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7481975 |
Hydrogen peroxide indicator and method
The present invention provides a hydrogen peroxide indicator that includes a substrate on which is disposed an indicator composition that includes at least one of a select group of colorants. As a...
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7476510 |
Miniaturized cell array methods and apparatus for cell-based screening
Methods and cassettes for cell-based toxin detection and organ localization are disclosed. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each...
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7473529 |
System and method for detecting cells or components thereof
A system and method for detecting a detectably labeled cell or component thereof in a sample comprising one or more cells or components thereof, at least one cell or component thereof of which is...
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7468255 |
Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
The present invention includes a method of measuring cytolytic activity including providing a device capable of monitoring cell-substrate impedance operably connected to an impedance analyzer,...
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7468260 |
Method of detecting and using an expression-enhancing sequence
The invention relates to a method of detecting a DNA sequence which at least partially contributes to promote the stable expression of a gene. To this end the DNA fragment to be examined is cloned...
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7465543 |
Multiplex DNA identification of clinical yeasts using flow cytometry
Oligonucleotide probes that are specific for pathogenic yeasts and which may be used for the detection of such yeasts in biological samples are described. These probes are specific for yeast...
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7465558 |
Perfusion system and apparatus for automated multi-channel patch-clamp recordings utilizing inside-out whole-cell configuration
A system and method for high throughput patch clamp measurements to study the effect of various chemicals on ion transfer channels is provided. One or more patch clamp configurations is...
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7462464 |
Method for the detection of antimicrobial residues in food and bodily fluid samples
The present invention relates to a novel method for the rapid detection of the presence or absence of antimicrobial residues in products preferably food products.
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7459287 |
Method for determination and quantification of radiation or genotoxin exposure
The present invention discloses methods for detecting exposure of a living subject to genotoxic agents, testing sensitivity to a genotoxic agent, and determining DNA damage caused by exposure to an...
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7452670 |
Methods of identifying agents that diminish cellular toxicity associated with an α-synuclein polypeptide of Parkinson's disease in yeast
Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and...
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7445888 |
Methods for assaying for antidepressant therapy markers
The present invention relates generally to methods for assaying for agents that modify the association of G sα with components of the plasma membrane or cytoskeleton of cells. The present...
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7447340 |
Device and method for automatically producing a thermal recoil response in nematodes
The invention relates to a device ( 10 ) and a method for automatically eliciting a thermal avoidance response in nematodes, particularly in order to test pharmaceutical substances. The device ( 10...
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7439015 |
Methods for detecting DNA viruses
A DNA virus in a sample is detected by contacting the sample with host cells that have been transiently transfected with a reporter sequence under the control of a virus-specific promoter, and then...
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7439062 |
Beads for capturing target cells from bodily fluid
Spheroidal beads present an exterior surface of a hydrophilic hydrogel, which is an isocyanate-functional polymer that is polymerized by urethane bonds and cross-linked by urethane and urea bonds....
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7439048 |
Apparatus for acoustic ejection of circumscribed volumes from a fluid
This invention is directed to the use of focused energy, particularly focused acoustic energy, in the spatially directed ejection of circumscribed volumes of a fluid which differ in acoustic...
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7432511 |
Method of operating liquid in the vacuum or low-pressure environment and observing the operation and device for the operation and observation
A method of operating liquid in a vacuum or low-pressure environment and observing the operation and a device for the operation and the observation respectively, including the steps of preparing a...
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7425411 |
Method for recovering microorganisms from a sample
The present invention provides for a method for recovering microorganisms from a sample that is rapid and provides microorganisms substantially free of adsorbents and other particles. The method...
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7425410 |
Methods for diagnosing a bipolar disorder and unipolar disorder
Changes that occur in Na+K+ ATPase regulation and therefore in the membrane potential in cells from bipolar individuals, as compared to cells from unaffected control individuals, are utilized to...
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7422868 |
Microbial ATP extraction and detection system
The present invention is directed to compositions and methods for single-step extraction and detection of ATP levels from microbial cells. The disclosed compositions are formulated to efficiently...
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7422871 |
Uropathogenic E. coli D-serine detoxification operon
Disclosed are methods of detecting uropathogenic E. coli genes that are differentially expressed in response to D-serine. Also disclosed are methods of characterizing bacterial isolates from...
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7415144 |
Cell observation device and cell observation method
The cell observation device and method aims to easily study the correlation between initial states of cells and their reactions without using a synchronous culture method. For this purpose, the...
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7413871 |
Scoring method for determining pancreas suitability for islet isolation
The invention relates to a method for evaluating a pancreas as a source of therapeutically useful islets. A scoring system is set forth whereby 5 criteria are listed. If three criteria are...
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7399608 |
Microbial detection and quantification
A method for semi-quantitatively or quantitatively detecting the presence of a microbe in a sample is provided. The method utilizes a test dye that undergoes a detectable color change in the...
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7390620 |
Screening method for anti-microbial drug targets by genome-saturating mutagenesis (GSM)
This invention relates to a novel method for the identification of obligatory essential nucleic acid sequences, in particular microbial sequences. Further, a method for the identification of novel...
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7390626 |
Methods and kit for diagnosing tick borne illnesses
ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different...
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7384733 |
Interface patch clamping
The invention provides a novel development of the conventional patch clamp technique for measurement of whole cell electrical activity. The invention provides for one or more cell or cells to be...
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7378232 |
Assay for melanogenesis
The invention provides methods for the identification of agents that modify or mimic P protein function. Cells expressing a P protein are generally more sensitive to toxins, and changes in cell...
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7374904 |
Products containing quantum of bioparticles and method for production thereof
A method for forming a substantially solid product containing a desired quantum of bioparticle, the method comprising (a) providing a sample of bioparticle in liquid form; (b) selecting a desired...
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7374903 |
Substrates with topographical features for the manipulation of cellular behavior and response
The present invention relates to novel substrates, to methods of making them and to uses therefor. The substrates of the invention comprise a base portion and a surface layer covering at least part...
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7374905 |
Medium composition, method and device for selectively enhancing the isolation of anaerobic microorganisms contained in a mixed sample with facultative microorganisms
The present invention is directed to a medium, broth or agar, and a method of utilizing the same, in order to isolate and/or identify anaerobes from a mixed sample that contains facultative...
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7371575 |
Process for ex vivo formation of mammalian bone and uses thereof
The present invention concerns methods for the ex vivo formation of mammalian bone and subsequent uses of the bone. A critical and distinguishing feature of the present invention are defined tissue...
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7368259 |
Method for generating diversity
The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a)...
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7368257 |
Modulators of lymphocyte activation, Mkk3b compositions and methods of use
The present invention provides compositions and methods for modulating lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating lymphocyte...
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7364899 |
Device for monitoring haptotaxis
The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first...
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7358064 |
Kits for measuring cellular transmembrane potential changes
The invention encompasses kits for an improved method for measuring membrane potential using compounds of the formula I as potentiometric probes. These probes may be used in combination with other...
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7358089 |
Process for producing a substrate for attachment of cells
A process for production of a substrate for attachment of cells at certain positions and a substrate for attachment of cells. A support structure comprising a hydrophobic resin base material and a...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7344853 |
Methods for diagnosis and monitoring of neurological disease by detection of an encephalotoxin
Encephalotoxin produced by activated mononuclear phagocytes is present in individuals having neurological disease including neurodegenerative and neuro-inflammatory diseases, such as Alzheimer's...
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7341845 |
Method for identifying kinesin inhibitors
The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin...
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7338778 |
Luminescent method for determining cell oxygen consumption
The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods...
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7335485 |
Device and method for determining antibiotic susceptibility
The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7332340 |
Process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis
The present invention relates to a process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis comprising testing M....
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7329504 |
Methods of preventing or treating cell migration mediated conditions or diseases
The present invention relates to methods of identifying agents which modulate the activity of PIPKIγ661. Methods of using such agents to prevent or treat a cell migration-mediated condition or...
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7323318 |
Assay for distinguishing live and dead cells
Image analysis methods and apparatus are used for distinguishing live and dead cells. The methods may involve segmenting an image to identify the region(s) occupied by one or more cells and...
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7316930 |
Use of vertically stacked photodiodes in a gene chip system
An improved gene chip system is arranged with vertically stacked photodiodes for sensing luminescence of genetic material. When genetic samples are combined with a reagent in an array of wells on a...
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7316913 |
Methods and means for influencing intracellular communication and intracellular organelle transport
The invention relates to a method for the investigation of intercellular communication and intercellular transport, wherein after singularisation cells are investigated for membrane tubes which...
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7314731 |
Method for selecting therapeutic agents for cancer
The present invention discloses in vitro methods for screening candidate therapeutic and/or chemotherapeutic agents for in vivo efficacy in a specific patient. The invention also includes methods...
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7312047 |
Screening assay for improvement of epithelial barrier function
The present invention relates to the use of an air-liquid interface culture model using asthmatic bronchial epithelial cells, which exhibit impaired epithelial barrier function. It is proposed to...
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7312046 |
Method of screening compounds using a nanoporous silicon support containing macrowells for cells
A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of...
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