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7521217 |
Carbonic anhydrase having increased stability under high temperature conditions
The present invention relates to polynucleotide and polypeptide sequences of carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic...
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7521537 |
Cytokine receptor zcytor17
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within...
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7521235 |
Unique novel Bacillus thuringiensis gene with Lepidopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
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7521594 |
CPC214 gene promoter sequences and methods of use
The present invention relates to polynucleotide molecules for regulating gene expression in plants. In particular, the invention relates to CPC214 promoters isolated from Zea mays that are useful...
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7521211 |
IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof
A chimeric protein comprising an IGF1 and an IGF2 component and optionally a fusion component (F) and/or a signal sequence, exhibiting improved activity relative to the native IGF1 or IGF2...
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7521228 |
Spider silk protein encoding nucleic acids, polypeptides, antibodies and methods of use thereof
Spider silk protein encoding nucleic acids, polypeptides and antibodies immunologically specific therefore are disclosed. Methods of use thereof are also provided.
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7521207 |
Rhesus monkey Nur77
The Macaca mulatta (rhesus monkey) Nur77 (rhNur77) nuclear receptor and the nucleic acid encoding the rhNur77 nuclear receptor are described. Further described are methods for identifying...
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7521182 |
Selection system containing non-antibiotic resistance selection marker
A selection system free of antibiotic resistance genes, which is based on the use of an araD gene as a selection marker carried on a vector which is inserted in a bacterial strain deficient of the...
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7521591 |
Transgenic chickens that lay eggs containing exogenous proteins
This invention provides eggs which contain exogenous proteins. The invention further provides transgenic chickens which express exogenous sequences in their oviducts, and vectors and methods for...
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7521216 |
Nitrilases and methods for making and using them
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
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7521208 |
Vectors encoding interleukin-17 receptor homologue
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
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7521205 |
Genes and polypeptides relating to prostate cancers
The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as...
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7521431 |
Compositions and methods for siRNA inhibition of HIF-1 alpha
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is...
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7521230 |
Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof
The present invention provides materials and methods for treating Alzheimer's disease and other tau related neurodegenerative disorders. A tau kinase, Brain Derived Tau Kinase (BDTK) is provided....
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7521215 |
Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described....
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7521222 |
Farnesyl dibenzodiazepinone and processes for its production
This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of...
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7521595 |
Repressor-mediated regulation system for control of gene expression in plants
The invention provides a method for selectively controlling the transcription of a gene of interest, comprising producing one or more plants that express either a first, a second, or both the first...
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7521593 |
Barley with altered branching enzyme activity and starch and starch containing products with an increased amylose content
Barley having a reduced level of SBEIIa activity produces grain having a high relative amylose content. The barley might additionally have reduced levels of SBEIIb activity. The barley grain of...
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7517684 |
Nucleic acid and amino acid sequences relating to Pseudomonas aeruginosa for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against...
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7518034 |
Compositions and methods for the modification of gene expression
Novel isolated plant polynucleotide promoter sequences are provided, together with genetic constructs comprising such polynucleotides. Methods for using such constructs in modulating the...
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7517670 |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins...
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7517971 |
Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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7517961 |
Homogeneous preparations of IL-28 and IL-29
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7517531 |
Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3′-UTR of dengue types 1,2,3, and 4, or antigenic chimeric dengue viruses 1,2,3, and 4
The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (Δ30) in the 3′-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4,...
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7517866 |
LIM mineralization protein splice variants
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide...
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7517972 |
Nucleic acid sequences encoding a bitter taste receptor, T2R76
Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods...
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7517689 |
Methods and compositions for regulating gene expression in plant cells
Novel chimeric plant promoter sequences are provided, together with plant gene expression cassettes comprising such sequences. Novel transcription factors are provided, together with nucleic acid...
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7517676 |
Human cyclooxygenase-3 enzyme and uses thereof
The present invention provides nucleic acid and polypeptide sequences describing a neve isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase 3. The isolated nucleic acid or...
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7517677 |
Recombinant D-amino acid oxidases
The present invention discloses two novel D-amino acid oxidases, whose activities of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid are at least 25% higher than that of...
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7517672 |
Nucleic acids encoding mammalian T-type calcium channels
Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the α 1G , α 1H and α 1I subunits are...
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7517685 |
Gene promoters
The invention is directed to a method for obtaining a promoter from an organism using a proteomics approach, isolated promoters from fungal species and uses of the isolated promoters.
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7517668 |
Process for the production of protein products in aspergillus
A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding...
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7517973 |
Astrocyte modulated genes and uses thereof
The present invention relates to Astrocyte Enhanced Genes (AEGs), the expression of which is upregulated in human astrocytes grown in primary cell cultures that are exposed to either the human...
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7517643 |
Compounds displayed on replicable genetic packages and methods of using same
Replicable genetic packages and collections thereof that display various compounds are provided. In some instances, the replicable genetic packages include nucleic acid tags that serve to record a...
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7517860 |
Inhibition of lipoprotein secretion
It has been discovered that the low density lipoprotein receptor (LDLR) degrades the lipoprotein apoB. Based on this observation, an artificial fusion protein has been designed containing an LDL...
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7517679 |
Recombinant watermelon (Citrullus lanatus) hydroperoxide lyase and uses thereof
Recombinant watermelon ( Citrullus lanatus )hydroperoxide lyase protein, DNA sequences encoding the protein, vectors containing the DNA sequences and hosts containing the vectors are provided,...
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7518035 |
Promoter molecules for use in plants
The present invention provides nucleic acid molecules isolated from Zea mays and Oryza sativa and useful for expressing transgenes in plants. The present invention also provides expression...
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7517683 |
HIV-like particles and the use thereof
Disclosed are alphavirus-based expression vectors expressing env, gag, pro, and/or pol genes of HIV-1, their transcripts, and transformed host cells. The present invention describes the expression...
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7517949 |
Livin-derived peptides, compositions and uses thereof
The present invention relates to livin-derived peptides with pro-apoptotic activity. More specifically, the present invention provides peptides p30-Livin α and p28-Livin β, derived from Livin α...
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7514238 |
Growth factor homolog zvegf4
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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7514239 |
Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods...
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7514536 |
Homogeneous preparations of IL-28A cysteine mutants
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
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7514252 |
Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression
The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populations of target cells. The viral mutants of the...
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7514542 |
Collagen-like protein CLAC, precursor thereof and genes encoding the same
A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific...
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7514222 |
Site selective acylation
Disclosed are novel polypeptides of a four helix bundle formed of two dimerized helix-loop-helix motifs, wherein either both have a sequence according to SEQ. ID No. 1, SEQ. ID No. 2, SEQ. ID No....
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7514253 |
URA5 gene and methods for stable genetic integration in yeast
A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous...
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7514403 |
Process for the stabilization of proteins in an aqueous solution comprising cysteine in a concentration between 150 and 220mM
The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein....
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7514548 |
Methods of inhibiting COX-2
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for COX-2, and further provides methods of reducing expression of COX-2 in cells (e.g., cancer cells).
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7514416 |
Interferon alpha and antisense K-ras RNA combination gene therapy
Methods of suppressing growth of pancreatic tumors or cancer cells having a K-ras gene point mutation in a mammal, comprising: administering therapeutically effective amounts of adenoviral vector...
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7514537 |
Chimeric immunoreceptor useful in treating human gliomas
The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region...
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