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8173438 |
Microbiological assessment method and device utilizing oxygen gradient sensing
There is disclosed a biological indicator (BI) test utilizing oxygen sensing within a microenvironment as a means for determining the presence of viable microorganisms capable of growth, a method...
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8158107 |
Genes and proteins associated with angiogenesis and uses thereof
Disclosed is a panel of biomarkers associated with angiogenesis, and the use of such biomarkers (genes, proteins, homologues and analogs thereof) to regulate angiogenesis. Methods for identifying...
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8158379 |
Methods for determining microbial contamination of allograft products
A method for determining microbial contamination of allograft products includes providing an extraction vessel having an outer container and a removable inner basket, placing the allograft product...
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8143018 |
Method for preparing a measurement sample for detecting live cells of a microorganism in a test sample
According to the following steps, live cells, injured cells, VNC cells and dead cells of a microorganism in a test sample are detected by flow cytometry: a) the step of treating the test sample...
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8110375 |
High throughput assay for cancer cell growth inhibition
A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media...
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8106152 |
Antimicrobial composition
The present invention relates to novel antimicrobial composition comprising a peptide which can be obtained from the milk protein casein or chemically synthesised or produced by recombinant DNA...
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8097434 |
Methods for the detection of beta-lactamases
Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases. AmpC beta-lactamases, and...
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8092810 |
Use of polypeptides having antimicrobial activity
The present invention relates to the use of polypeptides related to a Bacillus licheniformis polypeptide (amino acids 1-85 of SEQ ID NO: 2) as antimicrobial agents, for example in pharmaceutical...
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8080370 |
Screening method for prophylactic and/or therapeutic agent for disease accompanied by hepatitis C
An easy and efficient screening method for an agent useful for prevention and/or treatment of hepatitis C virus-related disease, and a prophylactic and/or therapeutic agent for hepatitis C...
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8058025 |
Methods for determining efficacy of chemotherapeutic agents
An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested,...
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8034580 |
Determining presence of antibiotic in a fluid
The pressure of an antibiotic in a fluid is determined by contacting a sample of the fluid suspected of containing an antibiotic with a test medium containing a microorganism, a substance that...
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8026079 |
Method for detection of microorganism and kit for detection of microorganism
According to the following steps, live cells, injured cells, VNC cells and dead cells of a microorganism in a test sample are detected by flow cytometry: a) the step of treating the test sample...
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8012711 |
Methods of screening for compounds that reduce microbial resistance to fluoroquinolones
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly...
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8012492 |
In vitro model of latent mycobacterial infection
A method of inducing latency in Mycobacterium permits preparation of an in vitro model system of latent mycobacterial infection. Latency is induced in a pure culture of Mycobacterium by exposing it...
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8012758 |
Method of monitoring microbiological activity in process streams
An apparatus and method for monitoring microbiological activity in a process stream by measuring dissolved oxygen is disclosed. Bulk microbiological activity and surface associated biological...
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7977092 |
Methods for identifying candidate anti-tumorigenic agents
Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions,...
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7960136 |
Direct antimicrobial susceptibility assay
An antimicrobial susceptibility assay, including the steps of: providing an assay dish; providing a growth medium in said dish; providing an antimicrobial agent sample; providing an interpretive...
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7955817 |
Vaccine protection assay
The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for...
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7947435 |
Neuronal regeneration material screening method by ex vivo model
The present invention relates to a neuronal regeneration material screening method using ex vivo models, more precisely a neuronal regeneration material screening method using an organotypic spinal...
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7939314 |
Methods and compositions for rapidly detecting and quantifying viable Legionella
Methods and compositions detect and quantify viable Legionella. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and...
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7935521 |
Methods and compositions for rapidly detecting and quantifying viable Legionella
Methods and compositions detect and quantify viable Legionella. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and...
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7932051 |
Blood and urine test
The present invention provides a test medium comprising a test microorganism, an indicator and a metal in ionized form, wherein the valence of said metal is at least 2 and the concentration of said...
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7928215 |
Methods of screening for compounds that inhibit the biosynthesis of GPI in malaria parasites
The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum. In addition, the inventors revealed that...
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7923204 |
Forward mutation assay based on 5-fluorouracil resistance
Disclosed herein is a novel forward mutation assay based on 5-fluorouracil (5-FU) resistance which utilizes a strain of Salmonella typhimurium derived from the Ames strain TA100. More specifically,...
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7901932 |
Methods and compositions for rapidly detecting and quantifying viable Legionella
Methods and compositions detect and quantify viable Legionella and other heterotrophic aerobic bacteria. Dip-slides that include an absorbent medium, growth promoting, and growth selective...
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7901903 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Determining presence of antibiotic in a fluid
The pressure of an antibiotic in a fluid is determined by contacting a sample of the fluid suspected of containing an antibiotic with a test medium containing a microorganism, a substance that...
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7897365 |
Method for adjusting antibiotic sensitivity of a test culture
The present invention relates to a method for adjusting the sensitivity of a microbial culture to an antibiotic. The method employs a substance derived from a bacterial species with sensitivity to...
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7892782 |
Screening process for antibacterial agents
The present invention relates to a method of preparing a phenotypically antibiotic-resistant subpopulation of stationary phase bacteria by treating stationary phase bacteria with high doses of...
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7888005 |
Inhibitors of macromolecular activity
The present invention relates generally to methods, kits, compositions, and combinations to identify anti-infective or anti-pathogenic agents. The present invention also relates to methods, kits,...
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7883711 |
Use of polypeptides having antimicrobial activity
The present invention relates to the use of polypeptides related to a Bacillus licheniformis polypeptide (amino acids 1-85 of SEQ ID NO: 2) as antimicrobial agents, for example in pharmaceutical...
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7879576 |
Marine actinomycete taxon for drug and fermentation product discovery
The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na+) for growth and unique 16S rRNA signature...
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7871790 |
Anthrax bioassays and methods of treating and diagnosing anthrax infection
Based on the observation that exposure of cells or animals to anthrax lethal toxin results in activation of the intracellular enzyme caspase-1/IL-1 converting enzyme (ICE), which, in turn, leads to...
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7867758 |
Bioluminogenic assay system for measuring beta-lactamase activity
A bioluminogenic assay system including: providing a bioluminogenic substrate incorporating a beta-lactam antibiotic, a bioluminescence initiating compound, and a chemical linkage joining the...
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7837947 |
Sample mixing on a microfluidic device
Mixing structures for use on sample processing devices are disclosed. The mixing structures include one or more mixing chambers in fluid communication with a process chamber, such that changing the...
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7829305 |
Method for monitoring the presence of biofilmforming microorganisms in paper industry
The invention is directed to a method for detecting the presence of biofilm-forming microorganisms in a paper or board making process for determining the need of an anti-biofilm agent in the...
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7824882 |
Oligosaccharides in a test system for the determination of the presence of an antibiotic in a fluid
Provided is a test system, a test method and a test kit for the determination of the presence of an antibiotic in a fluid based on a test medium comprising a test organism, at least one substance...
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7807403 |
Device and direct method for detection of antibiotic-inactivating enzymes
A method for determining whether a microorganism produces an AmpC β-lactamase is disclosed in which a culture of a microorganism suspected of producing a β-lactamase that inactivates a β...
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7794967 |
Method and kit for detection of novel pathogen inhibitors
The present invention relates to a method for detection of novel pathogen inhibitors using models of pathogen specific, and metal binding structures/domains representing essential cellular...
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7781186 |
Screening methods using normal human liver cell line
In this application is described the establishment and maintenance of a normal human hepatocyte cell line able to support complete development of malaria parasite development in vitro. The cell...
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7776527 |
Methods and compositions for reducing microbial induced apoptosis
The present invention relates to microbial infection, and in particular, the reduction of apoptosis associated with microbial infection, the screening of agents that reduce apoptosis, and the...
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7771963 |
Methods for determining efficacy of chemotherapeutic agents
An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested,...
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7736588 |
Apparatus and method for detecting undesired residues in a sample
Detection arrangement and method for detecting presence of a residue in a sample include determining color values of the sample, associated with the L*a*b color model. A value of a composite...
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7727731 |
Potent, selective and non toxic c-kit inhibitors
The present invention relates to a screening method allowing the identification and selection of compounds targeting the transphosphorylase (also called phosphotransferase) domain of c-kit, more...
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7718392 |
Device and direct method for detecting antibiotic-inactivating factors
The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is...
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7709246 |
Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids
Disclosed is a device for detecting bioelectric signals from spheroids comprising a measuring chamber having a measuring chamber wall which encloses a volume, which is open at least at one side, is...
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7670797 |
Method of determining toxicity with three dimensional structures
A method of determining toxicity of a test agent in a tissue including A) incubating a test agent within a three-dimensional tissue engineered structure comprising a first mold or polymer scaffold,...
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7648830 |
Method for determining the presence of bacteria resistant to cell lysing antibiotics
A method is provided for determining the presence of a target bacteria based on its resistance to a cell lysing antibiotic. Said antibiotic is used to lyse cells of non-target bacteria in a sample...
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7642068 |
Multiple-valent opsonophagocytic assay selection panel arrays and uses therefor
This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the...
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7632657 |
Method of detecting meticillin-resistant microorganisms
The invention relates to a novel solid medium for detecting meticillin-resistant micro-organisms, containing an antibiotic selected from the cephalosporin group, particularly second and third...
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7629141 |
Essential and important genes of Pseudomonas aeruginosa and the use thereof to design or identify antibacterial agents
The invention includes a database of candidate essential genes in Pseudomonas aeruginosa, as well as other important genes that, when mutated, lead to a growth attenuated phenotype. Such genes and...
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