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7309580 |
Chromogenic plating medium for the rapid presumptive identification of Bacillus anthrasis, Bacillus cereus, and Bacillus thuringiensis
A plating medium for the presumptive identification of Bacillus cereus, Bacillus thuringiensis and/or Bacillus anthrasis that includes a nutrient base to facilitate growth of Bacillus cereus,...
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7306905 |
Method of identifying substances useful for promoting resistance to cell stress
The invention is directed to methods for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The methods involve screening assays,...
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7303894 |
Detection of phenols using engineered bacteria
Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate...
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7303868 |
Mutant bank
The invention relates to a mutant bank of diploid micro-organisms which consists of a population of mutant cells in which at least one cell has a random mutation which disrupts the activity of at...
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7303885 |
Screening method for candidate drugs
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to...
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7300793 |
Method for preventing the adhesion of particles
A method for the prevention of the adhesion of particles, in particular cells and cellular components in solution to surfaces, characterized in that to the solution is added at least one polyalcohol.
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7297509 |
Intermediates and enzymes of the non-mevalonate isoprenoid pathway
The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in...
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7297551 |
Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for...
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7291481 |
Assays for trichomonal and other hydrolases
The release by trichomonads of a hydrolase that hydrolyzes a narrowly defined class of substrates at a low pH without interference from hydrolases that are unrelated to trichomoniasis is the basis...
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7285399 |
Compositions and methods using the yeast YMR107W promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7279158 |
Methods for the treatment of inflammatory joint disease
The use of compounds that block complement component C5 or its active fragments C5 a and/or C5 b (such compounds collectively referred to as “C5 blockers”) to treat established joint...
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7276350 |
Method for diagnosing infectious diseases
A method for diagnosing the presence in an animal of an infection due to a microorganism in which a test sample obtained from the animal is exposed to a population of the microorganism and the...
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7273712 |
Methods and compositions for detecting compounds that modulate inflammatory responses
The present invention relates to compositions and methods for identification and development of compounds or therapeutic agents that treat pathophysiological conditions arising from inflammatory...
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7270986 |
Ejection of localized volumes from fluids
A method is provided for acoustically ejecting from a channel or other container a plurality of fluid droplets, each of which contains one or more particles or other localized volumes. The...
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7270993 |
Protease deficient Caulobacter host cells
Caulobacter optimized for use in expression of heterologous peptides as part of a hybrid Caulobacter S-layer protein are provided as well as methods for producing such Caulobacter. Caulobacter ...
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7270977 |
Polypeptides for identifying fungicidally active compounds
The invention relates to polypeptides from phytopathogenic fungi with the biological activity of an inosine monophosphate dehydrogenase, to nucleic acids encoding them, to the use of the...
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7267962 |
Device and method for detecting antibiotic inactivating enzymes
The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is...
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7267937 |
Facile diagnosis and monitoring of pneumocystis carinii infection
Significantly low circulating S-adenosylmethionine levels were found to be diagnostic for human Pneumocystis carinii infection, and rise in levels towards normal correlated with successful...
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7269519 |
Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
The present invention provides a method for identifying a member of a mass-coded combinatorial library which is a ligand for biomolecule and assessing the effect of the binding of the ligand to the...
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7264972 |
Method and apparatus for sorting biological cells with a MEMS device
A micromechanical actuator for sorting hematopoietic stem cells for use in cancer therapies. The actuator operates by diverting cells into one of a number of possible pathways fabricated in the...
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7264815 |
Process for producing a recombinant protein in a mycobacterium host plasmid pJAM2
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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7262020 |
Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or...
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7256012 |
Fluorogenic protease substrates based on dye-dimerization
A method of biological assay comprises the steps of providing an enzyme substrate comprising two fluorescence dye groups bound to a flexible peptide, the dye groups being of proximity sufficiently...
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7256048 |
Method for detection of malaria and other parasite infections
A method of detecting parasite infection, particularly malaria, includes mixing a blood sample with a lytic reagent system to lyse red blood cells, and to form a sample mixture; performing a...
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7244412 |
Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood...
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7244579 |
Methods and materials for diagnosing unstable angina
The invention provides methods and materials for diagnosing an angina condition in a patient. Specifically, the invention provides methods and materials for classifying an angina condition as...
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7241905 |
Dioxin analogues and methods and kits for searching out dioxins-decomposing organisms or enzymes or dioxin-decomposing enzyme genes
The present invention provides a novel dioxin analogue for use in the search for organisms capable of degrading dioxin. The dioxin analogue is represented by the following chemical formula (1) or (2):
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7235403 |
Reagents and methods for identifying gene targets for treating cancer
The invention provides methods and reagents for identifying mammalian genes necessary for tumor cell growth as targets for developing drugs that inhibit expression of said genes and inhibit tumor...
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7235373 |
System for cell-based screening
The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers...
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7232686 |
Method of nanopatterning by forming cracks in a coated polymer substrate
Nanopatterned devices are easily fabricated, over large surface areas when desired, by forming a multilayer article of deformable substrate, brittle layer, and coating layer, and deforming the...
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7229838 |
MEMS actuator and method of manufacture for MEMS particle sorting device
A micromechanical particle sorting chip uses an actuator divided into two parts to direct a component of interest into one of a plurality of possible exit paths, based on detection of a fluorescent...
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7226740 |
Aza-benzazolium containing cyanine dyes
Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically...
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7223555 |
Method for detecting elevated activity of oxidases in insects
A method for checking for elevated activity of mixed-function oxidases using a single insect, includes homogenizing a single insect in an acid pH buffer, preferably by grinding it in a small tube,...
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7220594 |
Method and apparatus for sorting particles with a MEMS device
A micromechanical particle sorting chip uses laser light directed through at least one of a reflective and refractive surface to come to a focus in an optically transparent layer. The laser light...
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7217536 |
Medium and method for detecting/identifying microorganisms
A medium for biological analysis by biochemical means involving chromogenic or fluorogenic substrates that react with enzymes (esterases and/or osidases and/or peptidases and/or sulfatases and/or...
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7214505 |
Cell-based assay for the detection of toxic analytes
Cell-based reagents and methods of using the reagents for detecting analytes are provided. The adsorbing of cells with signal-generating metabolic activity to solid supports has been found to...
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7211407 |
High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
Disclosed are high throughput assay systems and methods for identifying agents that alter the level of surface expression of integral membrane proteins, such as cardiac ion channels, in mammalian...
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7208299 |
Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a...
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7208631 |
2-alkylcysteinamide or salt thereof, process for producing these, and use of these
A process for producing a 2-alkylcysteinamide, which comprises hydrolysis of a 4-alkylthiazolidine-4-carboxamide represented by the general formula (2) or a salt thereof:
wherein R represents a...
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7208286 |
Bioluminescent bioreporter integrated circuit devices and methods for detecting ammonia
Monolithic bioelectronic devices for the detection of ammonia includes a microorganism that metabolizes ammonia and which harbors a lux gene fused with a heterologous promoter gene stably...
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7205132 |
L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
A coryneform bacterium which has an L-glutamic acid-producing ability and grows at least at the same growth rate as a non-mutated strain or a wild-type strain and has intracellular α-ketoglutarate...
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7198946 |
Screening for agents effective in decreasing abnormal macrophages associated with amyotrophic lateral sclerosis
The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy by determining the level of HLA-DR expression by...
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7195899 |
Cell-based biosensor for harmful airborne agents
A method of monitoring an air atmosphere for a harmful biological or chemical agent includes providing a plurality of mammalian respiratory airway epithelial cells borne on a porous support;...
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7192783 |
Stokes shift emission spectroscopy for detection of disease and physiological state of specimen
The Stokes shift emission spectra were measured for various samples, including tissues containing photoactive bio-molecules such as tryptophan, elastin, collagen, NADH and flavin. This new approach...
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7186565 |
Sampling and toxicity monitoring device and method
A method and apparatus for testing an aqueous or gaseous environment for the presence of at least one chemical is provided in order to determine the toxicity of the chemical and optionally, the...
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7186521 |
Determining the effect of a substance on sequestration, uptake, and accumulation of amyloid in brain cells
The present invention provides brain cells, such as normal brain cells, apolipoprotein E deficient brain cells, or apoE4 containing brain cells, that are treated with a compound which can modulate...
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7183047 |
Reporter gene construct for the detection of HIV Rev and HIV Tat
The present invention relates to a reporter gene construct for the detection of the HIV Rev and HIV Tat proteins. Furthermore, the invention relates to a functionality test method for Rev and Rev...
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7183048 |
Kits and methods for determining the effectiveness of sterilization of disinfection processes
The invention relates to methods and kits and methods for assessing the effectiveness of a sterilization process by determining the release of dipicolinic acid (DPA) from bacterial or other spores...
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7183073 |
Method for detecting microorganisms
A device and method are provided for isolating and culturing microorganisms from a bulk fluid sample. The device comprises a container having therein a polymeric immobilization layer having...
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7169414 |
Antimicrobial agents isolated from aloe vera
Antimicrobial agents and method for isolation thereof from the gel liquid of Aloe vera includes at least one antimicrobial agent isolated from the clear gel isolated from the whole leaf of the ...
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