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5837480 |
Method and compounds for inhibiting lipid biosynthesis of bacteria and plants
This invention relates to InhA enzyme crystals and to methods of growing said crystals. This invention is further directed to the utilization of said crystals to determine the three dimensional...
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5821335 |
Biosynthetic gene murg from streptococcus pneumoniae
The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murG of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host...
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5821052 |
Control of the synthesis of proteins by anitisense RNA-tRNA complex
The inhibition of proteins synthesis by an antisense RNA-tRNA complex which is capable of inhibiting translation is described. Under certain conditions, growth of organisms is inhibited by...
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5811231 |
Methods and kits for eukaryotic gene profiling
This invention provides methods and diagnostic kits for identifying and characterizing toxic compounds. These methods and diagnostic kits measure transcription or translation levels from genes...
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5807699 |
Apparatus and method for monitoring condition of a biomass
The invention relates to apparatus (1) for monitoring condition of a biomass, particularly that naturally occurring in activated sewage sludge, comprising a vessel (2) for holding a liquid in the...
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5807700 |
Method of screening anti-amebic agents with an E. coli mutant having a deleted adhE gene complemented by the E. histolytica EhADH2 gene
There is disclosed an assay method of screening and identification of anti-amebic drugs which utilizes the ability to inhibit anaerobic growth of a novel bacterial mutant that expresses the EhADH2...
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5804406 |
Determining sensitivity of paraffinophilic microorganisms to antimicrobials
A method of determining the sensitivity of at least one paraffinophilic microorganism from a specimen obtained from a patient to different antimicrobial agents and predetermined quantities thereof...
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5801009 |
Method for determining the antimicrobial agent sensitivity of a paraffinophilic microorganism using various milieus and an associated apparatus
An apparatus for determining sensitivity of at least one paraffinophilic microorganism from a specimen obtained from a patient to different antimicrobial agents and predetermined quantities...
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5795731 |
Inteins as antimicrobial targets: genetic screens for intein function
The present invention relates to testing the efficacy of antimicrobial agents which inhibit intein function through genetic screens for monitoring the function of protein inteins, and isolating...
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5795730 |
Rapid read-out biological indicator
This invention relates to methods and the use of biological indicator systems to assess and determine the effectiveness of sterilization processes comprising the steps of contacting an indicator...
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5789191 |
Method of detecting and counting microorganisms
The invention provides a cosmetic or dermatological method for detecting and/or selectively quantifying individual microorganisms, and/or whole groups of microorganisms, which are present on human...
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5789242 |
Method and device for determining toxicity as well as the use thereof
The invention concerns a method for determining the toxicity of water-soluble substances or of substances which can be mixed with water and thus obtaining quantitative information concerning the...
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5789173 |
Methods for rapid antimicrobial susceptibility testing
The present invention discloses a method for rapid antimicrobial susceptibility testing to screen antibiotics in a few hours instead of days by conventional methods. This method can also be used to...
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5786166 |
Methods for determining effects of a compound on the activity of bacterial periplasmic oxidoreductase enzymes
A screening method to determine whether a chemical inhibits the function of a class of bacterial periplasmic oxidoreductase enzymes, exemplified by TcpG of Vibrio cholerae, DsbA E. coli, and Por of...
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5783411 |
Bacterial control of Fusarium dry rot of potatoes
Bacteria which will suppress fungus-induced potato disease under storage conditions have been screened and selected from soil samples. A method for isolating these antagonists, their use in...
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5770386 |
Methods and compositions for increasing the sensitivity of a cell to a DNA damaging agent
The invention provides a method of increasing the sensitivity of a cell to a DNA damaging agent comprising increasing the amount of an NM23 in the cell. The method is especially useful for...
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5770373 |
Rapid and sensitive detection of antibiotic-resistant mycobacteria using oligonucleotide probe specific for ribosomal RNA precursors
The invention relates to methods and oligonucleotide probe compositions useful for determining antibiotic resistance in Mycobacteria. Included are methods for freeing intact precursor ribosomal RNA...
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5763170 |
Method for forming an array of biological particles
A method for forming and using an array of, e.g., bacteria, yeast or bacteriophage for the purpose of identifying particular constituents thereof. The array is formed by directing a stream of...
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5759765 |
Human liver epithelial cell lines
Immortalized cell lines derived from normal adult human liver are described which express phenotypic characteristics of normal adult liver epithelial cells. The invention further provides methods...
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5759799 |
Marker for revealing contaminants and application method for performing an antibiogram carried out directly on a sample
An incubation limit marker for revealing the growth of contaminants present in a sample includes at least one strain or category of classically contaminant bacteria in dehydrated form which, once...
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5744321 |
Detection of fish spoilage by colorimetry
A rapid, on-site method for indicating the degree of spoilage, if any, of finfish by the level of bacteria present therein. A small quantity of flesh is cut from a representative fish and kneaded...
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5728541 |
Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested,...
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5705340 |
Methods for screening class B beta-lactamase enzymes from Bacteroides fragilis
This invention is directed to the elucidation of DNA sequences encoding Class B beta-lactamase enzymes from Bacteroides fragilis and the amino acid sequences of those enzymes. This invention is...
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5702915 |
Toxicity detecting biosensor system
A biosensor for detecting the toxicity of a sample includes a solid-state area image pickup element, a culture container positioned on an upper surface of a light-receiving portion of the element,...
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5698413 |
Method of evaluating chemotherapeutic agents in vivo
The present invention relates to a method of screening chemotherapeutic agents in vivo. The method comprises implanting into a laboratory animal a biocompatible, semi-permeable encapsulation device...
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5679515 |
Mycobacterial reporter strains and uses thereof
This invention relates to a method of quantifying bacteria in vivo or in vitro using bacterial reporter strains. In particular this invention provides a method utilizing mycobacterial reporter...
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5677135 |
Method for increasing the resistance of neural cells to βamyloid peptide toxicity
Neural cells which express P75 nerve growth factor receptor (p75 NTR ) and which have a low resistance to β-amyloid peptide toxicity are treated with a binding agent that binds with p75 NTR . The...
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5674701 |
Method of identifying plant pathogen tolerance
A process for identifying a plant having disease tolerance comprising administering to a plant an inhibitory amount of ethylene and screening for ethylene insensitivity, thereby identifying a...
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5674702 |
Determination of the toxicity of water using an anaerobic bacterial culture
Procedure and relative equipment for determining the presence of toxic substances in water destined for drinking and/or in water effluents, based on the inhibition of the production of biogas...
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5660986 |
Immortalized human cell lines containing exogenous cytochrome P450 genes
Non-tumorigenic, stable, human bronchial and liver epithelial cell lines are provided wherein the cell lines are capable of expressing human cytochrome P450 genes which have been inserted into the...
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5658749 |
Method for processing mycobacteria
A method for the preparation of Mycobacteria from any liquid, semi-solid or exotic source is described. The extracted Mycobacterial sample is suitable for detection by culture and amplification.
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5658748 |
Streptococcus thermophilus strains and their use
The invention relates to new Streptococcus thermophilus strains containing genes giving the bioluminescence property. The strains can be applied widely for analytical purposes, e.g. in the...
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5656424 |
Identification of mycobacterium tuberculosis complex species
Methods for using reporter mycobacteriophage (RM) and p-nitro-α-acetylamino-β-hydroxy-propiophenone (NAP) to identify TB complex mycobacteria and distinguish these species from MOTT. RM-infected...
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5654165 |
Antibacterial drug inspection method and apparatus therefor
A test solution including bacteria is added to a liquid sample in which antibacterial drug exists and to a liquid sample in which no antibacterial drug exists, and existence or non-existence of...
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5648231 |
Measurement of mold growth on amorphous substrates
A method for rapidly determining mold growth on feed is disclosed. The method comprises placing a sample of feed containing mold spores in a closed container; maintaining an environment that will...
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5645988 |
Methods of identifying drugs with selective effects against cancer cells
The present invention involves a method of identifying drugs which selectively inhibit the growth of particular cancer cells, which method comprises: (a) contacting with the drug at least two...
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5639632 |
Method and device for studying and quantifying interacting effects of substances on biological cells
Device and method for quantitative determination of the interacting effects of two or more substances on the promotion or inhibition of growth of microorganisms or other biological cells grown on a...
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5627045 |
Multi-test format with gel-forming matrix for characterization of microorganisms
The present invention is directed to methods and compositions for the characterization of various microorganisms. In particular, the present invention is suited for the characterization of commonly...
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5624814 |
Culture medium and method for culturing body fluids containing antibiotics
A nutrient culture medium which isolates antibiotics and other microbial growth inhibitors during culturing of a microorganism is shown. The culture medium includes an aqueous dispersion of...
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5618664 |
Process for simultaneously disinfecting and fixing biological fluids
Methods and kits for reducing the transmission of infectious agents contained in biological fluid samples are provided. The methods include contacting the biological sample with a fixative solution...
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5616461 |
Assay for antiviral activity using complex of herpesvirus origin of replication and cellular protein
The invention features methods and compositions useful for identifying candidate compounds for antiviral activity, useful for inhibiting replication of a DNA virus, and useful for treating an...
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5612183 |
Method for determining the effect of antimicrobial agents on growth using ribosomal nucleic acid subunit subsequence specific probes
A method for detecting and quantitating organisms containing R-RNA, t-RNA, other RNA, any member of a large, intermediate or small category or organisms such as any member of a bacterial taxonomic...
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5604112 |
Method for detecting the cardiotoxicity of compounds
The present invention provides methods of testing the cardiotoxicity of compounds and kits useful for the same.
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5604096 |
Fluorometric quantitation of mycoplasmas
The present invention pertains to methods of monitoring mycoplasmal growth whereby a culture of mycoplasmal cells is contacted with a fluorescent nucleic acid-binding agent under conditions which...
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5593853 |
Generation and screening of synthetic drug libraries
Methods are provided for generating highly diverse mixtures of compounds which may be screened for biological activities. Once the activity is found, the component of the mixture which is...
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5591599 |
Method for detecting antimicrobial compounds
A method for determining the possible presence of an antimicrobial compound in a sample. The method includes the steps of: (i) adding the sample to a culture medium; (ii) growing a microorganism in...
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5591576 |
Sterol Δ14 reductase screen
A binary assay identifies agents that inhibit sterol Δ14 reductase involved in ergosterol biosynthesis. In the primary screen, sterol Δ14 reductase inhibition by a test sample is assayed by...
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5589337 |
Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes
This invention provides methods and diagnostic kits for determining the toxicity of a compound. The methods and diagnostic kits of this invention employ a plurality of bacterial hosts, each of...
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5582997 |
Lysine/leucine polypeptides, mixture sets and libraries thereof
Polypeptides, sets and libraries of sets of polypeptides that are related in sequence to the polypeptide of SEQ ID NO:1 are disclosed that have antimicrobial, hemolytic and hydrolytically catalytic...
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5580781 |
Three-dimensional tumor cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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