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7402306 |
Cancer immunotherapy with semi-allogeneic cells
The present invention relates to improved semi-allogeneic immunogenic cells which act to stimulate and induce an immunological response when administered to an individual. In particular, it relates...
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7402730 |
Knockout animals manifesting hyperlipidemia
Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal...
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7402412 |
Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino...
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7402429 |
Host cells comprising cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, further encoding antigenically active proteins
The present invention relates, in general, to a methodology for the generation or nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued...
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7402310 |
Deoxyribonuclease, gene encoding same and use thereof
This invention provides a novel acid DNase (DLAD) which is an endonuclease capable of cleaving DNA independently from divalent cations, under acidic conditions, which retains its activity in acidic...
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7402430 |
MHC class II antigen-presenting systems and methods for activating CD4+ T cells
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC...
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7399465 |
Pharmaceutical compositions for treating arthritis and inflammatory disease
The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage...
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7399612 |
VEGF-binding fusion proteins and nucleic acids encoding the same
Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating...
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7399848 |
Polynucleotides encoding growth differentiation factor-8
Disclosed are polynucleotides encoding growth differentiation factor-8 (GDF-8) useful for increasing the muscle mass in chickens.
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7399750 |
Methods for cardiac gene transfer
Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are...
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7399631 |
Real-time impedance assay to follow the invasive activities of metastatic cells in culture
The present invention provides methods for the assessment of the metastatic potential of cells by measuring the effect of the cells on the impedance of an electrode. Accordingly, the present...
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7399829 |
Variants of RANKL protein
The present invention relates to novel, soluble, recombinant variants RANKL (Receptor Activator of Nuclear Factor—κB Ligand) proteins, which may be expressed solubly in E. coli, variants that...
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7399853 |
Modulation of glucagon receptor expression
Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor....
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7399634 |
Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same
The object of the present invention is to provide a method for preparing a basement membrane comprising extracellular matrices having a function to control morphology, differentiation,...
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7399753 |
Trans-splicing mediated photodynamic therapy
The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of...
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7399747 |
Peptides carrying substances across the blood brain barrier
The invention concerns the use of a linear peptide paired with an active substance for diagnosing or treating a CNS pathology by preparing a medicine capable of crossing the blood brain barrier to...
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7399900 |
Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of anematode gene
The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases in particular. Parkinsons disease, uses and methods for the discovery of substances and...
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7399470 |
Sandwich immunoassay kits for detecting ciguatoxin CTX3C
A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession...
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7399625 |
Scytalone dehydrogenase gene showing tolerance to agricultural pesticide
The present invention provides a gene that can be used extensively in studies relating to resistant rice blast fungi. The gene codes for either one of the following proteins (a) or (b): (a) a...
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7396681 |
Application of Hsp70 proteins
The invention relates to the use of Hsp70 protein or fragments thereof for the activation of NK-cells, pharmaceutical preparations, medical product or medical adjuvants containing a Hsp70 protein...
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7396680 |
Stem cell-specific promoters and their use
The present invention relates to a method of isolating stem cells from a mixed population of different cell types. This method involves selecting a promoter which functions only in said stem cells...
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7396915 |
Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical composition, and diagnostic reagent
A novel human monoclonal antibody specifically recognizing cancer cells such as non-small cell lung cancer, pancreatic cancer and gastric cancer cells is produced by hybridomas which are obtained...
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7396905 |
Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
This invention discloses endogenous calcineurin inhibitors, Calcipressin, Csp1, Csp2, and Csp3, as shown in SEQ ID Nos: 4-5, or 24. This invention also discloses nucleic acid sequences that can...
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7396669 |
Mammalian endonucleases and methods of use
Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular...
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7393682 |
Polynucleotides encoding promyostatin polypeptides
The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can...
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7393683 |
Mammalian host cell modified by RNAi to inhibit α 1,6-fucosyltransferase
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a...
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7393941 |
MxA as an antiviral drug and as a target for identification of antiviral drugs for DNA virus infections
The invention features methods and compositions for use in a screening assay to identify agents having antiviral activity against a DNA virus by assessing the effect of a candidate agent upon...
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7393687 |
Biomimetic 3-dimensional scaffold with metabolic stream separation for bioartificial liver device
A bio-artificial organ comprises a substrate comprising a roll of a substrate material, and a plurality of cells adhered to the substrate, the roll being formed from a sheet rolled to form a...
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7393671 |
Mutant carotenoid ketolases
CrtW carotenoid ketolases are provided that are useful for the production of astaxanthin and other cyclic ketocarotenoids. The mutant ketolase genes of the present invention encode polypeptides...
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7393943 |
Polynucleotides encoding a human chemotactic cytokine I
Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed...
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7393928 |
Recombinant gelatins
The present invention relates to recombinant gelatins and compositions thereof, and methods of producing and using the same.
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7393661 |
Nucleic acids encoding OBG3 polypeptides
The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. This application pertains to nucleic acids encoding a compound,...
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7393923 |
Red-shifted fluorescent proteins mPlum and mRaspberry and polynucleotides encoding the same
Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired...
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7393679 |
Whole cell catalyst
A whole cell catalyst is described comprising a hydantoinase, a racemase and a carbamoylase. Thus this catalyst is able to degrade hydantoins directly into the amino acids. Additionally, a process...
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7393927 |
Protein belonging to the TNF superfamily involved in signal transduction, nucleic acids encoding same, and methods of use thereof
A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells...
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7393629 |
Method and devices for transferring biological cells between a carrier and a probe
A cell transfer method is described, in which transfer of at least one biological cell ( 21 ) describing a natural cell locomotion between a carrier ( 80 ) and a probe ( 10 ) is provided, and...
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7390633 |
Methods for preparing low molecular weight heparin with modified heparinase III
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of...
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7390651 |
C3A serum-free clonal cell line and methods of use
A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from...
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7390894 |
Glutathione S-transferase sequence variants
Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if...
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7390484 |
Self-contained adipose derived stem cell processing unit
Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained...
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7390657 |
Method for generating primate trophoblasts
The first method to cause a culture of human and other primate stem cells to directly and uniformly differentiate into a committed cell lineage is disclosed. Treatment of primate stem cells with a...
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7390628 |
Microparticle-based diagnostic methods
The present invention concerns novel materials and methods to detect low frequency surface changes utilizing modified microspheres. Upon exposing the surface to the modified microspheres of the...
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7390485 |
Design and therapeutic use of adpase enhanced apyrases
The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and...
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7390638 |
S99T C-11 Truncated polynucleotides encoding interferon gamma polypeptide variants
When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this...
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7390659 |
Methods for inducing differentiation of embryonic stem cells and uses thereof
The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing...
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7390643 |
Geranyl diphosphate synthase molecules, and nucleic acid molecules encoding same
In one aspect, the present invention provides isolated nucleic acid molecules that each encode a geranyl diphosphate synthase protein, wherein each isolated nucleic acid molecule hybridizes to a...
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7390632 |
Soluble ErbB3 receptor isoforms
The present invention discloses a system and method using the human ErbB3 receptor, p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present...
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7387885 |
Growth factor homolog zvegf3 polynucleotides
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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7387893 |
Vectors, cells and processes for pyrimidine deoxyribonucleosides production
Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and...
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7388086 |
NPHS2 gene involved in the steroid-resistant nephrotic syndrome, protein encoded by said gene and diagnostic and therapeutic uses
The invention concerns a novel gene, called NPHS2 gene coding for a protein involved in the cortico-resistant nephrotic syndrome, and diagnostic and therapeutic uses of the novel identified...
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