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7384784 |
Pax-encoding vector and use thereof
The present invention provides cells transformed with a nucleotide sequence encoding Pax7, Pax3 or both. The present invention also pertains to Pax-encoding vector that comprises a sequence...
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7381800 |
Antibodies to HBIMF63 polypeptide
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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7381711 |
Substances for preventing and treating autoimmune diseases
A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence...
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7381542 |
Nucleic acids encoding a biogenic amine receptor
The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of...
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7381819 |
Composition for treatment or prevention of endometrial cancer and method of preventing or treating endometrial cancer using the composition
Provided are a composition for the treatment or prevention of an endometrial cancer including a nuclear acid molecule inducing RNA interference against human syndecan-1 gene expression and a...
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7381405 |
Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer
The invention provides methods of preparing autologous T-lymphocytes for re-introduction into a patient having cancer, which method comprises obtaining peripheral blood mononuclear cells (PBMCs)...
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7378277 |
Methods and compositions for transforming dendritic cells and activating T cells
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates...
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7378273 |
Expression vectors
The present invention provides novel regulatory elements and vectors for the expression of one or more proteins in a host cell. The present invention also provides methods for expressing one or...
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7378280 |
Apparatus and methods for conducting assays and high throughput screening
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and...
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7378086 |
Retroviral vector having an ovalbumin promoter
Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to...
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7378275 |
Canine IL-13 receptor alpha-1 subunit nucleic acid molecules
The invention relates to canine immunoglobulin G (IgG) and canine interleukin-13 receptors (IL-13R) as well as fusion proteins containing canine IgG and/or canine IL-13R. In particular, the present...
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7378257 |
Bacterial superantigen vaccines
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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7378078 |
Compositions and methods for detecting proteolytic activity
The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The...
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7378499 |
Genes encoding proteins with pesticidal activity
Compositions and methods for protecting a plant from an insect pest are provided. The invention provides mutagenized nucleic acids that have been engineered to encode pesticidal polypeptides having...
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7378261 |
Method for preparing para-hydroxystyrene by biocatalytic decarboxylation of para-hydroxycinnamic acid in a biphasic reaction medium
A biocatalytic method for preparing para-hydroxystyrene from para-hydroxycinnamic acid is described. The method uses an enzyme source having para-hydroxycinnamic acid decarboxylase activity to...
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7378087 |
Method of enhancing an immune response
A method of enhancing an immune response to an antigen is provided. The method involves augmenting the level of a TAP molecule in a target cell bearing the antigen. Preferably, the TAP molecules...
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7378274 |
Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses
The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol...
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7375093 |
Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain;...
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7375199 |
Cancer-associated genes
The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly...
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7374933 |
Human metalloprotease and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in thereapeutic, diagnostic, and pharmacogenomic applications.
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7374921 |
Cellulase tolerant to surfactants
Disclosed is a novel cellulase having an amino acid sequence in which the 162nd and/or 166th amino acid residues in the amino acid sequence of cellulase NCE5 are substituted. Further, a...
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7375079 |
Previns as specific inhibitors and therapeutic agents for botulinum toxin B and tetanus neurotoxins
The compounds of the invention are generally described by the formula:
B 1 Z* 2 B 3 Z* 4 X* 5 Q 6 F 7 X 8 X 9 X 10 X 11 , ...
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7374765 |
Methods and compositions for diagnosis and treatment of iron misregulation diseases
Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and...
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7374912 |
Nucleic acids encoding chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof
Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone...
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7374910 |
DNA encoding galanin receptor activating peptide
The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of...
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7375092 |
Lunasin peptides
The invention provides methods and compositions of selectively disrupting mitotic function in a target cell demonstrating undesirable mitotic function. Suitable target cells include mammalian,...
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7374934 |
Cell populations and methods of production thereof
The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay...
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7374911 |
Interleukin-1 related gene and protein
Disclosed in an interleukin-1 related gene and gene product. In particular, the invention relates to a protein that is highly homologous to known interleukin-1 cytokines, nucleic acid molecules...
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7375205 |
Elongase genes and uses thereof
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these...
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7374935 |
Human Rgr oncogene and truncated transcripts thereof detected in T cell malignancies, antibodies to the encoded polypeptides and methods of use
Naturally-occurring variants of human Rgr oncogene protein, in particular, abnormally truncated variants found in T cell malignancies, as well as the human Rgr protein are encompassed by the...
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7374909 |
Modulators of intracellular inflammation, cell death and cell survival pathways
A B1 protein, its isoforms, analogs, fragments and derivatives, DNA encoding it and recombinant production are provided. The protein is useful in the modulation of intracellular inflammation, cell...
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7375201 |
Fluorescent protein
An object of the present invention is to provide a fluorescent protein derived from organisms other than Aequorea victoria and having a novel primary structure. According to the present...
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7371550 |
Cholesterol oxidase stable in the presence of surfactant
A novel cholesterol oxidase having stability in the presence of surfactant and a gene encoding the novel cholesterol oxidase.
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7371559 |
Peptides and related molecules that modulate nerve growth factor activity
The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the...
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7371573 |
Propagation and/or derivation of embryonic stem cells
Embryonic stem (ES) cells are cultured in the presence of a compound which selectively inhibits propagation or survival of cells other than ES cells. The ES cells have not been genetically altered....
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7371843 |
Cultured Xenopus laevis cell lines expressing mutant Adenomatous polyposis coli gene
Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these...
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7371844 |
Nucleic acids encoding parathyroid hormone (PTH) derivatives
Parathyroid hormone(PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said...
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7371835 |
p53-dependent apoptosis-inducing protein and method of screening for apoptosis regulator
p53-dependent Damage-Inducible Nuclear Protein 1 (p53DINP1 protein) is a p53-induced nuclear protein that induces p53-dependent apoptosis by regulating p53 function through Ser 46 phosphorylation....
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7371536 |
Methods for transporting vitamin C
The invention provides methods for regulating the transport of vitamin C across membranes.
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7371540 |
Gene expression control DNA element and associated protein
Through screening of an expression library, a cDNA sequence has been identified that encodes a protein that interacts with human CD33, the DNA being highly homologous to a portion of the human...
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7371840 |
Isolation and characterization of ECA1, a gene overexpressed in endometrioid carcinomas of ovary and endometrium
This invention provides an isolated polynucleotide encoding an ECA1 polypeptide. Also provided is the isolated ECA1 polypeptide Further provided is an antibody that specifically recognizes and...
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7371921 |
Nonhuman animal model non-responsive to mycoplasma-origin lipoprotein/lipopeptide
An object of the present invention is to provide a non-human animal model unresponsive to a mycoplasma-derived lipoprotein/lipopeptide, and a method for screening an inhibitor or a promoter for a...
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7371569 |
Methods for preparing human thrombopoietin polypeptides by mammalian cell cultures
Procedures to produce a biologically active human TPO by mammalian cells in in vitro cultures are disclosed. Murine myeloma cells were genetically modified by introducing the gene of human...
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7371542 |
Gene expression system
The present invention relates to nucleic acid molecules and in particular to vectors, comprising at least one gene of interest, at least one scaffold/matrix attached region (S/MAR), at least one...
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7371841 |
Methods of modulating cold sensory perception
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein...
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7371568 |
Method for modifying chromosomes
The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign...
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7371836 |
PRO526 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host ceolls comprising those nucleic acid...
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7371555 |
Polypeptides having α-H-α-amino acid amide racemase activity and nucleic acids encoding the same
The invention relates to isolated polypeptides having α-H-α-amino acid amide racemase activity and nucleic acids encoding the same. The invention also relates to vectors and host cells comprising...
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7371570 |
Cell-specific adenovirus vector comprising EBV-specific promoter
Replication-competent adenoviral vectors comprising an EBV-specific transcriptional regulatory element (TRE) operably linked to a gene required for adenovirus replication are provided. By providing...
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7371845 |
MAGE-A3 peptides presented by HLA class II molecules
The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides...
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