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8183012 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
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8183023 |
Thermus egertssonii DNA polymerases
The present invention relates to a thermophilic polymerase, wherein the DNA polymerase has an in-vitro primer extension rate that is >35 bases/second and faster relative to the primer extension...
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8183436 |
Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants.
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8183038 |
Composition comprising recombinant nucleic acid encoding Sox2, Oct-4, Nanog and Lin28
The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The...
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8183352 |
Attenuated vif DNA immunization cassettes for genetic vaccines
The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted...
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8183014 |
High affinity antibodies to human IL-6 receptor
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In...
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8183016 |
Synthesis method of aromatic amino acids
A method for synthesizing aromatic amino acids according to one aspect of the present invention includes processes of: (a) of preparing a thermostable a Thermus thermophilus aspartate...
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8183037 |
Methods of genetically encoding unnatural amino acids in eukaryotic cells using orthogonal tRNA/synthetase pairs
This disclosure concerns compositions and methods for genetically encoding and expressing prokaryotic tRNAs in eukaryotic cells. In some embodiments, the disclosure concerns methods and...
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8183432 |
Plant having reduced lignin and cellulose contents without reducing glucan content, method of producing the same and utilization thereof
By inhibiting the function of a transcription factor that promotes transcription of a gene associated with the amounts of lignin and cellulose, a plant in which the amounts of lignin and cellulose...
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8183220 |
Double-effective vaccine vector against foot-and-mouth disease virus (FMDV), methods of preparing and using the same
A double-effective vaccine vector against foot-and-mouth disease virus having a bicistronic expression vector sequence, the bicistronic expression vector sequence is an antisense gene sequence...
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8183356 |
Lentiviral packaging constructs
The present invention provides novel lentiviral packaging constructs that are useful for the establishment of stable packaging cell lines and producer cell lines. In particular, the present...
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8182811 |
Antibodies to CXCL13
The present invention relates to binding members, especially antibody molecules, for CXCL13. The binding members are useful for the treatment of disorders associated with CXCL13, including...
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8183036 |
Luciferase biosensor
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
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8183433 |
Method of controlling gene expression in plants or plant cells
A method of controlling a genetically-modified plant or plant cells, said method comprising the following steps: (a) providing a genetically-modified plant or plant cells, said plant or plant cells...
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8183029 |
Replicable expression vector for bacterial expression of a mammalian polypeptide
Refractile particles containing a heterologous polypeptide as an insoluble aggregate are recovered from bacterial periplasm. The process involves culturing bacterial cells so as to express nucleic...
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8183221 |
Suppression of SCN9A gene expression and/or function for the treatment of pain
Disclosed herein are methods, sequences and nucleic acid molecules used to treat pain. Specifically, the methods and sequences include locally administering molecules that suppress the expression...
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8183358 |
Puumala virus full-length M segment-based DNA vaccines
The invention contemplates a new synthetic, codon-optimized Puumala virus (PUUV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The PUUV ORF was...
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8182987 |
Probe for visualizing cell-cycle
An object of an embodiment of the present invention is to provide a method with which it is possible to easily distinguish a proliferation phase of a cell cycle from a resting phase thereof in real...
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8178338 |
Inducible expression vectors and methods of use thereof
The present invention provides nucleic acids that include a promoter that is inducible by a transcriptional activator protein; and a nucleotide sequence that encodes the transcriptional activator...
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8178328 |
Fermentive production of four carbon alcohols
Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium...
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8178346 |
GPCR expression vector
The present invention provides expression vectors that facilitate high levels of expression of GPCR proteins. Encompassed by the invention are methods and compositions for recombinant cell lines...
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8178335 |
Intracellular production of a nuclease
Methods and compositions are provided that relate to obtaining a recombinant DNA and RNA cleaving nuclease. This involves the over-expression of a fusion protein between maltose-binding protein and...
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8178316 |
Evaluating proteins
The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence...
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8178334 |
Variant form of urate oxidase and use thereof
The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for...
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8178333 |
Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of...
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8178301 |
Mutant SepRS, and method for site-specific introduction of phosphoserine into protein using the same
A mutant SepRS which is suitable for a site-specific introduction of phosphoserine into a protein is prepared by analyzing the structure and functions of a phosphoseryl-tRNA synthetase (SepRS)...
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8178320 |
Artificial antibody library with super-repertory
An artificial antibody library with a super-repertory (1011 or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or...
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8178751 |
Use of stomatin (STM1) polynucleotides for achieving a pathogen resistance in plants
The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one stomatin polypeptide or a functional equivalent thereof. The...
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8178319 |
Peptides and uses thereof
The present invention relates to monovalent fucose-binding peptides. The peptides may be recombinantly produced or chemically synthesized. Preferably the peptides are derived from a lectin, in...
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8178337 |
Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate...
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8178750 |
Nucleotide sequences mediating male fertility and method of using same
Nucleotide sequences mediating male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The...
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8173871 |
Bacterial proteins with pesticidal activity
Provided are pesticidal, particularly insecticidal, proteins which resemble S- layer proteins, as well as variants or mutants thereof, and DNAs encoding them. Further provided are methods and means...
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8173794 |
Compositions and methods for enhancing disease resistance in plants
Compositions and methods for enhancing disease resistance in plants by modulating levels or activities of GmUBox1 polynucleotides and polypeptides are provided. Transformed plants, plant cells,...
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8173396 |
Methods for reducing gluconoylation of proteins
The present invention relates to methods of preventing glyconoylation of polypeptides produced in micororganisms.
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8173869 |
Plants expressing environmental stress tolerances having petunia CBF genes therein
The present invention provides a method of controlling a plant's tolerance to environmental stress and to a transgenic plant having the desired characteristics.
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8173617 |
RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma
RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
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8173410 |
Isoprene synthase variants for improved microbial production of isoprene
The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention...
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8173402 |
Modified yeasts and uses thereof, in particular for producing steroid derivatives
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More...
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8173409 |
Acid fungal proteases
The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic...
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8173397 |
Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine protease of the complement cascade obtainable by expression in a bacterial host, wherein said serine...
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8173790 |
Insect desiccation resistance genes and uses thereof
An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof cDNA libraries were produced from Polypedilum vanderplanki...
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8173408 |
Recombinant carrier molecule for expression, delivery and purification of target polypeptides
Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides)...
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8173395 |
Mussel bioadhesive
The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a...
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8173422 |
Method for improving protein production
The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a...
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8173863 |
Sucrose biosensors and methods of using the same
Sucrose biosensors are disclosed, which comprise a sucrose binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy...
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8173782 |
Fusion protein comprising growth hormone and growth hormone receptor
Agents which bind to cell surface receptors; methods to manufacture such agents; therapeutic compositions comprising such agents; and screening methods to identify novel agents.
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8173787 |
Plant wall degradative compounds and systems
The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.
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8173786 |
Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins...
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8173866 |
Modulation of plant xylan synthases
The present invention provides compositions and methods for manipulation of plant arabinoxylose and plant xylan synthases. Compositions include novel nucleotide sequences encoding xylan synthases...
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8173791 |
Luciferases and methods for making and using the same
Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type...
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