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6984498 |
Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
A cancer screening method is provided, wherein the method is characterized by administering a compound to a patient, the compound being a complex of a fluorescent marker and a radioactive marker,...
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6984490 |
Identification of genes
A method for identifying a microorganism having a reduced adaptation to a particular environment comprising the steps of:
(1) providing a plurality of microorganisms each of which is...
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6984297 |
Device for taking measurements of cells which are contained in a liquid environment
A method and a device are used for carrying out measurements on cells located in a liquid environment. Each cell is positioned with an underside of its membrane on a surface having a channel...
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6984374 |
Method for the evaluation of implantable materials
A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a...
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6982148 |
Progressive elevated gene-3 (PEG-3) induces aggressive cancer phenotype and regulates angiogenesis
The present invention provides a method for identifying a gene which is expressed at a modulated level in an aggressive cancer by: (a) measuring baseline expression levels of genes in cancer cells;...
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6979553 |
Use of Nernstein voltage sensitive dyes in measuring transmembrane voltage
Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and...
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6977157 |
Clock gene promoter
The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a...
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6974680 |
Virulence genes, proteins, and their use
A series of genes from Pseudomonas aeruginosa and Klebsiella are shown to encode products that are implicated in virulence. The identification of these genes therefore allows attenuated...
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6974679 |
Support with collagen base for tissue engineering and manufacture of biomaterials
The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin,...
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6972175 |
Inhibition of Egr-1 expression by ppar-gamma agonists and related compositions and methods
This invention provides methods for determining whether an agent increases PPAR-γ-mediated inhibition of Egr-1 expression. This invention also provides methods for inhibiting the onset of...
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6972196 |
Making surfaces inert by modifying with alkanethiolates
Alkanethiols of formula (1) and the enantiomers of the alkanethiol of formula (1):
HS-L-Q-T (1),
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6972184 |
Cell motility assay
An electrooptical method is disclosed for quantifying the motility response of cells to external stimuli, wherein a target cell population (formed as a function of said response) is subsequently...
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6967085 |
Flocculation of cell material
A process of flocculating microbial cell material from a suspending medium which contains cell material, comprising adding to the suspending medium a first polymeric material which is cationic and...
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6967077 |
Methods and compositions for regulating T cell subsets by modulating transcription factor activity
Methods for modulating production of a T helper type 2 (Th2)-associated cytokine, in particular interleukin-4, by modulating the activity of a transcription factor, in particular the...
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6964766 |
Peptides for use in immunotherapy of autoimmune diseases
The invention relates to the use of novel peptides in a peptide induced tolerance therapy to prevent autoimmune disorders and in particular their use in treatment of chronic destruction of...
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6964857 |
Measuring indigenous photosynthetic organisms to detect chemical warefare agents in water
A method of testing water to detect the presence of a chemical or biological warfare agent is disclosed. The method is carried out by establishing control data by providing control water containing...
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6958221 |
Cell flow apparatus and method for real-time measurements of patient cellular responses
The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents.
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6955924 |
Laminin chains: diagnostic uses
The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto.
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6955890 |
Method for the identification and treatment of pathogenic microorganisms infections by inhibiting one or more enzymes in an essential metabolic pathway
A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce...
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6955886 |
Scintillation proximity assay for the detection of peptidoglycan synthesis
The invention provides a scintillation proximity assay for detecting peptidoglycan synthesis. The assay is especially suitable for high throughput screening of compounds affecting peptidoglycan...
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6953671 |
Plasma phospholipid transfer protein (PLTP) deficiency represents an anti-atherogenic state and PLTP inhibitor has anti-atherosclerosis action
This invention provides methods of decreasing apolipoprotein B-containing lipoprotein and of treating atherosclerotic diseases and dyslipidemic diseases by reducing plasma phospholipid transfer...
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6953672 |
Screen for CDC7 inhibitors
Disclosed is a yeast cell whose genetic complement includes an inactive allele of the yeast CDC7 gene, a first nucleic acid that encodes a mammalian Cdc7 protein, and a second nucleic acid that...
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6951756 |
Closure of bacterial ghost
The invention relates to a method for preparing closed bacterial ghosts by means of vesicle membrane fusion and to the bacterial ghosts which can be obtained in this way. Active compounds, e.g....
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6949354 |
Methods for screening compounds active on neurons
The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and...
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6946260 |
Allergen/inflammatory testing and diagnosis
The invention relates to the use of a secretor variant cell-line expressing the alpha moiety of human IgE binding protein to determine the allergic status of a given individual. Moreover, the...
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6946140 |
Methods and compositions for enhancing fibroblast migration
Methods and compositions for enhancing fibroblast migration at a wound site are disclosed. The method includes contacting the wound site with fibrinogen that is prepared by a process which includes...
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6942988 |
Method of use of sonic hedgehog protein as a ligand for patched
The invention relates to hedgehog proteins that are involved in signaling developmental processes. The proteins of the invention modulate differentiation of neural plate. Also provided are methods...
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6939687 |
Method of testing adequacy of cells in a specimen
The present invention provides a device and method for determining the adequacy of squamous (ectocervical) cells, columnar (endocervical) cells, neutrophils, and noncellular material in a liquid...
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6939686 |
Methodology of using raman imaging microscopy for evaluating drug action within living cells
A method of using Raman imaging microscopy to evaluate drug actions in living cells is disclosed. Specifically the invention describes the methods of using Raman imaging microscopy to detect drug...
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6936426 |
Detection of antibody mediated inflammatory auto-immune disorders
The present invention describes a method to detect connective tissue pathologies associated with Graves' disease ophthalmopathy and other antibody mediated inflammatory autoimmune diseases. The...
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6936248 |
Methods of inhibiting GPR-9-6 function
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The...
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6936434 |
Vapor phase decontamination process biological indicator evaluator resistomer (BIER) vessel
A BIER vessel evaluates biological indicators for sterilization processes. By flowing gaseous sterilant, such as vaporized hydrogen peroxide, through a chamber ( 12 ) before, during, and after...
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6933129 |
Method for culturing and assaying cells
An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested,...
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6933154 |
Optimal windows for obtaining optical data for characterization of tissue samples
The invention provides methods for determining a characteristic of a tissue sample, such as a state of health, using spectral data and/or images obtained within an optimal period of time following...
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6929927 |
Method of evaluating antifungal agent
A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered...
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6929923 |
Modulators of leukocyte activation, BIC compositions and methods of use
The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte...
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6929909 |
Gene targeting vectors comprising conditional positive selection markers
The present invention is directed to methods and compositions useful in producing cells and animals having a disruption or modification of a target gene. Vectors useful in producing these cells and...
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6927031 |
Methods for identifying polypeptide factors interacting with RNA
The present invention relates to methods of screening for target polypeptides that bind to RNA, using affinity purification methods, and the use of such target polypeptide for drug discovery and in...
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6921667 |
Methods for direct detection of individual methotrexate metabolites
The present invention provides a method for determining a level of a methotrexate polyglutamate (MTXPG) in a cellular extract by resolving at least one MTXPG in a cellular extract obtained from a...
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6916658 |
Method for measurement of immature granulocytes
A method for measuring immature granulocytes in a blood sample is described. The method includes the steps of lysing red blood cells of a blood sample with a lytic reagent, analyzing the sample...
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6916611 |
Expression vector system and a method for optimization and confirmation of DNA delivery and quantification of targeting frequency
An expression vector system comprising a pair of expression vectors constructed from a wild-type and a mutant version of a maker, reporter or selection gene, and a method for optimization and...
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6913878 |
Method of detecting DNA single strand breaks
A method of detecting increased levels of DNA single strand breaks in a eukaryotic cell sample, comprising the steps of: (a) contacting a eukaryotic cell sample to a water-soluble tetrazolium salt...
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6913877 |
Methods for detecting bioactive compounds
Methods of detecting bioactive compounds include exposing compounds to one or more classes of chromatophores and measuring or sensing associated changes in one or more of the chromatophores....
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6913901 |
Procedure for controlling the enumeration of the absolute count of cells or other particles present in a sample
Procedure for controlling the enumeration of the absolute count of cells (or other particles) present in a sample. The procedure consists of the following: to prepare, in known quantities and...
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6911312 |
Detection and characterization of microorganisms
A method for separating microorganisms, especially infectious agents, from a mixture by two dimensional centrifugation on the basis of sedimentation rate and isopycnic banding density, for...
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6908766 |
Device and method for capturing biological tissues
A device and method for capturing a biological tissue, comprises cutting a minute biological cellular tissue using a contactless cutting apparatus, wherein, by inverting a biological tissue slide...
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6908746 |
Rapid method of detection and enumeration of sulfide-producing bacteria in food products
A rapid method for detecting spoilage of a food sample, particularly a fish sample, by detecting and enumerating sulfide-producing bacteria (SPB). A growth medium containing iron and sulfur is...
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6908745 |
Gamma sterilizable culture medium for the identification of yeasts and fungi
Gamma sterilizable culture medium for the selectively identification of yeasts and fungi with an addition of ciprofloxacin and, if necessary streptomycin or other antibiotics.
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6908744 |
Methods of stimulating cartilage formation
The disruption of the murine ROR2 gene leads to profound skeletal abnormalities, with essentially all endochondrally derived bones foreshortened and/or misshapen, albeit to differing degrees. ROR2...
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6905818 |
Method for the identification and characterization of interacting molecules by automated interaction mating
The present invention relates to an improved method for the identification and optionally the characterisation of interacting molecules designed to detect positive clones from the rather large...
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