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6468735 |
Angiogenesis assay
The present invention relates to assays and kits using porcine carotid arteries for screening compounds to identify modulators of angiogenesis. In particular, an assay for rapidly screening...
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6465205 |
In vitro cell culture device including cartilage and methods of using the same
The present invention relates to an in vitro cell culture device which includes a vessel comprising an inner surface, a layer of cartilage disposed on at least a portion of said inner surface, the...
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6465197 |
Assay for sperm quality
A method for evaluating sperm quality is disclosed. The first step of the method is to obtain a quantity of sample mammalian sperm and a sample of mature mammalian oocytes. The oocytes are...
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6461806 |
Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
The present invention relates to methods for measuring the proliferation and destruction rates of cells by measuring deoxyribonucleic acid (DNA) synthesis and/or destruction. In particular, the...
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6461860 |
Alignment mechanism for two-electrode voltage-clamp perfusion chamber for electrophysiological testing of oocytes
An automated mechanism for guiding a microelectrode toward an oocyte placed in a perfusion chamber consists of a movable guide tube holding the electrode and a fixed guide collar in fixed relation...
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6458553 |
Card for counting and characterizing microorganisms
The invention concerns an analysis card as well as a method for filing such a card and the use of said card. Said card comprises a body consisting of: a zone for injecting into the card a...
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6458322 |
Method for simplified shipping of clinical specimens and optional direct analysis
A method for shipping clinical specimens lawfully, safely, cheaply, and easily without regard to some or all of the laws, rules, and regulations regarding samples that may contain infectious and/or...
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6455271 |
Identification of novel antimicrobial agents using membrane potential indicator dyes
Novel screening methods for identifying antimicrobial agents involving use of membrane potential indicator dyes are provided.
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6455673 |
Multi-mutant diphtheria toxin vaccines
Disclosed are diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.
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6452065 |
Transgenic mouse expressing non-native wild-type and familial Alzheimer's Disease mutant presenilin 1 protein on native presenilin 1 null background
The present invention relates to a transgenic non-human animal embryo lacking native presenilin 1 and a transgenic non-human animal having only a non-native presenilin 1. The transgenic animals and...
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6451608 |
Method for measuring amount of active oxygen produced by leukocytes and oxidative stress
A method for measuring luminol enhancing light emission without separating leukocytes and erythrocytes, that is, using whole blood and a method for measuring the number of leukocytes trapped by the...
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6448030 |
Method for predicting the efficacy of anti-cancer drugs
A method for measuring both the anti-migratory and cytotoxic effects of anticancer drugs on cancer tissues measuring the chemosensitivity of human biopsies to therapeutic drugs. Single cell...
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6448069 |
Embryo-culturing apparatus and method
An embryo culturing method and apparatus enables a plurality of embryos to be grown in communal clusters in a culturing container. The embryos are kept separate from each other in open...
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6448085 |
Quality control material and calibrator for nucleated red blood cell tested on hematology analyzer
A method for the quality control of nucleated red blood cells on a hematology analyzer using a mixture of human and animal blood, particularly chicken blood and fixed human blood with nucleated red...
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6448009 |
Method for target site selection and discovery
Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.
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6444471 |
Reticulocyte containing complete blood control
A control composition, and method of preparing a control composition, that includes stabilized, maturation-arrested reticulocytes, and a complete blood count base including mature erythrocytes,...
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6440689 |
Measurement of microbiological activity in an opaque medium
A method for monitoring the microbiological contamination of opaque media is described and claimed. In this method, a Fluorogenic Dye is added to an Aliquot of opaque medium. After a certain time...
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6436632 |
Multi-through hole testing plate for high throughput screening
A method for holding samples for analysis and an apparatus thereof includes a testing plate with a pair of opposing surfaces and a plurality of holes. Each of the holes extends from one of the...
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6436659 |
Biological indicator for sterilization processes with double buffer system
A method and an apparatus for preventing reversion of the color of an indicator dye in a biological indicator is disclosed. The indicator dye changes color if viable microorganisms are present...
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6436631 |
Comparative phenotype analysis for assessment of biologically active compounds such as antimicrobials
The present invention relates to using multitest panels to improve the effectiveness, throughput, and efficiency of testing and commercial development of biologically active compounds, in...
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6436649 |
Method for detecting and/or quantifying a hapten in a homogeneous phase and device for implementation thereof
The invention discloses a method for detecting and/or quantifying a hapten in a homogeneous phase, comprising the following steps: adding a known quantity of a hapten inhibitor complex to the...
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6432665 |
Method of detecting microorganisms utilizing transparent sample container
The present invention relates to a transparent sample container containing, preferably, a liquid bacterial growth media for detecting microbacteria and a process for detecting microbacteria using...
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6432663 |
Multi-channel plate
The present invention relates to a novel container and process, and more specifically, to a rectilinear plastic container whose interior is divided into two or more channels (a multi-channel plate)...
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6432664 |
Processes of screening for an antimycotic agent
The invention provides an isolated gene coding for a protein regulating aureobasidin sensitivity; a process for cloning the gene with the use of the gene or a part of the same as a probe; a nucleic...
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6428973 |
Compositions and methods for evaluating bone resorption
Compositions and methods for the evaluation of bone resorption and bone resorption-related diseases are disclosed. The compositions include a human osteoclast-like cell line capable of resorbing...
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6428976 |
Rapid identification of microorganisms
A method of determining whether a test microorganism is a known microorganism, involving use of an agent that specifically affects the growth of the known microorganism. The invention also features...
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6428969 |
Method for determining oncogenic activity of a substance
A method for screening substances for oncogenic activity is disclosed. The method involves administering the substance to an animal lacking responsiveness to interferonγ and detecting a higher...
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6428746 |
Method for determining the efficacy of a decontamination procedure
A method determines an efficacy of a decontamination procedure. The method includes providing a test object and a control object. The test object is contaminated with a first known amount of...
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6423270 |
Flow cytometric characterization of amyloid fibrils
A method of detecting amyloid fibrils in biological samples utilizing flow cytometry is described. It has been found that the measurement of fluorescence from amyloidophilic dyes, such as...
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6423494 |
DR6 and uses thereof
Increased expression of DR6 is associated with drug resistance of certain cells (e.g., cancer cells). The invention provides methods for identifying drug resistant cells by measuring the expression...
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6423497 |
Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
This invention relates to methods of amplifying nucleic acids to minimize contamination by products of earlier amplification reactions. More particularly, it relates to methods of using nucleic...
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6420183 |
Masking background fluorescence and luminescence in optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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6416967 |
Method of using multicellular particulates to analyze malignant or hyperproliferative tissue
A comprehensive and integrated system for monitoring (identifying, tracking and analyzing) an individual patient's malignancy or hyperproliferative syndrome through the duration of a malignancy or...
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6413735 |
Method of screening for a modulator of angiogenesis
Polynucleotides encoding mammalian ECM signalling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis....
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6413782 |
Methods of manufacturing high-throughput screening systems
Microfluidic devices for analyzing a plurality of compounds are manufactured for performing high throughput screening assays. The methods are used to manufacture devices that screen large numbers...
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6413719 |
KCNQ2 and KCNQ3-potassium channel genes which are mutated in benign familial neonatal convulsions (BFNC) and other epilepsies
Generalized idiopathic epilepsies (IGE) cause 40% of all seizures and commonly have a genetic basis. One type of IGE is Benign Familial Neonatal Convulsions (BFNC), a dominantly inherited disorder...
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6413952 |
Agonizing dimeric cell-surface receptors with a receptor binding moiety and chelating metal
Dimeric cell-surface receptors in a subject are agonized by administering a metal chelated dimeric cell-surface receptor ligand formed by chelating a receptor binding moiety with a metal ion such...
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6410257 |
Methods to assay gene function with viral vectors
The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of...
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6410334 |
Method for determining the immune defense of blood and test kit for the same and use of a suitable blood sampling system
The invention relates to a method for the determination of the immune defence activity of blood by the stimulation of white cells in the whole blood, incubation of the whole blood, separation of...
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6410333 |
Assessment of human skin damage following exposure to harmful agents
The present invention relates to the assessment of ultraviolet radiation UV effects on sunscreen-treated and non-treated human skin using a more sensitive technique.
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6410256 |
Method of making biofilms
Biofilm forming organisms are incubated to form a biofilm on projections by providing a flow of liquid growth medium across projections, the direction of the flow of liquid being repeatedly...
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6406863 |
High throughput generation and screening of fully human antibody repertoire in yeast
Compostions, kits and methods are provided for generating highly diverse libraries of proteins such as antibodies via homologous recombination in vivo, and screening these libraries against...
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6406679 |
Use of HL-60-related lectins in drug delivery and detection of lectin-expressing cells
Pharmaceutical compositions useful in the treatment of autoimmune conditions include as an active ingredient a soluble lectin having a molecular weight of about 14 kilodaltons or a fragment...
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6406879 |
Device and method for testing biocidal efficacy of a liquid
A test device and a method for assessing the biocidal efficacy of a liquid are disclosed. The device includes: a vessel, an inlet in communication with said vessel, means for introducing a...
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6406881 |
Dosing and development of antimicrobial and antiviral drugs determined by restriction of resistant mutant selection
The invention is based on the discovery that, for many drugs (e.g., antiviral or antimicrobial drugs such as antifungal or antibacterial drugs, including bacteriocidal or bacteriostatic drugs) and...
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6403378 |
Cell viability assay reagent
A kit for labeling cells to determine their viability which includes a first dye for labeling non-viable cells and a second dye for labeling all cells, including non-viable cells in which the dyes...
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6403333 |
Method for determining the existence of a biological activity of microorganisms
The invention relates to a method enabling the existence of a biological activity of microorganisms to be determined quickly by applying an electric field. The inventive method includes the...
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6403376 |
Ultra rapid freezing for cell cryopreservation
A method for preserving biological material includes the steps of placing the biological material in thermal contact with a cryogenically coolable environment, cooling the surrounding environment...
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6395473 |
Adenoviral based promoter assay
Adenoviral vectors are used to transfer a promoter/reporter gene construct to mammalian cell cultures. The promoter/reporter gene construct is used to determine if a candidate inducing agent has...
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6395505 |
Cell activity assay apparatus and methods for making and using same
A cell activity assay apparatus (“CAAA”) and method using electromagnetic radiation detection beams to measure the cell activity, e.g., chemotactic response, includes an opaque membrane having...
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