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7425436 |
Covalent tethering of functional groups to proteins and substrates therefor
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
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7425444 |
Circovirus sequences associated with piglet weight loss disease (PWD)
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and...
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7425430 |
Probe for visualizing phosphorylation/dephosphorylation of protein and method of detecting and quantifying phosphorylation/dephosphorylation of protein
As a versatile method of detecting and assaying intracellular protein phosphorylation and dephosphorylation that enables nondestructive monitoring as well as spatial and temporal analysis for...
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7425440 |
Culture flask
A culture flask 10 comprises two or more internal chambers 18 - 21 defining a plurality of parallel surfaces of different sizes and means for fluid communication 24 between the chambers 18 -...
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7425445 |
Modulators that promote cell surface expression of odorant receptors
The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides...
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7425324 |
Antagonists of MCP proteins
Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N-terminal of MCP proteins, is eliminated...
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7422736 |
Somatic pluripotent cells
The present invention discloses a cultured somatic animal cell having a normal karyotype; the cell develops into an embryoid body when induced in vitro, or develops into a teratoma when introduced...
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7423010 |
Nonporous microparticle-prodrug conjugates for treatment of infection
This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such...
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7423134 |
Protein AMSH and cDNA thereof
This application provides a human protein AMSH having the amino acid sequence of SEQ ID No. 1 which is a novel signal transduction molecule interacting with the SH3 domain of cytokine based signal...
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7423139 |
High level expression of recombinant human erythropoietin having a modified 5′-UTR
The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin...
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7422896 |
Compositions for DNA mediated gene silencing
DNA compositions that mediate gene silencing via RNA interference are provided. The DNA compositions include an RNA polymerase III promoter, which drives expression of a nucleotide sequence...
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7423194 |
Animal models for demyelination disorders
This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or...
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7423135 |
β-actin and rpS21 promoters and uses thereof
The invention relates to isolation of novel β-actin and ribosomal protein S21 (rpS21) promoters and uses thereof. In particular, this invention features nucleotide sequences for rodent β-actin...
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7422900 |
System and method for forming a connective tissue construct
A system and method are provided for forming a connective tissue construct, such as a tendon construct, in vitro. A substrate is provided with at least two anchors secured thereto in spaced...
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7422897 |
Culture of undifferentiated chicken cells
A method of producing undifferentiated avian cells expressing an embryonic stem cell phenotype. The method includes the steps of collecting avian gonadal cells including primordial germ cells from...
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7422898 |
Nucleic acid encoding monkey Gpr103
There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for...
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7423142 |
Compositions and methods for inhibiting expression of anti-apoptotic genes
The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising an antisense strand having a nucleotide sequence...
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7422893 |
Apparatus for growing cells under variable hydrostatic pressures
An apparatus for growing cells in a 2-D cell cassette having a matrix for cell growth under pressure comprising two side assemblies which include a frame with a rigid support that fits over the 2-D...
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7419800 |
Estrogen receptor genes
The present invention relates to an estrogen receptor gene, characterized by comprising a nucleotide sequence coding for any one of the following amino acid sequences:
(a) the amino acid...
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7419803 |
Nucleic acids encoding human coagulation Factor VII polypeptides
The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as polynucleotide constructs encoding such variants, vectors and host cells...
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7419805 |
Polynucleotides encoding S99T interferon gamma polypeptide variants and means of expression
The present invention relates to novel interferon gamma polypeptide variants having interferon gamma (IFNG) activity, methods for their preparation, pharmaceutical compositions comprising the...
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7419804 |
CASH (Caspase Homologue) with death effector domain, modulators of the function of FAS
Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as...
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7419829 |
Vector system
The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can...
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7419827 |
Cell lines
Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the...
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7419950 |
Methods of inhibiting ectopic calcification
The invention provides a method of inhibiting ectopic calcification in an individual. The method consists of administering to the individual a therapeutically effective amount of osteopontin or a...
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7419779 |
Modulators of angiogenesis
The present invention relates to regulation of angiogenesis. More particularly, the present invention is directed to nucleic acids encoding “angiogenesis regulatory proteins and nucleic acids”...
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7419826 |
Human schwannoma cell line
In a preferred embodiment, the present invention relates to a Schwannoma cell line derived from a Schwann tumor in a patient with Neurofibromatosis type 2 (NF2) and immortalized with HPV E6-E7...
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7419825 |
Isolation of neural stem cells using gangliosides and other surface markers
During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number...
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7420038 |
Compositions for controlling hair growth
FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1...
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7416885 |
Proliferated cell lines and uses thereof
The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines...
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7416849 |
HBM variants that modulate bone mass and lipid levels
The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also...
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7416870 |
Methods of directing C-O bond formation utilizing a type II polyketide synthase system
The present invention provides methods of modifying a biological molecule by C—O bond formation utilizing a type II polyketide synthase (PKS) system from the nonactin biosynthesis gene cluster....
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7416886 |
Porcine uroplakin II promoter and the production method of useful proteins using said promoter
The present invention relates to a porcine uroplakin II gene promoter, an expression vector containing the promoter, and a method for producing useful proteins using the vector. The promoter of the...
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7416889 |
Methods and compositions for repairing cartilage
Disclosed is a method for inducing repair of a joint tissue in a mammal includes the steps of removing a sample of synovial membrane from a joint of the mammal, isolating type B synoviocytes from...
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7417137 |
Non-squamous epithelium-specific transcription
The invention relates to the field of cancer therapy and diagnosis, in particular of carcinomas. The invention provides an isolated and/or recombinant nucleic acid comprising a tissue specific...
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7416875 |
Cytotoxic ribonuclease variants
This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the...
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7416848 |
DNA encoding SNORF25 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors,...
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7416887 |
Methods for use of MPL ligands with primitive human stem cells
Myeloproliferative leukemia receptor (mpl) ligands, such as thrombopoietin, act on a primitive subpopulation of human stem cells having the characteristics of self-renewal and ability to give rise...
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7413875 |
ESTs and encoded human proteins
The sequences of 5′ ESTs and consensus contigated 5′ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs and consensus contigated 5′ESTs may be to obtain cDNAs and...
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7413901 |
Method of forming vertebrate pancreas in vitro
The present invention provides a pancreas induced in vitro that is useful for developmental engineering and organ engineering, and a method wherein a pancreas induced in vitro which contributes to...
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7413903 |
Methods of regulating differentiation in stem cells
The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and...
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7413896 |
Method for improving protein production
The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a...
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7413898 |
Cells and methods for estimation of effects on neurological dysfunction
The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed...
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7413895 |
DNA encoding neutral amino acid transporter
A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a...
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7413897 |
Primitive and proximal hepatic stem cells
Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for...
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7413900 |
Immortalized fibroblasts
Aspects of the invention provide an immortalized fibroblast cell line capable of the growth and maintenance of human embryonic stem cells. An immortalized fibroblast cell line derived from an early...
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7414169 |
Therapeutic and diagnostic tools for impaired glucose tolerance conditions
Disclosed herein are novel genes and methods for the screening of therapeutics useful for treating impaired glucose tolerance conditions, as well as diagnostics and therapeutic compositions for...
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7410778 |
Estrogen receptor genes and utilization thereof
A gene coding for any of the following estrogen receptors (a) to (c): (a) an estrogen receptor comprising the amino acid sequence represented by amino acid numbers 153 to 602 in the amino acid...
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7410797 |
Meningeal-derived stem cells
Stem cell lines derived from meningeal tissue such as dura mater, pia mater, or arachnoid mater, are disclosed. In various embodiments, the stem cell lines include greater than 80%, greater than...
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7410638 |
Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals
The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group...
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