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7547545 |
Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
The invention relates to methods for inducing marrow stromal cells to differentiate into neural cells by way of increasing intracellular levels of cyclic AMP. The invention also encompasses methods...
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7547511 |
Antisense inhibition of laminin-8 expression to inhibit human gliomas
Using gene array technology, we observed that an increase of the α4 chain-containing Laminin-8 correlated with poor prognosis for patients with brain gliomas. We established that inhibition of...
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7547549 |
Method to produce a hybrid cell having a single mitochondrial genotype
The present invention relates to a method of producing a viable hybrid cell having a single functional mitochondrial population. The method comprises the step of introducing genomic DNA from a...
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7547546 |
Progenitor cells from wharton's jelly of human umbilical cord
Human progenitor cells are extracted from perivascular tissue of human umbilical cord. The progenitor cell population proliferates rapidly, and harbours osteogenic progenitor cells and MHC−/−...
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7547547 |
Bioprocess for producing uniform embryoid bodies from embryonic stem cells in a high density bioreactor
The present inventors identified aggregation of embryonic stem cells and embryoid bodies (EBs) as the cause of the difficulty in generating large numbers of the embryonic stem cells (ES)...
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7547816 |
α(1,3)-galactosyltransferase knockout swine, tissues and organs
The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The...
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7544491 |
TANGO 240 nucleic acids and uses thereof
The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid...
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7544481 |
Nucleic acids encoding CD40 binding protein
This invention provides a novel purified mammalian protein having the ability to bind the cytoplasmic region or domain of a CD40 receptor and the nucleic acid molecules coding for this protein....
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7544492 |
OB polypeptides, modified forms and derivatives
The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to...
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7544485 |
Baldness related gene and the polypeptide encoded thereby, and uses
The invention has disclosed a baldness-related gene and the encoded polypeptide, and a process for producing the polypeptide by recombinant methods. It has also disclosed the use of Rhor gene and...
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7544482 |
Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7544669 |
Polynucleotide therapy
This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a...
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7544509 |
Method for preparing stem cell preparations
This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an...
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7544493 |
Method for the purification of an N-terminal fragment of hepatocyte growth factor
A method for the production of the N-terminal four kringle-containing fragment of hepatocyte growth factor (NK4) by expression of a nucleic acid encoding said NK4 in a microbial host cell,...
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7544484 |
Nucleic acids encoding membrane-binding proteins and methods of using same
A secretory or membrane-binding chimeric protein composed of an energy-generating protein and an energy-receiving protein linked one another wherein energy transfer can arise between the...
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7544488 |
Secretion, transcription and sporulation genes in Bacillus clausii
The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to...
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7544510 |
Stem cells of the islets of Langerhans and their use in treating diabetes mellitus
Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation...
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7541449 |
Human kunitz-type inhibitors and methods relating thereto
The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding...
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7541343 |
Inhibiting cellular proliferation by expressing yin yang-1
The present invention provides a method of preventing or reducing cellular proliferation. The method involves administering to cells a composition which increases the level of YY1 protein, in...
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7541438 |
Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
A human monoclonal antibody useful for the treatment of various diseases caused by human connective tissue growth factor (CTGF) and preventing the onset of the above diseases; medicinal uses...
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7541432 |
L-glutamate-gated chloride channel proteins from Rhipicephalus sanguineus
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also...
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7541188 |
Skin substitutes and uses thereof
The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of...
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7541434 |
Polypeptide for a TRP channel family member, TRP-PLIK2, and splice variants
The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and...
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7541186 |
Method of generating human retinal progenitors from embryonic stem cells
Methods are provided for the in vitro differentiation of human retinal progenitor cells from embryonic stem cells.
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7541441 |
Antibodies that specifically bind to TL5
The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune...
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7541143 |
Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
The present invention provides for novel reagents whose fluorescence changes upon cleavage or a change in conformation of a backbone. The reagents comprise a backbone (e.g. nucleic acid,...
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7541189 |
Transcription activation complex and utilization thereof
The present invention provides a complex of the transcription coupling factor of any of ARNT 1 to 3 and the transcription regulatory factor comprising any of the amino acid sequence from the amino...
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7541035 |
Immunogenic peptides for the treatment of prostate and breast cancer
Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino...
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7537928 |
Mutations in ion channel proteins associated with sudden cardiac death
Previously unknown mutations of the KCNH2, SCN5A and KCNQ1 genes are disclosed which are involved in ion channel disruptions associated with short QT syndrome, long QT syndrome, Brugada syndrome...
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7537904 |
Cell for measuring the ability to control the activity of a ligand-responsive transcription control factor
The present invention provides an animal cell expressing a gene coding a ligand-responsive transcription control factor and securely maintaining a DNA comprising in a molecule, the following genes...
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7537930 |
Mammalian cell lines for increasing longevity and protein yield from a cell culture
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies,...
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7538095 |
Genetic inhibition by double-stranded RNA
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with...
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7537756 |
Stem cells and their use in transplantation
Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation...
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7538200 |
Thermal tolerant avicelase from Acidothermus cellulolyticus
The invention provides a thermal tolerant (thermostable) cellulase, AviIII, that is a member of the glycoside hydrolase (GH) family. AviIII was isolated and characterized from Acidothermus...
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7534879 |
Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for...
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7534425 |
Animal model and cell-line expressing modified chlorine channel
The present invention relates to a test system for the identification and testing of active compounds which act on synapic transmission (active compounds for treatment of neuronal diseases), which...
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7534585 |
Multifunctional cytokines
The present invention relates to a novel fusion protein with the formula X—Y, or Y—X, wherein X represents a first immunoregulating polypeptide and Y represents a second immunoregulating...
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7534603 |
Fusion protein delivery system and uses thereof
The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is...
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7534424 |
Method of enhancing delivery of a therapeutic nucleic acid
The invention provides methods and compositions for increasing the delivery of nucleic acids into a host by administering a nucleic acid encoding a therapeutic nucleic acid along with an agent that...
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7534606 |
Placental stem cell and methods thereof
The present invention describes stem cells obtained from post-partum placenta and their methods of obtaining and culturing. The present invention also describes compositions comprising placental...
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7534604 |
Fusion polypeptides capable of activating receptors
A fusion polypeptide comprising (A) x -M-(A′) y , wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins...
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7534610 |
3D tissue constructs on the basis of colloidal crystals surface modified by sequential layering
A cell growth matrix for optimizing 3D organization nutrient delivery, controlling release of differentiation factors and facilitating attachment of cells to a scaffold Colloidal crystals and...
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7531643 |
Monoclonal antibody inducing apoptosis
The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, and the antigens that induce apoptosis of nucleated blood cells having...
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7531626 |
Tenebrio antifreeze proteins
A novel class of thermal hysteresis (antifreeze) proteins (THP) that have up to 100 times the specific activity of fish antifreeze proteins has been isolated and purified from the mealworm beetle, ...
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7531353 |
Non self-inactivating, expression targeted retroviral vectors
The present invention relates to a retroviral vector undergoing promoter conversion comprising a 5′LTR region of the structure U3-R-U5; one or more sequences selected from coding and non-coding...
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7531313 |
Screening for agents that modulate relaxin function
High affinity relaxin receptors, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided. These proteins, herein termed LGR7 and LGR8, are...
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7531715 |
Double nuclear transfer method and results thereof
A method is described for the production of an animal (offspring) by the process of nuclear transfer. The animal may be produced using donor genetic material in cells taken directly from any stage...
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7531523 |
Sodium channel protein type III alpha-subunit splice variant
The present invention is directed to a splice variant of a human sodium channel alpha subunit and methods and compositions for making and using the same.
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7531714 |
Melusin a muscle specific protein, as a drug target for prevention and treatment of heart failure
The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be...
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7531317 |
Fluorescence polarization assay to detect protease cleavage
The invention discloses a method of determining protease activity, in real time, using fluorescence polarization technology. In particular, the invention provides vectors and a method for their...
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