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7618392 |
Methods and compositions for detection of microbial contaminants in peritoneal dialysis solution
Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of...
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7615376 |
Masking background fluorescence and luminescence in the optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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7615361 |
Toxicity screening methods
The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining...
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7615360 |
Use of Saccharomyces cerevisiae erg4 mutants for expressing mammalian glucose transporter
The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be...
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7615207 |
Methods for treating irritable bowel syndrome
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
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7608418 |
NT-proANP and NT-proBNP for diagnosing cardiac diseases
Described are methods for diagnosing a cardiac disease, particularly an acute cardiac event, in a patient presenting with symptoms of acute cardiac decompensation, comprising the steps of (a)...
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7608417 |
Cell electro-physiological sensor and method of manufacturing the same
A cell electro-physiological sensor includes a sensor chip including a partition board having a first surface and a second surface opposite to the first surface, a member for forming a first region...
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7608245 |
Methods for manipulating satiety
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
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7601511 |
Biotin-facilitated transport in gram negative bacteria
Biotinylation of compounds such as peptides and peptidomimetics facilitates illicit transport of the compounds into Gram negative bacteria.
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7601490 |
Development of influenza A antivirals
The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein...
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7598079 |
Assay for identifying compounds which affect stability of mRNA
The present invention relates to an assay for the identification of biologically active compounds, in particular to a reporter gene assay for the identification of compounds, which have an effect...
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7595158 |
Bcl2L12 polypeptide activators and inhibitors
The invention provides methods and materials related to Bcl2L12 polypeptides and the biological activities of Bcl2L12 polypeptides. For example, the invention provides methods and materials related...
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7592154 |
Modulating SOS response induction by antimicrobial agents
Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a...
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7585618 |
Treatment of diabetes with milk protein hydrolysate
A milk protein hydrolysate which is preferably caseinoglycomacropeptide and/or a whey protein in a bioavailable form is used for the manufacture of a composition for the treatment or prevention of...
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7579320 |
IAP BIR domain binding compounds
Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II
or a salt thereof, in which R 1 , R 2 , R 3 , R 100 , R 200 , R 300 , A, A 1 , BG, Q...
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7575868 |
Methods for assessing efficacy of chemotherapeutic agents
Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the...
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7572601 |
Compositions and methods for determining oocyte development potential
The present invention relates to the field of reproduction (e.g., human reproduction). In particular, the present invention provides markers (e.g., pentraxin 3 and Annexin A6), and methods of using...
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7569373 |
Method for counting megakaryocytes
A method for counting megakaryocytes in a specimen is described. In the method, first, erythrocytes in the specimen are lysed and nucleic acid in the megakaryocytes is stained with a fluorescent...
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7563593 |
Method for preparing cell cultures from biological specimens for assaying secreted factors
The present invention provides an improved system for determining factors secreted from patient cells, in which a tissue sample from the patient is harvested and cultured. One particularly...
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7560233 |
Oxidative DNA damage protection
Provided herein are methods of screening compounds, gene sequences, and gene products in bacteria for agents that are protective against oxidative DNA damage in a human or animal. Gene sequences...
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7553633 |
Apparatus and method for detecting live cells with an integrated filter and growth detection device
A device for rapid concentration and detection of live cells in fluids includes a filter to capture a cell sample. The filter includes a first physical barrier with apertures of a first size and a...
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7553632 |
Luminogenic and nonluminogenic multiplex assay
A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
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7553453 |
Assay implementation in a microfluidic format
An assay implementation in a microfluidic format in a cartridge relating to a point-of-care instrument platform for monitoring and diagnosing infectious diseases (e.g., AIDS and malaria). The...
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7547525 |
Point source diffusion cell activity assay
Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in...
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7547508 |
Use of nanosecond scale, time-resolved, imaging to differentiate contemporaneous fluorescence responses from multiple substances
Time-dependent differences in fluorescence responses of normal surfaces of the fruit or vegetable as opposed to surfaces which are contaminated with feces, may be used for improved detection of...
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7537924 |
Virus strains
The present invention relates to clinical herpes simplex virus (HSV) isolates with improved oncolytic capabilities as compared to reference laboratory HSV strains. The present invention also...
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7537887 |
Net, a transcription factor of the TCF family, as regulator of angiogenic factor expression
The present invention relates to the regulation of the activity of NET (ERP/SAP-2) protein and to compounds which modify or regulate NET protein activity. The invention further relates to methods...
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7531318 |
Screening of agents for activity against ischemic myocardial insults
Integrin-linked kinase (ILK) and Akt/protein kinase B (PKB) are important mediators of signaling in cardiomyocytes and can both prevent damage and promote healing associated with ischemic injury to...
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7527940 |
Method for the determination of changes in a cellular morphological parameter
Disclosed is method for measuring a change in a cellular morphological parameter, for example, the position and/or the shape of a cell. The method comprises labelling a population of cells with a...
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7524623 |
Method and device for rapid detection of microorganisms by changing the shape of micro-colonies
This invention describes a method of rapid detection of micro-colonies of microorganisms by changing their shape from a regular semi-sphere to a long and thin cylinder. Cells are trapped by...
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7521246 |
Cell lysis by heating-cooling process through endothermic reaction
Provided is a cell lysis method including: preparing a cell sample to be lysed; heating the cell sample; and cooling the cell sample by causing an endothermic reaction near the cell sample....
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7521201 |
Bacteriophages as selective agents
Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages...
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7520970 |
Immobilization support, process for producing the same, electrode, process for producing the same, electrode reaction utilizing apparatus and process for producing the same
An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously...
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7517690 |
Cell lysis method using free radical
Provided is a method of lysing a cell or a virus using a free radical. The method includes: applying an electric field to a mixture of a metal ion, a peroxide, and a cell or virus solution to...
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7517667 |
Methods for promoting, inhibiting and detecting toxin entry into cells
In vitro delivery of the diphtheria toxin (DT) catalytic (C) domain from the lumen of purified early endosomes to the external milieu requires the addition of both ATP and a cytosolic translocation...
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7517665 |
Method and apparatus for concentrating and searching of microbiological specimens
The invention relates to a method for enriching and examining microbiological samples. In which method microbes are brought into a syringe or equivalent. In a method according to the invention the...
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7510854 |
Corynebacterium glutamicum genes encoding metabolic pathway proteins
Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic...
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7504251 |
Bacterial strain, processed plant extracts, compositions containing same, processes for their preparation and their therapeutic and industrial applications
The present invention discloses: (i) a non-pathogenic probiotic microorganism and its probiotic/therapeutic uses; (ii) a formulation comprising an aqueous solution of a volatile fraction (VF)...
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7504216 |
Bacterial counterselectable hybrid systems
The present application relates to the hybrid selection methods in prokaryotes using counterselectable reporter genes.
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7501260 |
Methods for determining efficacy of chemotherapeutic agents for a patient prior to treatment
An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested,...
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7498147 |
Diagnosis, prevention, and/or treatment of atherosclerosis and underlying and/or related diseases
Complement is recognized as an important, humoral defense system involved in the innate (nonspecific) recognition and elimination of microbial invaders, other foreign particles or molecules, and...
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7494768 |
Mutational profiles in HIV-1 protease and reverse transcriptase correlated with phenotypic drug resistance
The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More...
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7488585 |
Method of diagnosis of pregnancy-related complications
A method for diagnosing pregnancy-related complications in a pregnant woman. The method comprises (a) providing PP13-responding cells having a membrane; (b) exposing the cells to standard PP13; (c)...
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7481975 |
Hydrogen peroxide indicator and method
The present invention provides a hydrogen peroxide indicator that includes a substrate on which is disposed an indicator composition that includes at least one of a select group of colorants. As a...
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7476510 |
Miniaturized cell array methods and apparatus for cell-based screening
Methods and cassettes for cell-based toxin detection and organ localization are disclosed. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each...
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7473529 |
System and method for detecting cells or components thereof
A system and method for detecting a detectably labeled cell or component thereof in a sample comprising one or more cells or components thereof, at least one cell or component thereof of which is...
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7468260 |
Method of detecting and using an expression-enhancing sequence
The invention relates to a method of detecting a DNA sequence which at least partially contributes to promote the stable expression of a gene. To this end the DNA fragment to be examined is cloned...
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7468255 |
Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
The present invention includes a method of measuring cytolytic activity including providing a device capable of monitoring cell-substrate impedance operably connected to an impedance analyzer,...
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7465558 |
Perfusion system and apparatus for automated multi-channel patch-clamp recordings utilizing inside-out whole-cell configuration
A system and method for high throughput patch clamp measurements to study the effect of various chemicals on ion transfer channels is provided. One or more patch clamp configurations is...
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7465543 |
Multiplex DNA identification of clinical yeasts using flow cytometry
Oligonucleotide probes that are specific for pathogenic yeasts and which may be used for the detection of such yeasts in biological samples are described. These probes are specific for yeast...
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