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9040020 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
9040265 Oxidoreductases for the stereoselective reduction of keto compounds  
The invention relates to a process for the enantioselective enzymatic reduction of a keto compound to the corresponding chiral hydroxy compound, wherein the keto compound is reduced with an...
9040262 Biocatalysts for ezetimibe synthesis  
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
9040776 Genes regulating plant branching, promotors, genetic constructs containing same and uses thereof  
The invention relates to genes coding for TCP family transcription factors and having a biological role in the development of axillary buds and branch growth. Furthermore, the invention relates to...
9040294 Plasmid vector, method for detecting gene promoter activity, and assay kit  
According to one embodiment, a first gene encodes a reporter protein. The first gene is disposed at the downstream of the gene promoter. A second gene is disposed at the downstream of the gene...
9040676 Vigilant cells  
The invention concerns a system for modulating tissue physiology, for example, to prevent or reverse tissue damage caused by disease. The system utilizes vigilant cells that include stable vectors...
9040053 Her2 DNA vaccine as adjunct treatment for cancers in companion animals  
The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as...
9040774 Recombinant DNA constructs encoding ribonuclease cleavage blockers and methods for modulating expression of a target gene  
This invention provides recombinant DNA constructs and methods for manipulating expression of a target gene that is regulated by a small RNA, by interfering with the binding of the small RNA to...
9034611 Increasing NADPH availability for methionine production  
The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred...
9034608 Polypeptides with permease activity  
The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO:...
9034629 Recombinant synthesis of medium chain-length alkanes  
The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently produce alkanes, and in particular the use of such...
9034599 Polynucleotides encoding monomeric variants of the tetrameric eqFP611  
DNA encoding a monomeric variant of red fluorescent protein eqFP611 comprising an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 3 and SEQ ID No. 5. DNA...
9034641 Translation-coupling systems  
Disclosed are systems and methods for coupling translation of a target gene to a detectable response gene. A version of the invention includes a translation-coupling cassette. The...
9034643 Connective tissue growth factor antibodies  
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention...
9034600 DNA encoding antibody molecules which bind IL-17A and IL-17F  
The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said...
9034642 Genes of an otitis media isolate of nontypeable Haemophilus influenzae  
The invention relates to the polynucleotide sequence of a nontypeable strain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also...
9034836 Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders  
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is...
9034577 Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell  
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be...
9034344 Chimeric adenoviruses for use in cancer treatment  
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of...
9034313 Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same  
Nucleic acid molecules comprising a nucleotide sequence encoding RANTES and fragments and variants thereof are disclosed. Additionally, nucleic acid molecules and compositions comprising the...
9029114 Type II restriction-modification system methylation subunit of Alicyclobacillus acidocaldarius  
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering...
9029142 Recombinant vectors and hosts comprising human glucokinase encoding gene  
Gene encoding human glucokinase mutant is provided. The gene has the nucleotide sequence chosen from the nucleotide sequence listed as SEQ ID NO:2 and the nucleotide sequence wherein the ORF...
9029117 Modified rodent parvovirus capable of propagating and spreading through human gliomas  
Described are (a) parvovirus variants capable of propagating and spreading through human tumor cells which is obtainable by serially passaging a rodent parvovirus as starting strain in...
9029520 B7-1-PE40KDEL exotoxin fusion gene-based DNA vaccine and the use thereof  
The present invention relates to the fields of immunology and molecular biology and related to a B7-1-PE40KDEL exotoxin fusion gene-based DNA vaccine and the use thereof. Specifically, the DNA...
9029112 Ketoreductase-mediated stereoselective route to alpha chloroalcohols  
The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding...
9029087 Compositions, methods and related uses for cleaving modified DNA  
Compositions, methods and related uses are provided relating to cleaving modified DNA. For example, a set of DNA fragments obtainable by enzymatic cleavage of a large DNA is described where at...
9029107 Hydrolase protein  
It is an object of the present invention to provide a novel hydrolase, which is used when dialkyl 2-vinylcyclopropane-1,1-dicarboxylate is hydrolyzed with an enzyme, so as to efficiently obtain...
9029136 Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides  
The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or...
9029134 Linear vectors, host cells and cloning methods  
Linear vectors derived from bacteriophage of E. coli and host cells suitable for cloning are provided. The linear vectors include a left arm comprising a left telomere and a first selectable...
9029104 Method for producing an L-amino acid belonging to the glutamate family, using a coryneform bacterium  
The present invention provides a method for producing an L-amino acid belonging to the glutamate family, using a coryneform bacterium which has been modified so that expression of one or more...
9029097 Biosensors for monitoring receptor-mediated G-protein activation  
The present invention relates to novel biosensors that are based on bioluminescence resonance energy transfer (BRET). These biosensors may be used to monitor rapid interaction and conformational...
9029135 Kanamycin antisense nucleic acid for the treatment of cancer  
The invention relates to a nucleic acid comprising a sequence complementary to a fragment of the sequence coding for the kanamycin resistance protein. This nucleic acid is useful as a DNA vaccine...
9029122 Long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-CoA lysophospholipid acyltransferases  
Methods for increasing C18 to C20 elongation conversion efficiency and/or Δ4 desaturation conversion efficiency in long-chain polyunsaturated fatty acid [“LC-PUFA”]-producing recombinant...
9029137 ACP promoter  
Isolated nucleotide sequences encoding a promoter of the Acyl Carrier Protein (“ACP”).
9029508 Dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
9028813 Methods of degrading or inhibiting botulinum neurotoxin using designer ubiquitin ligases  
The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes a toxin binding domain that is specific for a toxin active fragment, wherein the toxin active...
9029638 Plants having altered growth and/or development resulted from modulated expression of ubiquitin-specific proteases and a method for making the same  
The present invention relates generally to the field of molecular biology and concerns a method for altering various aspects of plant growth and/or development by modulating expression in a plant...
9029106 Transaminase polypeptides  
The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides...
9029116 Glucoamylase variants  
The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to...
9029133 Recombinant virus comprising an intact tumor-therapeutic antibody with human constant regions and the use thereof  
The present invention provides a recombinant virus containing a nucleotide sequence encoding a tumor-therapeutic full-length antibody with human constant regions, and uses thereof. After a...
9029523 Promoter, promoter control elements, and combinations, and uses thereof  
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in...
9024111 Methods and materials for deconstruction of biomass for biofuels production  
The present invention relates to nucleic acids, peptides, vectors, cells, and plants useful in the production of biofuels. In certain embodiments, the invention relates to nucleic acid sequences...
9023620 Method of providing color clarification of laundry  
The present invention relates to enzyme preparations consisting essentially of an enzyme which has cellulytic activity, which perform very well in industrial applications such as laundry...
9024114 Soybean event 127 and methods related thereto  
Compositions and methods related to transgenic AHAS-inhibiting herbicide resistant soybean plants are provided. Event 127 soybean plants having a mutated AHAS coding sequence which imparts...
9023629 Transformed cells that ferment-pentose sugars and methods of their use  
The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence...
9023637 Enhanced citric acid production in Aspergillus with inactivated asparagine-linked glycosylation protein 3 (Alg3), and/or increased LaeA expression  
Provided herein are fungi, such as Aspergillus niger, having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of...
9023645 Isolated in vitro cell population comprising primate pluripotent stem cells containing a nucleic acid construct and differentiated progeny of the pluripotent stem cells  
This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector...
9024141 Maize ERECTA genes for improving plant growth, transpiration, efficiency and drought tolerance in crop plants  
The present invention provides polynucleotides and related polypeptides of the ZmERECTA gene family. The invention provides nucleic acid sequences for the Zm ERECTA genes. ZmERECTA is responsible...
9023636 Microorganisms and methods for the biosynthesis of propylene  
The invention provides non-naturally occurring microbial organisms having a propylene pathway. The invention additionally provides methods of using such organisms to produce propylene.
9024001 Alphavirus replicon packaging constructs  
Provided herein are modified, functional 5′ amplification sequences that are defective packaging signals. Also provided are compositions and methods comprising these modified 5′ amplification...