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7604959 |
Cell-based assays employing voltage and calcium dyes
Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in...
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7604969 |
Mutant glucose dehydrogenase
A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having...
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7605245 |
PUFA polyketide synthase systems and uses thereof
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated...
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7605115 |
Subtilisin variants
New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues,...
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7604803 |
Method to enhance an immune response of nucleic acid vaccination
A composition for the co-delivery to a cell of a nucleic acid and an assistor protein, comprising vesicles, nucleic acid and protein, wherein the nucleic acid operatively encodes an antigenic...
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7604808 |
Circovirus sequences associated with piglet weight loss disease (PWD)
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and...
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7604976 |
Sequence-determined DNA fragments encoding glutamine amidotransferase proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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RE40940 |
Yeast promoter and use thereof
The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity. to expression vectors comprising these sequences and to their use for the...
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7605247 |
Nucleic acid molecules encoding a wheat sucrose transporter
This invention relates to an isolated nucleic acid fragment encoding a sucrose transport protein. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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7604974 |
Bacillus 029cel cellulase
The present invention provides a novel cellulase nucleic acid sequence, designated 029cel, and the corresponding 029cel amino acid sequence. The invention also provides expression vectors and host...
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7604971 |
Sequence-determined DNA fragments encoding UBIE/COQ5 methyltransferase family proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
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7604980 |
Protein expression system
The present invention relates to proteomics, especially downstream processing of proteins. The present invention also relates to novel expression cassettes having unique cleavage sites for...
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7605303 |
Stress-responsive root-specific genes
The present inventors succeeded in cloning a rice stress-responsive gene, RSI1. They discovered that stress-responsive plants can be generated by using the isolated gene, or genes functionally...
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7604973 |
DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active Pasteurella multocida hyaluronate synthase (PmHAS), and to the use of this...
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7605000 |
Cold shock inducible expression and production of heterologous polypeptides
The present invention relates to a DNA molecule or vector and a host cell containing this DNA molecule or vector which can be used to produce a heterologous polypeptide under conditions that elicit...
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7604958 |
Synthetic mammalian α-N-acetylglucosaminidase and genetic sequences encoding same
The present invention relates generally to mammalian α-N-acetyglucosaminidase and to genetic sequences encoding same and to their use in the investigation, diagnosis and treatment of subjects...
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7604960 |
Transient protein expression methods
Described is a method for producing a protein of interest, the method comprising: a) providing a recombinant adenoviral vector comprising nucleic acid encoding the protein of interest under control...
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7601889 |
Elongase gene and production of Δ9-polyunsaturated fatty acids
This invention relates to a new elongase gene having the sequence SEQ ID NO: 1 or its derivatives, to a gene construct comprising this sequence or its derivatives and to its use. The inventive...
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7601812 |
Immunomodulating agents from parasitic worms and method for isolation thereof
The invention relates to active agents from parasitic worms, in particular Schistosoma mansoni , which induce a T-helper type 2 response (Th2 immune response).
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7601531 |
Chlamydia pneumoniae polynucleotides and uses thereof
The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae , such as cellular envelope polypeptides, which are secreted or...
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7601514 |
Nucleic acid encoding PRO10268 polypeptides
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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7601891 |
Optimizing glycan processing plants
The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus 5 containing...
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7601799 |
Methods and means to promote gut absorption
The present invention relates to epidermal growth factor (EGF) producing lactic acid bacteria and their use to increase intestinal villi height and to promote gut absorption. In particular, the...
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7601687 |
Mechanism for identifying drugs for the treatment of type II diabetes
Insulin resistance is a central feature of type II diabetes and other diseases, and may affect every tissue of the body, including the pancreatic beta cell. Insulin signaling is mediated by a...
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7601536 |
Plant-specific genetic elements and transfer cassettes for plant transformation
The present invention provides nucleic acid molecules and sequences, particularly those identified and obtained from plants, that are useful for transferring and integrating one polynucleotide into...
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7601807 |
Protease, DNA encoding the same, and method for manufacturing protease
A protease having the following characteristics:
(i) a molecular weight of 21,000±1,000 (by SDS-PAGE) and (ii) specific protease activity cutting the Gly-Phe site of a peptide or protein...
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7601522 |
PUFA polyketide synthase systems and uses thereof
Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana , and biologically...
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7601887 |
Banana resistance genes and uses thereof
The present invention relates to two banana resistant genes, RGA5 and RGA2, and methods of producing transgenic plants having resistance to fusarium by transforming the plants with RGA5 or RGA2...
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7601529 |
Pectate lyase variants
The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of...
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7601825 |
Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer
A novel gene (designated 121P1F1) and its encoded protein, and variants thereof, are described wherein 121P1F1 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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7601885 |
Transgenic plant comprising a cassava vein mosaic virus promoter and a heterologous nucleic acid sequence
The invention relates to compositions and methods useful for the production of transgenic plants. In particular, the invention relates to cassava vein mosaic virus (CsVMV) promoter sequences and...
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7601696 |
Oct-1 as an oncoprotein and use of nucleic acid inhibitors of Oct-1 for cancer treatment
Oct-1 is shown to be an oncoprotein because of its known role as an activator of the histone H2B gene and the importance of this gene during DNA synthesis. To determine the role of Oct-1 as an...
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7601890 |
Plant sterol acyltransferases
The present invention is directed to lecithin:cholesterol acyltransferase-like polypeptides (LCAT) and acyl CoA:cholesterol acyltransferases-like polypeptides (ACAT). The invention provides...
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7601516 |
Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
The invention provides novel heterodimeric fusion proteins comprising a first polypeptide including an alpha subunit of FSH (αFSH) linked directly or indirectly to a binding partner of neonatal Fc...
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7601826 |
Genes and polypeptides relating to human pancreatic cancers
The present application provides novel human genes C1958V1 or C1958V2 whose expression is markedly elevated in pancreatic cancers compared to corresponding non-cancerous tissues. The genes and...
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7601345 |
Lentivirus vectors for gene transfer to alveolar epithelial cells
The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical...
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7601518 |
Secretion of neublastin
The present invention concerns improved methods and compositions for producing a Neublastin polypeptide as well as local delivery of Neublastin to specific regions of the nervous system including...
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7598077 |
Compositions and methods for enhancing differential expression
Artificial TERT promoters, which are useful for enhancing the differential expression of operably linked heterologous nucleic acid sequences, such as polypeptide cytotoxins, are disclosed herein....
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7597889 |
Binding molecules derived from immunoglobulins which do not trigger complement mediated lysis
Disclosed are binding molecules which are recombinant polypeptides containing: (i) a binding domain capable of binding a target molecule, and (ii) an effector domain having an amino acid sequence...
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7598058 |
Nucleic acids encoding IL13 mutants
This invention provides nucleic acid molecules encoding mutant human interleukin 13 molecules showing varying specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13...
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7597905 |
Hollow protein nano-particles and method of introducing substances into cells
As a versatile means for specifically and safely transporting and transferring substances (genes, proteins, compounds, etc.) into target cells and tissues, hollow nano particles comprising a...
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7598084 |
Modifications of plant traits using cyclin A
Novel plant polysaccharide synthesis genes and polypeptides encoded by such genes are provided. These genes and polynucleotide sequences are useful regulating polysaccharide synthesis and plant...
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RE40930 |
Porcine adenovirus type 3 genome
The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells...
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7598059 |
Neublastin expression constructs
A method of producing a secreted neublastin polypeptide using a heterologous signal sequence is disclosed. The secreted neublastin does not contain a neublastin pro sequence.
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7598364 |
Plasmid encoding canine BMP-7
The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also...
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7598226 |
Compositions and methods for the therapy and diagnosis of breast cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic...
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7598067 |
PDEs and uses thereof
The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention...
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7598078 |
Settings for recombinant adenoviral-based vaccines
The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy....
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7598065 |
S-adenosylmethionine-6-N-lysine-methyltransferase from Neurospora crassa, a gene encoding the same, a vector and host cell containing the same, and method for producing trimethyllysine using the host cell
Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neurospora crassa , a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a...
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7598062 |
Process for the production of L-amino acids using strains of the family enterobacteriaceae that contain an attenuated fruR gene
A process for the production of L-amino acids, in particular L-threonine, in which the following steps are carried out:
(a) fermentation of the microorganisms of the family...
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