|
Match
|
Document |
Document Title |
|
|
7416849 |
HBM variants that modulate bone mass and lipid levels
The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also...
|
|
|
7416870 |
Methods of directing C-O bond formation utilizing a type II polyketide synthase system
The present invention provides methods of modifying a biological molecule by C—O bond formation utilizing a type II polyketide synthase (PKS) system from the nonactin biosynthesis gene cluster....
|
|
|
7416886 |
Porcine uroplakin II promoter and the production method of useful proteins using said promoter
The present invention relates to a porcine uroplakin II gene promoter, an expression vector containing the promoter, and a method for producing useful proteins using the vector. The promoter of the...
|
|
|
7416889 |
Methods and compositions for repairing cartilage
Disclosed is a method for inducing repair of a joint tissue in a mammal includes the steps of removing a sample of synovial membrane from a joint of the mammal, isolating type B synoviocytes from...
|
|
|
7417137 |
Non-squamous epithelium-specific transcription
The invention relates to the field of cancer therapy and diagnosis, in particular of carcinomas. The invention provides an isolated and/or recombinant nucleic acid comprising a tissue specific...
|
|
|
7416875 |
Cytotoxic ribonuclease variants
This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the...
|
|
|
7416848 |
DNA encoding SNORF25 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors,...
|
|
|
7416887 |
Methods for use of MPL ligands with primitive human stem cells
Myeloproliferative leukemia receptor (mpl) ligands, such as thrombopoietin, act on a primitive subpopulation of human stem cells having the characteristics of self-renewal and ability to give rise...
|
|
|
7413875 |
ESTs and encoded human proteins
The sequences of 5′ ESTs and consensus contigated 5′ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs and consensus contigated 5′ESTs may be to obtain cDNAs and...
|
|
|
7413901 |
Method of forming vertebrate pancreas in vitro
The present invention provides a pancreas induced in vitro that is useful for developmental engineering and organ engineering, and a method wherein a pancreas induced in vitro which contributes to...
|
|
|
7413903 |
Methods of regulating differentiation in stem cells
The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and...
|
|
|
7413896 |
Method for improving protein production
The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a...
|
|
|
7413898 |
Cells and methods for estimation of effects on neurological dysfunction
The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed...
|
|
|
7413895 |
DNA encoding neutral amino acid transporter
A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a...
|
|
|
7413897 |
Primitive and proximal hepatic stem cells
Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for...
|
|
|
7413900 |
Immortalized fibroblasts
Aspects of the invention provide an immortalized fibroblast cell line capable of the growth and maintenance of human embryonic stem cells. An immortalized fibroblast cell line derived from an early...
|
|
|
7414169 |
Therapeutic and diagnostic tools for impaired glucose tolerance conditions
Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for...
|
|
|
7410778 |
Estrogen receptor genes and utilization thereof
A gene coding for any of the following estrogen receptors (a) to (c): (a) an estrogen receptor comprising the amino acid sequence represented by amino acid numbers 153 to 602 in the amino acid...
|
|
|
7410797 |
Meningeal-derived stem cells
Stem cell lines derived from meningeal tissue such as dura mater, pia mater, or arachnoid mater, are disclosed. In various embodiments, the stem cell lines include greater than 80%, greater than...
|
|
|
7410638 |
Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals
The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group...
|
|
|
7410781 |
IL-4/IL-13 specific polypeptides and therapeutic uses thereof
Polypeptides and multimeric polypeptides capable of binding interleukin-4 (IL-4) and interluekin-13 (IL-13) which are useful therapeutically in methods of treating IL-4 and IL-13-related conditions...
|
|
|
7410787 |
Diagnosis of Whipple's disease
The invention relates to a method for in vitro seriological diagnosis of Whipple's disease, whereby the bacteria responsible for the disease are isolated and established in a culture and brought...
|
|
|
7410777 |
Non-endogenous, constitutively activated human G protein-coupled receptors
Disclosed herein are constitutively activated, non-endogenous versions of endogenous human G protein-coupled receptors comprising (a) the following amino acid sequence region (C-terminus to...
|
|
|
7411056 |
Polynucleotides encoding cytokine receptor zalpha11
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within...
|
|
|
7407785 |
Human DNase I hyperactive variants
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive...
|
|
|
7407801 |
Truncated CMV promoters and vectors containing same
The present invention relates to nucleic acid molecules comprising certain truncated forms of the human cytomegalovirus (CMV) immediate-early enhancer-promoter, either alone or operably linked to...
|
|
|
7407786 |
Lipase genes
New lipase enzymes (both nucleic acids and polypeptides) are provided. Compositions which include these polypeptides, proteins, nucleic acids, recombinant cells, as well as methods involving the...
|
|
|
7407777 |
IL-2 transmembrane construct
Compounds, genetic constructs, and cancer treatment methods are provided. Expression vectors were designed to express fusion genes including hIL-2 with a Fcε-γ transmembrane anchor derived from a...
|
|
|
7407791 |
Production of secreted polypeptides
Described herein are methods and compositions for the production and secretion of polypeptides. Included herein is the use of interrupting peptide transport activity for an increase in polypeptide...
|
|
|
7407677 |
Enzymes having alpha amylase activity and methods of use thereof
The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The...
|
|
|
7407788 |
BGL7 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host...
|
|
|
7407766 |
Screening method for agonists or antagonists of semaphorin 6C by determining the effect of a test compound on the interaction between semaphorin 6C and plexin-A1
The present invention provides screening methods for agonists or antagonists of Sema6C using Plexin-A1, and tools for the screening and the like. It evaluates a case of making a recombinant protein...
|
|
|
7407784 |
L-amino acid oxidase with cytotoxic activity from Aplysia punctata
The present invention relates to a cytotoxic polypeptide which is an L-amino acid oxidase isolated from the ink of the sea hare Aplysia punctata.
|
|
|
7407804 |
Human genes relating to respiratory diseases and obesity
This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or...
|
|
|
7407805 |
Skin substitutes with improved barrier function
The present invention relates to in vitro cultured skin substitutes, and in particular to in vitro cultured skin substitutes that have improved barrier function. In some embodiments, improved...
|
|
|
7408047 |
Fibroblast growth factor-like polypeptides
The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies...
|
|
|
7405037 |
Methods and tools for detecting collagen degradation
Fluorophore-labeled collagen covalently bound to a cell culture vessel can be used to assay collagen degradation by a variety of cell types, including osteoclasts and tumor cells. Such assays...
|
|
|
7405287 |
Method of treating a cancer
The present invention provides isolated nucleic acids encoding delta DNA methyltransferase 3B molecules that are involved in the treatment and prevention of cancers such as, but not limited to,...
|
|
|
7405081 |
Methods and kits for identifying scavengers of reactive oxygen species (ROS)
This invention relates to methods and kits for determining the level of H 2 O 2 inside a cell, and for determining whether a test compound has ability to scavenge a reactive oxygen species (ROS)....
|
|
|
7405284 |
Reducing cellular dysfunction caused by mitochondrial gene mutations
A synthetic, nuclear-encoded ND4 gene was linked to a mitochondrial targeting sequence and a FLAG epitope tag. This fusion construct was inserted into a rAAV vector. The ND4 fusion protein was...
|
|
|
7405051 |
Method of screening antiplatelet agents
A screening tool for an antiplatelet agent wherein the tool is a human ADP receptor P2T AC protein, a variation functionally equivalent thereto, or a homologous protein thereof, and a screening...
|
|
|
7405038 |
Stable cell lines resistant to apoptosis and nutrient stress and methods of making same
Cell lines that are commonly used for protein expression are engineered to include genes that encode suppressors of apoptosis (SA). Insect cell lines expressing these SA genes are resistant to...
|
|
|
7405290 |
Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
A gene (designated 161P2F10B) and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in...
|
|
|
7402309 |
Phage-associated lytic enzymes for treatment of Bacillus anthracis and related conditions
The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The...
|
|
|
7402410 |
Humanized immunoglobulin reactive with α4β7 integrin
The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin...
|
|
|
7402306 |
Cancer immunotherapy with semi-allogeneic cells
The present invention relates to improved semi-allogeneic immunogenic cells which act to stimulate and induce an immunological response when administered to an individual. In particular, it relates...
|
|
|
7402730 |
Knockout animals manifesting hyperlipidemia
Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal...
|
|
|
7402412 |
Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino...
|
|
|
7402429 |
Host cells comprising cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, further encoding antigenically active proteins
The present invention relates, in general, to a methodology for the generation or nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued...
|
|
|
7402310 |
Deoxyribonuclease, gene encoding same and use thereof
This invention provides a novel acid DNase (DLAD) which is an endonuclease capable of cleaving DNA independently from divalent cations, under acidic conditions, which retains its activity in acidic...
|