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7618794 |
Method for controlling environmental allergens
There is provided a method for controlling environmental allergens in articles including toys, bedding, clothing and the like that tend to collect house dust mite and other allergens. One method...
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7601512 |
Methods for identifying inhibitors of the 20S and 26S proteasome
The present invention relates to methods for identifying fungicides and also inhibitors of the 20S and 26S proteasomes, to methods for isolating 20S proteasomes, to the use of 20S proteasomes for...
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7601511 |
Biotin-facilitated transport in gram negative bacteria
Biotinylation of compounds such as peptides and peptidomimetics facilitates illicit transport of the compounds into Gram negative bacteria.
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7592154 |
Modulating SOS response induction by antimicrobial agents
Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a...
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7588912 |
Compositions and methods for preventing and treating anthrax diseases
Compounds, methods for identifying compounds and methods for using compounds which modulate interaction of lethal factor and anthrolysin O in the treatment and prevention of anthrax diseases are...
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7575889 |
Compound combinations for inhibiting cell division and methods for their identification and use
The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect...
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7575868 |
Methods for assessing efficacy of chemotherapeutic agents
Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the...
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7566550 |
Screening method for developing drugs against pathogenic microbes having two-component system
The present invention relates to a package of screening methods for developing drugs against pathogenic microbes having two-component system of DevR-DevS and/or DevR-Rv2027c and its homologues,...
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7537913 |
High throughput assay for cancer cell growth inhibition
A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media...
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7537910 |
Lactamase amplification substrate
An amplifiable β-lactamase substrate is provided comprising an enzyme donor fragment of β-galactosidase linked to form a ring to a β-lactam ring that is a substrate for lactamase and upon...
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7534584 |
Modular compositing-multiple lot screening protocols for detection of pathogens, microbial contaminants and/or constituents
Particular aspects provide a method of sampling, testing and validating test lots (e.g., single-unit production lots), comprising: assembling a plurality of product portions from each of a...
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7517666 |
Methods of inhibiting Helicobacter pylori
This application relates to methods of screening molecules capable of inhibiting the survival of Helicobacter pylori in vivo by specifically inhibiting the activity of UreI, to the molecules...
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7504380 |
Antimicrobial peptide isolated from halocynthia aurantium
The present invention relates to an antimicrobial peptide isolated from Halocynthia aurantium , more particularly, to an antimicrobial peptide isolated from the body fluid of Halocynthia...
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7504205 |
Uncharacterized ORF3 in SARS-coronavirus is a cyclic-AMP-dependent kinase and a target for SARS therapy
The present invention relates to novel methods for identifying antiviral agents which selectively interfere with viral proteins that cause the unique infectivity activity of the SARS-coronavirus in...
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7501260 |
Methods for determining efficacy of chemotherapeutic agents for a patient prior to treatment
An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested,...
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7497996 |
Liquid delivery apparatus and liquid delivery method
A liquid delivery apparatus 1 has a rotary substrate 2 . The substrate 2 formed with a fluid passage 8 A for communicating a supply chamber 6 A and target chamber 7 A. An inlet end portion ...
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7491708 |
Modified pectin
A modified pectin consists essentially of neutral sugar sequences with a low degree of branching capable of preventing tumor cell migration and cell to cell and cell to substratum adhesion.
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7465559 |
Method for calibrating antibiotic disk diffusion testing of microorganisms
A method for calibrating antimicrobic susceptibility testings of microorganisms comprises the steps of creating a histogram with a high response side and a low response side of isolates from a...
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7462693 |
Variants of the Gamma Chain of AMPX, DNA sequences encoding the same, and uses thereof
Variants of the gamma chain of vertebrate AMP-activated kinase (AMPK), as well as nucleic acid sequences encoding the variants and use thereof for the diagnosis or treatment of dysfunction of...
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7462472 |
Methods and compositions relating to anthrax pathogenesis
The structures of Edema Factor alone and Edema Factor bound to calmodulin without substrate has been crystallized and its structure determined by x-ray crystallography. Based upon these crystal...
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7462464 |
Method for the detection of antimicrobial residues in food and bodily fluid samples
The present invention relates to a novel method for the rapid detection of the presence or absence of antimicrobial residues in products preferably food products.
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7459303 |
Impedance based apparatuses and methods for analyzing cells and particles
A device for monitoring the migration or invasion of a biological particle such as a cell is disclosed. The device includes an upper chamber adapted to receive and retain a cell sample, a lower...
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7435538 |
High throughput screening method of drug for physiologically active protein
The present invention is intended to provide a safe and quick means for screening a drug to a bioactive protein, in particular, an inhibitor, using a cell-free protein synthesis system with the use...
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7425411 |
Method for recovering microorganisms from a sample
The present invention provides for a method for recovering microorganisms from a sample that is rapid and provides microorganisms substantially free of adsorbents and other particles. The method...
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7416840 |
Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells
Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the...
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7390873 |
Antimicrobial cationic peptides
A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas:
X 1 X 1 PX 2 X 3 X 2 P(X 2 X 2 P) n X 2 X 3 (X 5 ) 0 ; (SEQ ID...
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7378235 |
Method for screening compounds against Flaviviruses by using persistent virus-infected cell system
This invention provides a method for screening compounds against Flavivirus . More specifically, this invention provides a method for screening compounds against Flaviviruses by using a...
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7364874 |
Mediucm for detecting Van A and Van B vancomycin-resistant entercocci and method of using the same
Van A and Van B vancomycin resistant enterococci detection media as well as a method of selectively detecting Van A and Van B vancomycin resistant enterococci clinically important in vancomycin...
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7364856 |
PknB kinase and pstP phosphatase and methods of identifying inhibitory substances
The present invention relates to a pknB kinase and a pstP phosphatase as well as their use for identifying antibacterial substances.
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7355033 |
Screening for West Nile Virus antiviral therapy
The instant invention provides stable and novel lineage I WNV reverse genetics systems, and methods for making the reverse genetics systems, specifically, a fully-infectious lineage I WNV cDNA or...
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7354731 |
Method of screening for potential anti-bacterial agents
The invention provides a method of screening for potential anti-bacterial agents being antagonists of one or both of the transglycosylase and the transpeptidase enzymes involved in peptidoglycan...
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7348161 |
Macrolide efflux genetic assembly
Macrolide resistance associated with macrolide efflux (mef) in Streptococcus pneumoniae has been defined with respect to the genetic structure and dissemination of a novel mefE-containing...
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7344735 |
Method for excystation of sporocysts
A process to excystate protozoal sporocysts involves treatment of an infected tissue sample with a sodium hypochlorite solution to stimulate excystation of the sporocysts from the tissue....
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7338778 |
Luminescent method for determining cell oxygen consumption
The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods...
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7335485 |
Device and method for determining antibiotic susceptibility
The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is...
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7329508 |
Use of ylqF, yqeG, yybQ, and ysxC, essential bacterial genes and polypeptides
Disclosed are genes found in Streptococcus pneumoniae that are essential for survival for a wide range of bacteria. These genes are termed “S-ylqF,” “S-yqeG,” “S-yybQ,” “S-yerL,”...
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7314731 |
Method for selecting therapeutic agents for cancer
The present invention discloses in vitro methods for screening candidate therapeutic and/or chemotherapeutic agents for in vivo efficacy in a specific patient. The invention also includes methods...
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7312046 |
Method of screening compounds using a nanoporous silicon support containing macrowells for cells
A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of...
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7306938 |
High throughput screen for inhibitors of fatty acid biosynthesis in bacteria
Methods for identifying compounds that are inhibitors of bacterial fatty acid biosynthesis are disclosed. Such compounds can be used as lead compounds in methods for preparing antibacterial agents...
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7297551 |
Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for...
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7297509 |
Intermediates and enzymes of the non-mevalonate isoprenoid pathway
The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in...
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7297505 |
Use of MDCK cell line to predict corneal penetration of drugs
A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the...
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7270977 |
Polypeptides for identifying fungicidally active compounds
The invention relates to polypeptides from phytopathogenic fungi with the biological activity of an inosine monophosphate dehydrogenase, to nucleic acids encoding them, to the use of the...
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7267962 |
Device and method for detecting antibiotic inactivating enzymes
The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is...
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7264815 |
Process for producing a recombinant protein in a mycobacterium host plasmid pJAM2
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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7256009 |
Luminous bacteria and methods for the isolation, identification and quantitation of toxicants
Methods for the isolation and identification of a toxicant in a sample are disclosed. Luminescent biological agents (i.e., bacteria) having sensitivity to a toxicant or an isolatable component in a...
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7214506 |
Method for treating onychomycosis
A novel method for evaluating an effect of an antimicrobial agent which comprises removing the antimicrobial agent remaining in a biological sample or the like to thereby accurately evaluate the...
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7198906 |
Drug sensitivity measuring method
Disclosed herein is a method for determining the drug sensitivity of a microbe which comprises pouring a microbial suspension into each of the compartments or wells at a position which is in the...
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7186565 |
Sampling and toxicity monitoring device and method
A method and apparatus for testing an aqueous or gaseous environment for the presence of at least one chemical is provided in order to determine the toxicity of the chemical and optionally, the...
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7179615 |
Method of prophylaxis and treatment
The present invention relates generally to a method for the prophylaxis and treatment of parasitic infections in animals and birds. More particularly, the present invention contemplates a method...
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