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7514542 |
Collagen-like protein CLAC, precursor thereof and genes encoding the same
A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific...
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7514222 |
Site selective acylation
Disclosed are novel polypeptides of a four helix bundle formed of two dimerized helix-loop-helix motifs, wherein either both have a sequence according to SEQ. ID No. 1, SEQ. ID No. 2, SEQ. ID No....
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7514082 |
Anti-viral VSF protein and hybridoma producing the same
Disclosed are a novel virus suppressing factor (VSF) protein having antiviral activity against a variety of viruses and a hybridoma secreting such a VSF protein. In addition, the present invention...
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7514075 |
Systems and methods for separating and concentrating adipose derived stem cells from tissue
Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g.,...
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7514237 |
Systems and methods for protein production
The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing...
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7514545 |
Inducible eukaryotic expression system
Compositions and methods for the inducible expression of genes in eukaryotic cells. Expression of a nucleotide sequence of interest is controlled by a regulatory fusion protein that consists of a...
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7514403 |
Process for the stabilization of proteins in an aqueous solution comprising cysteine in a concentration between 150 and 220mM
The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein....
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7514548 |
Methods of inhibiting COX-2
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for COX-2, and further provides methods of reducing expression of COX-2 in cells (e.g., cancer cells).
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7514258 |
Mammalian cultured inner cell mass cell culture using a quiescent cell as nuclear
A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit...
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7510871 |
Alzheimer model for drug screening
The present invention relates to methods and reagents for drug screening. Screening methods are disclosed employing neuronal cells that have been treated so as to exhibit characteristics associated...
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7510876 |
Definitive endoderm
Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive...
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7510853 |
Nucleic acids encoding DCRS5
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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7510870 |
STAT3 activated stem cell
Stem cells modified to express activated form of STAT3 by genetic modification or protein delivery, and stem cells co-cultured with cells expressing activated form of STAT3 exhibit increased...
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7510877 |
Hematopoietic stem cell identification and isolation
The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides...
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7510706 |
Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity
The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane...
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7510851 |
Compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia
The present invention provides compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia. In particular, the invention provides methods of identifying...
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7510873 |
Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same
Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to...
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7510872 |
Recombinant adeno-associated virus production
The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, the invention relates to use of recombinant adenovirus encoding...
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7510874 |
Stable cell lines expressing HERG1a and HERG1b
A line of cultured mammalian cells includes HERG1b subunits and optionally HERG1a subunits.
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7510852 |
Biosynthetic genes and host cells for the synthesis of polyketide antibiotics and method of use
Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are...
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7510858 |
IRAK 1c splice variant and its use
IRAK 1c [Interleukin-1 Receptor-Associated Kinase 1c] splice variants and their preparation and use are described. The splice variants may be used in drug screening assays and methods for...
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7507872 |
Transgenic toll-like receptor 9 (TLR9) mice
The present invention provides a receptor protein specifically recognizing bacterial DNA having an unmethylated CpG sequence, a genomic DNA encoding it, an experimental animal model useful for...
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7507540 |
Catalytic anti-factor VIII allo-antibodies
A method is disclosed of determining the presence of catalytic anti-Factor VIII allo-antibodies capable of degrading Factor VIII in a mammal, and of characterising the cleavage sites in said Factor...
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7507580 |
Ztnfr14, a tumor necrosis factor receptor
Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for...
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7507557 |
Nucleic acids encoding PRO1375 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7504237 |
Polynucleotides encoding interferon gamma polypeptides
A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence...
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7504255 |
Compositions and methods for generation of infectious hepatitis C virus in immortalized human hepatocytes
The present invention provides a cell line capable producing infectious hepatitis C virus 1a (HCV 1a) particles in culture. Disclosed are compositions and methods for an HCV 1a (clone H77)...
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7504100 |
Method for delivering a biological compound using neural progenitor cells derived from whole bone marrow
A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with...
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7504203 |
Method for assessing sensitivity of a rice blast fungus to a scytalone dehydratase inhibitor
The present invention provides a method for assessing sensitivity of a rice blast fungus to a scytalone dehydratase inhibitor, comprising the steps of: (a) and (b), which (a) identifies an amino...
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7504258 |
Tissue engineered cellular sheets, methods of making and use thereof
The disclosure provides methods and composition to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel....
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7504242 |
Process for the fermentative production of amino acids using coryneform bacteria in which OpcA gene expression is amplified
The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
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7504253 |
Nucleic acid encoding proteins involved in protein degradation, products and methods related thereof
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
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7501280 |
Immobilized cells and liposomes and method of immobilizing the same
In an inexpensive and convenient method for immobilizing a suspension cell, a phospholipid vesicle or the like regardless of the type of cell, on the surface of a solid phase, a cell is immobilized...
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7501238 |
Skin substitutes for irritancy testing
The present invention relates to in vitro cultured skin substitutes, preferably to in vitro cultured skin substitutes that have improved barrier function. In particular, the present invention...
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7501281 |
Compositions, methods and kits related to thrombin, Notch signaling and stamatogenesis and growth of stem cells
The present invention relates to methods based on the interactions of thrombin as a biological regulator. More specifically, the invention relates to the interactions of thrombin with regard to...
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7501273 |
Peptidylarginine deiminase 6
A nucleotide acid sequence is provided encoding a peptidylargine deiminase 6. The gene is found to be expressed in gonads only and may be used as target for male and female contraception. Its...
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7498167 |
Keratinocytes expressing exogenous angiogenic growth factors
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
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7498127 |
Method of screening cell growth inhibitor and cell growth inhibitor
The present invention provides a method for screening a cytostatic agent characterized by determining an effect of inhibiting intracellular signaling mediated by a remaining fragment of a cell...
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7498154 |
Nucleic acid encoding a human interferon-like protein Zcyto21
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level....
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7498024 |
Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site
Single vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The vectors comprise a self-processing cleavage...
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7498171 |
Modulation of stem and progenitor cell differentiation, assays, and uses thereof
The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the...
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7498149 |
Proteins having effects of controlling cell migration and cell death
The present invention relates to proteins which have a role in controlling neuronal cell migration and cell death as well as to the DNA which encode those proteins. It is an object of the present...
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7498151 |
Variant TLR4 nucleic acid and uses thereof
The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
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7498158 |
Alpha-amylase variant with altered properties
The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent...
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7494807 |
Mammalian megakaryocyte progenitor cell
A substantially enriched mammalian hematopoietic cell population is provided, which is characterized as a progenitor cell committed to the megakaryocyte lineage. Methods are provided for the...
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7494804 |
Polynucleotide encoding cytokine receptor zcytor17 multimer
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors...
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